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Items: 1 to 50 of 233

1.

Correction: Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes.

Walter V, Yin X, Wilkerson MD, Cabanski CR, Zhao N, Du Y, Ang MK, Hayward MC, Salazar AH, Hoadley KA, Fritchie K, Sailey CJ, Weissler MC, Shockley WW, Zanation AM, Hackman T, Thorne LB, Funkhouser WD, Muldrew KL, Olshan AF, Randell SH, Wright FA, Shores CG, Hayes DN.

PLoS One. 2018 Mar 15;13(3):e0194674. doi: 10.1371/journal.pone.0194674. eCollection 2018.

2.

HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues.

Li G, Jima D, Wright FA, Nobel AB.

BMC Bioinformatics. 2018 Mar 9;19(1):95. doi: 10.1186/s12859-018-2088-3.

3.

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.

Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM.

BMC Bioinformatics. 2018 Mar 5;19(1):80. doi: 10.1186/s12859-018-2089-2.

4.

An improved and explicit surrogate variable analysis procedure by coefficient adjustment.

Lee S, Sun W, Wright FA, Zou F.

Biometrika. 2017 Jun;104(2):303-316. doi: 10.1093/biomet/asx018. Epub 2017 Apr 21.

PMID:
29430031
5.

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.

Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I.

Mamm Genome. 2018 Feb;29(1-2):168-181. doi: 10.1007/s00335-018-9734-y. Epub 2018 Jan 20.

PMID:
29353386
6.

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics.

House JS, Grimm FA, Jima DD, Zhou YH, Rusyn I, Wright FA.

Front Genet. 2017 Nov 1;8:168. doi: 10.3389/fgene.2017.00168. eCollection 2017.

7.

Estimation of cis-eQTL effect sizes using a log of linear model.

Palowitch J, Shabalin A, Zhou YH, Nobel AB, Wright FA.

Biometrics. 2017 Oct 26. doi: 10.1111/biom.12810. [Epub ahead of print]

PMID:
29073327
8.

An empirical Bayes approach for multiple tissue eQTL analysis.

Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB.

Biostatistics. 2017 Sep 25. doi: 10.1093/biostatistics/kxx048. [Epub ahead of print]

PMID:
29029013
9.

An improved and explicit surrogate variable analysis procedure by coefficient adjustment.

Lee S, Sun W, Wright FA, Zou F.

Biometrika. 2017 Jun 1;2(1):303-316. Epub 2017 Apr 21.

10.

Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.

Zhou YH, Cichocki JA, Soldatow VY, Scholl EH, Gallins PJ, Jima D, Yoo HS, Chiu WA, Wright FA, Rusyn I.

Toxicol Sci. 2017 Nov 1;160(1):95-110. doi: 10.1093/toxsci/kfx165.

PMID:
28973375
11.

A procedure to detect general association based on concentration of ranks.

Rudra P, Zhou Y, Wright FA.

Stat (Int Stat Inst). 2017;6(1):88-101. doi: 10.1002/sta4.138. Epub 2017 Feb 16.

12.

Airway Mucosal Host Defense Is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity.

Polineni D, Dang H, Gallins PJ, Jones LC, Pace RG, Stonebraker JR, Commander LA, Krenicky JE, Zhou YH, Corvol H, Cutting GR, Drumm ML, Strug LJ, Boyle MP, Durie PR, Chmiel JF, Zou F, Wright FA, O'Neal WK, Knowles MR.

Am J Respir Crit Care Med. 2018 Jan 1;197(1):79-93. doi: 10.1164/rccm.201701-0134OC.

PMID:
28853905
13.

Eigenvalue significance testing for genetic association.

Zhou YH, Marron JS, Wright FA.

Biometrics. 2017 Aug 29. doi: 10.1111/biom.12767. [Epub ahead of print]

PMID:
28853138
14.

Residential age care and domiciliary oral health services: Reach-OHT-The development of a metropolitan oral health programme in Sydney, Australia.

Wright FAC, Law G, Chu SK, Cullen JS, Le Couteur DG.

Gerodontology. 2017 Dec;34(4):420-426. doi: 10.1111/ger.12282. Epub 2017 Jul 19.

PMID:
28722250
15.

Computation of ancestry scores with mixed families and unrelated individuals.

Zhou YH, Marron JS, Wright FA.

Biometrics. 2018 Mar;74(1):155-164. doi: 10.1111/biom.12708. Epub 2017 Apr 27.

PMID:
28452052
16.

Multifunctional Telodendrimer Nanocarriers Restore Synergy of Bortezomib and Doxorubicin in Ovarian Cancer Treatment.

Wang L, Shi C, Wright FA, Guo D, Wang X, Wang D, Wojcikiewicz RJH, Luo J.

Cancer Res. 2017 Jun 15;77(12):3293-3305. doi: 10.1158/0008-5472.CAN-16-3119. Epub 2017 Apr 10.

PMID:
28396359
17.

Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism.

Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I.

Toxicol Sci. 2017 Jul 1;158(1):48-62. doi: 10.1093/toxsci/kfx065.

PMID:
28369613
18.

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues.

Liu X, Finucane HK, Gusev A, Bhatia G, Gazal S, O'Connor L, Bulik-Sullivan B, Wright FA, Sullivan PF, Neale BM, Price AL.

Am J Hum Genet. 2017 Apr 6;100(4):605-616. doi: 10.1016/j.ajhg.2017.03.002. Epub 2017 Mar 23.

19.

Conditional eQTL analysis reveals allelic heterogeneity of gene expression.

Jansen R, Hottenga JJ, Nivard MG, Abdellaoui A, Laport B, de Geus EJ, Wright FA, Penninx BWJH, Boomsma DI.

Hum Mol Genet. 2017 Apr 15;26(8):1444-1451. doi: 10.1093/hmg/ddx043.

PMID:
28165122
20.

A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives.

Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I.

Green Chem. 2016 Aug 21;18(16):4407-4419. doi: 10.1039/c6gc01147k. Epub 2016 May 16.

21.

A tiered, Bayesian approach to estimating of population variability for regulatory decision-making.

Chiu WA, Wright FA, Rusyn I.

ALTEX. 2017;34(3):377-388. doi: 10.14573/altex.1608251. Epub 2016 Dec 13.

22.

Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.

Tian X, Patel K, Ridpath JR, Chen Y, Zhou YH, Neo D, Clement J, Takata M, Takeda S, Sale J, Wright FA, Swenberg JA, Nakamura J.

PLoS One. 2016 Dec 1;11(12):e0167503. doi: 10.1371/journal.pone.0167503. eCollection 2016.

23.

Complete Genome Sequence of a Bacterium Representing a Deep Uncultivated Lineage within the Gammaproteobacteria Associated with the Degradation of Polycyclic Aromatic Hydrocarbons.

Singleton DR, Dickey AN, Scholl EH, Wright FA, Aitken MD.

Genome Announc. 2016 Oct 6;4(5). pii: e01086-16. doi: 10.1128/genomeA.01086-16.

24.

INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans.

Hegsted A, Wright FA, Votra S, Pruyne D.

Cytoskeleton (Hoboken). 2016 Dec;73(12):712-728. doi: 10.1002/cm.21341. Epub 2016 Nov 9.

25.

Chapter 4 - Inositol 1,4,5-Trisphosphate Receptor Ubiquitination.

Wright FA, Wojcikiewicz RJ.

Prog Mol Biol Transl Sci. 2016;141:141-59. doi: 10.1016/bs.pmbts.2016.02.004. Epub 2016 Mar 30. Review.

PMID:
27378757
26.

The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors.

Schulman JJ, Wright FA, Han X, Zluhan EJ, Szczesniak LM, Wojcikiewicz RJ.

J Biol Chem. 2016 May 27;291(22):11820-8. doi: 10.1074/jbc.M115.711242. Epub 2016 Apr 6.

27.

Integrative approaches for large-scale transcriptome-wide association studies.

Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B.

Nat Genet. 2016 Mar;48(3):245-52. doi: 10.1038/ng.3506. Epub 2016 Feb 8.

28.

Erratum: Prediction of human population responses to toxic compounds by a collaborative competition.

Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O; NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J.

Nat Biotechnol. 2015 Oct;33(10):1109. doi: 10.1038/nbt1015-1109a. No abstract available.

PMID:
26448092
29.

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis.

Corvol H, Blackman SM, Boëlle PY, Gallins PJ, Pace RG, Stonebraker JR, Accurso FJ, Clement A, Collaco JM, Dang H, Dang AT, Franca A, Gong J, Guillot L, Keenan K, Li W, Lin F, Patrone MV, Raraigh KS, Sun L, Zhou YH, O'Neal WK, Sontag MK, Levy H, Durie PR, Rommens JM, Drumm ML, Wright FA, Strug LJ, Cutting GR, Knowles MR.

Nat Commun. 2015 Sep 29;6:8382. doi: 10.1038/ncomms9382.

30.

In vitro screening for population variability in toxicity of pesticide-containing mixtures.

Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I.

Environ Int. 2015 Dec;85:147-55. doi: 10.1016/j.envint.2015.09.012. Epub 2015 Sep 19.

31.

Prediction of human population responses to toxic compounds by a collaborative competition.

Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O; NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J.

Nat Biotechnol. 2015 Sep;33(9):933-40. doi: 10.1038/nbt.3299. Epub 2015 Aug 10. Erratum in: Nat Biotechnol. 2015 Oct;33(10):1109. Friend, Stephen; Dearry, Allen; Simeonov, Anton; Tice, Raymond R; Rusyn, Ivan; Wright, Fred A; Stolovitzky, Gustavo; Xie, Yang; and Saez-Rodriguez, Julio [Added].

32.

Gene expression in major depressive disorder.

Jansen R, Penninx BW, Madar V, Xia K, Milaneschi Y, Hottenga JJ, Hammerschlag AR, Beekman A, van der Wee N, Smit JH, Brooks AI, Tischfield J, Posthuma D, Schoevers R, van Grootheest G, Willemsen G, de Geus EJ, Boomsma DI, Wright FA, Zou F, Sun W, Sullivan PF.

Mol Psychiatry. 2016 Mar;21(3):444. doi: 10.1038/mp.2015.94. Epub 2015 Jun 23. No abstract available.

PMID:
26100536
33.

The projack: a resampling approach to correct for ranking bias in high-throughput studies.

Zhou YH, Wright FA.

Biostatistics. 2016 Jan;17(1):54-64. doi: 10.1093/biostatistics/kxv022. Epub 2015 Jun 3.

34.

Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer.

Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, González-Horta Mdel C, Sánchez-Ramírez B, Ballinas-Casarrubias L, Gutiérrez-Torres DS, Drobná Z, Del Razo LM, García-Vargas GG, Kim WY, Zhou YH, Wright FA, Stýblo M, Fry RC.

Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.

35.

Gene expression in major depressive disorder.

Jansen R, Penninx BW, Madar V, Xia K, Milaneschi Y, Hottenga JJ, Hammerschlag AR, Beekman A, van der Wee N, Smit JH, Brooks AI, Tischfield J, Posthuma D, Schoevers R, van Grootheest G, Willemsen G, de Geus EJ, Boomsma DI, Wright FA, Zou F, Sun W, Sullivan PF.

Mol Psychiatry. 2016 Mar;21(3):339-47. doi: 10.1038/mp.2015.57. Epub 2015 May 26. Erratum in: Mol Psychiatry. 2016 Mar;21(3):444.

PMID:
26008736
36.

Sharing and Specificity of Co-expression Networks across 35 Human Tissues.

Pierson E; GTEx Consortium, Koller D, Battle A, Mostafavi S, Ardlie KG, Getz G, Wright FA, Kellis M, Volpi S, Dermitzakis ET.

PLoS Comput Biol. 2015 May 13;11(5):e1004220. doi: 10.1371/journal.pcbi.1004220. eCollection 2015 May.

37.

Human genomics. The human transcriptome across tissues and individuals.

Melé M, Ferreira PG, Reverter F, DeLuca DS, Monlong J, Sammeth M, Young TR, Goldmann JM, Pervouchine DD, Sullivan TJ, Johnson R, Segrè AV, Djebali S, Niarchou A; GTEx Consortium, Wright FA, Lappalainen T, Calvo M, Getz G, Dermitzakis ET, Ardlie KG, Guigó R.

Science. 2015 May 8;348(6235):660-5. doi: 10.1126/science.aaa0355.

38.

A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+ Signaling.

Wright FA, Lu JP, Sliter DA, Dupré N, Rouleau GA, Wojcikiewicz RJ.

J Biol Chem. 2015 May 29;290(22):13948-57. doi: 10.1074/jbc.M115.655043. Epub 2015 Apr 16.

39.

Complete Genome Sequence of a Novel Bacterium within the Family Rhodocyclaceae That Degrades Polycyclic Aromatic Hydrocarbons.

Singleton DR, Dickey AN, Scholl EH, Wright FA, Aitken MD.

Genome Announc. 2015 Apr 9;3(2). pii: e00251-15. doi: 10.1128/genomeA.00251-15.

40.

Hypothesis testing at the extremes: fast and robust association for high-throughput data.

Zhou YH, Wright FA.

Biostatistics. 2015 Jul;16(3):611-25. doi: 10.1093/biostatistics/kxv007. Epub 2015 Mar 18.

41.

An analysis of the therapeutic benefits of genotyping in pediatric hematopoietic stem cell transplantation.

Wright FA, Bebawy M, O'Brien TA.

Future Oncol. 2015;11(5):833-51. doi: 10.2217/fon.14.307. Review.

PMID:
25757685
42.

Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes.

O'Neal WK, Gallins P, Pace RG, Dang H, Wolf WE, Jones LC, Guo X, Zhou YH, Madar V, Huang J, Liang L, Moffatt MF, Cutting GR, Drumm ML, Rommens JM, Strug LJ, Sun W, Stonebraker JR, Wright FA, Knowles MR.

Am J Hum Genet. 2015 Feb 5;96(2):318-28. doi: 10.1016/j.ajhg.2014.12.022. Epub 2015 Jan 29.

43.

Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.

Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA.

Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.

44.

Metabolomic Evaluation of Neutrophilic Airway Inflammation in Cystic Fibrosis.

Esther CR Jr, Coakley RD, Henderson AG, Zhou YH, Wright FA, Boucher RC.

Chest. 2015 Aug;148(2):507-515. doi: 10.1378/chest.14-1800.

45.
46.

Heritability and genomics of gene expression in peripheral blood.

Wright FA, Sullivan PF, Brooks AI, Zou F, Sun W, Xia K, Madar V, Jansen R, Chung W, Zhou YH, Abdellaoui A, Batista S, Butler C, Chen G, Chen TH, D'Ambrosio D, Gallins P, Ha MJ, Hottenga JJ, Huang S, Kattenberg M, Kochar J, Middeldorp CM, Qu A, Shabalin A, Tischfield J, Todd L, Tzeng JY, van Grootheest G, Vink JM, Wang Q, Wang W, Wang W, Willemsen G, Smit JH, de Geus EJ, Yin Z, Penninx BW, Boomsma DI.

Nat Genet. 2014 May;46(5):430-7. doi: 10.1038/ng.2951. Epub 2014 Apr 13.

47.

Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):499-505. doi: 10.1289/ehp.1307539. Epub 2014 Feb 25.

48.

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Chiu WA, Campbell JL Jr, Clewell HJ 3rd, Zhou YH, Wright FA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):456-63. doi: 10.1289/ehp.1307623. Epub 2014 Feb 11.

49.

Sex differences in the human peripheral blood transcriptome.

Jansen R, Batista S, Brooks AI, Tischfield JA, Willemsen G, van Grootheest G, Hottenga JJ, Milaneschi Y, Mbarek H, Madar V, Peyrot W, Vink JM, Verweij CL, de Geus EJ, Smit JH, Wright FA, Sullivan PF, Boomsma DI, Penninx BW.

BMC Genomics. 2014 Jan 17;15:33. doi: 10.1186/1471-2164-15-33.

50.

Unified Analysis of Secondary Traits in Case-Control Association Studies.

Ghosh A, Wright FA, Zou F.

J Am Stat Assoc. 2013;108(502). doi: 10.1080/01621459.2013.793121.

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