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Items: 1 to 50 of 361

1.

Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin.

Sundberg M, Tochitsky I, Buchholz DE, Winden K, Kujala V, Kapur K, Cataltepe D, Turner D, Han MJ, Woolf CJ, Hatten ME, Sahin M.

Mol Psychiatry. 2018 Feb 15. doi: 10.1038/s41380-018-0018-4. [Epub ahead of print]

PMID:
29449635
2.

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.

Cobos EJ, Nickerson CA, Gao F, Chandran V, Bravo-Caparrós I, González-Cano R, Riva P, Andrews NA, Latremoliere A, Seehus CR, Perazzoli G, Nieto FR, Joller N, Painter MW, Ma CHE, Omura T, Chesler EJ, Geschwind DH, Coppola G, Rangachari M, Woolf CJ, Costigan M.

Cell Rep. 2018 Jan 30;22(5):1301-1312. doi: 10.1016/j.celrep.2018.01.006.

3.

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.

Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM.

Nat Commun. 2018 Jan 2;9(1):37. doi: 10.1038/s41467-017-02448-6.

4.

Sense and Immunity: Context-Dependent Neuro-Immune Interplay.

Foster SL, Seehus CR, Woolf CJ, Talbot S.

Front Immunol. 2017 Nov 3;8:1463. doi: 10.3389/fimmu.2017.01463. eCollection 2017. Review.

5.

Mouse embryonic stem cells can differentiate via multiple paths to the same state.

Briggs JA, Li VC, Lee S, Woolf CJ, Klein A, Kirschner MW.

Elife. 2017 Oct 9;6. pii: e26945. doi: 10.7554/eLife.26945.

6.

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.

Chen Y, Zeng X, Huang X, Serag S, Woolf CJ, Spiegelman BM.

Cell. 2017 Nov 2;171(4):836-848.e13. doi: 10.1016/j.cell.2017.09.015. Epub 2017 Oct 5.

PMID:
28988768
7.

Breaking barriers to novel analgesic drug development.

Yekkirala AS, Roberson DP, Bean BP, Woolf CJ.

Nat Rev Drug Discov. 2017 Nov;16(11):810. doi: 10.1038/nrd.2017.202. Epub 2017 Oct 6.

PMID:
28983099
8.

Optical cuff for optogenetic control of the peripheral nervous system.

Michoud F, Sottas L, Browne LE, Asboth L, Latremoliere A, Sakuma M, Courtine G, Woolf CJ, Lacour SP.

J Neural Eng. 2018 Feb;15(1):015002. doi: 10.1088/1741-2552/aa9126.

PMID:
28978778
9.

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury.

Lisi V, Singh B, Giroux M, Guzman E, Painter MW, Cheng YC, Huebner E, Coppola G, Costigan M, Woolf CJ, Kosik KS.

Cell Rep. 2017 Aug 1;20(5):1136-1147. doi: 10.1016/j.celrep.2017.07.010.

10.

Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses.

Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ.

Cell Rep. 2017 Jul 5;20(1):89-98. doi: 10.1016/j.celrep.2017.06.024.

11.

Breaking barriers to novel analgesic drug development.

Yekkirala AS, Roberson DP, Bean BP, Woolf CJ.

Nat Rev Drug Discov. 2017 Aug;16(8):545-564. doi: 10.1038/nrd.2017.87. Epub 2017 Jun 9. Review. Erratum in: Nat Rev Drug Discov. 2017 Oct 06;:.

12.

Decreased alertness due to sleep loss increases pain sensitivity in mice.

Alexandre C, Latremoliere A, Ferreira A, Miracca G, Yamamoto M, Scammell TE, Woolf CJ.

Nat Med. 2017 Jun;23(6):768-774. doi: 10.1038/nm.4329. Epub 2017 May 8.

13.

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity.

Hohmann SW, Angioni C, Tunaru S, Lee S, Woolf CJ, Offermanns S, Geisslinger G, Scholich K, Sisignano M.

Sci Rep. 2017 Mar 27;7(1):446. doi: 10.1038/s41598-017-00591-0.

14.

Time for nonaddictive relief of pain.

Grosser T, Woolf CJ, FitzGerald GA.

Science. 2017 Mar 10;355(6329):1026-1027. doi: 10.1126/science.aan0088. Epub 2017 Mar 9. No abstract available.

PMID:
28280170
15.

Substance P activates Mas-related G protein-coupled receptors to induce itch.

Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA.

J Allergy Clin Immunol. 2017 Aug;140(2):447-453.e3. doi: 10.1016/j.jaci.2016.12.980. Epub 2017 Feb 20.

16.

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.

Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. Epub 2016 Oct 17.

17.

Toward a Mechanism-Based Approach to Pain Diagnosis.

Vardeh D, Mannion RJ, Woolf CJ.

J Pain. 2016 Sep;17(9 Suppl):T50-69. doi: 10.1016/j.jpain.2016.03.001. Review.

18.

Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.

Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, Burlingame AL, Twiss JL, Fainzilber M.

Cell Rep. 2016 Aug 9;16(6):1664-1676. doi: 10.1016/j.celrep.2016.07.005. Epub 2016 Jul 28.

19.

Pain and infection: pathogen detection by nociceptors.

Chiu IM, Pinho-Ribeiro FA, Woolf CJ.

Pain. 2016 Jun;157(6):1192-3. doi: 10.1097/j.pain.0000000000000559. No abstract available.

20.

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.

Neuron. 2016 May 4;90(3):662. doi: 10.1016/j.neuron.2016.04.025. No abstract available.

21.

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.

Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA.

Sci Signal. 2016 Mar 29;9(421):ra32. doi: 10.1126/scisignal.aad0163.

22.

Neuroimmunity: Physiology and Pathology.

Talbot S, Foster SL, Woolf CJ.

Annu Rev Immunol. 2016 May 20;34:421-47. doi: 10.1146/annurev-immunol-041015-055340. Epub 2016 Feb 22. Review.

PMID:
26907213
23.

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program.

Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH.

Neuron. 2016 Mar 2;89(5):956-70. doi: 10.1016/j.neuron.2016.01.034. Epub 2016 Feb 18.

24.

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.

Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G.

Pain. 2016 Apr;157(4):901-9. doi: 10.1097/j.pain.0000000000000458. Review.

25.

CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.

Ghasemlou N, Chiu IM, Julien JP, Woolf CJ.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6808-17. doi: 10.1073/pnas.1501372112. Epub 2015 Nov 23.

26.

Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.

Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z.

Neuron. 2015 Nov 18;88(4):704-19. doi: 10.1016/j.neuron.2015.10.005. Epub 2015 Oct 29.

27.

Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure.

Sakuma M, Gorski G, Sheu SH, Lee S, Barrett LB, Singh B, Omura T, Latremoliere A, Woolf CJ.

Eur J Neurosci. 2016 Feb;43(3):451-62. doi: 10.1111/ejn.13059. Epub 2015 Sep 28.

28.

The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.

Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M.

J Neurosci. 2015 Jul 29;35(30):10762-72. doi: 10.1523/JNEUROSCI.4796-14.2015.

29.

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.

McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K.

Cell Stem Cell. 2015 Jul 2;17(1):8-10. doi: 10.1016/j.stem.2015.06.013.

30.

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ.

Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25.

31.

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.

Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ.

Neuron. 2015 Jun 17;86(6):1393-406. doi: 10.1016/j.neuron.2015.05.033.

32.

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.

Neuron. 2015 Jun 3;86(5):1215-27. doi: 10.1016/j.neuron.2015.05.005. Epub 2015 May 21.

33.

Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics.

Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA.

Neuron. 2015 May 20;86(4):1000-1014. doi: 10.1016/j.neuron.2015.03.060. Epub 2015 Apr 30.

34.

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.

Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R.

Nat Med. 2015 May;21(5):518-23. doi: 10.1038/nm.3852. Epub 2015 Apr 27.

35.

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H, Kitt RA, Kopecky EA, Malamut R, McDermott MP, Palmer P, Rappaport BA, Rauschkolb C, Steigerwald I, Tobias J, Walco GA.

Pain. 2015 Jul;156(7):1184-97. doi: 10.1097/j.pain.0000000000000191. Review.

36.

CNS injury: IL-33 sounds the alarm.

Foster SL, Talbot S, Woolf CJ.

Immunity. 2015 Mar 17;42(3):403-5. doi: 10.1016/j.immuni.2015.02.019.

37.

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ.

Elife. 2014 Dec 19;3. doi: 10.7554/eLife.04660. Erratum in: Elife. 2015;4:e06720.

38.

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ.

Nat Neurosci. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. Epub 2014 Nov 24.

39.

A three-dimensional human neural cell culture model of Alzheimer's disease.

Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY.

Nature. 2014 Nov 13;515(7526):274-8. doi: 10.1038/nature13800. Epub 2014 Oct 12.

40.

What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain?

Woolf CJ.

Pain. 2014 Oct;155(10):1911-2. doi: 10.1016/j.pain.2014.07.021. Epub 2014 Jul 30. No abstract available.

PMID:
25083929
41.

Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration.

Painter MW, Brosius Lutz A, Cheng YC, Latremoliere A, Duong K, Miller CM, Posada S, Cobos EJ, Zhang AX, Wagers AJ, Havton LA, Barres B, Omura T, Woolf CJ.

Neuron. 2014 Jul 16;83(2):331-343. doi: 10.1016/j.neuron.2014.06.016.

42.

Skin β-endorphin mediates addiction to UV light.

Fell GL, Robinson KC, Mao J, Woolf CJ, Fisher DE.

Cell. 2014 Jun 19;157(7):1527-34. doi: 10.1016/j.cell.2014.04.032.

43.

Casting light on pain.

Browne LE, Woolf CJ.

Nat Biotechnol. 2014 Mar;32(3):240-1. doi: 10.1038/nbt.2844. No abstract available.

PMID:
24727775
44.

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K.

Cell Stem Cell. 2014 Jun 5;14(6):781-95. doi: 10.1016/j.stem.2014.03.004. Epub 2014 Apr 3.

45.

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ.

Cell Rep. 2014 Apr 10;7(1):1-11. doi: 10.1016/j.celrep.2014.03.019. Epub 2014 Apr 3.

46.
47.

ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation.

Seijffers R, Zhang J, Matthews JC, Chen A, Tamrazian E, Babaniyi O, Selig M, Hynynen M, Woolf CJ, Brown RH Jr.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1622-7. doi: 10.1073/pnas.1314826111. Epub 2014 Jan 13.

48.

Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.

Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.

Br J Pharmacol. 2014 Jan;171(2):438-51. doi: 10.1111/bph.12466.

49.

Bacteria activate sensory neurons that modulate pain and inflammation.

Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ.

Nature. 2013 Sep 5;501(7465):52-7. doi: 10.1038/nature12479. Epub 2013 Aug 21.

50.

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.

Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ.

Nat Neurosci. 2013 Jul;16(7):910-8. doi: 10.1038/nn.3404. Epub 2013 May 19.

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