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Items: 1 to 50 of 343

1.

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

Andersson LE, Shcherbina L, Al-Majdoub M, Vishnu N, Arroyo CB, Aste Carrara J, Wollheim CB, Fex M, Mulder H, Wierup N, Spégel P.

Diabetes. 2018 Mar;67(3):372-384. doi: 10.2337/db16-1441. Epub 2017 Dec 11.

PMID:
29229616
2.

The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis.

Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR.

Hum Mol Genet. 2018 Jan 15;27(2):406. doi: 10.1093/hmg/ddx402. No abstract available.

PMID:
29186426
3.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

4.

Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production.

Tubbs E, Axelsson AS, Vial G, Wollheim CB, Rieusset J, Rosengren AH.

Mol Cell Endocrinol. 2018 Feb 5;461:205-214. doi: 10.1016/j.mce.2017.09.016. Epub 2017 Sep 18.

PMID:
28923347
5.

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y, Fahey JW, Derry JMJ, Wollheim CB, Wierup N, Haymond MW, Friend SH, Mulder H, Rosengren AH.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaah4477. doi: 10.1126/scitranslmed.aah4477.

PMID:
28615356
6.

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.

Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH.

Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652.

7.

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell.

Ofori JK, Salunkhe VA, Bagge A, Vishnu N, Nagao M, Mulder H, Wollheim CB, Eliasson L, Esguerra JL.

Sci Rep. 2017 Mar 23;7:44986. doi: 10.1038/srep44986.

8.

Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.

Shcherbina L, Edlund A, Esguerra JL, Abels M, Zhou Y, Ottosson-Laakso E, Wollheim CB, Hansson O, Eliasson L, Wierup N.

Mol Cell Endocrinol. 2017 May 15;447:52-60. doi: 10.1016/j.mce.2017.02.027. Epub 2017 Feb 24.

PMID:
28237718
9.

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes.

Ly LD, Xu S, Choi SK, Ha CM, Thoudam T, Cha SK, Wiederkehr A, Wollheim CB, Lee IK, Park KS.

Exp Mol Med. 2017 Feb 3;49(2):e291. doi: 10.1038/emm.2016.157. Review.

10.

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

Pournourmohammadi S, Grimaldi M, Stridh MH, Lavallard V, Waagepetersen HS, Wollheim CB, Maechler P.

Int J Biochem Cell Biol. 2017 Jul;88:220-225. doi: 10.1016/j.biocel.2017.01.012. Epub 2017 Jan 27.

PMID:
28137482
11.

Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.

Nguyen TT, Quan X, Xu S, Das R, Cha SK, Kong ID, Shong M, Wollheim CB, Park KS.

FASEB J. 2016 Dec;30(12):3979-3988. Epub 2016 Aug 26.

PMID:
27565711
12.

Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722; DOI: 10.2337/db05-1430.

Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

Diabetes. 2016 Aug;65(8):2462. doi: 10.2337/db16-ec08a. No abstract available.

13.

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N.

Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. Epub 2016 Jun 23.

PMID:
27338624
14.

Physiology: Microbial signals to the brain control weight.

Trajkovski M, Wollheim CB.

Nature. 2016 Jun 9;534(7606):185-7. doi: 10.1038/534185a. No abstract available.

PMID:
27279209
15.

Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.

Prasad RB, Lessmark A, Almgren P, Kovacs G, Hansson O, Oskolkov N, Vitai M, Ladenvall C, Kovacs P, Fadista J, Lachmann M, Zhou Y, Sonestedt E, Poon W, Wollheim CB, Orho-Melander M, Stumvoll M, Tuomi T, Pääbo S, Koranyi L, Groop L.

Diabetologia. 2016 Aug;59(8):1702-13. doi: 10.1007/s00125-016-3973-9. Epub 2016 May 7.

PMID:
27155871
16.

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function.

Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Wollheim CB, Urano F, Mills JC.

J Biol Chem. 2016 Mar 18;291(12):6146-57. doi: 10.1074/jbc.M115.685750. Epub 2016 Jan 20.

17.

Thrombin stimulates insulin secretion via protease-activated receptor-3.

Hänzelmann S, Wang J, Güney E, Tang Y, Zhang E, Axelsson AS, Nenonen H, Salehi AS, Wollheim CB, Zetterberg E, Berntorp E, Costa IG, Castelo R, Rosengren AH.

Islets. 2015;7(4):e1118195. doi: 10.1080/19382014.2015.1118195.

18.

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress.

Xu S, Nam SM, Kim JH, Das R, Choi SK, Nguyen TT, Quan X, Choi SJ, Chung CH, Lee EY, Lee IK, Wiederkehr A, Wollheim CB, Cha SK, Park KS.

Cell Death Dis. 2015 Nov 19;6:e1976. doi: 10.1038/cddis.2015.331.

19.

Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.

Nguyen TT, Quan X, Hwang KH, Xu S, Das R, Choi SK, Wiederkehr A, Wollheim CB, Cha SK, Park KS.

Am J Physiol Endocrinol Metab. 2015 Jun 1;308(11):E933-41. doi: 10.1152/ajpendo.00009.2015. Epub 2015 Apr 7.

20.

Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

Wollheim CB, Maechler P.

Nat Med. 2015 Apr;21(4):310-1. doi: 10.1038/nm.3835. No abstract available.

PMID:
25849270
21.

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.

Stamenkovic JA, Andersson LE, Adriaenssens AE, Bagge A, Sharoyko VV, Gribble F, Reimann F, Wollheim CB, Mulder H, Spégel P.

Biochem J. 2015 May 15;468(1):49-63. doi: 10.1042/BJ20140697.

PMID:
25731850
22.

Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.

Quan X, Nguyen TT, Choi SK, Xu S, Das R, Cha SK, Kim N, Han J, Wiederkehr A, Wollheim CB, Park KS.

J Biol Chem. 2015 Feb 13;290(7):4086-96. doi: 10.1074/jbc.M114.632547. Epub 2014 Dec 29.

23.

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.

Taneera J, Fadista J, Ahlqvist E, Atac D, Ottosson-Laakso E, Wollheim CB, Groop L.

Hum Mol Genet. 2015 Apr 1;24(7):1945-55. doi: 10.1093/hmg/ddu610. Epub 2014 Dec 8.

PMID:
25489054
24.

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.

Fadista J, Vikman P, Laakso EO, Mollet IG, Esguerra JL, Taneera J, Storm P, Osmark P, Ladenvall C, Prasad RB, Hansson KB, Finotello F, Uvebrant K, Ofori JK, Di Camillo B, Krus U, Cilio CM, Hansson O, Eliasson L, Rosengren AH, Renström E, Wollheim CB, Groop L.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13924-9. doi: 10.1073/pnas.1402665111. Epub 2014 Sep 8.

25.

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.

Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T, Bacos K, Ling C.

PLoS Genet. 2014 Mar 6;10(3):e1004160. doi: 10.1371/journal.pgen.1004160. eCollection 2014 Mar.

26.

Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells.

Quan X, Das R, Xu S, Cline GW, Wiederkehr A, Wollheim CB, Park KS.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):198-209. doi: 10.1016/j.mce.2013.08.003. Epub 2013 Aug 9.

PMID:
23939247
27.

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

Hall E, Dayeh T, Kirkpatrick CL, Wollheim CB, Dekker Nitert M, Ling C.

BMC Med Genet. 2013 Jul 23;14:76. doi: 10.1186/1471-2350-14-76.

28.

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.

Spégel P, Sharoyko VV, Goehring I, Danielsson AP, Malmgren S, Nagorny CL, Andersson LE, Koeck T, Sharp GW, Straub SG, Wollheim CB, Mulder H.

Biochem J. 2013 Mar 15;450(3):595-605. doi: 10.1042/BJ20121349.

PMID:
23282133
29.

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.

Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH.

Cell Metab. 2012 Nov 7;16(5):625-33. doi: 10.1016/j.cmet.2012.10.009.

30.

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.

Marchetti P, Lupi R, Bugliani M, Kirkpatrick CL, Sebastiani G, Grieco FA, Del Guerra S, D'Aleo V, Piro S, Marselli L, Boggi U, Filipponi F, Tinti L, Salvini L, Wollheim CB, Purrello F, Dotta F.

Diabetologia. 2012 Dec;55(12):3262-72. doi: 10.1007/s00125-012-2716-9. Epub 2012 Sep 11.

PMID:
22965295
31.

Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells.

Akhmedov D, De Marchi U, Wollheim CB, Wiederkehr A.

Biochim Biophys Acta. 2012 Oct;1823(10):1815-24. doi: 10.1016/j.bbamcr.2012.07.005. Epub 2012 Jul 15.

32.

Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box.

Perakakis N, Danassi D, Alt M, Tsaroucha E, Mehana AE, Rimmer N, Laubner K, Wang H, Wollheim CB, Seufert J, Päth G.

Mol Cell Endocrinol. 2012 Nov 5;363(1-2):20-6. doi: 10.1016/j.mce.2012.07.003. Epub 2012 Jul 16.

PMID:
22801105
33.

A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.

Taneera J, Lang S, Sharma A, Fadista J, Zhou Y, Ahlqvist E, Jonsson A, Lyssenko V, Vikman P, Hansson O, Parikh H, Korsgren O, Soni A, Krus U, Zhang E, Jing XJ, Esguerra JL, Wollheim CB, Salehi A, Rosengren A, Renström E, Groop L.

Cell Metab. 2012 Jul 3;16(1):122-34. doi: 10.1016/j.cmet.2012.06.006.

34.

Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.

Yang BT, Dayeh TA, Volkov PA, Kirkpatrick CL, Malmgren S, Jing X, Renström E, Wollheim CB, Nitert MD, Ling C.

Mol Endocrinol. 2012 Jul;26(7):1203-12. doi: 10.1210/me.2012-1004. Epub 2012 May 8.

35.

Improved characterization of the insulin secretory granule proteomes.

Schvartz D, Brunner Y, Couté Y, Foti M, Wollheim CB, Sanchez JC.

J Proteomics. 2012 Aug 3;75(15):4620-31. doi: 10.1016/j.jprot.2012.04.023. Epub 2012 Apr 27.

PMID:
22569486
36.

Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.

Schvartz D, Couté Y, Brunner Y, Wollheim CB, Sanchez JC.

Mol Cell Proteomics. 2012 Aug;11(8):244-54. doi: 10.1074/mcp.M112.018051. Epub 2012 Mar 16.

37.

Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells.

Park KS, Wiederkehr A, Wollheim CB.

Korean J Physiol Pharmacol. 2012 Feb;16(1):71-7. doi: 10.4196/kjpp.2012.16.1.71. Epub 2012 Feb 28.

38.

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells.

Epstein S, Kirkpatrick CL, Castillon GA, Muñiz M, Riezman I, David FP, Wollheim CB, Riezman H.

J Lipid Res. 2012 Mar;53(3):412-20. doi: 10.1194/jlr.M022186. Epub 2011 Dec 30.

39.

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL.

Diabetes. 2011 Nov;60(11):2872-82. doi: 10.2337/db11-0876. Epub 2011 Sep 16.

40.

Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.

Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB.

J Biol Chem. 2011 Sep 16;286(37):32300-12. doi: 10.1074/jbc.M111.247866. Epub 2011 Jul 22.

41.

Mitochondrial signals drive insulin secretion in the pancreatic β-cell.

Wiederkehr A, Wollheim CB.

Mol Cell Endocrinol. 2012 Apr 28;353(1-2):128-37. doi: 10.1016/j.mce.2011.07.016. Epub 2011 Jul 19. Review.

PMID:
21784130
42.

Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.

Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH.

J Biol Chem. 2011 Jul 22;286(29):25719-28. doi: 10.1074/jbc.M110.215525. Epub 2011 May 31.

43.

The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis.

Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR.

Hum Mol Genet. 2011 Jul 15;20(14):2823-33. doi: 10.1093/hmg/ddr193. Epub 2011 May 2.

PMID:
21536586
44.

Mitochondrial matrix calcium is an activating signal for hormone secretion.

Wiederkehr A, Szanda G, Akhmedov D, Mataki C, Heizmann CW, Schoonjans K, Pozzan T, Spät A, Wollheim CB.

Cell Metab. 2011 May 4;13(5):601-11. doi: 10.1016/j.cmet.2011.03.015.

45.

In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.

Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR.

Diabetes. 2011 Jun;60(6):1705-15. doi: 10.2337/db10-1102. Epub 2011 Apr 26.

46.

Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.

Feldmann N, del Rio RM, Gjinovci A, Tamarit-Rodriguez J, Wollheim CB, Wiederkehr A.

Mol Cell Endocrinol. 2011 May 16;338(1-2):46-57. doi: 10.1016/j.mce.2011.02.019. Epub 2011 Mar 1.

PMID:
21371522
47.

Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo.

Uhles S, Wang H, Bénardeau A, Prummer M, Brecheisen M, Sewing S, Tobalina L, Bosco D, Wollheim CB, Migliorini C, Sebokova E.

Diabetes Obes Metab. 2011 Apr;13(4):326-36. doi: 10.1111/j.1463-1326.2010.01352.x.

PMID:
21205124
48.

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.

Yang BT, Dayeh TA, Kirkpatrick CL, Taneera J, Kumar R, Groop L, Wollheim CB, Nitert MD, Ling C.

Diabetologia. 2011 Feb;54(2):360-7. doi: 10.1007/s00125-010-1967-6. Epub 2010 Nov 23.

49.

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.

Kilbride SM, Farrelly AM, Bonner C, Ward MW, Nyhan KC, Concannon CG, Wollheim CB, Byrne MM, Prehn JH.

J Biol Chem. 2010 Nov 12;285(46):36199-206. doi: 10.1074/jbc.M110.138107. Epub 2010 Sep 14.

50.

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.

Bonner C, Bacon S, Concannon CG, Rizvi SR, Baquié M, Farrelly AM, Kilbride SM, Dussmann H, Ward MW, Boulanger CM, Wollheim CB, Graf R, Byrne MM, Prehn JH.

Diabetes. 2010 Nov;59(11):2799-808. doi: 10.2337/db09-1478. Epub 2010 Aug 3.

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