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Items: 21


The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.

Stypulkowski E, Asangani IA, Witze ES.

Sci Signal. 2018 Jan 2;11(511). pii: eaam8705. doi: 10.1126/scisignal.aam8705.


A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12.


Induced sensitivity to EGFR inhibitors is mediated by palmitoylated cysteine 1025 of EGFR and requires oncogenic Kras.

Kharbanda A, Runkle K, Wang W, Witze ES.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):213-219. doi: 10.1016/j.bbrc.2017.09.044. Epub 2017 Sep 9.


Wnt-Dependent Control of Cell Polarity in Cultured Cells.

Runkle KB, Witze ES.

Methods Mol Biol. 2016;1481:61-8. doi: 10.1007/978-1-4939-6393-5_7.


Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.

Runkle KB, Kharbanda A, Stypulkowski E, Cao XJ, Wang W, Garcia BA, Witze ES.

Mol Cell. 2016 May 5;62(3):385-396. doi: 10.1016/j.molcel.2016.04.003.


Menin localization in cell membrane compartment.

He X, Wang L, Yan J, Yuan C, Witze ES, Hua X.

Cancer Biol Ther. 2016;17(1):114-22. doi: 10.1080/15384047.2015.1108497.


Spontaneous Cell Competition in Immortalized Mammalian Cell Lines.

Penzo-Méndez AI, Chen YJ, Li J, Witze ES, Stanger BZ.

PLoS One. 2015 Jul 22;10(7):e0132437. doi: 10.1371/journal.pone.0132437. eCollection 2015.


Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production.

Wang W, Snyder N, Worth AJ, Blair IA, Witze ES.

Oncogenesis. 2015 Jun 1;4:e154. doi: 10.1038/oncsis.2015.15.


Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior.

Wang W, Runkle KB, Terkowski SM, Ekaireb RI, Witze ES.

J Biol Chem. 2015 Jun 19;290(25):15707-16. doi: 10.1074/jbc.M115.639609. Epub 2015 May 5.


A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype.

Schwartz MP, Rogers RE, Singh SP, Lee JY, Loveland SG, Koepsel JT, Witze ES, Montanez-Sauri SI, Sung KE, Tokuda EY, Sharma Y, Everhart LM, Nguyen EH, Zaman MH, Beebe DJ, Ahn NG, Murphy WL, Anseth KS.

PLoS One. 2013 Dec 3;8(12):e81689. doi: 10.1371/journal.pone.0081689. eCollection 2013.


Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge.

Witze ES, Connacher MK, Houel S, Schwartz MP, Morphew MK, Reid L, Sacks DB, Anseth KS, Ahn NG.

Dev Cell. 2013 Sep 30;26(6):645-57. doi: 10.1016/j.devcel.2013.08.019.


DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation.

Londoño Gentile T, Lu C, Lodato PM, Tse S, Olejniczak SH, Witze ES, Thompson CB, Wellen KE.

Mol Cell Biol. 2013 Oct;33(19):3864-78. doi: 10.1128/MCB.01495-12. Epub 2013 Jul 29.


Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.

Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C.

Mol Pharmacol. 2013 Mar;83(3):594-604. doi: 10.1124/mol.112.081810. Epub 2012 Dec 10.


PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA.

Mol Cell Biol. 2012 Jun;32(12):2268-78. doi: 10.1128/MCB.00063-12. Epub 2012 Apr 9.


A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme.

Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG.

Mol Cell Proteomics. 2009 Oct;8(10):2308-20. doi: 10.1074/mcp.M900178-MCP200. Epub 2009 Jul 20.


Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.

Old WM, Shabb JB, Houel S, Wang H, Couts KL, Yen CY, Litman ES, Croy CH, Meyer-Arendt K, Miranda JG, Brown RA, Witze ES, Schweppe RE, Resing KA, Ahn NG.

Mol Cell. 2009 Apr 10;34(1):115-31. doi: 10.1016/j.molcel.2009.03.007.


C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm.

Witze ES, Field ED, Hunt DF, Rothman JH.

Dev Biol. 2009 Mar 1;327(1):12-23. doi: 10.1016/j.ydbio.2008.11.015. Epub 2008 Dec 3.


Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.

Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG.

Science. 2008 Apr 18;320(5874):365-9. doi: 10.1126/science.1151250.


Mapping protein post-translational modifications with mass spectrometry.

Witze ES, Old WM, Resing KA, Ahn NG.

Nat Methods. 2007 Oct;4(10):798-806. Review.


Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.

Bloss TA, Witze ES, Rothman JH.

Nature. 2003 Aug 28;424(6952):1066-71.


Cell fusion: an EFFicient sculptor.

Witze E, Rothman JH.

Curr Biol. 2002 Jul 9;12(13):R467-9. Review.

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