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SORCS1 and SORCS3 control energy balance and orexigenic peptide production.

Subkhangulova A, Malik AR, Hermey G, Popp O, Dittmar G, Rathjen T, Poy MN, Stumpf A, Beed PS, Schmitz D, Breiderhoff T, Willnow TE.

EMBO Rep. 2018 Feb 12. pii: e44810. doi: 10.15252/embr.201744810. [Epub ahead of print]


Cadm2 regulates body weight and energy homeostasis in mice.

Yan X, Wang Z, Schmidt V, Gauert A, Willnow TE, Heinig M, Poy MN.

Mol Metab. 2018 Feb;8:180-188. doi: 10.1016/j.molmet.2017.11.010. Epub 2017 Nov 22.


Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria.

Breiderhoff T, Himmerkus N, Drewell H, Plain A, Günzel D, Mutig K, Willnow TE, Müller D, Bleich M.

Kidney Int. 2017 Nov 10. pii: S0085-2538(17)30667-1. doi: 10.1016/j.kint.2017.08.029. [Epub ahead of print]


SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.

Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H.

J Exp Med. 2017 Dec 4;214(12):3669-3685. doi: 10.1084/jem.20171413. Epub 2017 Nov 7.


Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S.

Cell Mol Life Sci. 2018 Jan;75(2):301-322. doi: 10.1007/s00018-017-2625-7. Epub 2017 Aug 10.


Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.

Willnow TE, Christ A.

Pflugers Arch. 2017 Aug;469(7-8):907-916. doi: 10.1007/s00424-017-1992-0. Epub 2017 May 11. Review.


Nanotubes, the fast track to treatment of Dent disease?

Willnow TE.

Kidney Int. 2017 Apr;91(4):776-778. doi: 10.1016/j.kint.2016.12.030.


Sorting receptor SORLA: cellular mechanisms and implications for disease.

Schmidt V, Subkhangulova A, Willnow TE.

Cell Mol Life Sci. 2017 Apr;74(8):1475-1483. doi: 10.1007/s00018-016-2410-z. Epub 2016 Nov 10. Review.


Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.

Andersen OM, Rudolph IM, Willnow TE.

Acta Neuropathol. 2016 Nov;132(5):653-665. Epub 2016 Sep 16. Review.


SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein.

Huang TY, Zhao Y, Li X, Wang X, Tseng IC, Thompson R, Tu S, Willnow TE, Zhang YW, Xu H.

J Neurosci. 2016 Jul 27;36(30):7996-8011. doi: 10.1523/JNEUROSCI.0206-16.2016.


SorCS2 is required for BDNF-dependent plasticity in the hippocampus.

Glerup S, Bolcho U, Mølgaard S, Bøggild S, Vaegter CB, Smith AH, Nieto-Gonzalez JL, Ovesen PL, Pedersen LF, Fjorback AN, Kjolby M, Login H, Holm MM, Andersen OM, Nyengaard JR, Willnow TE, Jensen K, Nykjaer A.

Mol Psychiatry. 2016 Dec;21(12):1740-1751. doi: 10.1038/mp.2016.108. Epub 2016 Jul 26.


SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.

Schmidt V, Schulz N, Yan X, Schürmann A, Kempa S, Kern M, Blüher M, Poy MN, Olivecrona G, Willnow TE.

J Clin Invest. 2016 Jul 1;126(7):2706-20. doi: 10.1172/JCI84708. Epub 2016 Jun 20.


LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.

Christ A, Herzog K, Willnow TE.

Dev Dyn. 2016 May;245(5):569-79. doi: 10.1002/dvdy.24394. Epub 2016 Mar 4. Review.


Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases.

Schmidt V, Willnow TE.

Atherosclerosis. 2016 Feb;245:194-9. doi: 10.1016/j.atherosclerosis.2015.11.027. Epub 2015 Dec 8. Review.


Role of Sortilin in Models of Autoimmune Neuroinflammation.

Reuter E, Weber J, Paterka M, Ploen R, Breiderhoff T, van Horssen J, Willnow TE, Siffrin V, Zipp F.

J Immunol. 2015 Dec 15;195(12):5762-9. doi: 10.4049/jimmunol.1403156. Epub 2015 Nov 13.


LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli.

Christ A, Christa A, Klippert J, Eule JC, Bachmann S, Wallace VA, Hammes A, Willnow TE.

Dev Cell. 2015 Oct 12;35(1):36-48. doi: 10.1016/j.devcel.2015.09.001. Epub 2015 Oct 1.


Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain.

Dumanis SB, Burgert T, Caglayan S, Füchtbauer A, Füchtbauer EM, Schmidt V, Willnow TE.

J Neurosci. 2015 Sep 16;35(37):12703-13. doi: 10.1523/JNEUROSCI.0427-15.2015.


Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ Cotransporter.

Borschewski A, Himmerkus N, Boldt C, Blankenstein KI, McCormick JA, Lazelle R, Willnow TE, Jankowski V, Plain A, Bleich M, Ellison DH, Bachmann S, Mutig K.

J Am Soc Nephrol. 2016 Jan;27(1):107-19. doi: 10.1681/ASN.2014070728. Epub 2015 May 12.


SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

Glerup S, Olsen D, Vaegter CB, Gustafsen C, Sjoegaard SS, Hermey G, Kjolby M, Molgaard S, Ulrichsen M, Boggild S, Skeldal S, Fjorback AN, Nyengaard JR, Jacobsen J, Bender D, Bjarkam CR, Sørensen ES, Füchtbauer EM, Eichele G, Madsen P, Willnow TE, Petersen CM, Nykjaer A.

Neuron. 2014 Jun 4;82(5):1074-87. doi: 10.1016/j.neuron.2014.04.022.


Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

Carlo AS, Nykjaer A, Willnow TE.

J Mol Med (Berl). 2014 Sep;92(9):905-11. doi: 10.1007/s00109-014-1152-3. Epub 2014 May 18. Review.


LRP2 mediates folate uptake in the developing neural tube.

Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A.

J Cell Sci. 2014 May 15;127(Pt 10):2261-8. doi: 10.1242/jcs.140145. Epub 2014 Mar 17.


Apolipoprotein E receptor pathways in Alzheimer disease.

Schmidt V, Carlo AS, Willnow TE.

Wiley Interdiscip Rev Syst Biol Med. 2014 May-Jun;6(3):255-70. doi: 10.1002/wsbm.1262. Epub 2014 Mar 6. Review.


Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.

Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Füchtbauer EM, Füchtbauer A, Holtzman DM, Takagi J, Willnow TE.

Sci Transl Med. 2014 Feb 12;6(223):223ra20. doi: 10.1126/scitranslmed.3007747.


Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.

Kooij G, Kopplin K, Blasig R, Stuiver M, Koning N, Goverse G, van der Pol SM, van Het Hof B, Gollasch M, Drexhage JA, Reijerkerk A, Meij IC, Mebius R, Willnow TE, Müller D, Blasig IE, de Vries HE.

Acta Neuropathol. 2014 Aug;128(2):267-77. doi: 10.1007/s00401-013-1227-1. Epub 2013 Dec 20.


Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.

Breiderhoff T, Christiansen GB, Pallesen LT, Vaegter C, Nykjaer A, Holm MM, Glerup S, Willnow TE.

PLoS One. 2013 Sep 19;8(9):e75006. doi: 10.1371/journal.pone.0075006. eCollection 2013.


SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.

Burgert T, Schmidt V, Caglayan S, Lin F, Füchtbauer A, Füchtbauer EM, Nykjaer A, Carlo AS, Willnow TE.

Mol Cell Biol. 2013 Nov;33(21):4308-20. doi: 10.1128/MCB.00628-13. Epub 2013 Sep 3.


SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.

Rohe M, Hartl D, Fjorback AN, Klose J, Willnow TE.

PLoS One. 2013 Aug 19;8(8):e72164. doi: 10.1371/journal.pone.0072164. eCollection 2013.


Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease.

Willnow TE, Andersen OM.

J Cell Sci. 2013 Jul 1;126(Pt 13):2751-60. doi: 10.1242/jcs.125393. Epub 2013 Jun 26. Review.


Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons.

Hartl D, Klatt S, Roch M, Konthur Z, Klose J, Willnow TE, Rohe M.

PLoS One. 2013 Jun 11;8(6):e65920. doi: 10.1371/journal.pone.0065920. Print 2013.


The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.

Carlo AS, Gustafsen C, Mastrobuoni G, Nielsen MS, Burgert T, Hartl D, Rohe M, Nykjaer A, Herz J, Heeren J, Kempa S, Petersen CM, Willnow TE.

J Neurosci. 2013 Jan 2;33(1):358-70. doi: 10.1523/JNEUROSCI.2425-12.2013.


Endocytic receptor-mediated control of morphogen signaling.

Willnow TE, Christ A, Hammes A.

Development. 2012 Dec 1;139(23):4311-9. doi: 10.1242/dev.084467. Review.


The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.

Herda S, Raczkowski F, Mittrücker HW, Willimsky G, Gerlach K, Kühl AA, Breiderhoff T, Willnow TE, Dörken B, Höpken UE, Rehm A.

Immunity. 2012 Nov 16;37(5):854-66. doi: 10.1016/j.immuni.2012.07.012. Epub 2012 Oct 16.


SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.

Capsoni S, Carlo AS, Vignone D, Amato G, Criscuolo C, Willnow TE, Cattaneo A.

J Alzheimers Dis. 2013;33(2):357-71. doi: 10.3233/JAD-2012-121399.


Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.

Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C, Meij IC, Bachmann S, Bleich M, Willnow TE, Müller D.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14241-6. doi: 10.1073/pnas.1203834109. Epub 2012 Aug 13. Erratum in: Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15072.


Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease.

Lao A, Schmidt V, Schmitz Y, Willnow TE, Wolkenhauer O.

BMC Syst Biol. 2012 Jun 22;6:74. doi: 10.1186/1752-0509-6-74.


Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.

Caglayan S, Bauerfeind A, Schmidt V, Carlo AS, Prabakaran T, Hübner N, Willnow TE.

Arch Neurol. 2012 Mar;69(3):373-9. doi: 10.1001/archneurol.2011.788.


Sortilin: a receptor to regulate neuronal viability and function.

Nykjaer A, Willnow TE.

Trends Neurosci. 2012 Apr;35(4):261-70. doi: 10.1016/j.tins.2012.01.003. Epub 2012 Feb 16. Review.


LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.

Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A.

Dev Cell. 2012 Feb 14;22(2):268-78. doi: 10.1016/j.devcel.2011.11.023.


Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.

Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, Militz D, Schmidt V, Madsen P, Nyengaard JR, Willnow TE, Christensen EI, Mobley WB, Nykjær A, Andersen OM.

J Neurosci. 2012 Jan 25;32(4):1467-80. doi: 10.1523/JNEUROSCI.2272-11.2012.


Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.

Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, Wiesner B, Petersen CM, Nykjaer A, Wolf J, Wolkenhauer O, Willnow TE.

EMBO J. 2012 Jan 4;31(1):187-200. doi: 10.1038/emboj.2011.352. Epub 2011 Oct 11.


Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.

Kur E, Christa A, Veth KN, Gajera CR, Andrade-Navarro MA, Zhang J, Willer JR, Gregg RG, Abdelilah-Seyfried S, Bachmann S, Link BA, Hammes A, Willnow TE.

Dev Dyn. 2011 Jun;240(6):1567-77. doi: 10.1002/dvdy.22624. Epub 2011 Mar 31.


CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia.

Stuiver M, Lainez S, Will C, Terryn S, Günzel D, Debaix H, Sommer K, Kopplin K, Thumfart J, Kampik NB, Querfeld U, Willnow TE, Němec V, Wagner CA, Hoenderop JG, Devuyst O, Knoers NV, Bindels RJ, Meij IC, Müller D.

Am J Hum Genet. 2011 Mar 11;88(3):333-43. doi: 10.1016/j.ajhg.2011.02.005.


Sortilins: new players in lipoprotein metabolism.

Willnow TE, Kjølby M, Nykjaer A.

Curr Opin Lipidol. 2011 Apr;22(2):79-85. doi: 10.1097/MOL.0b013e3283416f2b. Review.


Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.

Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, Lewin GR, Willnow TE, Chao MV, Nykjaer A.

Nat Neurosci. 2011 Jan;14(1):54-61. doi: 10.1038/nn.2689. Epub 2010 Nov 21. Erratum in: Nat Neurosci. 2011 Sep;14(9):1217.


SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease.

Willnow TE, Carlo AS, Rohe M, Schmidt V.

Rev Neurosci. 2010;21(4):315-29.


Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Kjolby M, Andersen OM, Breiderhoff T, Fjorback AW, Pedersen KM, Madsen P, Jansen P, Heeren J, Willnow TE, Nykjaer A.

Cell Metab. 2010 Sep 8;12(3):213-23. doi: 10.1016/j.cmet.2010.08.006.


Cubilin is essential for albumin reabsorption in the renal proximal tubule.

Amsellem S, Gburek J, Hamard G, Nielsen R, Willnow TE, Devuyst O, Nexo E, Verroust PJ, Christensen EI, Kozyraki R.

J Am Soc Nephrol. 2010 Nov;21(11):1859-67. doi: 10.1681/ASN.2010050492. Epub 2010 Aug 26.


The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo.

Christ A, Terryn S, Schmidt V, Christensen EI, Huska MR, Andrade-Navarro MA, Hübner N, Devuyst O, Hammes A, Willnow TE.

Kidney Int. 2010 Sep;78(5):473-7. doi: 10.1038/ki.2010.169. Epub 2010 Jun 9.


LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.

Gajera CR, Emich H, Lioubinski O, Christ A, Beckervordersandforth-Bonk R, Yoshikawa K, Bachmann S, Christensen EI, Götz M, Kempermann G, Peterson AS, Willnow TE, Hammes A.

J Cell Sci. 2010 Jun 1;123(Pt 11):1922-30. doi: 10.1242/jcs.065912. Epub 2010 May 11.


SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

Reiche J, Theilig F, Rafiqi FH, Carlo AS, Militz D, Mutig K, Todiras M, Christensen EI, Ellison DH, Bader M, Nykjaer A, Bachmann S, Alessi D, Willnow TE.

Mol Cell Biol. 2010 Jun;30(12):3027-37. doi: 10.1128/MCB.01560-09. Epub 2010 Apr 12.

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