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Items: 42


Correction: A Fusion Protein Encoding the Second Extracellular Domain of CCR5 Arrests Chemokine-Induced Cosignaling and Effectively Suppresses Ongoing Experimental Autoimmune Encephalomyelitis.

Sapir Y, Vitenshtein A, Barsheshet Y, Zohar Y, Wildbaum G, Karin N.

J Immunol. 2018 Feb 21. pii: ji1800166. doi: 10.4049/jimmunol.1800166. [Epub ahead of print] No abstract available.


CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development.

Hawila E, Razon H, Wildbaum G, Blattner C, Sapir Y, Shaked Y, Umansky V, Karin N.

Cell Rep. 2017 Nov 21;21(8):2212-2222. doi: 10.1016/j.celrep.2017.10.104.


CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions.

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, Utikal J, Karin N, Umansky V.

Cancer Res. 2018 Jan 1;78(1):157-167. doi: 10.1158/0008-5472.CAN-17-0348. Epub 2017 Oct 31.


CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N.

J Clin Invest. 2017 Oct 2;127(10):3913. doi: 10.1172/JCI97015. Epub 2017 Aug 28. No abstract available.


CCR8+FOXp3+ Treg cells as master drivers of immune regulation.

Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6086-6091. doi: 10.1073/pnas.1621280114. Epub 2017 May 22.


Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encephalomyelitis.

Harris N, Koppel J, Zsila F, Juhas S, Il'kova G, Kogan FY, Lahmy O, Wildbaum G, Karin N, Zhuk R, Gregor P.

Inflamm Res. 2016 Apr;65(4):285-94. doi: 10.1007/s00011-016-0915-4. Epub 2016 Jan 21.


Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets.

Karin N, Wildbaum G, Thelen M.

J Leukoc Biol. 2016 Jun;99(6):857-62. doi: 10.1189/jlb.2MR0915-441R. Epub 2015 Dec 9. Review.


The Role of Chemokines in Shaping the Balance Between CD4(+) T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases.

Karin N, Wildbaum G.

Front Immunol. 2015 Nov 30;6:609. doi: 10.3389/fimmu.2015.00609. eCollection 2015. Review.


Duodenal Expression of 25 Hydroxyvitamin D3-1α-hydroxylase Is Higher in Adolescents Than in Children and Adults.

Gawlik A, Gepstein V, Rozen N, Dahan A, Ben-Yosef D, Wildbaum G, Verbitsky O, Shaoul R, Weisman Y, Tiosano D.

J Clin Endocrinol Metab. 2015 Oct;100(10):3668-75. doi: 10.1210/jc.2015-1483. Epub 2015 Aug 20.


The role of chemokines in adjusting the balance between CD4+ effector T cell subsets and FOXp3-negative regulatory T cells.

Karin N, Wildbaum G.

Int Immunopharmacol. 2015 Oct;28(2):829-35. doi: 10.1016/j.intimp.2015.03.037. Epub 2015 Apr 20. Review.


CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N.

J Clin Invest. 2014 May;124(5):2009-22. doi: 10.1172/JCI71951. Epub 2014 Apr 8.


Heparanase enhances myeloma progression via CXCL10 downregulation.

Barash U, Zohar Y, Wildbaum G, Beider K, Nagler A, Karin N, Ilan N, Vlodavsky I.

Leukemia. 2014 Nov;28(11):2178-87. doi: 10.1038/leu.2014.121. Epub 2014 Apr 4.


Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion.

Wildbaum G, Shahar E, Katz R, Karin N, Etzioni A, Pollack S.

J Allergy Clin Immunol. 2013 Sep;132(3):761-764. doi: 10.1016/j.jaci.2013.04.018. Epub 2013 Jun 20. No abstract available.


The role of vitamin D receptor in innate and adaptive immunity: a study in hereditary vitamin D-resistant rickets patients.

Tiosano D, Wildbaum G, Gepstein V, Verbitsky O, Weisman Y, Karin N, Eztioni A.

J Clin Endocrinol Metab. 2013 Apr;98(4):1685-93. doi: 10.1210/jc.2012-3858. Epub 2013 Mar 12.


Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis.

Izhak L, Wildbaum G, Jung S, Stein A, Shaked Y, Karin N.

PLoS One. 2012;7(1):e28305. doi: 10.1371/journal.pone.0028305. Epub 2012 Jan 18.


Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.

Liu L, Okada S, Kong XF, Kreins AY, Cypowyj S, Abhyankar A, Toubiana J, Itan Y, Audry M, Nitschke P, Masson C, Toth B, Flatot J, Migaud M, Chrabieh M, Kochetkov T, Bolze A, Borghesi A, Toulon A, Hiller J, Eyerich S, Eyerich K, Gulácsy V, Chernyshova L, Chernyshov V, Bondarenko A, Grimaldo RM, Blancas-Galicia L, Beas IM, Roesler J, Magdorf K, Engelhard D, Thumerelle C, Burgel PR, Hoernes M, Drexel B, Seger R, Kusuma T, Jansson AF, Sawalle-Belohradsky J, Belohradsky B, Jouanguy E, Bustamante J, Bué M, Karin N, Wildbaum G, Bodemer C, Lortholary O, Fischer A, Blanche S, Al-Muhsen S, Reichenbach J, Kobayashi M, Rosales FE, Lozano CT, Kilic SS, Oleastro M, Etzioni A, Traidl-Hoffmann C, Renner ED, Abel L, Picard C, Maródi L, Boisson-Dupuis S, Puel A, Casanova JL.

J Exp Med. 2011 Aug 1;208(8):1635-48. doi: 10.1084/jem.20110958. Epub 2011 Jul 4.


A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis.

Sapir Y, Vitenshtein A, Barsheshet Y, Zohar Y, Wildbaum G, Karin N.

J Immunol. 2010 Aug 15;185(4):2589-99. doi: 10.4049/jimmunol.1000666. Epub 2010 Jul 16. Erratum in: J Immunol. 2018 Feb 21;:.


Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17.

Wildbaum G, Zohar Y, Karin N.

Am J Pathol. 2010 Jun;176(6):2764-75. doi: 10.2353/ajpath.2010.090855. Epub 2010 Apr 9.


Predominant expression of CCL2 at the tumor site of prostate cancer patients directs a selective loss of immunological tolerance to CCL2 that could be amplified in a beneficial manner.

Izhak L, Wildbaum G, Weinberg U, Shaked Y, Alami J, Dumont D, Friedman B, Stein A, Karin N.

J Immunol. 2010 Jan 15;184(2):1092-101. doi: 10.4049/jimmunol.0902725. Epub 2009 Dec 7. Erratum in: J Immunol. 2010 May 1;184(9):5414. Uri, Weinberg [corrected to Weinberg, Uri]; Friedman, Boris [added].


Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor-alpha and interferon-alpha.

Bergman R, Ramon M, Wildbaum G, Avitan-Hersh E, Mayer E, Shemer A, Karin N.

J Dermatol Sci. 2009 Dec;56(3):163-7. doi: 10.1016/j.jdermsci.2009.08.006. Epub 2009 Oct 2.


A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Izhak L, Wildbaum G, Zohar Y, Anunu R, Klapper L, Elkeles A, Seagal J, Yefenof E, Ayalon-Soffer M, Karin N.

J Immunol. 2009 Jul 1;183(1):732-9. doi: 10.4049/jimmunol.0802746. Epub 2009 Jun 17.


Selective autoantibody production against CCL3 is associated with human type 1 diabetes mellitus and serves as a novel biomarker for its diagnosis.

Shehadeh N, Pollack S, Wildbaum G, Zohar Y, Shafat I, Makhoul R, Daod E, Hakim F, Perlman R, Karin N.

J Immunol. 2009 Jun 15;182(12):8104-9. doi: 10.4049/jimmunol.0803348.


CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.

Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N.

J Exp Med. 2008 Oct 27;205(11):2643-55. doi: 10.1084/jem.20080730. Epub 2008 Oct 13.


Beneficial autoimmunity participates in the regulation of rheumatoid arthritis.

Zohar Y, Wildbaum G, Karin N.

Front Biosci. 2006 Jan 1;11:368-79. Review.


Targeted overexpression of IL-18 binding protein at the central nervous system overrides flexibility in functional polarization of antigen-specific Th2 cells.

Schif-Zuck S, Westermann J, Netzer N, Zohar Y, Meiron M, Wildbaum G, Karin N.

J Immunol. 2005 Apr 1;174(7):4307-15.


Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27.

Goldberg R, Zohar Y, Wildbaum G, Geron Y, Maor G, Karin N.

J Immunol. 2004 Nov 15;173(10):6465-71.


Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27.

Goldberg R, Wildbaum G, Zohar Y, Maor G, Karin N.

J Immunol. 2004 Jul 15;173(2):1171-8.


Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Igmu-deficient/lpr mice.

Seagal J, Leider N, Wildbaum G, Karin N, Melamed D.

Int Immunol. 2003 Sep;15(9):1045-52.


TNFalpha DNA vaccination prevents clinical manifestations of experimental antiphospholipid syndrome.

Blank M, Krause I, Wildbaum G, Karin N, Shoenfeld Y.

Lupus. 2003;12(7):546-9.


Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading.

Wildbaum G, Netzer N, Karin N.

J Clin Invest. 2002 Sep;110(5):701-10.


Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis.

Salomon I, Netzer N, Wildbaum G, Schif-Zuck S, Maor G, Karin N.

J Immunol. 2002 Sep 1;169(5):2685-93.


C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis.

Youssef S, Maor G, Wildbaum G, Grabie N, Gour-Lavie A, Karin N.

J Clin Invest. 2000 Aug;106(3):361-71.


Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines.

Youssef S, Wildbaum G, Karin N.

J Autoimmun. 1999 Aug;13(1):21-9.


Expansion of neonatal tolerance to self in adult life: I. The role of a bacterial adjuvant in tolerance spread.

Grabie N, Wohl I, Youssef S, Wildbaum G, Karin N.

Int Immunol. 1999 Jun;11(6):899-906.


Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis.

Wildbaum G, Youssef S, Grabie N, Karin N.

J Immunol. 1998 Dec 1;161(11):6368-74.


Long-lasting protective immunity to experimental autoimmune encephalomyelitis following vaccination with naked DNA encoding C-C chemokines.

Youssef S, Wildbaum G, Maor G, Lanir N, Gour-Lavie A, Grabie N, Karin N.

J Immunol. 1998 Oct 15;161(8):3870-9.

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