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Items: 1 to 50 of 100

1.

Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats.

Gao X, Lindqvist A, Sandberg M, Groop L, Wierup N, Jansson L.

Physiol Rep. 2018 Apr;6(8):e13685. doi: 10.14814/phy2.13685.

2.

Intestinal CART is a regulator of GIP and GLP-1 secretion and expression.

Shcherbina L, Lindqvist A, Thorén Fischer AH, Ahlqvist E, Zhang E, Falkmer SE, Renström E, Koffert J, Honka H, Wierup N.

Mol Cell Endocrinol. 2018 Apr 6. pii: S0303-7207(18)30121-7. doi: 10.1016/j.mce.2018.04.002. [Epub ahead of print]

PMID:
29627317
3.

N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism.

Ström K, Morales-Alamo D, Ottosson F, Edlund A, Hjort L, Jörgensen SW, Almgren P, Zhou Y, Martin-Rincon M, Ekman C, Pérez-López A, Ekström O, Perez-Suarez I, Mattiasson M, de Pablos-Velasco P, Oskolkov N, Ahlqvist E, Wierup N, Eliasson L, Vaag A, Groop L, Stenkula KG, Fernandez C, Calbet JAL, Holmberg HC, Hansson O.

Sci Rep. 2018 Feb 14;8(1):3016. doi: 10.1038/s41598-018-21099-1.

4.

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

Andersson LE, Shcherbina L, Al-Majdoub M, Vishnu N, Arroyo CB, Aste Carrara J, Wollheim CB, Fex M, Mulder H, Wierup N, Spégel P.

Diabetes. 2018 Mar;67(3):372-384. doi: 10.2337/db16-1441. Epub 2017 Dec 11.

PMID:
29229616
5.

Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats.

Medina A, Parween S, Ullsten S, Vishnu N, Siu YT, Quach M, Bennet H, Balhuizen A, Åkesson L, Wierup N, Carlsson PO, Ahlgren U, Lernmark Å, Fex M.

Diabetologia. 2018 Apr;61(4):896-905. doi: 10.1007/s00125-017-4512-z. Epub 2017 Dec 6.

PMID:
29209740
6.

Genetic determinants of circulating GIP and GLP-1 concentrations.

Almgren P, Lindqvist A, Krus U, Hakaste L, Ottosson-Laakso E, Asplund O, Sonestedt E, Prasad RB, Laurila E, Orho-Melander M, Melander O, Tuomi T, Holst JJ, Nilsson PM, Wierup N, Groop L, Ahlqvist E.

JCI Insight. 2017 Nov 2;2(21). pii: 93306. doi: 10.1172/jci.insight.93306. [Epub ahead of print]

7.

Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease.

Sjögren M, Duarte AI, McCourt AC, Shcherbina L, Wierup N, Björkqvist M.

Sci Rep. 2017 Oct 24;7(1):13896. doi: 10.1038/s41598-017-13713-5.

8.

Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model.

Pierzynowski SG, Goncharova K, Gregory PC, Weström B, Podpryatov SE, Podpriatov SS, Woliński J, Repich H, Wierup N, Lozinska L.

Sci Rep. 2017 Aug 17;7(1):8628. doi: 10.1038/s41598-017-07387-2.

9.

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells.

Nicholas LM, Valtat B, Medina A, Andersson L, Abels M, Mollet IG, Jain D, Eliasson L, Wierup N, Fex M, Mulder H.

Mol Metab. 2017 May 19;6(7):651-663. doi: 10.1016/j.molmet.2017.05.005. eCollection 2017 Jul.

10.

Ghrelin Is a Regulator of Glucagon-Like Peptide 1 Secretion and Transcription in Mice.

Lindqvist A, Shcherbina L, Fischer AT, Wierup N.

Front Endocrinol (Lausanne). 2017 Jun 19;8:135. doi: 10.3389/fendo.2017.00135. eCollection 2017.

11.

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.

Johansson BB, Fjeld K, Solheim MH, Shirakawa J, Zhang E, Keindl M, Hu J, Lindqvist A, Døskeland A, Mellgren G, Flatmark T, Njølstad PR, Kulkarni RN, Wierup N, Aukrust I, Bjørkhaug L.

Mol Cell Endocrinol. 2017 Oct 15;454:146-157. doi: 10.1016/j.mce.2017.06.020. Epub 2017 Jun 22.

PMID:
28648619
12.

The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes.

Lundberg M, Lindqvist A, Wierup N, Krogvold L, Dahl-Jørgensen K, Skog O.

PLoS One. 2017 Jun 19;12(6):e0179911. doi: 10.1371/journal.pone.0179911. eCollection 2017.

13.

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y, Fahey JW, Derry JMJ, Wollheim CB, Wierup N, Haymond MW, Friend SH, Mulder H, Rosengren AH.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaah4477. doi: 10.1126/scitranslmed.aah4477.

PMID:
28615356
14.

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

Edlund A, Pedersen MG, Lindqvist A, Wierup N, Flodström-Tullberg M, Eliasson L.

Sci Rep. 2017 Mar 7;7(1):90. doi: 10.1038/s41598-017-00098-8.

15.

Effects of meal and incretins in the regulation of splanchnic blood flow.

Koffert J, Honka H, Teuho J, Kauhanen S, Hurme S, Parkkola R, Oikonen V, Mari A, Lindqvist A, Wierup N, Groop L, Nuutila P.

Endocr Connect. 2017 Apr;6(3):179-187. doi: 10.1530/EC-17-0015. Epub 2017 Mar 3.

16.

The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model.

Lindqvist A, Ekelund M, Garcia-Vaz E, Ståhlman M, Pierzynowski S, Gomez MF, Rehfeld JF, Groop L, Hedenbro J, Wierup N, Spégel P.

PLoS One. 2017 Mar 3;12(3):e0173137. doi: 10.1371/journal.pone.0173137. eCollection 2017.

17.

Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels.

Lindqvist A, Ekelund M, Pierzynowski S, Groop L, Hedenbro J, Wierup N.

Peptides. 2017 Apr;90:78-82. doi: 10.1016/j.peptides.2017.02.009. Epub 2017 Feb 24.

PMID:
28242256
18.

Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.

Shcherbina L, Edlund A, Esguerra JL, Abels M, Zhou Y, Ottosson-Laakso E, Wollheim CB, Hansson O, Eliasson L, Wierup N.

Mol Cell Endocrinol. 2017 May 15;447:52-60. doi: 10.1016/j.mce.2017.02.027. Epub 2017 Feb 24.

PMID:
28237718
19.

Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes.

Honka H, Koffert J, Kauhanen S, Teuho J, Hurme S, Mari A, Lindqvist A, Wierup N, Groop L, Nuutila P.

Diabetes. 2017 Apr;66(4):880-885. doi: 10.2337/db16-0762. Epub 2017 Jan 17.

20.

Roux-en-Y gastric bypass versus calorie restriction: support for surgery per se as the direct contributor to altered responses of insulin and incretins to a mixed meal.

Berggren J, Lindqvist A, Hedenbro J, Groop L, Wierup N.

Surg Obes Relat Dis. 2017 Feb;13(2):234-242. doi: 10.1016/j.soard.2016.09.017. Epub 2016 Sep 28.

PMID:
27894746
21.

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N.

Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. Epub 2016 Jun 23.

PMID:
27338624
22.

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes.

Tuomi T, Nagorny CLF, Singh P, Bennet H, Yu Q, Alenkvist I, Isomaa B, Östman B, Söderström J, Pesonen AK, Martikainen S, Räikkönen K, Forsén T, Hakaste L, Almgren P, Storm P, Asplund O, Shcherbina L, Fex M, Fadista J, Tengholm A, Wierup N, Groop L, Mulder H.

Cell Metab. 2016 Jun 14;23(6):1067-1077. doi: 10.1016/j.cmet.2016.04.009. Epub 2016 May 12.

23.

HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.

Zhou Y, Oskolkov N, Shcherbina L, Ratti J, Kock KH, Su J, Martin B, Oskolkova MZ, Göransson O, Bacon J, Li W, Bucciarelli S, Cilio C, Brazma A, Thatcher B, Rung J, Wierup N, Renström E, Groop L, Hansson O.

Mol Cell Endocrinol. 2016 Jul 15;430:138-45. doi: 10.1016/j.mce.2016.01.027. Epub 2016 Feb 1.

PMID:
26845344
24.

Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Bennet H, Mollet IG, Balhuizen A, Medina A, Nagorny C, Bagge A, Fadista J, Ottosson-Laakso E, Vikman P, Dekker-Nitert M, Eliasson L, Wierup N, Artner I, Fex M.

Diabetologia. 2016 Apr;59(4):744-54. doi: 10.1007/s00125-015-3847-6. Epub 2016 Jan 6.

PMID:
26733006
25.

Decreased insulin secretion and glucose clearance in exocrine pancreas-insufficient pigs.

Lozinska L, Weström B, Prykhodko O, Lindqvist A, Wierup N, Ahrén B, Szwiec K, Pierzynowski SG.

Exp Physiol. 2016 Jan;101(1):100-12. doi: 10.1113/EP085431. Epub 2015 Dec 9.

26.

Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease.

McCourt AC, O'Donovan KL, Ekblad E, Sand E, Craufurd D, Rosser A, Sanders D, Stoy N, Rickards H, Wierup N, Bates GP, Björkqvist M, Quarrell O.

PLoS Curr. 2015 Jun 26;7. pii: ecurrents.hd.858b4cc7f235df068387e9c20c436a79. doi: 10.1371/currents.hd.858b4cc7f235df068387e9c20c436a79.

27.

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

Bennet H, Balhuizen A, Medina A, Dekker Nitert M, Ottosson Laakso E, Essén S, Spégel P, Storm P, Krus U, Wierup N, Fex M.

Peptides. 2015 Sep;71:113-20. doi: 10.1016/j.peptides.2015.07.008. Epub 2015 Jul 20.

PMID:
26206285
28.

Mucosal glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide cell numbers in the super-obese human foregut after gastric bypass.

Nergård BJ, Lindqvist A, Gislason HG, Groop L, Ekelund M, Wierup N, Hedenbro JL.

Surg Obes Relat Dis. 2015 Nov-Dec;11(6):1237-46. doi: 10.1016/j.soard.2015.03.021. Epub 2015 Apr 2.

PMID:
26143297
29.

Malignant presacral ghrelinoma with long-standing hyperghrelinaemia.

Falkmer UG, Gustafsson T, Wenzel R, Wierup N, Sundler F, Kulkarni H, Baum RP, Falkmer SE.

Ups J Med Sci. 2015;120(4):299-304. doi: 10.3109/03009734.2015.1054453. Epub 2015 Jun 20. Review.

30.

Short- and long-term hormonal and metabolic consequences of reversing gastric bypass to normal anatomy in a type 2 diabetes patient.

Wierup N, Lindqvist A, Spégel P, Groop L, Hedenbro J, Ekelund M.

Obes Surg. 2015 Jan;25(1):180-5. doi: 10.1007/s11695-014-1459-8.

PMID:
25330869
31.

TCF7L2 is a master regulator of insulin production and processing.

Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O.

Hum Mol Genet. 2014 Dec 15;23(24):6419-31. doi: 10.1093/hmg/ddu359. Epub 2014 Jul 11.

32.

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

Sharoyko VV, Abels M, Sun J, Nicholas LM, Mollet IG, Stamenkovic JA, Göhring I, Malmgren S, Storm P, Fadista J, Spégel P, Metodiev MD, Larsson NG, Eliasson L, Wierup N, Mulder H.

Hum Mol Genet. 2014 Nov 1;23(21):5733-49. doi: 10.1093/hmg/ddu288. Epub 2014 Jun 10.

PMID:
24916378
33.

A central role for GRB10 in regulation of islet function in man.

Prokopenko I, Poon W, Mägi R, Prasad B R, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N, Wierup N, Fall T, Stančáková A, Barker A, Lagou V, Osmond C, Xie W, Lahti J, Jackson AU, Cheng YC, Liu J, O'Connell JR, Blomstedt PA, Fadista J, Alkayyali S, Dayeh T, Ahlqvist E, Taneera J, Lecoeur C, Kumar A, Hansson O, Hansson K, Voight BF, Kang HM, Levy-Marchal C, Vatin V, Palotie A, Syvänen AC, Mari A, Weedon MN, Loos RJ, Ong KK, Nilsson P, Isomaa B, Tuomi T, Wareham NJ, Stumvoll M, Widen E, Lakka TA, Langenberg C, Tönjes A, Rauramaa R, Kuusisto J, Frayling TM, Froguel P, Walker M, Eriksson JG, Ling C, Kovacs P, Ingelsson E, McCarthy MI, Shuldiner AR, Silver KD, Laakso M, Groop L, Lyssenko V.

PLoS Genet. 2014 Apr 3;10(4):e1004235. doi: 10.1371/journal.pgen.1004235. eCollection 2014 Apr.

34.

Gastric bypass improves β-cell function and increases β-cell mass in a porcine model.

Lindqvist A, Spégel P, Ekelund M, Garcia Vaz E, Pierzynowski S, Gomez MF, Mulder H, Hedenbro J, Groop L, Wierup N.

Diabetes. 2014 May;63(5):1665-71. doi: 10.2337/db13-0969. Epub 2014 Jan 31.

35.

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Spégel P, Lindqvist A, Sandberg M, Wierup N.

Regul Pept. 2014 Feb 10;189:11-6. doi: 10.1016/j.regpep.2013.12.009. Epub 2014 Jan 8.

PMID:
24412429
36.

The islet ghrelin cell.

Wierup N, Sundler F, Heller RS.

J Mol Endocrinol. 2013 Dec 19;52(1):R35-49. doi: 10.1530/JME-13-0122. Print 2014 Feb. Review.

PMID:
24049065
37.

Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets.

Kanatsuna N, Taneera J, Vaziri-Sani F, Wierup N, Larsson HE, Delli A, Skärstrand H, Balhuizen A, Bennet H, Steiner DF, Törn C, Fex M, Lernmark Å.

J Biol Chem. 2013 Oct 4;288(40):29013-23. doi: 10.1074/jbc.M113.478222. Epub 2013 Aug 9.

38.

Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.

Taneera J, Fadista J, Ahlqvist E, Zhang M, Wierup N, Renström E, Groop L.

Mol Cell Endocrinol. 2013 Aug 15;375(1-2):35-42. doi: 10.1016/j.mce.2013.05.003. Epub 2013 May 22.

PMID:
23707792
39.

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans.

Lindqvist A, Spégel P, Ekelund M, Mulder H, Groop L, Hedenbro J, Wierup N.

J Clin Endocrinol Metab. 2013 May;98(5):E856-61. doi: 10.1210/jc.2012-3996. Epub 2013 Apr 30.

PMID:
23633201
40.

Link between GIP and osteopontin in adipose tissue and insulin resistance.

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, Pihlajamäki J, Wierup N, Vaag A, Groop L, Lyssenko V.

Diabetes. 2013 Jun;62(6):2088-94. doi: 10.2337/db12-0976. Epub 2013 Jan 24.

41.

Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.

Banke E, Riva M, Shcherbina L, Wierup N, Degerman E.

Regul Pept. 2013 Mar 10;182:35-40. doi: 10.1016/j.regpep.2012.12.011. Epub 2013 Jan 11.

PMID:
23318496
42.

Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.

Sathanoori R, Olde B, Erlinge D, Göransson O, Wierup N.

J Biol Chem. 2013 Feb 1;288(5):3208-18. doi: 10.1074/jbc.M112.437145. Epub 2012 Dec 16.

43.

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.

Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW.

Endocrinology. 2012 Dec;153(12):5782-95. doi: 10.1210/en.2012-1595. Epub 2012 Oct 12.

PMID:
23064014
44.

Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes.

Nitert MD, Dayeh T, Volkov P, Elgzyri T, Hall E, Nilsson E, Yang BT, Lang S, Parikh H, Wessman Y, Weishaupt H, Attema J, Abels M, Wierup N, Almgren P, Jansson PA, Rönn T, Hansson O, Eriksson KF, Groop L, Ling C.

Diabetes. 2012 Dec;61(12):3322-32. doi: 10.2337/db11-1653. Epub 2012 Oct 1.

45.

HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.

Asad S, Nikamo P, Gyllenberg A, Bennet H, Hansson O, Wierup N; Diabetes Incidence in Sweden Study Group, Carlsson A, Forsander G, Ivarsson SA, Larsson H, Lernmark Å, Lindblad B, Ludvigsson J, Marcus C, Rønningen KS, Nerup J, Pociot F, Luthman H, Fex M, Kockum I.

PLoS One. 2012;7(5):e35439. doi: 10.1371/journal.pone.0035439. Epub 2012 May 1.

46.

Expression of cocaine- and amphetamine-regulated transcript is associated with worse survival in small bowel carcinoid tumors.

Landerholm K, Shcherbina L, Falkmer SE, Järhult J, Wierup N.

Clin Cancer Res. 2012 Jul 1;18(13):3668-76. doi: 10.1158/1078-0432.CCR-11-2513. Epub 2012 May 2.

47.

β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia.

Egerod KL, Jin C, Petersen PS, Wierup N, Sundler F, Holst B, Schwartz TW.

Int J Endocrinol. 2011;2011:401258. doi: 10.1155/2011/401258. Epub 2011 Nov 17.

48.

Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects.

Riva M, Nitert MD, Voss U, Sathanoori R, Lindqvist A, Ling C, Wierup N.

Cell Tissue Res. 2011 Dec;346(3):393-405. doi: 10.1007/s00441-011-1268-5. Epub 2011 Nov 23.

PMID:
22108805
49.

Cocaine- and amphetamine-regulated transcript in neuroendocrine tumors.

Landerholm K, Falkmer SE, Järhult J, Sundler F, Wierup N.

Neuroendocrinology. 2011;94(3):228-36. doi: 10.1159/000329044. Epub 2011 Aug 11.

PMID:
21832817
50.

Pleiotropic effects of GIP on islet function involve osteopontin.

Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, Ahlqvist E, Kieffer TJ, Tuomi T, Isomaa B, Melander O, Sonestedt E, Orho-Melander M, Nilsson P, Bonetti S, Bonadonna R, Miccoli R, Delprato S, Marchetti P, Madsbad S, Poulsen P, Vaag A, Laakso M, Gomez MF, Groop L.

Diabetes. 2011 Sep;60(9):2424-33. doi: 10.2337/db10-1532. Epub 2011 Aug 1. Erratum in: Diabetes. 2012 Jun;61(6):1648.

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