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The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.

Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, Wichmann C, Strenzke N, Grabner C, Moser T.

Elife. 2018 Jan 12;7. pii: e29275. doi: 10.7554/eLife.29275.


Depressive symptoms, impaired glucose metabolism, high visceral fat, and high systolic blood pressure in a subgroup of women with recent gestational diabetes.

Ferrari U, Banning F, Freibothe I, Tröndle K, Sacco V, Wichmann C, Reif S, Moschko S, Potzel A, Gar C, Sommer NN, Popp D, Seissler J, Lechner A, Künzel H.

J Psychiatr Res. 2018 Feb;97:89-93. doi: 10.1016/j.jpsychires.2017.12.001. Epub 2017 Dec 5.


RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.

Krinner S, Butola T, Jung S, Wichmann C, Moser T.

Front Cell Neurosci. 2017 Nov 2;11:334. doi: 10.3389/fncel.2017.00334. eCollection 2017.


Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.

Butola T, Wichmann C, Moser T.

Front Synaptic Neurosci. 2017 Oct 25;9:14. doi: 10.3389/fnsyn.2017.00014. eCollection 2017.


Physical fitness and plasma leptin in women with recent gestational diabetes.

Gar C, Rottenkolber M, Grallert H, Banning F, Freibothe I, Sacco V, Wichmann C, Reif S, Potzel A, Dauber V, Schendell C, Sommer NN, Wolfarth B, Seissler J, Lechner A, Ferrari U.

PLoS One. 2017 Jun 13;12(6):e0179128. doi: 10.1371/journal.pone.0179128. eCollection 2017.


ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Thirant C, Ignacimouttou C, Lopez CK, Diop M, Le Mouël L, Thiollier C, Siret A, Dessen P, Aid Z, Rivière J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, Petit A, Raslova H, Carmichael CL, Kile BT, Soler E, Crispino JD, Wichmann C, Pflumio F, Schwaller J, Vainchenker W, Lobry C, Droin N, Bernard OA, Malinge S, Mercher T.

Cancer Cell. 2017 Mar 13;31(3):452-465. doi: 10.1016/j.ccell.2017.02.006.


Cultivation-Free Raman Spectroscopic Investigations of Bacteria.

Lorenz B, Wichmann C, Stöckel S, Rösch P, Popp J.

Trends Microbiol. 2017 May;25(5):413-424. doi: 10.1016/j.tim.2017.01.002. Epub 2017 Feb 7. Review.


Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells.

Moslem M, Eggenschwiler R, Wichmann C, Buhmann R, Cantz T, Henschler R.

Stem Cells Int. 2017;2017:7316354. doi: 10.1155/2017/7316354. Epub 2017 Jan 9.


Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization.

Schanda J, Lee CW, Wohlan K, Müller-Kuller U, Kunkel H, Coco IQ, Stein S, Metz A, Koch J, Lausen J, Platzbecker U, Medyouf H, Gohlke H, Heuser M, Eder M, Grez M, Scherr M, Wichmann C.

Haematologica. 2017 May;102(5):e170-e174. doi: 10.3324/haematol.2016.161570. Epub 2017 Feb 2. No abstract available.


Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.

Strenzke N, Chakrabarti R, Al-Moyed H, Müller A, Hoch G, Pangrsic T, Yamanbaeva G, Lenz C, Pan KT, Auge E, Geiss-Friedlander R, Urlaub H, Brose N, Wichmann C, Reisinger E.

EMBO J. 2016 Dec 1;35(23):2519-2535. Epub 2016 Oct 11.


Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.

Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršič T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T.

EMBO J. 2016 Dec 1;35(23):2536-2552. Epub 2016 Jul 25.


ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA.

Nat Commun. 2016 Jun 2;7:11733. doi: 10.1038/ncomms11733.


A polarizable QM/MM approach to the molecular dynamics of amide groups solvated in water.

Schwörer M, Wichmann C, Tavan P.

J Chem Phys. 2016 Mar 21;144(11):114504. doi: 10.1063/1.4943972.


MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.

Kohrs N, Kolodziej S, Kuvardina ON, Herglotz J, Yillah J, Herkt S, Piechatzek A, Salinas Riester G, Lingner T, Wichmann C, Bonig H, Seifried E, Platzbecker U, Medyouf H, Grez M, Lausen J.

PLoS Genet. 2016 Mar 18;12(3):e1005946. doi: 10.1371/journal.pgen.1005946. eCollection 2016 Mar.


Simulated Solute Tempering in Fully Polarizable Hybrid QM/MM Molecular Dynamics Simulations.

Schwörer M, Wichmann C, Gawehn E, Mathias G.

J Chem Theory Comput. 2016 Mar 8;12(3):992-9. doi: 10.1021/acs.jctc.5b00951. Epub 2016 Feb 19.


Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T.

EMBO J. 2015 Nov 3;34(21):2686-702. doi: 10.15252/embj.201591885. Epub 2015 Oct 7.


Molecularly and structurally distinct synapses mediate reliable encoding and processing of auditory information.

Wichmann C.

Hear Res. 2015 Dec;330(Pt B):178-90. doi: 10.1016/j.heares.2015.07.008. Epub 2015 Jul 15. Review.


Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.

Jung S, Oshima-Takago T, Chakrabarti R, Wong AB, Jing Z, Yamanbaeva G, Picher MM, Wojcik SM, Göttfert F, Predoehl F, Michel K, Hell SW, Schoch S, Strenzke N, Wichmann C, Moser T.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3141-9. doi: 10.1073/pnas.1417207112. Epub 2015 Jun 1.


Relating structure and function of inner hair cell ribbon synapses.

Wichmann C, Moser T.

Cell Tissue Res. 2015 Jul;361(1):95-114. doi: 10.1007/s00441-014-2102-7. Epub 2015 Jan 22. Review.


RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1.

Ponnusamy K, Kohrs N, Ptasinska A, Assi SA, Herold T, Hiddemann W, Lausen J, Bonifer C, Henschler R, Wichmann C.

Oncogenesis. 2015 Apr 13;4:e146. doi: 10.1038/oncsis.2015.6.


Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C.

J Cell Sci. 2015 Feb 15;128(4):638-44. doi: 10.1242/jcs.162099. Epub 2015 Jan 20.


Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells.

Hennig D, Müller S, Wichmann C, Drube S, Pietschmann K, Pelzl L, Grez M, Bug G, Heinzel T, Krämer OH.

Br J Cancer. 2015 Jan 20;112(2):329-37. doi: 10.1038/bjc.2014.589. Epub 2014 Dec 16.


Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis.

Chapochnikov NM, Takago H, Huang CH, Pangršič T, Khimich D, Neef J, Auge E, Göttfert F, Hell SW, Wichmann C, Wolf F, Moser T.

Neuron. 2014 Sep 17;83(6):1389-403. doi: 10.1016/j.neuron.2014.08.003. Epub 2014 Sep 4.


The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells.

Ponnusamy K, Chen-Wichmann L, Kuvardina ON, Lausen J, Henschler R, Wichmann C.

Haematologica. 2014 Dec;99(12):e253-6. doi: 10.3324/haematol.2014.106088. Epub 2014 Aug 8. No abstract available.


Including the Dispersion Attraction into Structure-Adapted Fast Multipole Expansions for MD Simulations.

Lorenzen K, Wichmann C, Tavan P.

J Chem Theory Comput. 2014 Aug 12;10(8):3244-59. doi: 10.1021/ct500319a. No abstract available.


Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.

Li L, Tian X, Zhu M, Bulgari D, Böhme MA, Goettfert F, Wichmann C, Sigrist SJ, Levitan ES, Wu C.

J Neurosci. 2014 Jun 18;34(25):8474-87. doi: 10.1523/JNEUROSCI.0409-14.2014.


Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.

Wichmann C, Quagliano-Lo Coco I, Yildiz Ö, Chen-Wichmann L, Weber H, Syzonenko T, Döring C, Brendel C, Ponnusamy K, Kinner A, Brandts C, Henschler R, Grez M.

Leukemia. 2015 Feb;29(2):279-89. doi: 10.1038/leu.2014.179. Epub 2014 Jun 4.


A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.

Podufall J, Tian R, Knoche E, Puchkov D, Walter AM, Rosa S, Quentin C, Vukoja A, Jung N, Lampe A, Wichmann C, Böhme M, Depner H, Zhang YQ, Schmoranzer J, Sigrist SJ, Haucke V.

Cell Rep. 2014 Jun 12;7(5):1417-1425. doi: 10.1016/j.celrep.2014.04.051. Epub 2014 May 29.


An unusual case of mediastinal mass and bilateral nodules.

Wichmann CL, Helmchen B, Weber A, Wildi S, Carboni GL.

Asian Cardiovasc Thorac Ann. 2014 Jun;22(5):623-6. doi: 10.1177/0218492313483586. Epub 2013 Oct 8.


Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.

Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T.

EMBO J. 2014 Mar 3;33(5):512-27. doi: 10.1002/embj.201385887. Epub 2014 Jan 17.


Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.

Wong AB, Rutherford MA, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, Michanski S, Hell S, Wolf F, Wichmann C, Moser T.

EMBO J. 2014 Feb 3;33(3):247-64. doi: 10.1002/embj.201387110. Epub 2014 Jan 17.


Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.

Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T.

J Neurosci. 2014 Jan 15;34(3):705-16. doi: 10.1523/JNEUROSCI.3313-13.2014.


Fully automated synthesis and coupling of [(18) F]FBEM to glutathione using the iPHASE FlexLab module.

Ackermann U, Plougastel L, Wichmann C, Goh YW, Yeoh SD, Poniger SS, Tochon-Danguy HJ, Scott AM.

J Labelled Comp Radiopharm. 2014 Feb;57(2):115-20. doi: 10.1002/jlcr.3175. Epub 2014 Jan 7.


Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells.

Faridi F, Ponnusamy K, Quagliano-Lo Coco I, Chen-Wichmann L, Grez M, Henschler R, Wichmann C.

Front Genet. 2013 Nov 28;4:254. doi: 10.3389/fgene.2013.00254. Review.


One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging.

Haskali MB, Roselt PD, Karas JA, Noonan W, Wichmann CW, Katsifis A, Hicks RJ, Hutton CA.

J Labelled Comp Radiopharm. 2013 Dec;56(14):726-30. doi: 10.1002/jlcr.3111. Epub 2013 Sep 16.


[Ethical topics in geriatric nursing: the project "closer inspection". Reflective thinking, deciding and managing].

Wichmann C.

Pflege Z. 2013 Oct;66(10):582-5. German. No abstract available.


The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.

Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ.

J Cell Biol. 2013 Aug 19;202(4):667-83. doi: 10.1083/jcb.201301072.


From determinants of RUNX1/ETO tetramerization to small-molecule protein-protein interaction inhibitors targeting acute myeloid leukemia.

Metz A, Schanda J, Grez M, Wichmann C, Gohlke H.

J Chem Inf Model. 2013 Sep 23;53(9):2197-202. doi: 10.1021/ci400332e. Epub 2013 Sep 12.


Interference with RUNX1/ETO leukemogenic function by cell-penetrating peptides targeting the NHR2 oligomerization domain.

Bartel Y, Grez M, Wichmann C.

Biomed Res Int. 2013;2013:297692. doi: 10.1155/2013/297692. Epub 2013 Jun 25.


Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.

Owald D, Khorramshahi O, Gupta VK, Banovic D, Depner H, Fouquet W, Wichmann C, Mertel S, Eimer S, Reynolds E, Holt M, Aberle H, Sigrist SJ.

Nat Neurosci. 2012 Sep;15(9):1219-26. doi: 10.1038/nn.3183. Epub 2012 Aug 5.


RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.

Liu KS, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Bückers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ.

Science. 2011 Dec 16;334(6062):1565-9. doi: 10.1126/science.1212991.


Presynapses in Kenyon cell dendrites in the mushroom body calyx of Drosophila.

Christiansen F, Zube C, Andlauer TF, Wichmann C, Fouquet W, Owald D, Mertel S, Leiss F, Tavosanis G, Luna AJ, Fiala A, Sigrist SJ.

J Neurosci. 2011 Jun 29;31(26):9696-707. doi: 10.1523/JNEUROSCI.6542-10.2011.


Naked dense bodies provoke depression.

Hallermann S, Kittel RJ, Wichmann C, Weyhersmüller A, Fouquet W, Mertel S, Owald D, Eimer S, Depner H, Schwärzel M, Sigrist SJ, Heckmann M.

J Neurosci. 2010 Oct 27;30(43):14340-5. doi: 10.1523/JNEUROSCI.2495-10.2010.


Molecular targeting of aberrant transcription factors in leukemia: strategies for RUNX1/ETO.

Wichmann C, Grez M, Lausen J.

Curr Drug Targets. 2010 Sep;11(9):1181-91. Review.


The active zone T-bar--a plasticity module?

Wichmann C, Sigrist SJ.

J Neurogenet. 2010 Sep;24(3):133-45. doi: 10.3109/01677063.2010.489626. Review.


Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions.

Banovic D, Khorramshahi O, Owald D, Wichmann C, Riedt T, Fouquet W, Tian R, Sigrist SJ, Aberle H.

Neuron. 2010 Jun 10;66(5):724-38. doi: 10.1016/j.neuron.2010.05.020.


Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity.

Wichmann C, Becker Y, Chen-Wichmann L, Vogel V, Vojtkova A, Herglotz J, Moore S, Koch J, Lausen J, Mäntele W, Gohlke H, Grez M.

Blood. 2010 Jul 29;116(4):603-13. doi: 10.1182/blood-2009-10-248047. Epub 2010 Apr 29.


A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.

Bachmann A, Kobler O, Kittel RJ, Wichmann C, Sierralta J, Sigrist SJ, Gundelfinger ED, Knust E, Thomas U.

J Neurosci. 2010 Apr 28;30(17):5811-24. doi: 10.1523/JNEUROSCI.0778-10.2010.


Spectroscopic polarizable force field for amide groups in polypeptides.

Schropp B, Wichmann C, Tavan P.

J Phys Chem B. 2010 May 20;114(19):6740-50. doi: 10.1021/jp101358r.


A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.

Owald D, Fouquet W, Schmidt M, Wichmann C, Mertel S, Depner H, Christiansen F, Zube C, Quentin C, Körner J, Urlaub H, Mechtler K, Sigrist SJ.

J Cell Biol. 2010 Feb 22;188(4):565-79. doi: 10.1083/jcb.200908055.

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