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Items: 1 to 50 of 146


An evidence-based review of pregabalin for the treatment of fibromyalgia.

Arnold L, Choy E, Clauw DJ, Oka H, Whalen E, Semel D, Pauer L, Knapp L.

Curr Med Res Opin. 2018 Mar 9:1-26. doi: 10.1080/03007995.2018.1450743. [Epub ahead of print]


Allergen induced activation of NK cells represents an early life immune response in development of allergic asthma.

Altman MC, Whalen E, Togias A, O'Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, LeBeau P, Jaffee K, Visness CM, Busse WW, Gern JE.

J Allergy Clin Immunol. 2018 Mar 5. pii: S0091-6749(18)30307-5. doi: 10.1016/j.jaci.2018.02.019. [Epub ahead of print]


Dose Titration of Pregabalin in Patients with Painful Diabetic Peripheral Neuropathy: Simulation Based on Observational Study Patients Enriched with Data from Randomized Studies.

Alexander J Jr, Edwards RA, Manca L, Grugni R, Bonfanti G, Emir B, Whalen E, Watt S, Parsons B.

Adv Ther. 2018 Mar;35(3):382-394. doi: 10.1007/s12325-018-0664-6. Epub 2018 Feb 23.


Time Series Disturbance Detection for Hypothesis-Free Signal Detection in Longitudinal Observational Databases.

Whalen E, Hauben M, Bate A.

Drug Saf. 2018 Feb 21. doi: 10.1007/s40264-018-0640-8. [Epub ahead of print]


Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.

Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS.

J Allergy Clin Immunol. 2017 Oct 26. pii: S0091-6749(17)31645-7. doi: 10.1016/j.jaci.2017.10.004. [Epub ahead of print]


Dose-response of pregabalin for diabetic peripheral neuropathy, postherpetic neuralgia, and fibromyalgia.

Arnold LM, McCarberg BH, Clair AG, Whalen E, Thomas N, Jorga A, Pauer L, Vissing R, Park PW.

Postgrad Med. 2017 Nov;129(8):921-933. doi: 10.1080/00325481.2017.1384691. Epub 2017 Oct 16.


A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.

Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam9171. doi: 10.1126/scitranslmed.aam9171.


Integrating data from randomized controlled trials and observational studies to predict the response to pregabalin in patients with painful diabetic peripheral neuropathy.

Alexander J, Edwards RA, Savoldelli A, Manca L, Grugni R, Emir B, Whalen E, Watt S, Brodsky M, Parsons B.

BMC Med Res Methodol. 2017 Jul 20;17(1):113. doi: 10.1186/s12874-017-0389-2.


Modular transcriptional repertoire analyses identify a blood neutrophil signature as a candidate biomarker for lupus nephritis.

Jourde-Chiche N, Whalen E, Gondouin B, Speake C, Gersuk V, Dussol B, Burtey S, Pascual V, Chaussabel D, Chiche L.

Rheumatology (Oxford). 2017 Mar 1;56(3):477-487. doi: 10.1093/rheumatology/kew439.


Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home.

Speake C, Whalen E, Gersuk VH, Chaussabel D, Odegard JM, Greenbaum CJ.

Clin Exp Immunol. 2017 May;188(2):226-233. doi: 10.1111/cei.12916. Epub 2017 Mar 2.


Small-molecule WNK inhibition regulates cardiovascular and renal function.

Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L.

Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5.


Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.

Hundhausen C, Roth A, Whalen E, Chen J, Schneider A, Long SA, Wei S, Rawlings R, Kinsman M, Evanko SP, Wight TN, Greenbaum CJ, Cerosaletti K, Buckner JH.

Sci Transl Med. 2016 Sep 14;8(356):356ra119. doi: 10.1126/scitranslmed.aad9943.


An appraisal of meta-analysis guidelines: how do they relate to safety outcomes?

Bennetts M, Whalen E, Ahadieh S, Cappelleri JC.

Res Synth Methods. 2017 Mar;8(1):64-78. doi: 10.1002/jrsm.1219. Epub 2016 Sep 9. Review.


Early improvement with pregabalin predicts endpoint response in patients with generalized anxiety disorder: an integrated and predictive data analysis.

Montgomery SA, Lyndon G, Almas M, Whalen E, Prieto R.

Int Clin Psychopharmacol. 2017 Jan;32(1):41-48.


Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria.

Tran TM, Jones MB, Ongoiba A, Bijker EM, Schats R, Venepally P, Skinner J, Doumbo S, Quinten E, Visser LG, Whalen E, Presnell S, O'Connell EM, Kayentao K, Doumbo OK, Chaussabel D, Lorenzi H, Nutman TB, Ottenhoff TH, Haks MC, Traore B, Kirkness EF, Sauerwein RW, Crompton PD.

Sci Rep. 2016 Aug 10;6:31291. doi: 10.1038/srep31291.


Pregabalin Improves Pain Scores in Patients with Fibromyalgia Irrespective of Comorbid Osteoarthritis.

Argoff CE, Emir B, Whalen E, Ortiz M, Pauer L, Clair A.

Pain Med. 2016 Nov;17(11):2100-2108. Epub 2016 Jun 1.


Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF.

J Immunol. 2016 May 1;196(9):3966. doi: 10.4049/jimmunol.1600364. No abstract available.


Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB?

Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-Stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV.

Am J Gastroenterol. 2016 Jun;111(6):852-63. doi: 10.1038/ajg.2016.51. Epub 2016 Mar 22.


CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF.

J Immunol. 2016 Mar 1;196(5):2051-2062. doi: 10.4049/jimmunol.1501491. Epub 2016 Jan 29. Erratum in: J Immunol. 2016 May 1;196(9):3966.


An interactive web application for the dissemination of human systems immunology data.

Speake C, Presnell S, Domico K, Zeitner B, Bjork A, Anderson D, Mason MJ, Whalen E, Vargas O, Popov D, Rinchai D, Jourde-Chiche N, Chiche L, Quinn C, Chaussabel D.

J Transl Med. 2015 Jun 19;13:196. doi: 10.1186/s12967-015-0541-x.


Prior Opioid Use Does Not Impact the Response to Pregabalin in Patients With Fibromyalgia.

Argoff CE, Clair A, Emir B, Whalen E, Ortiz M, Pauer L.

Clin J Pain. 2016 Jul;32(7):555-61. doi: 10.1097/AJP.0000000000000232.


Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis.

Linsley PS, Speake C, Whalen E, Chaussabel D.

PLoS One. 2014 Oct 14;9(10):e109760. doi: 10.1371/journal.pone.0109760. eCollection 2014.


Targeting survival pathways to create infarct-spanning bridges of human embryonic stem cell-derived cardiomyocytes.

Luo J, Weaver MS, Dennis JE, Whalen E, Laflamme MA, Allen MD.

J Thorac Cardiovasc Surg. 2014 Dec;148(6):3180-8.e1. doi: 10.1016/j.jtcvs.2014.06.087. Epub 2014 Jul 24.


Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures.

Chiche L, Jourde-Chiche N, Whalen E, Presnell S, Gersuk V, Dang K, Anguiano E, Quinn C, Burtey S, Berland Y, Kaplanski G, Harle JR, Pascual V, Chaussabel D.

Arthritis Rheumatol. 2014 Jun;66(6):1583-95. doi: 10.1002/art.38628.


A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients' plasma.

Khaenam P, Rinchai D, Altman MC, Chiche L, Buddhisa S, Kewcharoenwong C, Suwannasaen D, Mason M, Whalen E, Presnell S, Susaengrat W, O'Brien K, Nguyen QA, Gersuk V, Linsley PS, Lertmemongkolchai G, Chaussabel D.

J Transl Med. 2014 Mar 11;12:65. doi: 10.1186/1479-5876-12-65.


Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.

Cerosaletti K, Schneider A, Schwedhelm K, Frank I, Tatum M, Wei S, Whalen E, Greenbaum C, Kita M, Buckner J, Long SA.

PLoS One. 2013 Dec 23;8(12):e83811. doi: 10.1371/journal.pone.0083811. eCollection 2013.


A comprehensive drug safety evaluation of pregabalin in peripheral neuropathic pain.

Freynhagen R, Serpell M, Emir B, Whalen E, Parsons B, Clair A, Latymer M.

Pain Pract. 2015 Jan;15(1):47-57. doi: 10.1111/papr.12146. Epub 2013 Nov 27.


Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats.

Whalen EJ, Johnson AK, Lewis SJ.

Microvasc Res. 2014 Jan;91:22-9. doi: 10.1016/j.mvr.2013.11.001. Epub 2013 Nov 16.


Designing a new proof-of-principle trial for treatment of partial seizures to demonstrate efficacy with minimal sample size and duration-a case study.

French JA, Cabrera J, Emir B, Whalen E, Lu F.

Epilepsy Res. 2013 Sep;106(1-2):230-6. doi: 10.1016/j.eplepsyres.2013.04.008. Epub 2013 May 30.


Relationship between pain relief and improvements in patient function/quality of life in patients with painful diabetic peripheral neuropathy or postherpetic neuralgia treated with pregabalin.

Vinik A, Emir B, Cheung R, Whalen E.

Clin Ther. 2013 May;35(5):612-23. doi: 10.1016/j.clinthera.2013.03.008. Epub 2013 Mar 28.


A randomized trial of pregabalin in patients with neuropathic pain due to spinal cord injury.

Cardenas DD, Nieshoff EC, Suda K, Goto S, Sanin L, Kaneko T, Sporn J, Parsons B, Soulsby M, Yang R, Whalen E, Scavone JM, Suzuki MM, Knapp LE.

Neurology. 2013 Feb 5;80(6):533-9. doi: 10.1212/WNL.0b013e318281546b. Epub 2013 Jan 23.


Meta-analysis of clinical trial safety data in a drug development program: answers to frequently asked questions.

Berlin JA, Crowe BJ, Whalen E, Xia HA, Koro CE, Kuebler J.

Clin Trials. 2013 Feb;10(1):20-31. doi: 10.1177/1740774512465495. Epub 2012 Nov 21.


Pioneers in trauma care at Harborview Medical Center.

Whalen E, Hecker CJ, Butler S.

Crit Care Nurs Q. 2012 Jul-Sep;35(3):205-7. doi: 10.1097/CNQ.0b013e3182542e7e.


Characterizing and understanding body weight patterns in patients treated with pregabalin.

Cabrera J, Emir B, Dills D, Murphy TK, Whalen E, Clair A.

Curr Med Res Opin. 2012 Jun;28(6):1027-37. doi: 10.1185/03007995.2012.684044. Epub 2012 May 3.


Effect of pregabalin on sleep in patients with fibromyalgia and sleep maintenance disturbance: a randomized, placebo-controlled, 2-way crossover polysomnography study.

Roth T, Lankford DA, Bhadra P, Whalen E, Resnick EM.

Arthritis Care Res (Hoboken). 2012 Apr;64(4):597-606. doi: 10.1002/acr.21595.


Sensory pain qualities in neuropathic pain.

Mackey S, Carroll I, Emir B, Murphy TK, Whalen E, Dumenci L.

J Pain. 2012 Jan;13(1):58-63. doi: 10.1016/j.jpain.2011.10.002. Epub 2011 Dec 15.


Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.

Zennadi R, Whalen EJ, Soderblom EJ, Alexander SC, Thompson JW, Dubois LG, Moseley MA, Telen MJ.

Blood. 2012 Feb 2;119(5):1217-27. doi: 10.1182/blood-2011-03-344440. Epub 2011 Dec 6.


A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.

Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.


Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure.

Boerrigter G, Lark MW, Whalen EJ, Soergel DG, Violin JD, Burnett JC Jr.

Circ Heart Fail. 2011 Nov;4(6):770-8. doi: 10.1161/CIRCHEARTFAILURE.111.962571. Epub 2011 Aug 11.


Correlations between fibromyalgia symptom and function domains and patient global impression of change: a pooled analysis of three randomized, placebo-controlled trials of pregabalin.

Arnold LM, Zlateva G, Sadosky A, Emir B, Whalen E.

Pain Med. 2011 Feb;12(2):260-7. doi: 10.1111/j.1526-4637.2010.01047.x. Epub 2011 Jan 25.


Therapeutic potential of β-arrestin- and G protein-biased agonists.

Whalen EJ, Rajagopal S, Lefkowitz RJ.

Trends Mol Med. 2011 Mar;17(3):126-39. doi: 10.1016/j.molmed.2010.11.004. Epub 2010 Dec 21. Review.


Relationships among pain and depressive and anxiety symptoms in clinical trials of pregabalin in fibromyalgia.

Arnold LM, Leon T, Whalen E, Barrett J.

Psychosomatics. 2010 Nov-Dec;51(6):489-97. doi: 10.1176/appi.psy.51.6.489.


Treatment response to pregabalin in fibromyalgia pain: effect of patient baseline characteristics.

Emir B, Murphy TK, Petersel DL, Whalen E.

Expert Opin Pharmacother. 2010 Oct;11(14):2275-80. doi: 10.1517/14656566.2010.509717.


Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW.

J Pharmacol Exp Ther. 2010 Dec;335(3):572-9. doi: 10.1124/jpet.110.173005. Epub 2010 Aug 26.


A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures.

Baulac M, Leon T, O'Brien TJ, Whalen E, Barrett J.

Epilepsy Res. 2010 Sep;91(1):10-9. doi: 10.1016/j.eplepsyres.2010.05.008. Epub 2010 Aug 8.


Long-term add-on pregabalin treatment in patients with partial-onset epilepsy: pooled analysis of open-label clinical trials.

Uthman BM, Bazil CW, Beydoun A, Schulze-Bonhage A, Benabou R, Whalen E, Emir B, Griesing T, Leon T.

Epilepsia. 2010 Jun;51(6):968-78. doi: 10.1111/j.1528-1167.2010.02532.x. Epub 2010 Mar 19.


Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial.

Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R; 1066 HIV Neuropathy Study Group.

Neurology. 2010 Feb 2;74(5):413-20. doi: 10.1212/WNL.0b013e3181ccc6ef.


Pressure ulcers and nutritional support: a partnership to improve patient outcomes.

Barrett R, Tuttle V, Whalen E, Gatchell C, Dawe A.

J Nurs Care Qual. 2010 Apr-Jun;25(2):145-50. doi: 10.1097/NCQ.0b013e3181b7679e.


Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS.

Sci Signal. 2009 Jul 7;2(78):ra33. doi: 10.1126/scisignal.2000444.

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