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Items: 1 to 50 of 364

1.

Pre-treatment tumour perfusion parameters and initial RECIST response do not predict long-term survival outcomes for patients with head and neck squamous cell carcinoma treated with induction chemotherapy.

Lowe NM, Kershaw LE, Bernstein JM, Withey SB, Mais K, Homer JJ, Slevin NJ, Bonington SC, Carrington BM, West CM.

PLoS One. 2018 Mar 28;13(3):e0194841. doi: 10.1371/journal.pone.0194841. eCollection 2018.

2.

Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy.

Yang L, West CM.

Br J Radiol. 2018 Mar 20:20180036. doi: 10.1259/bjr.20180036. [Epub ahead of print]

PMID:
29513038
3.

Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts.

Yang L, Forker L, Irlam JJ, Pillay N, Choudhury A, West CML.

Oncotarget. 2017 Dec 12;9(3):3946-3955. doi: 10.18632/oncotarget.23280. eCollection 2018 Jan 9.

4.

Glycosylation Promotes the Random Coil to Helix Transition in a Region of a Protist Skp1 Associated with F-Box Binding.

Xu X, Eletsky A, Sheikh MO, Prestegard JH, West CM.

Biochemistry. 2018 Feb 6;57(5):511-515. doi: 10.1021/acs.biochem.7b01033. Epub 2017 Dec 28.

PMID:
29251491
5.

The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma.

Forker L, Gaunt P, Sioletic S, Shenjere P, Potter R, Roberts D, Irlam J, Valentine H, Hughes D, Hughes A, Billingham L, Grimer R, Seddon B, Choudhury A, Robinson M, West CML.

Br J Cancer. 2018 Mar 6;118(5):698-704. doi: 10.1038/bjc.2017.430. Epub 2017 Dec 12.

6.

Taxane, platinum and 5-FU prior to chemoradiotherapy benefits patients with stage IV neck node-positive head and neck cancer and a good performance status.

Lowe NM, Bernstein JM, Mais K, Garcez K, Lee LW, Sykes A, Thomson DJ, Homer JJ, West CM, Slevin NJ.

J Cancer Res Clin Oncol. 2018 Feb;144(2):389-401. doi: 10.1007/s00432-017-2553-9. Epub 2017 Dec 8.

PMID:
29222650
7.

Precision Oncology and Genomically Guided Radiation Therapy: A Report From the American Society for Radiation Oncology/American Association of Physicists in Medicine/National Cancer Institute Precision Medicine Conference.

Hall WA, Bergom C, Thompson RF, Baschnagel AM, Vijayakumar S, Willers H, Li XA, Schultz CJ, Wilson GD, West CML, Capala J, Coleman CN, Torres-Roca JF, Weidhaas J, Feng FY.

Int J Radiat Oncol Biol Phys. 2017 Jun 9. pii: S0360-3016(17)30982-3. doi: 10.1016/j.ijrobp.2017.05.044. [Epub ahead of print]

PMID:
28964588
8.

Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit.

Rahman K, Mandalasi M, Zhao P, Sheikh MO, Taujale R, Kim HW, van der Wel H, Matta K, Kannan N, Glushka JN, Wells L, West CM.

J Biol Chem. 2017 Nov 10;292(45):18644-18659. doi: 10.1074/jbc.M117.809301. Epub 2017 Sep 19.

PMID:
28928220
9.

O2 sensing-associated glycosylation exposes the F-box-combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases.

Sheikh MO, Thieker D, Chalmers G, Schafer CM, Ishihara M, Azadi P, Woods RJ, Glushka JN, Bendiak B, Prestegard JH, West CM.

J Biol Chem. 2017 Nov 17;292(46):18897-18915. doi: 10.1074/jbc.M117.809160. Epub 2017 Sep 19.

PMID:
28928219
10.

Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome.

Salem A, Asselin MC, Reymen B, Jackson A, Lambin P, West CML, O'Connor JPB, Faivre-Finn C.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx160. Review.

PMID:
28922791
11.

Nucleocytoplasmic Glycosylation.

West CM, Hart GW.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 18.
2017.

12.

Radiogenomics and radiotherapy response modeling.

El Naqa I, Kerns SL, Coates J, Luo Y, Speers C, West CML, Rosenstein BS, Ten Haken RK.

Phys Med Biol. 2017 Aug 1;62(16):R179-R206. doi: 10.1088/1361-6560/aa7c55. Review.

PMID:
28657906
13.

Data-Based Radiation Oncology: Design of Clinical Trials in the Toxicity Biomarkers Era.

Azria D, Lapierre A, Gourgou S, De Ruysscher D, Colinge J, Lambin P, Brengues M, Ward T, Bentzen SM, Thierens H, Rancati T, Talbot CJ, Vega A, Kerns SL, Andreassen CN, Chang-Claude J, West CML, Gill CM, Rosenstein BS.

Front Oncol. 2017 Apr 27;7:83. doi: 10.3389/fonc.2017.00083. eCollection 2017. Review.

14.

The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability.

Dickie BR, Rose CJ, Kershaw LE, Withey SB, Carrington BM, Davidson SE, Hutchison G, West CML.

Br J Cancer. 2017 May 23;116(11):1436-1443. doi: 10.1038/bjc.2017.121. Epub 2017 Apr 27.

PMID:
28449009
15.

Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector.

Taylor-Mulneix DL, Bendor L, Linz B, Rivera I, Ryman VE, Dewan KK, Wagner SM, Wilson EF, Hilburger LJ, Cuff LE, West CM, Harvill ET.

PLoS Biol. 2017 Apr 12;15(4):e2000420. doi: 10.1371/journal.pbio.2000420. eCollection 2017 Apr.

16.

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients.

Yang L, Taylor J, Eustace A, Irlam JJ, Denley H, Hoskin PJ, Alsner J, Buffa FM, Harris AL, Choudhury A, West CML.

Clin Cancer Res. 2017 Aug 15;23(16):4761-4768. doi: 10.1158/1078-0432.CCR-17-0038. Epub 2017 Apr 11.

PMID:
28400426
17.

Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases.

Sheikh MO, Halmo SM, Patel S, Middleton D, Takeuchi H, Schafer CM, West CM, Haltiwanger RS, Avci FY, Moremen KW, Wells L.

Glycobiology. 2017 Mar 1;27(3):206-212. doi: 10.1093/glycob/cww114.

18.

The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 trial (CRUK/01/004).

Choudhury A, West CM, Porta N, Hall E, Denley H, Hendron C, Lewis R, Hussain SA, Huddart R, James N.

Br J Cancer. 2017 Feb 28;116(5):649-657. doi: 10.1038/bjc.2017.2. Epub 2017 Jan 26.

19.

Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic.

Oguejiofor K, Galletta-Williams H, Dovedi SJ, Roberts DL, Stern PL, West CM.

Oncotarget. 2017 Feb 28;8(9):14416-14427. doi: 10.18632/oncotarget.14796.

20.

HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology.

Schache AG, Powell NG, Cuschieri KS, Robinson M, Leary S, Mehanna H, Rapozo D, Long A, Cubie H, Junor E, Monaghan H, Harrington KJ, Nutting CM, Schick U, Lau AS, Upile N, Sheard J, Brougham K, West CM, Oguejiofor K, Thomas S, Ness AR, Pring M, Thomas GJ, King EV, McCance DJ, James JA, Moran M, Sloan P, Shaw RJ, Evans M, Jones TM.

Cancer Res. 2016 Nov 15;76(22):6598-6606. doi: 10.1158/0008-5472.CAN-16-0633. Epub 2016 Aug 28.

21.

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

Herskind C, Talbot CJ, Kerns SL, Veldwijk MR, Rosenstein BS, West CM.

Cancer Lett. 2016 Nov 1;382(1):95-109. doi: 10.1016/j.canlet.2016.02.035. Epub 2016 Mar 2. Review.

22.

Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.

Burrows N, Williams J, Telfer BA, Resch J, Valentine HR, Fitzmaurice RJ, Eustace A, Irlam J, Rowling EJ, Hoang-Vu C, West CM, Brabant G, Williams KJ.

Oncotarget. 2016 Sep 27;7(39):63106-63123. doi: 10.18632/oncotarget.11056.

23.

Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer.

Kerns SL, Dorling L, Fachal L, Bentzen S, Pharoah PD, Barnes DR, Gómez-Caamaño A, Carballo AM, Dearnaley DP, Peleteiro P, Gulliford SL, Hall E, Michailidou K, Carracedo Á, Sia M, Stock R, Stone NN, Sydes MR, Tyrer JP, Ahmed S, Parliament M, Ostrer H, Rosenstein BS, Vega A, Burnet NG, Dunning AM, Barnett GC, West CM; Radiogenomics Consortium.

EBioMedicine. 2016 Aug;10:150-63. doi: 10.1016/j.ebiom.2016.07.022. Epub 2016 Jul 20.

24.

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.

Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA, Barnett GC, Dunning AM, Dorling L, West CML, Burnet NG, Elliott R, Coles C, Hall E, Fachal L, Vega A, Gómez-Caamaño A, Talbot CJ, Symonds RP, De Ruyck K, Thierens H, Ost P, Chang-Claude J, Seibold P, Popanda O, Overgaard M, Dearnaley D, Sydes MR, Azria D, Koch CA, Parliament M, Blackshaw M, Sia M, Fuentes-Raspall MJ, Ramon Y Cajal T, Barnadas A, Vesprini D, Gutiérrez-Enríquez S, Mollà M, Díez O, Yarnold JR, Overgaard J, Bentzen SM, Alsner J; International Radiogenomics Consortium (RgC).

Radiother Oncol. 2016 Dec;121(3):431-439. doi: 10.1016/j.radonc.2016.06.017. Epub 2016 Jul 18.

25.

Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer.

Irlam-Jones JJ, Eustace A, Denley H, Choudhury A, Harris AL, Hoskin PJ, West CM.

Br J Cancer. 2016 Aug 23;115(5):571-8. doi: 10.1038/bjc.2016.218. Epub 2016 Jul 21.

26.

Identification of Apolipoprotein A-I as a Retinoic Acid-binding Protein in the Eye.

Summers JA, Harper AR, Feasley CL, Van-Der-Wel H, Byrum JN, Hermann M, West CM.

J Biol Chem. 2016 Sep 2;291(36):18991-9005. doi: 10.1074/jbc.M116.725523. Epub 2016 Jul 11.

27.

Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity.

Ahmed M, Dorling L, Kerns S, Fachal L, Elliott R, Partliament M, Rosenstein BS, Vega A, Gómez-Caamaño A, Barnett G, Dearnaley DP, Hall E, Sydes M, Burnet N, Pharoah PD, Eeles R, West CM.

Br J Cancer. 2016 May 10;114(10):1165-74. doi: 10.1038/bjc.2016.94. Epub 2016 Apr 12.

28.

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.

Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L.

Gastroenterology. 2016 Jul;151(1):152-164.e11. doi: 10.1053/j.gastro.2016.03.039. Epub 2016 Apr 6.

29.

The E3 Ubiquitin Ligase Adaptor Protein Skp1 Is Glycosylated by an Evolutionarily Conserved Pathway That Regulates Protist Growth and Development.

Rahman K, Zhao P, Mandalasi M, van der Wel H, Wells L, Blader IJ, West CM.

J Biol Chem. 2016 Feb 26;291(9):4268-80. doi: 10.1074/jbc.M115.703751. Epub 2015 Dec 30.

30.

Pre-treatment lymphocytopaenia is an adverse prognostic biomarker in muscle-invasive and advanced bladder cancer.

Joseph N, Dovedi SJ, Thompson C, Lyons J, Kennedy J, Elliott T, West CM, Choudhury A.

Ann Oncol. 2016 Feb;27(2):294-9. doi: 10.1093/annonc/mdv546. Epub 2015 Nov 16.

PMID:
26578732
31.

Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy Toxicity.

Dorling L, Barnett GC, Michailidou K, Coles CE, Burnet NG, Yarnold J, Elliott RM, Dunning AM, Pharoah PD, West CM.

Clin Cancer Res. 2016 Mar 15;22(6):1413-20. doi: 10.1158/1078-0432.CCR-15-1080. Epub 2015 Oct 28.

32.

Prevalence and Factors Associated With Severe Physical Intimate Partner Violence Among U.S. Black Women: A Comparison of African American and Caribbean Blacks.

Lacey KK, West CM, Matusko N, Jackson JS.

Violence Against Women. 2016 May;22(6):651-70. doi: 10.1177/1077801215610014. Epub 2015 Oct 26.

PMID:
26503860
33.

Improved accuracy and precision of tracer kinetic parameters by joint fitting to variable flip angle and dynamic contrast enhanced MRI data.

Dickie BR, Banerji A, Kershaw LE, McPartlin A, Choudhury A, West CM, Rose CJ.

Magn Reson Med. 2016 Oct;76(4):1270-81. doi: 10.1002/mrm.26013. Epub 2015 Oct 19.

PMID:
26480291
34.

Cediranib combined with carboplatin and paclitaxel in patients with metastatic or recurrent cervical cancer (CIRCCa): a randomised, double-blind, placebo-controlled phase 2 trial.

Symonds RP, Gourley C, Davidson S, Carty K, McCartney E, Rai D, Banerjee S, Jackson D, Lord R, McCormack M, Hudson E, Reed N, Flubacher M, Jankowska P, Powell M, Dive C, West CML, Paul J.

Lancet Oncol. 2015 Nov;16(15):1515-1524. doi: 10.1016/S1470-2045(15)00220-X. Epub 2015 Oct 22.

35.

The 2015 Karl Meyer Lectureship Award and the Rosalind Kornfeld Award for Lifetime Achievement in Glycobiology, from the Society for Glycobiology.

West CM.

Glycobiology. 2015 Nov;25(11):1137-8. doi: 10.1093/glycob/cwv086. No abstract available.

PMID:
26443531
36.

Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma.

Oguejiofor K, Hall J, Slater C, Betts G, Hall G, Slevin N, Dovedi S, Stern PL, West CM.

Br J Cancer. 2015 Sep 15;113(6):886-93. doi: 10.1038/bjc.2015.277. Epub 2015 Aug 27.

37.

Gene Expression Signatures as Biomarkers of Tumour Hypoxia.

Harris BH, Barberis A, West CM, Buffa FM.

Clin Oncol (R Coll Radiol). 2015 Oct;27(10):547-60. doi: 10.1016/j.clon.2015.07.004. Epub 2015 Aug 14. Review.

PMID:
26282471
38.

Chemical Synthesis of a Glycopeptide Derived from Skp1 for Probing Protein Specific Glycosylation.

Chinoy ZS, Schafer CM, West CM, Boons GJ.

Chemistry. 2015 Aug 10;21(33):11779-87. doi: 10.1002/chem.201501598. Epub 2015 Jul 15.

39.

Biomarkers and Imaging for Precision Radiotherapy.

West CM, Huddart RA.

Clin Oncol (R Coll Radiol). 2015 Oct;27(10):545-6. doi: 10.1016/j.clon.2015.06.021. Epub 2015 Jul 11. No abstract available.

PMID:
26173954
40.

Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.

Barnett GC, Kerns SL, Noble DJ, Dunning AM, West CM, Burnet NG.

Clin Oncol (R Coll Radiol). 2015 Oct;27(10):579-87. doi: 10.1016/j.clon.2015.06.013. Epub 2015 Jul 10. Review.

PMID:
26166774
41.

Exploiting biological and physical determinants of radiotherapy toxicity to individualize treatment.

Scaife JE, Barnett GC, Noble DJ, Jena R, Thomas SJ, West CM, Burnet NG.

Br J Radiol. 2015 Jul;88(1051):20150172. doi: 10.1259/bjr.20150172. Epub 2015 May 26. Review.

42.

XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients.

Seibold P, Behrens S, Schmezer P, Helmbold I, Barnett G, Coles C, Yarnold J, Talbot CJ, Imai T, Azria D, Koch CA, Dunning AM, Burnet N, Bliss JM, Symonds RP, Rattay T, Suga T, Kerns SL, Bourgier C, Vallis KA, Sautter-Bihl ML, Claßen J, Debus J, Schnabel T, Rosenstein BS, Wenz F, West CM, Popanda O, Chang-Claude J.

Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1084-1092. doi: 10.1016/j.ijrobp.2015.04.011. Epub 2015 Apr 11.

PMID:
26072091
43.

Oxygen sensing by protozoans: how they catch their breath.

West CM, Blader IJ.

Curr Opin Microbiol. 2015 Aug;26:41-7. doi: 10.1016/j.mib.2015.04.006. Epub 2015 May 17. Review.

44.

Evolutionary diversity of social amoebae N-glycomes may support interspecific autonomy.

Feasley CL, van der Wel H, West CM.

Glycoconj J. 2015 Aug;32(6):345-59. doi: 10.1007/s10719-015-9592-8. Epub 2015 May 19.

45.

Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer.

Bernstein JM, Kershaw LE, Withey SB, Lowe NM, Homer JJ, Slevin NJ, Bonington SC, Carrington BM, West CM.

Oral Oncol. 2015 May;51(5):508-13. doi: 10.1016/j.oraloncology.2015.01.013. Epub 2015 Feb 18.

PMID:
25700703
46.

Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.

Langford DJ, Paul SM, West CM, Dunn LB, Levine JD, Kober KM, Dodd MJ, Miaskowski C, Aouizerat BE.

Pain. 2015 Mar;156(3):371-80. doi: 10.1097/01.j.pain.0000460319.87643.11.

PMID:
25599232
47.

Hyaluronan synthase assembles chitin oligomers with -GlcNAc(α1→)UDP at the reducing end.

Weigel PH, West CM, Zhao P, Wells L, Baggenstoss BA, Washburn JL.

Glycobiology. 2015 Jun;25(6):632-43. doi: 10.1093/glycob/cwv006. Epub 2015 Jan 12.

48.

Radiogenomics: the search for genetic predictors of radiotherapy response.

Kerns SL, West CM, Andreassen CN, Barnett GC, Bentzen SM, Burnet NG, Dekker A, De Ruysscher D, Dunning A, Parliament M, Talbot C, Vega A, Rosenstein BS.

Future Oncol. 2014 Dec;10(15):2391-406. doi: 10.2217/fon.14.173. Review.

PMID:
25525847
49.

Detection of distinct glycosylation patterns on human γ-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology.

West MB, Partyka K, Feasley CL, Maupin KA, Goppallawa I, West CM, Haab BB, Hanigan MH.

BMC Biotechnol. 2014 Dec 6;14:101. doi: 10.1186/s12896-014-0101-0.

50.

Glycosylation of Skp1 promotes formation of Skp1-cullin-1-F-box protein complexes in dictyostelium.

Sheikh MO, Xu Y, van der Wel H, Walden P, Hartson SD, West CM.

Mol Cell Proteomics. 2015 Jan;14(1):66-80. doi: 10.1074/mcp.M114.044560. Epub 2014 Oct 23.

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