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Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer.

Pierpont TM, Lyndaker AM, Anderson CM, Jin Q, Moore ES, Roden JL, Braxton A, Bagepalli L, Kataria N, Hu HZ, Garness J, Cook MS, Capel B, Schlafer DH, Southard T, Weiss RS.

Cell Rep. 2017 Nov 14;21(7):1896-1909. doi: 10.1016/j.celrep.2017.10.078.


TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9.

Liu Y, Cussiol JR, Dibitetto D, Sims JR, Twayana S, Weiss RS, Freire R, Marini F, Pellicioli A, Smolka MB.

J Cell Biol. 2017 Mar 6;216(3):623-639. doi: 10.1083/jcb.201607031. Epub 2017 Feb 22.


Matrix stiffening promotes a tumor vasculature phenotype.

Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):492-497. doi: 10.1073/pnas.1613855114. Epub 2016 Dec 29.


Optogenetic stimulation of the cochlea-A review of mechanisms, measurements, and first models.

Weiss RS, Voss A, Hemmert W.

Network. 2016;27(2-3):212-236. Epub 2016 Sep 20.


Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.

Subbaramaiah K, Brown KA, Zahid H, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ.

J Biol Chem. 2016 Jul 29;291(31):16011-23. doi: 10.1074/jbc.M115.698902. Epub 2016 Jun 1.


A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.

Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H.

Cancer Cell. 2016 May 9;29(5):767-768. doi: 10.1016/j.ccell.2016.04.005. Epub 2016 May 9. No abstract available.


Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition.

Wisitpitthaya S, Zhao Y, Long MJ, Li M, Fletcher EA, Blessing WA, Weiss RS, Aye Y.

ACS Chem Biol. 2016 Jul 15;11(7):2021-32. doi: 10.1021/acschembio.6b00303. Epub 2016 May 20.


A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.

Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H.

Cancer Cell. 2016 Apr 11;29(4):607. doi: 10.1016/j.ccell.2016.03.011. No abstract available.


Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.

Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4320-5. doi: 10.1073/pnas.1519858113. Epub 2016 Apr 5.


A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.

Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H.

Cancer Cell. 2016 Mar 14;29(3):297-310. doi: 10.1016/j.ccell.2016.02.007. Erratum in: Cancer Cell. 2016 Apr 11;29(4):607. Giannakakou, Paraszkevi [corrected to Giannakakou, Paraskevi]. Cancer Cell. 2016 May 9;29(5):767-768.


Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors.

Bordeleau F, Califano JP, Negrón Abril YL, Mason BN, LaValley DJ, Shin SJ, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8314-9. doi: 10.1073/pnas.1505421112. Epub 2015 Jun 23.


HUS1 regulates in vivo responses to genotoxic chemotherapies.

Balmus G, Lim PX, Oswald A, Hume KR, Cassano A, Pierre J, Hill A, Huang W, August A, Stokol T, Southard T, Weiss RS.

Oncogene. 2016 Feb 4;35(5):662-9. doi: 10.1038/onc.2015.118. Epub 2015 Apr 27.


Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.

Lim PX, Patel DR, Poisson KE, Basuita M, Tsai C, Lyndaker AM, Hwang BJ, Lu AL, Weiss RS.

J Biol Chem. 2015 Jun 12;290(24):14826-40. doi: 10.1074/jbc.M114.630640. Epub 2015 Apr 24.


Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.

Aye Y, Li M, Long MJ, Weiss RS.

Oncogene. 2015 Apr 16;34(16):2011-21. doi: 10.1038/onc.2014.155. Epub 2014 Jun 9. Review.


p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression.

Okayama S, Kopelovich L, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ, Subbaramaiah K.

J Biol Chem. 2014 Mar 7;289(10):6513-25. doi: 10.1074/jbc.M113.532523. Epub 2014 Jan 22.


Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images.

Li M, Jirapatnakul A, Biancardi A, Riccio ML, Weiss RS, Reeves AP.

PLoS One. 2013 Dec 23;8(12):e83806. doi: 10.1371/journal.pone.0083806. eCollection 2013.


Metabolic characterization of a Sirt5 deficient mouse model.

Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J.

Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806.


Dual modality endomicroscope with optical zoom capability.

Ouzounov DG, Rivera DR, Williams WO, Stupinski JA, Southard TL, Hume KH, Bentley J, Weiss RS, Webb WW, Xu C.

Biomed Opt Express. 2013 Aug 1;4(9):1494-503. doi: 10.1364/BOE.4.001494. eCollection 2013.


Clamping down on mammalian meiosis.

Lyndaker AM, Vasileva A, Wolgemuth DJ, Weiss RS, Lieberman HB.

Cell Cycle. 2013 Oct 1;12(19):3135-45. doi: 10.4161/cc.26061. Epub 2013 Aug 26.


Transgenic overexpression of ribonucleotide reductase improves cardiac performance.

Nowakowski SG, Kolwicz SC, Korte FS, Luo Z, Robinson-Hamm JN, Page JL, Brozovich F, Weiss RS, Tian R, Murry CE, Regnier M.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6187-92. doi: 10.1073/pnas.1220693110. Epub 2013 Mar 25.


Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.

Lyndaker AM, Lim PX, Mleczko JM, Diggins CE, Holloway JK, Holmes RJ, Kan R, Schlafer DH, Freire R, Cohen PE, Weiss RS.

PLoS Genet. 2013;9(2):e1003320. doi: 10.1371/journal.pgen.1003320. Epub 2013 Feb 28.


A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt sensitivity of blood pressure in exfoliated human renal proximal tubule cells: the virtual renal biopsy.

Gildea JJ, Lahiff DT, Van Sciver RE, Weiss RS, Shah N, McGrath HE, Schoeffel CD, Jose PA, Carey RM, Felder RA.

Clin Chim Acta. 2013 Jun 5;421:236-42. doi: 10.1016/j.cca.2013.02.021. Epub 2013 Feb 27.


Sensitizing cancer cells: is it really all about U?

Stover PJ, Weiss RS.

Cancer Cell. 2012 Jul 10;22(1):3-4. doi: 10.1016/j.ccr.2012.06.010.


Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR, Lee J, Riccio ML, Reeves AP, Sutter NB, Noden DM, Peters RM, Weiss RS.

Hum Mol Genet. 2012 Aug 1;21(15):3408-20. doi: 10.1093/hmg/dds173. Epub 2012 May 9.


The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.

Daugherity EK, Balmus G, Al Saei A, Moore ES, Abi Abdallah D, Rogers AB, Weiss RS, Maurer KJ.

Cell Cycle. 2012 May 15;11(10):1918-28. doi: 10.4161/cc.20259. Epub 2012 May 15.


Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung.

Pavlova I, Hume KR, Yazinski SA, Flanders J, Southard TL, Weiss RS, Webb WW.

J Biomed Opt. 2012 Mar;17(3):036014. doi: 10.1117/1.JBO.17.3.036014.


A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.

Qi Q, Huang W, Bai Y, Balmus G, Weiss RS, August A.

J Immunol. 2012 Apr 15;188(8):3611-9. doi: 10.4049/jimmunol.1102475. Epub 2012 Mar 7.


Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.

Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, Freire R, Weiss RS, Cohen PE.

PLoS Genet. 2011 Jun;7(6):e1002094. doi: 10.1371/journal.pgen.1002094. Epub 2011 Jun 2.


Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages.

Jinadasa RN, Bloom SE, Weiss RS, Duhamel GE.

Microbiology. 2011 Jul;157(Pt 7):1851-75. doi: 10.1099/mic.0.049536-0. Epub 2011 May 12. Review.


Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile.

Selvaraj V, Asano A, Page JL, Nelson JL, Kothapalli KS, Foster JA, Brenna JT, Weiss RS, Travis AJ.

Dev Biol. 2010 Dec 15;348(2):177-89. doi: 10.1016/j.ydbio.2010.09.019. Epub 2010 Oct 20.


Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.

Ylikallio E, Page JL, Xu X, Lampinen M, Bepler G, Ide T, Tyynismaa H, Weiss RS, Suomalainen A.

Nucleic Acids Res. 2010 Dec;38(22):8208-18. doi: 10.1093/nar/gkq735. Epub 2010 Aug 19.


A novel role for Fanconi anemia (FA) pathway effector protein FANCD2 in cell cycle progression of untransformed primary human cells.

Song IY, Barkley LR, Day TA, Weiss RS, Vaziri C.

Cell Cycle. 2010 Jun 15;9(12):2375-88. Epub 2010 Jun 15.


Multiphoton microscopy as a diagnostic imaging modality for lung cancer.

Pavlova I, Hume KR, Yazinski SA, Peters RM, Weiss RS, Webb WW.

Proc SPIE Int Soc Opt Eng. 2010 Jan 24;7569:756918.


Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.

Yazinski SA, Westcott PM, Ong K, Pinkas J, Peters RM, Weiss RS.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21282-7. doi: 10.1073/pnas.0904965106. Epub 2009 Nov 16.


Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm.

Selvaraj V, Asano A, Buttke DE, Sengupta P, Weiss RS, Travis AJ.

J Cell Physiol. 2009 Mar;218(3):522-36. doi: 10.1002/jcp.21624.


Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.

Meyerkord CL, Takahashi Y, Araya R, Takada N, Weiss RS, Wang HG.

Oncogene. 2008 Dec 11;27(58):7248-59. doi: 10.1038/onc.2008.336. Epub 2008 Sep 15.


Re: White M, Maatman T. Comparative analysis of effectiveness of two local anesthetic techniques in men undergoing no-scalpel vasectomy. (Urology 2007;70:1187-1189).

Weiss RS.

Urology. 2008 Aug;72(2):462. doi: 10.1016/j.urology.2008.01.085. Epub 2008 Jun 24. No abstract available.


Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.

Xu X, Page JL, Surtees JA, Liu H, Lagedrost S, Lu Y, Bronson R, Alani E, Nikitin AY, Weiss RS.

Cancer Res. 2008 Apr 15;68(8):2652-60. doi: 10.1158/0008-5472.CAN-07-5873.


Functionally distinct monomers and trimers produced by a viral oncoprotein.

Chung SH, Weiss RS, Frese KK, Prasad BV, Javier RT.

Oncogene. 2008 Feb 28;27(10):1412-20. Epub 2007 Sep 10.


A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles.

Chung SH, Frese KK, Weiss RS, Prasad BV, Javier RT.

J Virol. 2007 May;81(9):4787-97. Epub 2007 Feb 21.


Need telomere maintenance? Call 911.

Francia S, Weiss RS, d'Adda di Fagagna F.

Cell Div. 2007 Jan 17;2:3.


Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.

Levitt PS, Zhu M, Cassano A, Yazinski SA, Liu H, Darfler J, Peters RM, Weiss RS.

Mol Cell Biol. 2007 Mar;27(6):2189-201. Epub 2007 Jan 12.


Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex.

Francia S, Weiss RS, Hande MP, Freire R, d'Adda di Fagagna F.

Curr Biol. 2006 Aug 8;16(15):1551-8.


Re: no-needle jet anesthetic technique for no-scalpel vasectomy.

Weiss RS.

J Urol. 2006 Aug;176(2):842-3. No abstract available.


Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding.

Berghorn KA, Clark-Campbell PA, Han L, McGrattan M, Weiss RS, Roberson MS.

J Biol Chem. 2006 Jul 21;281(29):20357-67. Epub 2006 May 10.


Targeted ablation of Par-4 reveals a cell type-specific susceptibility to apoptosis-inducing agents.

Affar el B, Luke MP, Gay F, Calvo D, Sui G, Weiss RS, Li E, Shi Y.

Cancer Res. 2006 Apr 1;66(7):3456-62.


The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining.

Wang X, Hu B, Weiss RS, Wang Y.

Oncogene. 2006 Mar 23;25(13):1980-3. Erratum in: Oncogene. 2008 Feb 21;27(9):1343.


Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells.

Latorre IJ, Roh MH, Frese KK, Weiss RS, Margolis B, Javier RT.

J Cell Sci. 2005 Sep 15;118(Pt 18):4283-93. Epub 2005 Sep 1.

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