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Understanding the tumor immune microenvironment (TIME) for effective therapy.

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF.

Nat Med. 2018 May;24(5):541-550. doi: 10.1038/s41591-018-0014-x. Epub 2018 Apr 23. Review.


The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan3464. doi: 10.1126/scitranslmed.aan3464.


EMT in cancer.

Brabletz T, Kalluri R, Nieto MA, Weinberg RA.

Nat Rev Cancer. 2018 Feb;18(2):128-134. doi: 10.1038/nrc.2017.118. Epub 2018 Jan 12. Review.


The SUMO guards for SNAIL.

Ye X, Weinberg RA.

Oncotarget. 2017 Nov 15;8(58):97701-97702. doi: 10.18632/oncotarget.22432. eCollection 2017 Nov 17. No abstract available.


EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.

Guen VJ, Chavarria TE, Kröger C, Ye X, Weinberg RA, Lees JA.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10532-E10539. doi: 10.1073/pnas.1711534114. Epub 2017 Nov 20.


Upholding a role for EMT in pancreatic cancer metastasis.

Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ.

Nature. 2017 Jul 5;547(7661):E7-E8. doi: 10.1038/nature22963. No abstract available.


Upholding a role for EMT in breast cancer metastasis.

Ye X, Brabletz T, Kang Y, Longmore GD, Nieto MA, Stanger BZ, Yang J, Weinberg RA.

Nature. 2017 Jul 5;547(7661):E1-E3. doi: 10.1038/nature22816. No abstract available.


Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL.

J Exp Med. 2017 Aug 7;214(8):2243-2255. doi: 10.1084/jem.20161950. Epub 2017 Jun 30.


Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas.

Dongre A, Rashidian M, Reinhardt F, Bagnato A, Keckesova Z, Ploegh HL, Weinberg RA.

Cancer Res. 2017 Aug 1;77(15):3982-3989. doi: 10.1158/0008-5472.CAN-16-3292. Epub 2017 Apr 20.


EMT, CSCs, and drug resistance: the mechanistic link and clinical implications.

Shibue T, Weinberg RA.

Nat Rev Clin Oncol. 2017 Oct;14(10):611-629. doi: 10.1038/nrclinonc.2017.44. Epub 2017 Apr 11. Review.


LACTB is a tumour suppressor that modulates lipid metabolism and cell state.

Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt F, Thiru P, Golub TR, Vance JE, Weinberg RA.

Nature. 2017 Mar 30;543(7647):681-686. doi: 10.1038/nature21408. Epub 2017 Mar 22.


Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346. doi: 10.1073/pnas.1618298114. Epub 2017 Mar 7.


Emerging Biological Principles of Metastasis.

Lambert AW, Pattabiraman DR, Weinberg RA.

Cell. 2017 Feb 9;168(4):670-691. doi: 10.1016/j.cell.2016.11.037. Review.


Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based Therapy.

Pattabiraman DR, Weinberg RA.

Cold Spring Harb Symp Quant Biol. 2016;81:11-19. doi: 10.1101/sqb.2016.81.030957. Epub 2017 Jan 5. Review.


EMT, cell plasticity and metastasis.

Chaffer CL, San Juan BP, Lim E, Weinberg RA.

Cancer Metastasis Rev. 2016 Dec;35(4):645-654. doi: 10.1007/s10555-016-9648-7. Review.


Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency.

De Cock JM, Shibue T, Dongre A, Keckesova Z, Reinhardt F, Weinberg RA.

Cancer Res. 2016 Dec 1;76(23):6778-6784. Epub 2016 Aug 16.


Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.

Spiegel A, Brooks MW, Houshyar S, Reinhardt F, Ardolino M, Fessler E, Chen MB, Krall JA, DeCock J, Zervantonakis IK, Iannello A, Iwamoto Y, Cortez-Retamozo V, Kamm RD, Pittet MJ, Raulet DH, Weinberg RA.

Cancer Discov. 2016 Jun;6(6):630-49. doi: 10.1158/2159-8290.CD-15-1157. Epub 2016 Apr 12.


Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.

Pattabiraman DR, Bierie B, Kober KI, Thiru P, Krall JA, Zill C, Reinhardt F, Tam WL, Weinberg RA.

Science. 2016 Mar 4;351(6277):aad3680. doi: 10.1126/science.aad3680.


Addendum: A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.

Lu H, Clauser KR, Tam WL, Fröse J, Ye X, Eaton EN, Reinhardt F, Donnenberg VS, Bhargava R, Carr SA, Weinberg RA.

Nat Cell Biol. 2015 Dec;17(12):1607. doi: 10.1038/ncb3281. No abstract available.


Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression.

Ye X, Weinberg RA.

Trends Cell Biol. 2015 Nov;25(11):675-86. doi: 10.1016/j.tcb.2015.07.012. Epub 2015 Oct 1. Review.


Distinct EMT programs control normal mammary stem cells and tumour-initiating cells.

Ye X, Tam WL, Shibue T, Kaygusuz Y, Reinhardt F, Ng Eaton E, Weinberg RA.

Nature. 2015 Sep 10;525(7568):256-60. doi: 10.1038/nature14897. Epub 2015 Sep 2.


Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells.

Watnick RS, Rodriguez RK, Wang S, Blois AL, Rangarajan A, Ince T, Weinberg RA.

Oncogene. 2015 May 28;34(22):2949-50. doi: 10.1038/onc.2015.183. No abstract available.


Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.

Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM.

Science. 2015 Apr 17;348(6232):340-3. doi: 10.1126/science.1260384. Epub 2015 Apr 2.


How does multistep tumorigenesis really proceed?

Chaffer CL, Weinberg RA.

Cancer Discov. 2015 Jan;5(1):22-4. doi: 10.1158/2159-8290.CD-14-0788. Review.


The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming.

Unternaehrer JJ, Zhao R, Kim K, Cesana M, Powers JT, Ratanasirintrawoot S, Onder T, Shibue T, Weinberg RA, Daley GQ.

Stem Cell Reports. 2014 Nov 11;3(5):691-8. doi: 10.1016/j.stemcr.2014.09.008. Epub 2014 Oct 11.


A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.

Lu H, Clauser KR, Tam WL, Fröse J, Ye X, Eaton EN, Reinhardt F, Donnenberg VS, Bhargava R, Carr SA, Weinberg RA.

Nat Cell Biol. 2014 Nov;16(11):1105-17. doi: 10.1038/ncb3041. Epub 2014 Sep 28. Erratum in: Nat Cell Biol. 2015 Dec;17(12):1607.


Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.


Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells.

Watnick RS, Rodriguez RK, Wang S, Blois AL, Rangarajan A, Ince T, Weinberg RA.

Oncogene. 2015 May 28;34(22):2823-35. doi: 10.1038/onc.2014.228. Epub 2014 Aug 11. Erratum in: Oncogene. 2015 May 28;34(22):2949-50.


The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.

McAllister SS, Weinberg RA.

Nat Cell Biol. 2014 Aug;16(8):717-27. doi: 10.1038/ncb3015. Review.


Tackling the cancer stem cells - what challenges do they pose?

Pattabiraman DR, Weinberg RA.

Nat Rev Drug Discov. 2014 Jul;13(7):497-512. doi: 10.1038/nrd4253. Review.


Coming full circle-from endless complexity to simplicity and back again.

Weinberg RA.

Cell. 2014 Mar 27;157(1):267-71. doi: 10.1016/j.cell.2014.03.004. Review.


The epigenetics of epithelial-mesenchymal plasticity in cancer.

Tam WL, Weinberg RA.

Nat Med. 2013 Nov;19(11):1438-49. doi: 10.1038/nm.3336. Epub 2013 Nov 7. Review.


An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization.

Shibue T, Brooks MW, Weinberg RA.

Cancer Cell. 2013 Oct 14;24(4):481-98. doi: 10.1016/j.ccr.2013.08.012. Epub 2013 Sep 12. Erratum in: Cancer Cell. 2013 Dec 9;24(6):806-8.


Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells.

Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, Chen X, Liu XS, Brown M, Lim B, Weinberg RA.

Cancer Cell. 2013 Sep 9;24(3):347-64. doi: 10.1016/j.ccr.2013.08.005.


Poised with purpose: cell plasticity enhances tumorigenicity.

Marjanovic ND, Weinberg RA, Chaffer CL.

Cell Cycle. 2013 Sep 1;12(17):2713-4. doi: 10.4161/cc.26075. Epub 2013 Aug 19. No abstract available.


Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity.

Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, Reinhardt F, D'Alessio AC, Young RA, Weinberg RA.

Cell. 2013 Jul 3;154(1):61-74. doi: 10.1016/j.cell.2013.06.005.


Cell plasticity and heterogeneity in cancer.

Marjanovic ND, Weinberg RA, Chaffer CL.

Clin Chem. 2013 Jan;59(1):168-79. doi: 10.1373/clinchem.2012.184655. Epub 2012 Dec 6. Review.


Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling.

Li HJ, Reinhardt F, Herschman HR, Weinberg RA.

Cancer Discov. 2012 Sep;2(9):840-55. doi: 10.1158/2159-8290.CD-12-0101. Epub 2012 Jul 3.


The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions.

Shibue T, Brooks MW, Inan MF, Reinhardt F, Weinberg RA.

Cancer Discov. 2012 Aug;2(8):706-21. doi: 10.1158/2159-8290.CD-11-0239. Epub 2012 May 18.


Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links.

Scheel C, Weinberg RA.

Semin Cancer Biol. 2012 Oct;22(5-6):396-403. doi: 10.1016/j.semcancer.2012.04.001. Epub 2012 Apr 23. Review.


Bengt Westermark and our current understanding of tumor pathogenesis.

Weinberg RA.

Ups J Med Sci. 2012 May;117(2):81-2. doi: 10.3109/03009734.2012.670978. No abstract available.


Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1.

Emmons TL, Wrightstone AD, Baima ET, Brown S, Sommers CD, Hirsch JL, Pegg LE, Weinberg RA, Fischer HD, Wittwer AJ, Tomasselli AG.

Protein Pept Lett. 2012 May;19(5):485-91.


Slug and Sox9 cooperatively determine the mammary stem cell state.

Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA.

Cell. 2012 Mar 2;148(5):1015-28. doi: 10.1016/j.cell.2012.02.008.


Tumor metastasis: molecular insights and evolving paradigms.

Valastyan S, Weinberg RA.

Cell. 2011 Oct 14;147(2):275-92. doi: 10.1016/j.cell.2011.09.024. Review.


Hunting the elusive oncogene: a stroke of good luck.

Weinberg RA.

Nat Cell Biol. 2011 Aug 1;13(8):876. doi: 10.1038/ncb2302. No abstract available.


Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?

Scheel C, Weinberg RA.

Int J Cancer. 2011 Nov 15;129(10):2310-4. doi: 10.1002/ijc.26311. Epub 2011 Aug 29.


Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.

Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL, Weinberg RA.

Cell. 2011 Jun 10;145(6):926-40. doi: 10.1016/j.cell.2011.04.029.


Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state.

Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Brooks M, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Weinberg RA.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7950-5. doi: 10.1073/pnas.1102454108. Epub 2011 Apr 15.


A perspective on cancer cell metastasis.

Chaffer CL, Weinberg RA.

Science. 2011 Mar 25;331(6024):1559-64. doi: 10.1126/science.1203543. Review.


Activation of miR-31 function in already-established metastases elicits metastatic regression.

Valastyan S, Chang A, Benaich N, Reinhardt F, Weinberg RA.

Genes Dev. 2011 Mar 15;25(6):646-59. doi: 10.1101/gad.2004211. Retraction in: Genes Dev. 2015 Mar 15;29(6):686.

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