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Items: 1 to 50 of 702

1.

JAK2 inhibitor SAR302503 abrogates PD-L1 expression and targets therapy resistant non-small cell lung cancers.

Pitroda S, Stack M, Liu GF, Song SS, Chen L, Liang H, Parekh AD, Huang X, Roach PB, Posner MC, Weichselbaum RR, Khodarev NN.

Mol Cancer Ther. 2018 Feb 21. pii: molcanther.0667.2017. doi: 10.1158/1535-7163.MCT-17-0667. [Epub ahead of print]

PMID:
29467274
2.

Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.

Luke JJ, Lemons JM, Karrison TG, Pitroda SP, Melotek JM, Zha Y, Al-Hallaq HA, Arina A, Khodarev NN, Janisch L, Chang P, Patel JD, Fleming GF, Moroney J, Sharma MR, White JR, Ratain MJ, Gajewski TF, Weichselbaum RR, Chmura SJ.

J Clin Oncol. 2018 Feb 13:JCO2017762229. doi: 10.1200/JCO.2017.76.2229. [Epub ahead of print]

PMID:
29437535
3.

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance.

Liang H, Deng L, Hou Y, Meng X, Huang X, Rao E, Zheng W, Mauceri H, Mack M, Xu M, Fu YX, Weichselbaum RR.

Nat Commun. 2017 Nov 23;8(1):1736. doi: 10.1038/s41467-017-01566-5.

4.

Retuning the Radio in Radiobiology.

Chmura SJ, Connell PP, Weichselbaum RR.

J Natl Cancer Inst. 2017 Nov 3. doi: 10.1093/jnci/djx234. [Epub ahead of print] No abstract available.

PMID:
29126281
5.

A phase 1 trial of autologous stem cell transplantation conditioned with melphalan 200 mg/m2 and total marrow irradiation (TMI) in patients with relapsed/refractory multiple myeloma.

Patel P, Oh AL, Koshy M, Sweiss K, Saraf SL, Quigley JG, Khan I, Mahmud N, Hacker E, Ozer H, Peace DJ, Weichselbaum RR, Aydogan B, Rondelli D.

Leuk Lymphoma. 2017 Oct 25:1-6. doi: 10.1080/10428194.2017.1390231. [Epub ahead of print]

PMID:
29065747
6.

HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation.

Efimova EV, Ricco N, Labay E, Mauceri HJ, Flor AC, Ramamurthy A, Sutton HG, Weichselbaum RR, Kron SJ.

Mol Cancer Ther. 2018 Feb;17(2):407-418. doi: 10.1158/1535-7163.MCT-17-0288. Epub 2017 Oct 13.

7.

Survival outcomes for postoperative chemoradiation in intermediate-risk oral tongue cancers.

Spiotto MT, Jefferson GD, Wenig B, Markiewicz MR, Weichselbaum RR, Koshy M.

Head Neck. 2017 Dec;39(12):2537-2548. doi: 10.1002/hed.24932. Epub 2017 Sep 27.

PMID:
28960621
8.

Association between hospital volume and receipt of treatment and survival in patients with glioblastoma.

Koshy M, Sher DJ, Spiotto M, Husain Z, Engelhard H, Slavin K, Nicholas MK, Weichselbaum RR, Rusthoven C.

J Neurooncol. 2017 Dec;135(3):529-534. doi: 10.1007/s11060-017-2598-2. Epub 2017 Aug 23.

PMID:
28836140
9.

TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response.

Murley JS, Miller RC, Weichselbaum RR, Grdina DJ.

Radiat Res. 2017 Nov;188(5):579-590. doi: 10.1667/RR14831.1. Epub 2017 Aug 16.

PMID:
28813624
10.

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.

Xu MM, Pu Y, Han D, Shi Y, Cao X, Liang H, Chen X, Li XD, Deng L, Chen ZJ, Weichselbaum RR, Fu YX.

Immunity. 2017 Aug 15;47(2):363-373.e5. doi: 10.1016/j.immuni.2017.07.016. Epub 2017 Aug 8.

PMID:
28801234
11.

Rhythmic radiotherapy beats down TGF-β.

Chmura SJ, Weichselbaum RR.

Cell Cycle. 2017 Aug 3;16(15):1391. doi: 10.1080/15384101.2017.1337970. Epub 2017 Jul 19. No abstract available.

PMID:
28727497
12.

Rhythmic radiotherapy beats down TGF-β.

Chmura SJ, Weichselbaum RR.

Cell Cycle. 2017 Aug 3;16(15):1391. doi: 10.1080/15384101.2017.1337970. Epub 2017 Jul 19. No abstract available.

PMID:
28723240
13.

Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation.

Zhang Y, Kim TJ, Wroblewska JA, Tesic V, Upadhyay V, Weichselbaum RR, Tumanov AV, Tang H, Guo X, Tang H, Fu YX.

Cell Mol Immunol. 2017 Jun 5. doi: 10.1038/cmi.2017.25. [Epub ahead of print]

PMID:
28579615
14.

In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases.

Oshima G, Guo N, He C, Stack ME, Poon C, Uppal A, Wightman SC, Parekh A, Skowron KB, Posner MC, Lin W, Khodarev NN, Weichselbaum RR.

Mol Ther. 2017 Jul 5;25(7):1588-1595. doi: 10.1016/j.ymthe.2017.04.005. Epub 2017 Apr 28.

PMID:
28457664
15.

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.

Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T.

Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26.

16.

Differences in Survival With Surgery and Postoperative Radiotherapy Compared With Definitive Chemoradiotherapy for Oral Cavity Cancer: A National Cancer Database Analysis.

Spiotto MT, Jefferson G, Wenig B, Markiewicz M, Weichselbaum RR, Koshy M.

JAMA Otolaryngol Head Neck Surg. 2017 Jul 1;143(7):691-699. doi: 10.1001/jamaoto.2017.0012.

PMID:
28426848
17.

Systemic delivery of the tumor necrosis factor gene to tumors by a novel dual DNA-nanocomplex in a nanoparticle system.

Shukla V, Dalela M, Vij M, Weichselbaum R, Kharbanda S, Ganguli M, Kufe D, Singh H.

Nanomedicine. 2017 Jul;13(5):1833-1839. doi: 10.1016/j.nano.2017.03.004. Epub 2017 Mar 23.

PMID:
28343015
18.

Low Recombination Proficiency Score (RPS) Predicts Heightened Sensitivity to DNA-Damaging Chemotherapy in Breast Cancer.

Pitroda SP, Bao R, Andrade J, Weichselbaum RR, Connell PP.

Clin Cancer Res. 2017 Aug 1;23(15):4493-4500. doi: 10.1158/1078-0432.CCR-16-2845. Epub 2017 Mar 24.

PMID:
28341751
19.

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.

Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, Kim J, Zhao JC, Putzbach W, Murmann AE, Chen Z, Chen W, Liu X, Salomon AR, Liu H, Weichselbaum RR, Yu J, Peter ME.

Cell Rep. 2017 Mar 7;18(10):2373-2386. doi: 10.1016/j.celrep.2017.02.037.

20.

Radiotherapy and immunotherapy: a beneficial liaison?

Weichselbaum RR, Liang H, Deng L, Fu YX.

Nat Rev Clin Oncol. 2017 Jun;14(6):365-379. doi: 10.1038/nrclinonc.2016.211. Epub 2017 Jan 17. Review.

PMID:
28094262
21.

Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication.

Arina A, Karrison T, Galka E, Schreiber K, Weichselbaum RR, Schreiber H.

Cancer Immunol Res. 2017 Feb;5(2):127-136. doi: 10.1158/2326-6066.CIR-16-0293. Epub 2017 Jan 11.

22.

The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications.

Spiotto M, Fu YX, Weichselbaum RR.

Sci Immunol. 2016 Sep;1(3). pii: EAAG1266. doi: 10.1126/sciimmunol.aag1266. Epub 2016 Sep 30.

23.

Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop.

Smith GL, Ganz PA, Bekelman JE, Chmura SJ, Dignam JJ, Efstathiou JA, Jagsi R, Johnstone PA, Steinberg ML, Williams SB, Yu JB, Zietman AL, Weichselbaum RR, Tina Shih YC.

Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):450-461. doi: 10.1016/j.ijrobp.2016.10.042. Epub 2016 Nov 8.

PMID:
28011046
24.

Photodynamic Therapy Mediated by Nontoxic Core-Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer.

Duan X, Chan C, Guo N, Han W, Weichselbaum RR, Lin W.

J Am Chem Soc. 2016 Dec 28;138(51):16686-16695. doi: 10.1021/jacs.6b09538. Epub 2016 Dec 15.

25.

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones.

Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN.

J Vis Exp. 2016 Nov 30;(117). doi: 10.3791/54657.

PMID:
27929457
26.

Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers.

Skowron KB, Pitroda SP, Namm JP, Balogun O, Beckett MA, Zenner ML, Fayanju O, Huang X, Fernandez C, Zheng W, Qiao G, Chin R, Kron SJ, Khodarev NN, Posner MC, Steinberg GD, Weichselbaum RR.

Sci Rep. 2016 Oct 24;6:35854. doi: 10.1038/srep35854.

27.

Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity.

Miller RC, Murley JS, Rademaker AW, Woloschak GE, Li JJ, Weichselbaum RR, Grdina DJ.

Free Radic Biol Med. 2016 Oct;99:110-119. doi: 10.1016/j.freeradbiomed.2016.07.009. Epub 2016 Jul 15.

PMID:
27427516
28.

Chlorin-Based Nanoscale Metal-Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy.

Lu K, He C, Guo N, Chan C, Ni K, Weichselbaum RR, Lin W.

J Am Chem Soc. 2016 Sep 28;138(38):12502-10. doi: 10.1021/jacs.6b06663. Epub 2016 Sep 14.

29.

Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment.

Appelbe OK, Zhang Q, Pelizzari CA, Weichselbaum RR, Kron SJ.

Mol Pharm. 2016 Oct 3;13(10):3457-3467. Epub 2016 Sep 1.

30.

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy.

He C, Duan X, Guo N, Chan C, Poon C, Weichselbaum RR, Lin W.

Nat Commun. 2016 Aug 17;7:12499. doi: 10.1038/ncomms12499.

31.

Integrating conventional and antibody-based targeted anticancer treatment into immunotherapy.

Michelle Xu M, Pu Y, Weichselbaum RR, Fu YX.

Oncogene. 2017 Feb 2;36(5):585-592. doi: 10.1038/onc.2016.231. Epub 2016 Jul 18. Review.

32.

Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance.

Zheng W, Skowron KB, Namm JP, Burnette B, Fernandez C, Arina A, Liang H, Spiotto MT, Posner MC, Fu YX, Weichselbaum RR.

Oncotarget. 2016 Jul 12;7(28):43039-43051. doi: 10.18632/oncotarget.9915.

33.

Tumor-associated fibroblasts predominantly come from local and not circulating precursors.

Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7551-6. doi: 10.1073/pnas.1600363113. Epub 2016 Jun 17.

34.

Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury.

Wang T, Mathew B, Wu X, Shimizu Y, Rizzo AN, Dudek SM, Weichselbaum RR, Jacobson JR, Hecker L, Garcia JG.

Pulm Circ. 2016 Jun;6(2):234-9. doi: 10.1086/686491.

35.

Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma.

Rolle CE, Tan YC, Seiwert TY, Vora S, Kanteti R, Hasina R, Carey GB, Surati M, Weichselbaum RR, Lingen MW, Vokes EE, Salgia R.

Oncotarget. 2017 Mar 21;8(12):18726-18734. doi: 10.18632/oncotarget.9640.

36.

Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT).

Wong AC, Watson SP, Pitroda SP, Son CH, Das LC, Stack ME, Uppal A, Oshima G, Khodarev NN, Salama JK, Weichselbaum RR, Chmura SJ.

Cancer. 2016 Jul 15;122(14):2242-50. doi: 10.1002/cncr.30058. Epub 2016 May 20.

37.

In Reply to Zaghloul.

Liauw SL, Reddy AV, Weichselbaum RR, Smith ND, Steinberg GD.

Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):855. doi: 10.1016/j.ijrobp.2016.01.050. No abstract available.

PMID:
27131088
38.

Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers.

Labay E, Mauceri HJ, Efimova EV, Flor AC, Sutton HG, Kron SJ, Weichselbaum RR.

Oncotarget. 2016 Jun 7;7(23):33919-33. doi: 10.18632/oncotarget.8984.

39.

Stereotactic body radiotherapy for oligometastatic breast cancer: a new standard of care, or a medical reversal in waiting?

Drazer MW, Salama JK, Hahn OM, Weichselbaum RR, Chmura SJ.

Expert Rev Anticancer Ther. 2016 Jun;16(6):625-32. doi: 10.1080/14737140.2016.1178577. Epub 2016 May 10. Review.

PMID:
27078719
40.

Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.

Ranoa DR, Parekh AD, Pitroda SP, Huang X, Darga T, Wong AC, Huang L, Andrade J, Staley JP, Satoh T, Akira S, Weichselbaum RR, Khodarev NN.

Oncotarget. 2016 May 3;7(18):26496-515. doi: 10.18632/oncotarget.8420.

41.

Patterns of Failure After Radical Cystectomy for pT3-4 Bladder Cancer: Implications for Adjuvant Radiation Therapy.

Reddy AV, Pariser JJ, Pearce SM, Weichselbaum RR, Smith ND, Steinberg GD, Liauw SL.

Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1031-9. doi: 10.1016/j.ijrobp.2015.10.051. Epub 2015 Nov 5.

PMID:
27026309
42.

Response.

Koshy M, Malik R, Mahmood U, Husain Z, Weichselbaum RR, Sher DJ.

J Natl Cancer Inst. 2016 Jan 7;108(3). pii: djv413. doi: 10.1093/jnci/djv413. Print 2016 Mar. No abstract available.

PMID:
26744479
43.

Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.

Leisegang M, Engels B, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Uckert W, Nakamura Y, Schreiber H.

Clin Cancer Res. 2016 Jun 1;22(11):2734-43. doi: 10.1158/1078-0432.CCR-15-2361. Epub 2015 Dec 14.

44.

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.

Efimova EV, Takahashi S, Shamsi NA, Wu D, Labay E, Ulanovskaya OA, Weichselbaum RR, Kozmin SA, Kron SJ.

Mol Cancer Res. 2016 Feb;14(2):173-84. doi: 10.1158/1541-7786.MCR-15-0263. Epub 2015 Nov 4.

45.

Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury.

Mathew B, Takekoshi D, Sammani S, Epshtein Y, Sharma R, Smith BD, Mitra S, Desai AA, Weichselbaum RR, Garcia JG, Jacobson JR.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1420-9. doi: 10.1152/ajplung.00146.2014. Epub 2015 Oct 23.

46.

Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1.

Bronova I, Smith B, Aydogan B, Weichselbaum RR, Vemuri K, Erdelyi K, Makriyannis A, Pacher P, Berdyshev EV.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):555-62. doi: 10.1165/rcmb.2014-0331OC.

47.

Prevalence and Predictors of Inappropriate Delivery of Palliative Thoracic Radiotherapy for Metastatic Lung Cancer.

Koshy M, Malik R, Mahmood U, Husain Z, Weichselbaum RR, Sher DJ.

J Natl Cancer Inst. 2015 Sep 30;107(12):djv278. doi: 10.1093/jnci/djv278. Print 2015 Dec.

48.

From DNA Damage to Nucleic Acid Sensing: A Strategy to Enhance Radiation Therapy.

Deng L, Liang H, Fu S, Weichselbaum RR, Fu YX.

Clin Cancer Res. 2016 Jan 1;22(1):20-5. doi: 10.1158/1078-0432.CCR-14-3110. Epub 2015 Sep 11. Review.

49.

Nanomedicine for Combination Therapy of Cancer.

He C, Chan C, Weichselbaum RR, Fleming GF, Yamada SD, Lin W.

EBioMedicine. 2015 May 13;2(5):366-7. doi: 10.1016/j.ebiom.2015.05.013. eCollection 2015 May. No abstract available.

50.

Evidence for the Use of Multiple Mechanisms by Herpes Simplex Virus-1 R7020 to Inhibit Intimal Hyperplasia.

McCormick S, He Q, Stern J, Khodarev N, Weichselbaum R, Skelly CL.

PLoS One. 2015 Jul 1;10(7):e0130264. doi: 10.1371/journal.pone.0130264. eCollection 2015.

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