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Items: 37


Thermo-kinetic analysis space expansion for cyclophilin-ligand interactions - identification of a new nonpeptide inhibitor using Biacore™ T200.

Wear MA, Nowicki MW, Blackburn EA, McNae IW, Walkinshaw MD.

FEBS Open Bio. 2017 Feb 23;7(4):533-549. doi: 10.1002/2211-5463.12201. eCollection 2017 Apr.


Molecular basis for Cdk1-regulated timing of Mis18 complex assembly and CENP-A deposition.

Spiller F, Medina-Pritchard B, Abad MA, Wear MA, Molina O, Earnshaw WC, Jeyaprakash AA.

EMBO Rep. 2017 Jun;18(6):894-905. doi: 10.15252/embr.201643564. Epub 2017 Apr 4.


A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using ÄKTAxpressTM.

Nowicki MW, Blackburn EA, McNae IW, Wear MA.

PLoS One. 2015 Dec 30;10(12):e0146164. doi: 10.1371/journal.pone.0146164. eCollection 2015.


Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90.

Blackburn EA, Wear MA, Landré V, Narayan V, Ning J, Erman B, Ball KL, Walkinshaw MD.

Biosci Rep. 2015 Sep 1;35(5). pii: e00258. doi: 10.1042/BSR20150124.


Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.

McNeil EM, Astell KR, Ritchie AM, Shave S, Houston DR, Bakrania P, Jones HM, Khurana P, Wallace C, Chapman T, Wear MA, Walkinshaw MD, Saxty B, Melton DW.

DNA Repair (Amst). 2015 Jul;31:19-28. doi: 10.1016/j.dnarep.2015.04.002. Epub 2015 Apr 22.


Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states.

Blackburn EA, Fuad FA, Morgan HP, Nowicki MW, Wear MA, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD.

Biochem Biophys Res Commun. 2014 Jul 25;450(2):936-41. doi: 10.1016/j.bbrc.2014.06.113. Epub 2014 Jun 28.


Triazole biotin: a tight-binding biotinidase-resistant conjugate.

Germeroth AI, Hanna JR, Karim R, Kundel F, Lowther J, Neate PG, Blackburn EA, Wear MA, Campopiano DJ, Hulme AN.

Org Biomol Chem. 2013 Nov 28;11(44):7700-4. doi: 10.1039/c3ob41837e. Epub 2013 Oct 10.


Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli.

Bushell SR, Mainprize IL, Wear MA, Lou H, Whitfield C, Naismith JH.

Structure. 2013 May 7;21(5):844-53. doi: 10.1016/j.str.2013.03.010. Epub 2013 Apr 25.


M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.

Morgan HP, O'Reilly FJ, Wear MA, O'Neill JR, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5881-6. doi: 10.1073/pnas.1217157110. Epub 2013 Mar 25.


A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

Morgan HP, Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD.

Biochem J. 2012 Nov 15;448(1):67-72. doi: 10.1042/BJ20121014.


The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.

Soares DC, Bradshaw NJ, Zou J, Kennaway CK, Hamilton RS, Chen ZA, Wear MA, Blackburn EA, Bramham J, Böttcher B, Millar JK, Barlow PN, Walkinshaw MD, Rappsilber J, Porteous DJ.

J Biol Chem. 2012 Sep 21;287(39):32381-93. Epub 2012 Jul 27.


A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.

Eykelenboom JE, Briggs GJ, Bradshaw NJ, Soares DC, Ogawa F, Christie S, Malavasi EL, Makedonopoulou P, Mackie S, Malloy MP, Wear MA, Blackburn EA, Bramham J, McIntosh AM, Blackwood DH, Muir WJ, Porteous DJ, Millar JK.

Hum Mol Genet. 2012 Aug 1;21(15):3374-86. doi: 10.1093/hmg/dds169. Epub 2012 Apr 30.


Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans.

Dunsmore CJ, Malone KJ, Bailey KR, Wear MA, Florance H, Shirran S, Barran PE, Page AP, Walkinshaw MD, Turner NJ.

Chembiochem. 2011 Mar 21;12(5):802-10. doi: 10.1002/cbic.201000413. Epub 2011 Feb 17.


Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium.

Morgan HP, Wear MA, McNae I, Gallagher MP, Walkinshaw MD.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1240-5. doi: 10.1107/S1744309109033788. Epub 2009 Nov 27.


Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless.

Powell LM, Deaton AM, Wear MA, Jarman AP.

Genes Cells. 2008 Sep;13(9):915-29. doi: 10.1111/j.1365-2443.2008.01217.x. Epub 2008 Aug 4.


Radioprotectant Activity of 5-Diethylsulfonamoylsalicylatocopper(II) in Gamma Irradiated Mice.

Kuykendall Iii JA, Simmons Iii H, Irving HJ, Wear MA, Sorenson PG, Tipton LG, Maddox KM, Williams EL, Pham-Tran VA, Credit C, Chowdhury IL, Khan S, Tipton JB, Willingham WM, Sorenson JR.

Met Based Drugs. 1999;6(2):135-41. doi: 10.1155/MBD.1999.135.


Correction: Radioprotectant Activity of 5-Diethylsulfonamoylsalicylatocopper(II) in Gamma Irradiated Mice.

Kuykendall Iii JA, Simmons Iii H, Irving HJ, Wear MA, Sorenson PG, Tipton LG, Maddox KM, Williams EL, Pham-Tran VA, Credit C, Chowdhury IL, Khan S, Tipton JB, Willingham WM, Sorenson JR.

Met Based Drugs. 1999;6(3):193. doi: 10.1155/MBD.1999.193. No abstract available.


Cloning, purification and characterization of the Caenorhabditis elegans small glutamine-rich tetratricopeptide repeat-containing protein.

Worrall LJ, Wear MA, Page AP, Walkinshaw MD.

Biochim Biophys Acta. 2008 Mar;1784(3):496-503. doi: 10.1016/j.bbapap.2007.12.003. Epub 2007 Dec 15.


Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans.

Yang Y, Moir E, Kontopidis G, Taylor P, Wear MA, Malone K, Dunsmore CJ, Page AP, Turner NJ, Walkinshaw MD.

Biochem Biophys Res Commun. 2007 Nov 30;363(4):1013-9. Epub 2007 Oct 1.


Experimental determination of van der waals energies in a biological system.

Wear MA, Kan D, Rabu A, Walkinshaw MD.

Angew Chem Int Ed Engl. 2007;46(34):6453-6. No abstract available.


Tropomyosin regulates elongation by formin at the fast-growing end of the actin filament.

Wawro B, Greenfield NJ, Wear MA, Cooper JA, Higgs HN, Hitchcock-DeGregori SE.

Biochemistry. 2007 Jul 10;46(27):8146-55. Epub 2007 Jun 15.


Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach.

Morgan HP, Estibeiro P, Wear MA, Max KE, Heinemann U, Cubeddu L, Gallagher MP, Sadler PJ, Walkinshaw MD.

Nucleic Acids Res. 2007;35(10):e75. Epub 2007 May 8.


A kinetically trapped intermediate of FK506 binding protein forms in vitro: chaperone machinery dominates protein folding in vivo.

Wear MA, Patterson A, Walkinshaw MD.

Protein Expr Purif. 2007 Jan;51(1):80-95. Epub 2006 Jun 28.


A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A.

Wear MA, Patterson A, Malone K, Dunsmore C, Turner NJ, Walkinshaw MD.

Anal Biochem. 2005 Oct 15;345(2):214-26.


Mammalian CARMIL inhibits actin filament capping by capping protein.

Yang C, Pring M, Wear MA, Huang M, Cooper JA, Svitkina TM, Zigmond SH.

Dev Cell. 2005 Aug;9(2):209-21.


Capping protein: new insights into mechanism and regulation.

Wear MA, Cooper JA.

Trends Biochem Sci. 2004 Aug;29(8):418-28. Review.


Biological role and structural mechanism of twinfilin-capping protein interaction.

Falck S, Paavilainen VO, Wear MA, Grossmann JG, Cooper JA, Lappalainen P.

EMBO J. 2004 Aug 4;23(15):3010-9. Epub 2004 Jul 29.


Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance.

Kim K, Yamashita A, Wear MA, Maéda Y, Cooper JA.

J Cell Biol. 2004 Feb 16;164(4):567-80. Epub 2004 Feb 9.


End versus side branching by Arp2/3 complex.

Carlsson AE, Wear MA, Cooper JA.

Biophys J. 2004 Feb;86(2):1074-81.


How capping protein binds the barbed end of the actin filament.

Wear MA, Yamashita A, Kim K, Maéda Y, Cooper JA.

Curr Biol. 2003 Sep 2;13(17):1531-7.


Arp2/3 complex: advances on the inner workings of a molecular machine.

Cooper JA, Wear MA, Weaver AM.

Cell. 2001 Dec 14;107(6):703-5. Review.


Interactions with PIP2, ADP-actin monomers, and capping protein regulate the activity and localization of yeast twinfilin.

Palmgren S, Ojala PJ, Wear MA, Cooper JA, Lappalainen P.

J Cell Biol. 2001 Oct 15;155(2):251-60. Epub 2001 Oct 15.


Actin dynamics: assembly and disassembly of actin networks.

Wear MA, Schafer DA, Cooper JA.

Curr Biol. 2000 Dec 14-28;10(24):R891-5. Review.

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