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Androgen Deprivation Therapy Potentiates the Efficacy of Vascular Targeted Photodynamic Therapy of Prostate Cancer Xenografts.

Kim K, Watson PA, Lebdai S, Jebiwott S, Somma AJ, La Rosa S, Mehta D, Murray KS, Lilja H, Ulmert D, Monette S, Scherz A, Coleman JA.

Clin Cancer Res. 2018 Feb 20. doi: 10.1158/1078-0432.CCR-17-3474. [Epub ahead of print]


Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner.

Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA.

World J Cardiol. 2017 Aug 26;9(8):673-684. doi: 10.4330/wjc.v9.i8.673.


Androgen Receptor Signaling in Salivary Gland Cancer.

Dalin MG, Watson PA, Ho AL, Morris LG.

Cancers (Basel). 2017 Feb 8;9(2). pii: E17. doi: 10.3390/cancers9020017. Review.


Intrinsic material property differences in bone tissue from patients suffering low-trauma osteoporotic fractures, compared to matched non-fracturing women.

Vennin S, Desyatova A, Turner JA, Watson PA, Lappe JM, Recker RR, Akhter MP.

Bone. 2017 Apr;97:233-242. doi: 10.1016/j.bone.2017.01.031. Epub 2017 Jan 27.


SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.

Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL.

Science. 2017 Jan 6;355(6320):84-88. doi: 10.1126/science.aah4307.


Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis.

Thorek DL, Watson PA, Lee SG, Ku AT, Bournazos S, Braun K, Kim K, Sjöström K, Doran MG, Lamminmäki U, Santos E, Veach D, Turkekul M, Casey E, Lewis JS, Abou DS, van Voss MR, Scardino PT, Strand SE, Alpaugh ML, Scher HI, Lilja H, Larson SM, Ulmert D.

Sci Transl Med. 2016 Nov 30;8(367):367ra167.


Efficacy of a hospital-wide environmental cleaning protocol on hospital-acquired methicillin-resistant Staphylococcus aureus rates.

Watson PA, Watson LR, Torress-Cook A.

J Infect Prev. 2016 Jul;17(4):171-176. doi: 10.1177/1757177416645342. Epub 2016 May 13.


Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer.

Watson PA, Arora VK, Sawyers CL.

Nat Rev Cancer. 2015 Dec;15(12):701-11. doi: 10.1038/nrc4016. Epub 2015 Nov 13. Review.


Annotating STEAP1 regulation in prostate cancer with 89Zr immuno-PET.

Doran MG, Watson PA, Cheal SM, Spratt DE, Wongvipat J, Steckler JM, Carrasquillo JA, Evans MJ, Lewis JS.

J Nucl Med. 2014 Dec;55(12):2045-9. doi: 10.2967/jnumed.114.145185. Epub 2014 Nov 5.


Diet and sex modify exercise and cardiac adaptation in the mouse.

Konhilas JP, Chen H, Luczak E, McKee LA, Regan J, Watson PA, Stauffer BL, Khalpey ZI, Mckinsey TA, Horn T, LaFleur B, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H135-45. doi: 10.1152/ajpheart.00532.2014. Epub 2014 Nov 14.


Enhancing the Quality of Prevention Research Supported by the National Institutes of Health.

Murray DM, Cross WP, Simons-Morton D, Engel J, Portnoy B, Wu J, Watson PA, Olkkola S.

Am J Public Health. 2015 Jan;105(1):9-12.


Targeting mitochondria to restore failed adaptation to exercise in diabetes.

Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE.

Biochem Soc Trans. 2014 Apr;42(2):231-8. doi: 10.1042/BST20130283. Review.


Androgen receptor signaling regulates DNA repair in prostate cancers.

Polkinghorn WR, Parker JS, Lee MX, Kass EM, Spratt DE, Iaquinta PJ, Arora VK, Yen WF, Cai L, Zheng D, Carver BS, Chen Y, Watson PA, Shah NP, Fujisawa S, Goglia AG, Gopalan A, Hieronymus H, Wongvipat J, Scardino PT, Zelefsky MJ, Jasin M, Chaudhuri J, Powell SN, Sawyers CL.

Cancer Discov. 2013 Nov;3(11):1245-53. doi: 10.1158/2159-8290.CD-13-0172. Epub 2013 Sep 11.


Relationship of CD146 expression to activation of circulating T cells: exploratory studies in healthy donors and patients with connective tissue diseases.

Hadjinicolaou AV, Wu L, Fang B, Watson PA, Hall FC, Busch R.

Clin Exp Immunol. 2013 Oct;174(1):73-88. doi: 10.1111/cei.12151.


Nitric oxide regulates vascular adaptive mitochondrial dynamics.

Miller MW, Knaub LA, Olivera-Fragoso LF, Keller AC, Balasubramaniam V, Watson PA, Reusch JE.

Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1624-33. doi: 10.1152/ajpheart.00987.2012. Epub 2013 Apr 12.


Overcoming mutation-based resistance to antiandrogens with rational drug design.

Balbas MD, Evans MJ, Hosfield DJ, Wongvipat J, Arora VK, Watson PA, Chen Y, Greene GL, Shen Y, Sawyers CL.

Elife. 2013 Apr 9;2:e00499. doi: 10.7554/eLife.00499.


Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS.

Östör A, Watson PA.

Evid Based Med. 2013 Oct;18(5):174-5. doi: 10.1136/eb-2012-101083. Epub 2012 Dec 12. No abstract available.


Impaired response to exercise intervention in the vasculature in metabolic syndrome.

Knaub LA, McCune S, Chicco AJ, Miller M, Moore RL, Birdsey N, Lloyd MI, Villarreal J, Keller AC, Watson PA, Reusch JE.

Diab Vasc Dis Res. 2013 May;10(3):222-38. doi: 10.1177/1479164112459664. Epub 2012 Nov 16.


Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease.

Haines CD, Harvey PA, Luczak ED, Barthel KK, Konhilas JP, Watson PA, Stauffer BL, Leinwand LA.

Endocrinology. 2012 Sep;153(9):4470-9. doi: 10.1210/en.2012-1391. Epub 2012 Jul 9.


Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.

Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA.

Circ Res. 2012 Mar 2;110(5):739-48. doi: 10.1161/CIRCRESAHA.111.258426. Epub 2012 Jan 26.


Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.

Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, Watson PA, Birdsey N, Bao J, Gius D, Sack MN, Jing E, Kahn CR, Friedman JE, Jonscher KR.

Biochem J. 2011 Feb 1;433(3):505-14. doi: 10.1042/BJ20100791.


Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice.

Watson PA, Birdsey N, Huggins GS, Svensson E, Heppe D, Knaub L.

Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H2056-68. doi: 10.1152/ajpheart.00394.2010. Epub 2010 Oct 8.


Can we cure rheumatoid arthritis?

Watson PA, Ostör AJ.

Br J Hosp Med (Lond). 2010 Sep;71(9):486-7. No abstract available.


Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor.

Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16759-65. doi: 10.1073/pnas.1012443107. Epub 2010 Sep 7.


Fatty acids increase glucose uptake and metabolism in C2C12 myoblasts stably transfected with human lipoprotein lipase.

Capell WH, Schlaepfer IR, Wolfe P, Watson PA, Bessesen DH, Pagliassotti MJ, Eckel RH.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E576-83. doi: 10.1152/ajpendo.00618.2009. Epub 2010 Jul 13.


Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors.

Traynor AM, Hewitt M, Liu G, Flaherty KT, Clark J, Freedman SJ, Scott BB, Leighton AM, Watson PA, Zhao B, O'Dwyer PJ, Wilding G.

Cancer Chemother Pharmacol. 2011 Feb;67(2):305-14. doi: 10.1007/s00280-010-1318-9. Epub 2010 Apr 13.


CREB downregulation in vascular disease: a common response to cardiovascular risk.

Schauer IE, Knaub LA, Lloyd M, Watson PA, Gliwa C, Lewis KE, Chait A, Klemm DJ, Gunter JM, Bouchard R, McDonald TO, O'Brien KD, Reusch JE.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):733-41. doi: 10.1161/ATVBAHA.109.199133. Epub 2010 Feb 11.


Development of a second-generation antiandrogen for treatment of advanced prostate cancer.

Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL.

Science. 2009 May 8;324(5928):787-90. doi: 10.1126/science.1168175. Epub 2009 Apr 9.


Novel use of antimicrobial hand sanitizer in treatment of nosocomial acinetobacter infection.

Donahue M, Watson LR, Torress-Cook A, Watson PA.

Orthopedics. 2009 Jan;32(1):58.


Fracture strength and fatigue resistance of all-ceramic molar crowns manufactured with CAD/CAM technology.

Zahran M, El-Mowafy O, Tam L, Watson PA, Finer Y.

J Prosthodont. 2008 Jul;17(5):370-7. doi: 10.1111/j.1532-849X.2008.00305.x.


Epidermal growth factor receptor vIII expression in U87 glioblastoma cells alters their proteasome composition, function, and response to irradiation.

Kim K, Brush JM, Watson PA, Cacalano NA, Iwamoto KS, McBride WH.

Mol Cancer Res. 2008 Mar;6(3):426-34. doi: 10.1158/1541-7786.MCR-07-0313.


Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.

Jiao J, Wang S, Qiao R, Vivanco I, Watson PA, Sawyers CL, Wu H.

Cancer Res. 2007 Jul 1;67(13):6083-91.


Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise.

Watson PA, Reusch JE, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Sparagna GC, Long CS, Moore RL.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H246-59. Epub 2007 Mar 2.


Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas.

Woditschka S, Haag JD, Waller JL, Monson DM, Hitt AA, Brose HL, Hu R, Zheng Y, Watson PA, Kim K, Lindstrom MJ, Mau B, Steele VE, Lubet RA, Gould MN.

Cancer Res. 2006 Jul 1;66(13):6884-91.


Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy.

Konhilas JP, Watson PA, Maass A, Boucek DM, Horn T, Stauffer BL, Luckey SW, Rosenberg P, Leinwand LA.

Circ Res. 2006 Mar 3;98(4):540-8. Epub 2006 Jan 26.


Context-dependent hormone-refractory progression revealed through characterization of a novel murine prostate cancer cell line.

Watson PA, Ellwood-Yen K, King JC, Wongvipat J, Lebeau MM, Sawyers CL.

Cancer Res. 2005 Dec 15;65(24):11565-71.


Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat.

Brown DA, Chicco AJ, Jew KN, Johnson MS, Lynch JM, Watson PA, Moore RL.

J Physiol. 2005 Dec 15;569(Pt 3):913-24. Epub 2005 Oct 13.


Removal, replacement and placement of amalgam restorations by Ontario dentists in 2002.

Adegbembo AO, Watson PA.

J Can Dent Assoc. 2005 Sep;71(8):565.


Loss of CREB regulation of vascular smooth muscle cell quiescence in diabetes.

Reusch JE, Watson PA.

Rev Endocr Metab Disord. 2004 Aug;5(3):209-19. Review. No abstract available.


Estimating the weight of dental amalgam restorations.

Adegbembo AO, Watson PA, Rokni S.

J Can Dent Assoc. 2004 Jan;70(1):30.


Novel actions of thiazolidinediones on vascular function and exercise capacity.

Reusch JE, Regensteiner JG, Watson PA.

Am J Med. 2003 Dec 8;115 Suppl 8A:69S-74S. Review.


Why do older people not get immunised against influenza? A community survey.

Evans MR, Watson PA.

Vaccine. 2003 Jun 2;21(19-20):2421-7.


Androgen-dependent mammary carcinogenesis in rats transgenic for the Neu proto-oncogene.

Watson PA, Kim K, Chen KS, Gould MN.

Cancer Cell. 2002 Jul;2(1):67-79.


Biomimetic dental implants--new ways to enhance osseointegration.

Simon Z, Watson PA.

J Can Dent Assoc. 2002 May;68(5):286-8. No abstract available.


Diabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration.

Watson PA, Nesterova A, Burant CF, Klemm DJ, Reusch JE.

J Biol Chem. 2001 Dec 7;276(49):46142-50. Epub 2001 Sep 17.

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