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PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma.

Waschek JA, Baca SM, Akerman S.

J Headache Pain. 2018 Mar 13;19(1):23. doi: 10.1186/s10194-018-0850-6.


Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.

Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman JD, Rajbhandari AK, Fanselow MS, Hashimoto H, Waschek JA.

Neurobiol Learn Mem. 2017 Nov;145:222-231. doi: 10.1016/j.nlm.2017.10.010. Epub 2017 Oct 10.


Erratum to: VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage.

Abad C, Jayaram B, Becquet L, Wang Y, O'Dorisio MS, Waschek JA, Tan YV.

J Neuroinflammation. 2017 Aug 4;14(1):157. doi: 10.1186/s12974-017-0927-1. No abstract available.


High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H.

Neuron. 2017 Jun 21;94(6):1085-1100.e6. doi: 10.1016/j.neuron.2017.05.017.


PACAP Promotes Matrix-Driven Adhesion of Cultured Adult Murine Neural Progenitors.

Waschek JA, Cohen JR, Chi GC, Proszynski TJ, Niewiadomski P.

ASN Neuro. 2017 May-Jun;9(3):1759091417708720. doi: 10.1177/1759091417708720.


Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain.

Missig G, Mei L, Vizzard MA, Braas KM, Waschek JA, Ressler KJ, Hammack SE, May V.

Biol Psychiatry. 2017 Apr 15;81(8):671-682. doi: 10.1016/j.biopsych.2016.08.025. Epub 2016 Aug 29.


Graded fear generalization enhances the level of cfos-positive neurons specifically in the basolateral amygdala.

Rajbhandari AK, Zhu R, Adling C, Fanselow MS, Waschek JA.

J Neurosci Res. 2016 Dec;94(12):1393-1399. doi: 10.1002/jnr.23947. Epub 2016 Sep 23.


VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage.

Abad C, Jayaram B, Becquet L, Wang Y, O'Dorisio MS, Waschek JA, Tan YV.

J Neuroinflammation. 2016 Jun 29;13(1):169. doi: 10.1186/s12974-016-0626-3. Erratum in: J Neuroinflammation. 2017 Aug 4;14 (1):157.


High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons.

Condro MC, Matynia A, Foster NN, Ago Y, Rajbhandari AK, Van C, Jayaram B, Parikh S, Diep AL, Nguyen E, May V, Dong HW, Waschek JA.

J Comp Neurol. 2016 Dec 15;524(18):3827-3848. doi: 10.1002/cne.24035. Epub 2016 Jun 3.


Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications.

Marzagalli R, Scuderi S, Drago F, Waschek JA, Castorina A.

Int J Endocrinol. 2015;2015:160928. doi: 10.1155/2015/160928. Epub 2015 May 14. Review.


Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice.

Wu X, Conlin VS, Morampudi V, Ryz NR, Nasser Y, Bhinder G, Bergstrom KS, Yu HB, Waterhouse CC, Buchan AM, Popescu OE, Gibson WT, Waschek JA, Vallance BA, Jacobson K.

PLoS One. 2015 May 1;10(5):e0125225. doi: 10.1371/journal.pone.0125225. eCollection 2015.


Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide.

Shibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.

Neuroscience. 2015 Jun 25;297:95-104. doi: 10.1016/j.neuroscience.2015.03.062. Epub 2015 Apr 1.


CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice.

Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata KY, Nakamura M, Hashimoto R, Matsuda T, Waschek JA, Kasai A, Nagayasu K, Baba A, Hashimoto H.

Behav Brain Res. 2015 May 1;284:131-7. doi: 10.1016/j.bbr.2015.02.013. Epub 2015 Feb 16.


PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures.

Castorina A, Waschek JA, Marzagalli R, Cardile V, Drago F.

PLoS One. 2015 Feb 6;10(2):e0117799. doi: 10.1371/journal.pone.0117799. eCollection 2015.


Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist.

Ago Y, Condro MC, Tan YV, Ghiani CA, Colwell CS, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.

Psychopharmacology (Berl). 2015 Jun;232(12):2181-9. doi: 10.1007/s00213-014-3848-z. Epub 2015 Jan 11.


Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.

Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, Matsuda T, Baba A, Hashimoto H.

J Neurochem. 2015 Feb;132(4):418-28. doi: 10.1111/jnc.12999. Epub 2015 Jan 23.


Vasoactive intestinal peptide-deficient mice exhibit reduced pathology in trinitrobenzene sulfonic acid-induced colitis.

Abad C, Cheung-Lau G, Coûté-Monvoisin AC, Waschek JA.

Neuroimmunomodulation. 2015;22(3):203-12. doi: 10.1159/000364912. Epub 2014 Oct 3.


Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice.

Vu JP, Million M, Larauche M, Luong L, Norris J, Waschek JA, Pothoulakis C, Pisegna JR, Germano PM.

J Mol Neurosci. 2014 Jan;52(1):37-47. doi: 10.1007/s12031-013-0205-3. Epub 2014 Jan 7.


Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.

Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y.

J Immunol. 2014 Jan 1;192(1):110-22. doi: 10.4049/jimmunol.1302586. Epub 2013 Dec 4.


Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma.

Abad C, Nobuta H, Li J, Kasai A, Yong WH, Waschek JA.

J Leukoc Biol. 2014 Feb;95(2):357-67. doi: 10.1189/jlb.1012531. Epub 2013 Sep 25.


Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA.

Niewiadomski P, Zhujiang A, Youssef M, Waschek JA.

Cell Signal. 2013 Nov;25(11):2222-30. doi: 10.1016/j.cellsig.2013.07.012. Epub 2013 Jul 18.


Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate-protein kinase a pathway.

Ji H, Zhang Y, Liu Y, Shen XD, Gao F, Nguyen TT, Busuttil RW, Waschek JA, Kupiec-Weglinski JW.

Liver Transpl. 2013 Sep;19(9):945-56. doi: 10.1002/lt.23681. Epub 2013 Jul 26.


Pituitary adenylate cyclase activating peptide deficient mice exhibit impaired thymic and extrathymic regulatory T cell proliferation during EAE.

Tan YV, Abad C, Wang Y, Lopez R, Waschek JA.

PLoS One. 2013 Apr 16;8(4):e61200. doi: 10.1371/journal.pone.0061200. Print 2013.


VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair.

Waschek JA.

Br J Pharmacol. 2013 Jun;169(3):512-23. doi: 10.1111/bph.12181. Review.


PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice.

Watson MB, Nobuta H, Abad C, Lee SK, Bala N, Zhu C, Richter F, Chesselet MF, Waschek JA.

Neuroscience. 2013 Jun 14;240:277-86. doi: 10.1016/j.neuroscience.2013.03.002. Epub 2013 Mar 14.


Vulnerability imposed by diet and brain trauma for anxiety-like phenotype: implications for post-traumatic stress disorders.

Tyagi E, Agrawal R, Zhuang Y, Abad C, Waschek JA, Gomez-Pinilla F.

PLoS One. 2013;8(3):e57945. doi: 10.1371/journal.pone.0057945. Epub 2013 Mar 6.


STAT3-mediated astrogliosis protects myelin development in neonatal brain injury.

Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA.

Ann Neurol. 2012 Nov;72(5):750-65. doi: 10.1002/ana.23670. Epub 2012 Aug 31.


VIP deficient mice exhibit resistance to lipopolysaccharide induced endotoxemia with an intrinsic defect in proinflammatory cellular responses.

Abad C, Tan YV, Cheung-Lau G, Nobuta H, Waschek JA.

PLoS One. 2012;7(5):e36922. doi: 10.1371/journal.pone.0036922. Epub 2012 May 17. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/c70f1786-cb3f-4677-9a7c-0182dfbec74c.


Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway.

Ji H, Zhang Y, Shen XD, Gao F, Huang CY, Abad C, Busuttil RW, Waschek JA, Kupiec-Weglinski JW.

Hepatology. 2013 Mar;57(3):1225-37. doi: 10.1002/hep.25802. Epub 2013 Jan 18.


Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.

Harmar AJ, Fahrenkrug J, Gozes I, Laburthe M, May V, Pisegna JR, Vaudry D, Vaudry H, Waschek JA, Said SI.

Br J Pharmacol. 2012 May;166(1):4-17. doi: 10.1111/j.1476-5381.2012.01871.x. Review.


Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat.

Ghiani CA, Mattan NS, Nobuta H, Malvar JS, Boles J, Ross MG, Waschek JA, Carpenter EM, Fisher RS, de Vellis J.

ASN Neuro. 2011 Nov 17;3(4). pii: e00068. doi: 10.1042/AN20110027.


Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis.

Tan YV, Waschek JA.

ASN Neuro. 2011 Oct 6;3(4). pii: e00065. doi: 10.1042/AN20110024. Review.


Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures.

Hirose M, Niewiadomski P, Tse G, Chi GC, Dong H, Lee A, Carpenter EM, Waschek JA.

J Neurosci Res. 2011 Sep;89(9):1363-74. doi: 10.1002/jnr.22675. Epub 2011 Jun 14.


Effects of vasoactive intestinal peptide genotype on circadian gene expression in the suprachiasmatic nucleus and peripheral organs.

Loh DH, Dragich JM, Kudo T, Schroeder AM, Nakamura TJ, Waschek JA, Block GD, Colwell CS.

J Biol Rhythms. 2011 Jun;26(3):200-9. doi: 10.1177/0748730411401740.


Immunomodulatory roles of VIP and PACAP in models of multiple sclerosis.

Abad C, Waschek JA.

Curr Pharm Des. 2011;17(10):1025-35. Review.


Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.


Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis.

Abad C, Tan YV, Lopez R, Nobuta H, Dong H, Phan P, Feng JM, Campagnoni AT, Waschek JA.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19555-60. doi: 10.1073/pnas.1007622107. Epub 2010 Oct 26.


Expression analysis of PAC1-R and PACAP genes in zebrafish embryos.

Alexandre D, Alonzeau J, Bill BR, Ekker SC, Waschek JA.

J Mol Neurosci. 2011 Jan;43(1):94-100. doi: 10.1007/s12031-010-9397-y. Epub 2010 Jun 5.


The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus.

Dragich JM, Loh DH, Wang LM, Vosko AM, Kudo T, Nakamura TJ, Odom IH, Tateyama S, Hagopian A, Waschek JA, Colwell CS.

Eur J Neurosci. 2010 Mar;31(5):864-75. doi: 10.1111/j.1460-9568.2010.07119.x. Epub 2010 Feb 17.


Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression.

Martin B, Shin YK, White CM, Ji S, Kim W, Carlson OD, Napora JK, Chadwick W, Chapter M, Waschek JA, Mattson MP, Maudsley S, Egan JM.

Diabetes. 2010 May;59(5):1143-52. doi: 10.2337/db09-0807. Epub 2010 Feb 11.


VIP, PACAP-38, BDNF and ADNP in NMDA-induced excitotoxicity in the rat retina.

Teuchner B, Dimmer A, Humpel C, Amberger A, Fischer-Colbrie R, Nemeth J, Waschek JA, Kieselbach G, Kralinger M, Schmid E, Bechrakis N, Troger J.

Acta Ophthalmol. 2011 Nov;89(7):670-5. doi: 10.1111/j.1755-3768.2009.01828.x. Epub 2010 Jan 8.


Negative regulation of Hedgehog signaling by liver X receptors.

Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F.

Mol Endocrinol. 2009 Oct;23(10):1532-43. doi: 10.1210/me.2008-0453. Epub 2009 Jul 16.


The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice.

Marquez P, Bebawy D, Lelièvre V, Coûté AC, Evans CJ, Waschek JA, Lutfy K.

Psychopharmacology (Berl). 2009 Jun;204(3):457-63. doi: 10.1007/s00213-009-1476-9. Epub 2009 Feb 8.


Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis.

Tan YV, Abad C, Lopez R, Dong H, Liu S, Lee A, Gomariz RP, Leceta J, Waschek JA.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2012-7. doi: 10.1073/pnas.0812257106. Epub 2009 Feb 3.


Vasoactive intestinal peptide is critical for circadian regulation of glucocorticoids.

Loh DH, Abad C, Colwell CS, Waschek JA.

Neuroendocrinology. 2008;88(4):246-55. doi: 10.1159/000140676. Epub 2008 Jun 19.


Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- mice.

Studeny S, Cheppudira BP, Meyers S, Balestreire EM, Apodaca G, Birder LA, Braas KM, Waschek JA, May V, Vizzard MA.

J Mol Neurosci. 2008 Nov;36(1-3):175-87. doi: 10.1007/s12031-008-9100-8. Epub 2008 Jun 17.


Mice deficient in both pituitary adenylyl cyclase-activating polypeptide and vasoactive intestinal peptide survive, but display growth retardation and sex-dependent early death.

Niewiadomski P, Coûté-Monvoisin AC, Abad C, Ngo D, Menezes A, Waschek JA.

J Mol Neurosci. 2008 Nov;36(1-3):200-7. doi: 10.1007/s12031-008-9085-3. Epub 2008 May 20.


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