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The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection.

Desai P, Tahiliani V, Hutchinson TE, Dastmalchi F, Stanfield J, Abboud G, Thomas PG, Ware CF, Song J, Croft M, Salek-Ardakani S.

J Immunol. 2018 Mar 7. pii: ji1701499. doi: 10.4049/jimmunol.1701499. [Epub ahead of print]


Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.

Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA.

Cell Rep. 2017 Nov 28;21(9):2500-2514. doi: 10.1016/j.celrep.2017.10.119.


Impairment of Bone Remodeling in LIGHT/TNFSF14-Deficient Mice.

Brunetti G, Faienza MF, Colaianni G, Gigante I, Oranger A, Pignataro P, Ingravallo G, Di Benedetto A, Bortolotti S, Di Comite M, Storlino G, Lippo L, Ward-Kavanagh L, Mori G, Reseland JE, Passeri G, Schipani E, Tamada K, Ware CF, Colucci S, Grano M.

J Bone Miner Res. 2017 Nov 27. doi: 10.1002/jbmr.3345. [Epub ahead of print]


A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator.

Šedý JR, Balmert MO, Ware BC, Smith W, Nemčovičova I, Norris PS, Miller BR, Aivazian D, Ware CF.

J Biol Chem. 2017 Dec 22;292(51):21060-21070. doi: 10.1074/jbc.M117.813295. Epub 2017 Oct 23.


Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction.

Colbeck EJ, Jones E, Hindley JP, Smart K, Schulz R, Browne M, Cutting S, Williams A, Parry L, Godkin A, Ware CF, Ager A, Gallimore A.

Cancer Immunol Res. 2017 Nov;5(11):1005-1015. doi: 10.1158/2326-6066.CIR-17-0131. Epub 2017 Sep 25.


HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity.

Desai P, Abboud G, Stanfield J, Thomas PG, Song J, Ware CF, Croft M, Salek-Ardakani S.

J Immunol. 2017 Oct 15;199(8):2968-2975. doi: 10.4049/jimmunol.1700959. Epub 2017 Sep 1.


Characterizing Social Determinants of Health for Adolescent Mothers during the Prenatal and Postpartum Periods.

Kumar NR, Raker CA, Ware CF, Phipps MG.

Womens Health Issues. 2017 Sep - Oct;27(5):565-572. doi: 10.1016/j.whi.2017.03.009. Epub 2017 Apr 24.


Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus.

Lucas B, James KD, Cosway EJ, Parnell SM, Tumanov AV, Ware CF, Jenkinson WE, Anderson G.

J Immunol. 2016 Oct 1;197(7):2665-72. doi: 10.4049/jimmunol.1601189. Epub 2016 Aug 22.


Deletion of P2Y2 receptor reveals a role for lymphotoxin-α in fatty streak formation.

Qian S, Hoggatt A, Jones-Hall YL, Ware CF, Herring P, Seye CI.

Vascul Pharmacol. 2016 Oct;85:11-20. doi: 10.1016/j.vph.2016.06.001. Epub 2016 Jun 26.


The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.

Ward-Kavanagh LK, Lin WW, Šedý JR, Ware CF.

Immunity. 2016 May 17;44(5):1005-19. doi: 10.1016/j.immuni.2016.04.019. Review.


Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.

Lechtenberg BC, Rajput A, Sanishvili R, Dobaczewska MK, Ware CF, Mace PD, Riedl SJ.

Nature. 2016 Jan 28;529(7587):546-50. doi: 10.1038/nature16511. Epub 2016 Jan 20.


LTβR signalling preferentially accelerates oncogenic AKT-initiated liver tumours.

Scarzello AJ, Jiang Q, Back T, Dang H, Hodge D, Hanson C, Subleski J, Weiss JM, Stauffer JK, Chaisaingmongkol J, Rabibhadana S, Ruchirawat M, Ortaldo J, Wang XW, Norris PS, Ware CF, Wiltrout RH.

Gut. 2016 Oct;65(10):1765-75. doi: 10.1136/gutjnl-2014-308810. Epub 2015 Jul 23.


Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.

Li H, Fu YX, Wu Q, Zhou Y, Crossman DK, Yang P, Li J, Luo B, Morel LM, Kabarowski JH, Yagita H, Ware CF, Hsu HC, Mountz JD.

J Clin Invest. 2015 Jul 1;125(7):2877-90. doi: 10.1172/JCI81059. Epub 2015 Jun 22.


Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.

Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA.

J Virol. 2015 May;89(9):4748-59. doi: 10.1128/JVI.02976-14. Epub 2015 Feb 11.


Commensal microbiota influence systemic autoimmune responses.

Van Praet JT, Donovan E, Vanassche I, Drennan MB, Windels F, Dendooven A, Allais L, Cuvelier CA, van de Loo F, Norris PS, Kruglov AA, Nedospasov SA, Rabot S, Tito R, Raes J, Gaboriau-Routhiau V, Cerf-Bensussan N, Van de Wiele T, Eberl G, Ware CF, Elewaut D.

EMBO J. 2015 Feb 12;34(4):466-74. doi: 10.15252/embj.201489966. Epub 2015 Jan 19.


NLRs: Sentinels of innate immunity or cancer culprits?

Correa RG, Ware CF, Reed JC.

Oncoscience. 2014 May 26;1(5):308-9. eCollection 2014. No abstract available.


Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells.

Bekiaris V, Šedý JR, Ware CF.

Front Immunol. 2014 Dec 18;5:654. doi: 10.3389/fimmu.2014.00654. eCollection 2014. Review.


Tumor necrosis factor superfamily in innate immunity and inflammation.

Šedý J, Bekiaris V, Ware CF.

Cold Spring Harb Perspect Biol. 2014 Dec 18;7(4):a016279. doi: 10.1101/cshperspect.a016279. Review.


p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation.

Tao Z, Fusco A, Huang DB, Gupta K, Young Kim D, Ware CF, Van Duyne GD, Ghosh G.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15946-51. doi: 10.1073/pnas.1408552111. Epub 2014 Oct 27.


Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells.

Kurtz CC, Drygiannakis I, Naganuma M, Feldman S, Bekiaris V, Linden J, Ware CF, Ernst PB.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G338-46. doi: 10.1152/ajpgi.00404.2013. Epub 2014 May 29.


The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.

Gommerman JL, Browning JL, Ware CF.

Cytokine Growth Factor Rev. 2014 Apr;25(2):139-45. doi: 10.1016/j.cytogfr.2014.02.002. Epub 2014 Mar 12. Review.


The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.

Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC.

Oncotarget. 2014 Mar 30;5(6):1666-82.


Pillars article: A lymphotoxin-B-specific receptor. Science. 1994. 264: 707-710.

Crowe PD, Vanarsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA.

J Immunol. 2014 Mar 1;192(5):2015-8. No abstract available.


The inhibitory receptor BTLA controls γδ T cell homeostasis and inflammatory responses.

Bekiaris V, Šedý JR, Macauley MG, Rhode-Kurnow A, Ware CF.

Immunity. 2013 Dec 12;39(6):1082-1094. doi: 10.1016/j.immuni.2013.10.017. Epub 2013 Dec 5.


Interactions between herpesvirus entry mediator (TNFRSF14) and latency-associated transcript during herpes simplex virus 1 latency.

Allen SJ, Rhode-Kurnow A, Mott KR, Jiang X, Carpenter D, Rodriguez-Barbosa JI, Jones C, Wechsler SL, Ware CF, Ghiasi H.

J Virol. 2014 Feb;88(4):1961-71. doi: 10.1128/JVI.02467-13. Epub 2013 Dec 4.


BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection.

Steinberg MW, Huang Y, Wang-Zhu Y, Ware CF, Cheroutre H, Kronenberg M.

PLoS One. 2013 Oct 30;8(10):e77992. doi: 10.1371/journal.pone.0077992. eCollection 2013.


CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.

Flynn R, Hutchinson T, Murphy KM, Ware CF, Croft M, Salek-Ardakani S.

PLoS One. 2013 Oct 29;8(10):e77991. doi: 10.1371/journal.pone.0077991. eCollection 2013.


Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αβ and are elevated in rheumatoid arthritis.

Bekiaris V, Šedy JR, Rossetti M, Spreafico R, Sharma S, Rhode-Kurnow A, Ware BC, Huang N, Macauley MG, Norris PS, Albani S, Ware CF.

J Immunol. 2013 Nov 1;191(9):4611-8. doi: 10.4049/jimmunol.1301672. Epub 2013 Sep 27.


CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells.

Šedý JR, Bjordahl RL, Bekiaris V, Macauley MG, Ware BC, Norris PS, Lurain NS, Benedict CA, Ware CF.

J Immunol. 2013 Jul 15;191(2):828-36. doi: 10.4049/jimmunol.1300894. Epub 2013 Jun 12.


Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemčovičová I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA.

Cell Host Microbe. 2013 Mar 13;13(3):324-35. doi: 10.1016/j.chom.2013.02.003.


Protein therapeutics targeted at the TNF superfamily.

Ware CF.

Adv Pharmacol. 2013;66:51-80. doi: 10.1016/B978-0-12-404717-4.00002-0. Review.


Lymphotoxin β receptor mediates caspase-dependent tumor cell apoptosis in vitro and tumor suppression in vivo despite induction of NF-κB activation.

Hu X, Zimmerman MA, Bardhan K, Yang D, Waller JL, Liles GB, Lee JR, Pollock R, Lev D, Ware CF, Garber E, Bailly V, Browning JL, Liu K.

Carcinogenesis. 2013 May;34(5):1105-14. doi: 10.1093/carcin/bgt014. Epub 2013 Jan 24. No abstract available.


Lymphotoxin network pathways shape the tumor microenvironment.

Bjordahl RL, Steidl C, Gascoyne RD, Ware CF.

Curr Opin Immunol. 2013 Apr;25(2):222-9. doi: 10.1016/j.coi.2013.01.001. Epub 2013 Jan 20. Review.


Clinical targeting of the TNF and TNFR superfamilies.

Croft M, Benedict CA, Ware CF.

Nat Rev Drug Discov. 2013 Feb;12(2):147-68. doi: 10.1038/nrd3930. Epub 2013 Jan 21. Review.


Randomized controlled trial to prevent postpartum depression in adolescent mothers.

Phipps MG, Raker CA, Ware CF, Zlotnick C.

Am J Obstet Gynecol. 2013 Mar;208(3):192.e1-6. doi: 10.1016/j.ajog.2012.12.036. Epub 2013 Jan 8.


TRAIL: not just for tumors anymore?

Benedict CA, Ware CF.

J Exp Med. 2012 Oct 22;209(11):1903-6. doi: 10.1084/jem.20122235. Review.


Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells.

Bénézech C, Mader E, Desanti G, Khan M, Nakamura K, White A, Ware CF, Anderson G, Caamaño JH.

Immunity. 2012 Oct 19;37(4):721-34. doi: 10.1016/j.immuni.2012.06.010. Epub 2012 Aug 30.


Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture.

Glatman Zaretsky A, Silver JS, Siwicki M, Durham A, Ware CF, Hunter CA.

Infect Immun. 2012 Oct;80(10):3602-10. doi: 10.1128/IAI.00333-12. Epub 2012 Jul 30.


Selective blockade of herpesvirus entry mediator-B and T lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction.

del Rio ML, Jones ND, Buhler L, Norris P, Shintani Y, Ware CF, Rodriguez-Barbosa JI.

J Immunol. 2012 May 15;188(10):4885-96. doi: 10.4049/jimmunol.1103698. Epub 2012 Apr 6.


Mousing around with caspases and IAPs.

Rickert RC, Salvesen GS, Ware CF.

Biochem J. 2012 Apr 15;443(2):e1-2. doi: 10.1042/BJ20120402.



Cohavy O, Shih DQ, Doherty TM, Ware CF, Targan SR.

Eur J Microbiol Immunol (Bp). 2011 Mar;1(1):70-79.


Innate B cells: oxymoron or validated concept?

Ware CF, Benedict C.

F1000Res. 2012 Aug 2;1:8. doi: 10.12688/f1000research.1-8.v1. eCollection 2012.


The role of inflammation in the pathophysiology of depression: different treatments and their effects.

Lotrich FE, El-Gabalawy H, Guenther LC, Ware CF.

J Rheumatol Suppl. 2011 Nov;88:48-54. doi: 10.3899/jrheum.110903. Review.


Validity of quality of life measurement tools--from generic to disease-specific.

Wells GA, Russell AS, Haraoui B, Bissonnette R, Ware CF.

J Rheumatol Suppl. 2011 Nov;88:2-6. doi: 10.3899/jrheum.110906.


The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation.

Steinberg MW, Cheung TC, Ware CF.

Immunol Rev. 2011 Nov;244(1):169-87. doi: 10.1111/j.1600-065X.2011.01064.x. Review.


The TNF receptor super family in immune regulation.

Ware CF.

Immunol Rev. 2011 Nov;244(1):5-8. doi: 10.1111/j.1600-065X.2011.01065.x. No abstract available.


TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14).

Ware CF, Sedý JR.

Curr Opin Immunol. 2011 Oct;23(5):627-31. doi: 10.1016/j.coi.2011.08.008. Epub 2011 Sep 13. Review.


Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.

Sato-Hashimoto M, Saito Y, Ohnishi H, Iwamura H, Kanazawa Y, Kaneko T, Kusakari S, Kotani T, Mori M, Murata Y, Okazawa H, Ware CF, Oldenborg PA, Nojima Y, Matozaki T.

J Immunol. 2011 Jul 1;187(1):291-7. doi: 10.4049/jimmunol.1100528. Epub 2011 Jun 1.


The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.

Doherty TA, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho JY, Norris PS, Choi H, Scheu S, Pfeffer K, Zuraw BL, Ware CF, Broide DH, Croft M.

Nat Med. 2011 May;17(5):596-603. doi: 10.1038/nm.2356. Epub 2011 Apr 17.


Tumor necrosis factor and anti-tumor necrosis factor therapies.

Keystone EC, Ware CF.

J Rheumatol Suppl. 2010 May;85:27-39. doi: 10.3899/jrheum.091463. Review.


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