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Structural and Molecular Biology of Type IV Secretion Systems.

Terradot L, Bergé C, Waksman G.

Curr Top Microbiol Immunol. 2017;413:31-60. doi: 10.1007/978-3-319-75241-9_2.


Protein-Injection Machines in Bacteria.

Galán JE, Waksman G.

Cell. 2018 Mar 8;172(6):1306-1318. doi: 10.1016/j.cell.2018.01.034. Review.


Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system.

Meir A, Chetrit D, Liu L, Roy CR, Waksman G.

Nat Commun. 2018 Feb 6;9(1):507. doi: 10.1038/s41467-017-02578-x.


Translocation through the conjugative Type 4 secretion system requires unfolding of its protein substrate.

Trokter M, Waksman G.

J Bacteriol. 2018 Jan 8. pii: JB.00615-17. doi: 10.1128/JB.00615-17. [Epub ahead of print]


Type IV secretion in Gram-negative and Gram-positive bacteria.

Grohmann E, Christie PJ, Waksman G, Backert S.

Mol Microbiol. 2018 Feb;107(4):455-471. doi: 10.1111/mmi.13896. Epub 2018 Jan 18. Review.


The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod.

Hospenthal MK, Zyla D, Costa TRD, Redzej A, Giese C, Lillington J, Glockshuber R, Waksman G.

Structure. 2017 Dec 5;25(12):1829-1838.e4. doi: 10.1016/j.str.2017.10.004. Epub 2017 Nov 9.


Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery.

Redzej A, Ukleja M, Connery S, Trokter M, Felisberto-Rodrigues C, Cryar A, Thalassinos K, Hayward RD, Orlova EV, Waksman G.

EMBO J. 2017 Oct 16;36(20):3080-3095. doi: 10.15252/embj.201796629. Epub 2017 Sep 18.


The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery.

Prevost MS, Pinotsis N, Dumoux M, Hayward RD, Waksman G.

Sci Rep. 2017 Aug 25;7(1):9450. doi: 10.1038/s41598-017-10249-6.


Reconstitution of a minimal machinery capable of assembling periplasmic type IV pili.

Goosens VJ, Busch A, Georgiadou M, Castagnini M, Forest KT, Waksman G, Pelicic V.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4978-E4986. doi: 10.1073/pnas.1618539114. Epub 2017 Jun 6.


Structural and Molecular Biology of a Protein-Polymerizing Nanomachine for Pilus Biogenesis.

Waksman G.

J Mol Biol. 2017 Aug 18;429(17):2654-2666. doi: 10.1016/j.jmb.2017.05.016. Epub 2017 May 25. Review.


A comprehensive guide to pilus biogenesis in Gram-negative bacteria.

Hospenthal MK, Costa TRD, Waksman G.

Nat Rev Microbiol. 2017 May 12;15(6):365-379. doi: 10.1038/nrmicro.2017.40. Review.


Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation.

Ilangovan A, Kay CWM, Roier S, El Mkami H, Salvadori E, Zechner EL, Zanetti G, Waksman G.

Cell. 2017 May 4;169(4):708-721.e12. doi: 10.1016/j.cell.2017.04.010. Epub 2017 Apr 27.


Use of chimeric type IV secretion systems to define contributions of outer membrane subassemblies for contact-dependent translocation.

Gordon JE, Costa TRD, Patel RS, Gonzalez-Rivera C, Sarkar MK, Orlova EV, Waksman G, Christie PJ.

Mol Microbiol. 2017 Jul;105(2):273-293. doi: 10.1111/mmi.13700. Epub 2017 May 18.


Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila.

Pinotsis N, Waksman G.

J Biol Chem. 2017 Jun 2;292(22):9240-9251. doi: 10.1074/jbc.M117.781948. Epub 2017 Apr 7.


Correction: Allosteric signalling in the outer membrane translocation domain of PapC usher.

Farabella I, Pham T, Henderson NS, Geibel S, Phan G, Thanassi DG, Delcour AH, Waksman G, Topf M.

Elife. 2016 Sep 27;5. pii: e21585. doi: 10.7554/eLife.21585. No abstract available.


Editorial overview: Membranes.

Gulbis JM, Waksman G.

Curr Opin Struct Biol. 2016 Aug;39:vii-ix. doi: 10.1016/ Epub 2016 Sep 17. No abstract available.


Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex.

Costa TRD, Ilangovan A, Ukleja M, Redzej A, Santini JM, Smith TK, Egelman EH, Waksman G.

Cell. 2016 Sep 8;166(6):1436-1444.e10. doi: 10.1016/j.cell.2016.08.025.


Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine.

Stubenrauch C, Belousoff MJ, Hay ID, Shen HH, Lillington J, Tuck KL, Peters KM, Phan MD, Lo AW, Schembri MA, Strugnell RA, Waksman G, Lithgow T.

Nat Microbiol. 2016 May 16;1(7):16064. doi: 10.1038/nmicrobiol.2016.64.


Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.

Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G.

Cell. 2016 Jan 14;164(1-2):269-278. doi: 10.1016/j.cell.2015.11.049. Epub 2015 Dec 24.


Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide.

Papaioannou D, Geibel S, Kunze MB, Kay CW, Waksman G.

Protein Sci. 2016 Mar;25(3):627-37. doi: 10.1002/pro.2856. Epub 2015 Dec 29.


Structural Biology of Bacterial Type IV Secretion Systems.

Chandran Darbari V, Waksman G.

Annu Rev Biochem. 2015;84:603-29. doi: 10.1146/annurev-biochem-062911-102821. Review.


Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR.

Kaplan M, Cukkemane A, van Zundert GC, Narasimhan S, Daniëls M, Mance D, Waksman G, Bonvin AM, Fronzes R, Folkers GE, Baldus M.

Nat Methods. 2015 Jul;12(7):649-52. doi: 10.1038/nmeth.3406. Epub 2015 May 18.


Secretion systems in Gram-negative bacteria: structural and mechanistic insights.

Costa TR, Felisberto-Rodrigues C, Meir A, Prevost MS, Redzej A, Trokter M, Waksman G.

Nat Rev Microbiol. 2015 Jun;13(6):343-59. doi: 10.1038/nrmicro3456. Review.


Structural biology of the Gram-negative bacterial conjugation systems.

Ilangovan A, Connery S, Waksman G.

Trends Microbiol. 2015 May;23(5):301-10. doi: 10.1016/j.tim.2015.02.012. Epub 2015 Mar 27. Review.


Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation.

Garnett JA, Muhl D, Douse CH, Hui K, Busch A, Omisore A, Yang Y, Simpson P, Marchant J, Waksman G, Matthews S, Filloux A.

Protein Sci. 2015 May;24(5):670-87. doi: 10.1002/pro.2640. Epub 2015 Feb 24.


Molecular mechanism of bacterial type 1 and P pili assembly.

Busch A, Phan G, Waksman G.

Philos Trans A Math Phys Eng Sci. 2015 Mar 6;373(2036). pii: 20130153. doi: 10.1098/rsta.2013.0153.


Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms.

Ruer S, Pinotsis N, Steadman D, Waksman G, Remaut H.

Chem Biol Drug Des. 2015 Oct;86(4):379-99. doi: 10.1111/cbdd.12517. Epub 2015 Feb 6.


2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion.

Sayer JR, Walldén K, Pesnot T, Campbell F, Gane PJ, Simone M, Koss H, Buelens F, Boyle TP, Selwood DL, Waksman G, Tabor AB.

Bioorg Med Chem. 2014 Nov 15;22(22):6459-70. doi: 10.1016/j.bmc.2014.09.036. Epub 2014 Sep 28.


Allosteric signalling in the outer membrane translocation domain of PapC usher.

Farabella I, Pham T, Henderson NS, Geibel S, Phan G, Thanassi DG, Delcour AH, Waksman G, Topf M.

Elife. 2014 Oct 28;3. doi: 10.7554/eLife.03532. Erratum in: Elife. 2016;5. pii: e21585. doi: 10.7554/eLife.21585.


Editorial overview: Membranes: recent methods in the study of membrane protein structure.

Gonen T, Waksman G.

Curr Opin Struct Biol. 2014 Aug;27:iv-v. doi: 10.1016/ Epub 2014 Sep 18. No abstract available.


Bacterial surface appendages as targets for novel antibacterial therapeutics.

Steadman D, Lo A, Waksman G, Remaut H.

Future Microbiol. 2014;9(7):887-900. doi: 10.2217/fmb.14.46. Review.


Reprint of "Biogenesis and adhesion of type 1 and P pili".

Lillington J, Geibel S, Waksman G.

Biochim Biophys Acta. 2015 Mar;1850(3):554-64. doi: 10.1016/j.bbagen.2014.07.009. Epub 2014 Jul 22. Review.


Biogenesis and adhesion of type 1 and P pili.

Lillington J, Geibel S, Waksman G.

Biochim Biophys Acta. 2014 Sep;1840(9):2783-93. doi: 10.1016/j.bbagen.2014.04.021. Epub 2014 May 2. Review.


Recent advances in the structural and molecular biology of type IV secretion systems.

Trokter M, Felisberto-Rodrigues C, Christie PJ, Waksman G.

Curr Opin Struct Biol. 2014 Aug;27:16-23. doi: 10.1016/ Epub 2014 Apr 5. Review.


Structure of a type IV secretion system.

Low HH, Gubellini F, Rivera-Calzada A, Braun N, Connery S, Dujeancourt A, Lu F, Redzej A, Fronzes R, Orlova EV, Waksman G.

Nature. 2014 Apr 24;508(7497):550-553. doi: 10.1038/nature13081. Epub 2014 Mar 9.


Structural organisation of the type IV secretion systems.

Waksman G, Orlova EV.

Curr Opin Microbiol. 2014 Feb;17:24-31. doi: 10.1016/j.mib.2013.11.001. Epub 2013 Dec 5. Review.


Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization.

Lo AW, Van de Water K, Gane PJ, Chan AW, Steadman D, Stevens K, Selwood DL, Waksman G, Remaut H.

J Antimicrob Chemother. 2014 Apr;69(4):1017-26. doi: 10.1093/jac/dkt467. Epub 2013 Dec 8.


Molecular basis of usher pore gating in Escherichia coli pilus biogenesis.

Volkan E, Kalas V, Pinkner JS, Dodson KW, Henderson NS, Pham T, Waksman G, Delcour AH, Thanassi DG, Hultgren SJ.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20741-6. doi: 10.1073/pnas.1320528110. Epub 2013 Dec 2.


The molecular dissection of the chaperone-usher pathway.

Geibel S, Waksman G.

Biochim Biophys Acta. 2014 Aug;1843(8):1559-67. doi: 10.1016/j.bbamcr.2013.09.023. Epub 2013 Oct 16. Review.


Seaside transportation--from structure to function of translocation machines.

Lithgow T, Waksman G.

EMBO Rep. 2013 Jul;14(7):585-7. doi: 10.1038/embor.2013.79. Epub 2013 Jun 14.


Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems.

Redzej A, Ilangovan A, Lang S, Gruber CJ, Topf M, Zangger K, Zechner EL, Waksman G.

Mol Microbiol. 2013 Jul;89(2):324-33. doi: 10.1111/mmi.12275. Epub 2013 Jun 14.


Structural and energetic basis of folded-protein transport by the FimD usher.

Geibel S, Procko E, Hultgren SJ, Baker D, Waksman G.

Nature. 2013 Apr 11;496(7444):243-6. doi: 10.1038/nature12007.


dNTP-dependent conformational transitions in the fingers subdomain of Klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state.

Rothwell PJ, Allen WJ, Sisamakis E, Kalinin S, Felekyan S, Widengren J, Waksman G, Seidel CA.

J Biol Chem. 2013 May 10;288(19):13575-91. doi: 10.1074/jbc.M112.432690. Epub 2013 Mar 22.


Structure of a bacterial type IV secretion core complex at subnanometre resolution.

Rivera-Calzada A, Fronzes R, Savva CG, Chandran V, Lian PW, Laeremans T, Pardon E, Steyaert J, Remaut H, Waksman G, Orlova EV.

EMBO J. 2013 Apr 17;32(8):1195-204. doi: 10.1038/emboj.2013.58. Epub 2013 Mar 19.


Dissection of pilus tip assembly by the FimD usher monomer.

Allen WJ, Phan G, Hultgren SJ, Waksman G.

J Mol Biol. 2013 Mar 11;425(5):958-67. doi: 10.1016/j.jmb.2012.12.024. Epub 2013 Jan 4.


Ordered and ushered; the assembly and translocation of the adhesive type I and p pili.

Lillington J, Waksman G.

Biology (Basel). 2013 Jun 26;2(3):841-60. doi: 10.3390/biology2030841.


The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket.

Ford B, Verger D, Dodson K, Volkan E, Kostakioti M, Elam J, Pinkner J, Waksman G, Hultgren S.

J Bacteriol. 2012 Dec;194(23):6390-7. doi: 10.1128/JB.06651-11. Epub 2012 Sep 21.


Crystal structure of the MrkD1P receptor binding domain of Klebsiella pneumoniae and identification of the human collagen V binding interface.

Rêgo AT, Johnson JG, Gelbel S, Enguita FJ, Clegg S, Waksman G.

Mol Microbiol. 2012 Nov;86(4):882-93. doi: 10.1111/mmi.12023. Epub 2012 Sep 18.


Recent progress in membrane protein structures and investigation methods.

Gonen T, Waksman G.

Curr Opin Struct Biol. 2012 Aug;22(4):467-8. doi: 10.1016/ Epub 2012 Jul 19. No abstract available.


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