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Items: 1 to 50 of 60

1.

Methylindoles and methoxyindoles are agonists and antagonists of human aryl hydrocarbon receptor AhR.

Stepankova M, Bartonkova I, Jiskrova E, Vrzal R, Mani S, Kortagere S, Dvorak Z.

Mol Pharmacol. 2018 Apr 6. pii: mol.118.112151. doi: 10.1124/mol.118.112151. [Epub ahead of print]

2.

Profiling of bisphenol S towards nuclear receptors activities in human reporter cell lines.

Zenata O, Dvorak Z, Vrzal R.

Toxicol Lett. 2017 Nov 5;281:10-19. doi: 10.1016/j.toxlet.2017.09.006. Epub 2017 Sep 12.

PMID:
28916285
3.

Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.

Vrzal R, Vrzalova A, Grycova A, Dvorak Z.

Toxicol Lett. 2017 Jun 5;275:77-82. doi: 10.1016/j.toxlet.2017.05.001. Epub 2017 May 3.

PMID:
28478156
4.

Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications.

Zenata O, Vrzal R.

Oncotarget. 2017 May 23;8(21):35390-35402. doi: 10.18632/oncotarget.15697. Review.

5.

In vitro modulatory effects of functionalized pyrimidines and piperidine derivatives on Aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) activities.

Yar M, Shahzadi L, Farooq A, Jalil Imran S, Cerón-Carrasco JP, den-Haan H, Kumar S, Peña-García J, Pérez-Sánchez H, Grycova A, Dvorak Z, Vrzal R.

Bioorg Chem. 2017 Apr;71:285-293. doi: 10.1016/j.bioorg.2017.02.013. Epub 2017 Feb 21.

PMID:
28267985
6.

Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.

Doricakova A, Theile D, Weiss J, Vrzal R.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):49-59. doi: 10.1007/s00210-016-1304-9. Epub 2016 Sep 27.

PMID:
27678410
7.

Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study.

Vrzal R, Illes P, Dvorak Z.

Pharmacol Rep. 2016 Oct;68(5):1008-14. doi: 10.1016/j.pharep.2016.06.001. Epub 2016 Jul 17.

PMID:
27428762
9.

Anthocyanidins but not anthocyanins inhibit P-glycoprotein-mediated calcein extrusion - possible implication for orally administered drugs.

Vrzal R.

Fundam Clin Pharmacol. 2016 Jun;30(3):248-52. doi: 10.1111/fcp.12183. Epub 2016 Feb 15.

PMID:
26821071
10.

Different regulation of aryl hydrocarbon receptor-regulated genes in response to dioxin in undifferentiated and neuronally differentiated human neuroblastoma SH-SY5Y cells.

Imran S, Ferretti P, Vrzal R.

Toxicol Mech Methods. 2015;25(9):689-97. doi: 10.3109/15376516.2015.1070227. Epub 2015 Aug 31.

PMID:
26567990
11.

A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes.

Doricakova A, Vrzal R.

Toxicology. 2015 Nov 4;337:72-8. doi: 10.1016/j.tox.2015.08.012. Epub 2015 Sep 2.

PMID:
26341324
12.

Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.

Vrzal R, Zenata O, Doricakova A, Dvorak Z.

Toxicol Lett. 2015 Oct 1;238(1):43-53. doi: 10.1016/j.toxlet.2015.07.008. Epub 2015 Jul 18. Erratum in: Toxicol Lett. 2015 Nov 19;239(1):65.

PMID:
26196221
13.

The effects of drugs with immunosuppressive or immunomodulatory activities on xenobiotics-metabolizing enzymes expression in primary human hepatocytes.

Vrzal R, Zenata O, Bachleda P, Dvorak Z.

Toxicol In Vitro. 2015 Aug;29(5):1088-99. doi: 10.1016/j.tiv.2015.04.013. Epub 2015 Apr 28.

PMID:
25929522
14.

The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes.

Dvorak Z, Srovnalova A, Svecarova M, Vrzal R.

Food Funct. 2014 Sep;5(9):2145-51. doi: 10.1039/c4fo00347k.

PMID:
25008252
15.

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

Smutny T, Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, Pavek P.

Arch Toxicol. 2014 Dec;88(12):2243-59. doi: 10.1007/s00204-014-1254-2. Epub 2014 May 14.

PMID:
24819614
16.

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P.

Pharmacol Rep. 2013;65(5):1322-35.

17.

Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line.

Stejskalova L, Rulcova A, Vrzal R, Dvorak Z, Pavek P.

Toxicol Lett. 2013 Nov 25;223(2):183-91. doi: 10.1016/j.toxlet.2013.09.014. Epub 2013 Sep 30.

PMID:
24091107
18.

Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells.

Vrzal R, Frauenstein K, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T.

PLoS One. 2013 Sep 19;8(9):e74917. doi: 10.1371/journal.pone.0074917. eCollection 2013.

19.

Effects of oral anorexiant sibutramine on the expression of cytochromes P450s in human hepatocytes and cancer cell lines.

Vrzal R, Knoppová B, Bachleda P, Dvořák Z.

J Biochem Mol Toxicol. 2013 Dec;27(12):515-21. doi: 10.1002/jbt.21516. Epub 2013 Aug 23.

PMID:
24038852
20.
21.

Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor.

Belic A, Tóth K, Vrzal R, Temesvári M, Porrogi P, Orbán E, Rozman D, Dvorak Z, Monostory K.

Chem Biol Interact. 2013 May 25;203(3):597-603. doi: 10.1016/j.cbi.2013.04.002. Epub 2013 Apr 17.

PMID:
23603339
22.

Valproate activates ERK signaling pathway in primary human hepatocytes.

Bitman M, Vrzal R, Dvorak Z, Pavek P.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014;158(1):39-43. doi: 10.5507/bp.2012.038. Epub 2012 Jun 1.

23.

The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.

Doricakova A, Novotna A, Vrzal R, Pavek P, Dvorak Z.

Arch Toxicol. 2013 Feb;87(2):291-301. doi: 10.1007/s00204-012-0937-9. Epub 2012 Sep 14.

PMID:
22976785
24.

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes.

Pavek P, Stejskalova L, Krausova L, Bitman M, Vrzal R, Dvorak Z.

Front Pharmacol. 2012 Jan 19;3:1. doi: 10.3389/fphar.2012.00001. eCollection 2012.

25.

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.

Krausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P.

Biochem Pharmacol. 2011 Dec 1;82(11):1771-80. doi: 10.1016/j.bcp.2011.08.023. Epub 2011 Sep 6.

26.

Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells.

Novotna A, Doricakova A, Vrzal R, Pavek P, Dvorak Z.

Eur J Pharmacol. 2011 Nov 1;669(1-3):45-50. doi: 10.1016/j.ejphar.2011.07.049. Epub 2011 Aug 19.

PMID:
21871880
27.

Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures.

Stejskalova L, Vecerova L, Peréz LM, Vrzal R, Dvorak Z, Nachtigal P, Pavek P.

Toxicol Sci. 2011 Sep;123(1):26-36. doi: 10.1093/toxsci/kfr150. Epub 2011 Jun 10.

PMID:
21666223
28.

Regulation of phase II biotransformation enzymes by steroid hormones.

Kohalmy K, Vrzal R.

Curr Drug Metab. 2011 Feb;12(2):104-23. Review.

PMID:
21401512
29.

Berberine reduces insulin resistance: the roles for glucocorticoid receptor and aryl hydrocarbon receptor.

Dvorak Z, Vrzal R.

Fertil Steril. 2011 Feb;95(2):e7; author reply e8-9. doi: 10.1016/j.fertnstert.2010.11.014. Epub 2010 Dec 3. No abstract available.

PMID:
21130434
30.

Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia?

Vrzal R, Doricakova A, Novotna A, Bachleda P, Bitman M, Pavek P, Dvorak Z.

Toxicol Lett. 2011 Feb 5;200(3):146-53. doi: 10.1016/j.toxlet.2010.11.008. Epub 2010 Nov 27.

PMID:
21115105
31.

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes.

Rulcova A, Prokopova I, Krausova L, Bitman M, Vrzal R, Dvorak Z, Blahos J, Pavek P.

J Thromb Haemost. 2010 Dec;8(12):2708-17. doi: 10.1111/j.1538-7836.2010.04036.x.

32.

Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: preparation, characterization and in vitro cytotoxicity.

Trávnícek Z, Starha P, Popa I, Vrzal R, Dvorák Z.

Eur J Med Chem. 2010 Oct;45(10):4609-14. doi: 10.1016/j.ejmech.2010.07.025. Epub 2010 Jul 21.

PMID:
20692737
33.

Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II) and palladium(II) oxalato complexes with adenine derivatives as carrier ligands.

Vrzal R, Starha P, Dvorák Z, Trávnícek Z.

J Inorg Biochem. 2010 Oct;104(10):1130-2. doi: 10.1016/j.jinorgbio.2010.07.002. Epub 2010 Jul 31.

PMID:
20673688
34.

Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells.

Novotna A, Doricakova A, Vrzal R, Maurel P, Pavek P, Dvorak Z.

Eur J Pharm Sci. 2010 Oct 9;41(2):276-80. doi: 10.1016/j.ejps.2010.06.019. Epub 2010 Jul 3.

PMID:
20599501
35.

Resveratrol enhances NK cell cytotoxicity: possible role for aryl hydrocarbon receptor.

Bachleda P, Vrzal R, Dvorak Z.

J Cell Physiol. 2010 Nov;225(2):289-90. doi: 10.1002/jcp.22233. No abstract available.

PMID:
20506381
36.

Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells.

Vrzal R, Gerbal-Chaloin S, Maurel P, Dvorák Z.

Int J Toxicol. 2010 May-Jun;29(3):326-35. doi: 10.1177/1091581810366486.

PMID:
20448266
37.

Investigation of the CYP2C9 induction profile in human hepatocytes by combining experimental and modelling approaches.

Belic A, Temesvári M, Kohalmy K, Vrzal R, Dvorak Z, Rozman D, Monostory K.

Curr Drug Metab. 2009 Dec;10(10):1066-74. Review.

PMID:
20167002
38.

Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.

Vrzal R, Kubesova K, Pavek P, Dvorak Z.

Toxicol Lett. 2010 Mar 15;193(2):183-8. doi: 10.1016/j.toxlet.2010.01.004. Epub 2010 Jan 18.

PMID:
20080160
39.

Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes.

Bachleda P, Vrzal R, Dvorák Z.

Gen Physiol Biophys. 2009 Sep;28(3):316-20.

PMID:
20037198
40.

Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes.

Dvorák Z, Vrzal R, Starha P, Klanicová A, Trávnícek Z.

Toxicol In Vitro. 2010 Mar;24(2):425-9. doi: 10.1016/j.tiv.2009.10.012. Epub 2009 Oct 23.

PMID:
19854261
41.

Examination of Zolpidem effects on AhR- and PXR-dependent expression of drug-metabolizing cytochromes P450 in primary cultures of human hepatocytes.

Bachleda P, Vrzal R, Pivnicka J, Cvek B, Dvorak Z.

Toxicol Lett. 2009 Dec 1;191(1):74-8. doi: 10.1016/j.toxlet.2009.08.009. Epub 2009 Aug 15.

PMID:
19686824
42.

Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines.

Pospechova K, Rozehnal V, Stejskalova L, Vrzal R, Pospisilova N, Jamborova G, May K, Siegmund W, Dvorak Z, Nachtigal P, Semecky V, Pavek P.

Mol Cell Endocrinol. 2009 Feb 27;299(2):178-87. doi: 10.1016/j.mce.2008.12.003. Epub 2008 Dec 24.

PMID:
19133314
43.

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes.

Vrzal R, Stejskalova L, Monostory K, Maurel P, Bachleda P, Pavek P, Dvorak Z.

Chem Biol Interact. 2009 May 15;179(2-3):288-96. doi: 10.1016/j.cbi.2008.10.035. Epub 2008 Nov 5.

PMID:
19022236
44.

SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.

Henklova P, Vrzal R, Papouskova B, Bednar P, Jancova P, Anzenbacherova E, Ulrichova J, Maurel P, Pavek P, Dvorak Z.

Eur J Pharmacol. 2008 Sep 28;593(1-3):16-23. doi: 10.1016/j.ejphar.2008.07.007. Epub 2008 Jul 10.

PMID:
18655782
45.

Role of mitogen-activated protein kinases in aryl hydrocarbon receptor signaling.

Henklová P, Vrzal R, Ulrichová J, Dvorák Z.

Chem Biol Interact. 2008 Mar 27;172(2):93-104. doi: 10.1016/j.cbi.2007.12.005. Epub 2007 Dec 31. Review.

PMID:
18282562
46.

Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.

Vrzal R, Daujat-Chavanieu M, Pascussi JM, Ulrichova J, Maurel P, Dvorak Z.

Eur J Pharmacol. 2008 Mar 10;581(3):244-54. doi: 10.1016/j.ejphar.2007.11.059. Epub 2007 Dec 3.

PMID:
18177856
47.

The effect of all-trans retinoic acid and/or colchicine on expression of rexinoid and thyroid hormone nuclear receptors and their coregulators in primary rat hepatocytes.

Macejová D, Dvorák Z, Vrzal R, Ulrichová J, Ondková S, Brtko J.

Gen Physiol Biophys. 2007 Sep;26(3):240-2.

PMID:
18063853
48.

Glucocorticoid receptor functions in HeLa Cells are perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD).

Vrzal R, Ulrichová J, Dvorák Z, Pávek P.

Drug Metab Lett. 2007 Dec;1(4):311-4.

PMID:
19356061
49.

Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P.

Drug Metab Dispos. 2008 Feb;36(2):339-48. Epub 2007 Nov 12.

50.

JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.

Dvorak Z, Vrzal R, Henklova P, Jancova P, Anzenbacherova E, Maurel P, Svecova L, Pavek P, Ehrmann J, Havlik R, Bednar P, Lemr K, Ulrichova J.

Biochem Pharmacol. 2008 Jan 15;75(2):580-8. Epub 2007 Sep 16.

PMID:
17959153

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