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Items: 21


Tissue Multiplatform-Based Metabolomics/Metabonomics for Enhanced Metabolome Coverage.

Vorkas PA, Abellona U MR, Li JV.

Methods Mol Biol. 2018;1738:239-260. doi: 10.1007/978-1-4939-7643-0_17.


Expanding lipidome coverage using MS/MS-aided untargeted data-independent RP-UPLC-TOF-MSE acquisition.

Vorkas PA.

Bioanalysis. 2018 Mar 1;10(5):307-319. doi: 10.4155/bio-2017-0249. Epub 2018 Mar 1.


A comprehensive characterisation of the metabolic profile of varicose veins; implications in elaborating plausible cellular pathways for disease pathogenesis.

Anwar MA, Adesina-Georgiadis KN, Spagou K, Vorkas PA, Li JV, Shalhoub J, Holmes E, Davies AH.

Sci Rep. 2017 Jun 7;7(1):2989. doi: 10.1038/s41598-017-02529-y.


Lessons from Metabonomics on the Neurobiology of Stroke.

Qureshi MI, Vorkas PA, Coupland AP, Jenkins IH, Holmes E, Davies AH.

Neuroscientist. 2016 Oct 1:1073858416673327. doi: 10.1177/1073858416673327. [Epub ahead of print]


Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research.

Qureshi MI, Greco M, Vorkas PA, Holmes E, Davies AH.

J Proteome Res. 2017 Jul 7;16(7):2325-2332. doi: 10.1021/acs.jproteome.6b00894. Epub 2017 Jun 19. Review.


Replication of LC-MS untargeted lipidomics results in patients with calcific coronary disease: An interlaboratory reproducibility study.

Djekic D, Pinto R, Vorkas PA, Henein MY.

Int J Cardiol. 2016 Nov 1;222:1042-1048. doi: 10.1016/j.ijcard.2016.07.214. Epub 2016 Aug 2.


Prolonged Mechanical Circumferential Stretch Induces Metabolic Changes in Rat Inferior Vena Cava.

Anwar MA, Vorkas PA, Li J, Adesina-Georgiadis KN, Reslan OM, Raffetto JD, Want EJ, Khalil RA, Holmes E, Davies AH.

Eur J Vasc Endovasc Surg. 2016 Oct;52(4):544-552. doi: 10.1016/j.ejvs.2016.07.002. Epub 2016 Aug 11.


Metabolic Phenotypes of Carotid Atherosclerotic Plaques Relate to Stroke Risk: An Exploratory Study.

Vorkas PA, Shalhoub J, Lewis MR, Spagou K, Want EJ, Nicholson JK, Davies AH, Holmes E.

Eur J Vasc Endovasc Surg. 2016 Jul;52(1):5-10. doi: 10.1016/j.ejvs.2016.01.022. Epub 2016 May 23.


Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis.

Lamour SD, Gomez-Romero M, Vorkas PA, Alibu VP, Saric J, Holmes E, Sternberg JM.

PLoS Negl Trop Dis. 2015 Oct 27;9(10):e0004200. doi: 10.1371/journal.pntd.0004200. eCollection 2015.


Optimization of metabolite extraction of human vein tissue for ultra performance liquid chromatography-mass spectrometry and nuclear magnetic resonance-based untargeted metabolic profiling.

Anwar MA, Vorkas PA, Li JV, Shalhoub J, Want EJ, Davies AH, Holmes E.

Analyst. 2015 Nov 21;140(22):7586-97. doi: 10.1039/c5an01041a.


Perturbations in fatty acid metabolism and apoptosis are manifested in calcific coronary artery disease: An exploratory lipidomic study.

Vorkas PA, Isaac G, Holmgren A, Want EJ, Shockcor JP, Holmes E, Henein MY.

Int J Cardiol. 2015 Oct 15;197:192-9. doi: 10.1016/j.ijcard.2015.06.048. Epub 2015 Jun 23.


Untargeted UPLC-MS profiling pipeline to expand tissue metabolome coverage: application to cardiovascular disease.

Vorkas PA, Isaac G, Anwar MA, Davies AH, Want EJ, Nicholson JK, Holmes E.

Anal Chem. 2015 Apr 21;87(8):4184-93. doi: 10.1021/ac503775m. Epub 2015 Apr 8.


Metabolic phenotyping of atherosclerotic plaques reveals latent associations between free cholesterol and ceramide metabolism in atherogenesis.

Vorkas PA, Shalhoub J, Isaac G, Want EJ, Nicholson JK, Holmes E, Davies AH.

J Proteome Res. 2015 Mar 6;14(3):1389-99. doi: 10.1021/pr5009898. Epub 2015 Feb 23.


Systems biology of human atherosclerosis.

Shalhoub J, Sikkel MB, Davies KJ, Vorkas PA, Want EJ, Davies AH.

Vasc Endovascular Surg. 2014 Jan;48(1):5-17. doi: 10.1177/1538574413510628. Epub 2013 Nov 7. Review.


Chemical mapping of the colorectal cancer microenvironment via MALDI imaging mass spectrometry (MALDI-MSI) reveals novel cancer-associated field effects.

Mirnezami R, Spagou K, Vorkas PA, Lewis MR, Kinross J, Want E, Shion H, Goldin RD, Darzi A, Takats Z, Holmes E, Cloarec O, Nicholson JK.

Mol Oncol. 2014 Feb;8(1):39-49. doi: 10.1016/j.molonc.2013.08.010. Epub 2013 Sep 14.


Clinical evaluation of microRNA expression profiling in non small cell lung cancer.

Markou A, Sourvinou I, Vorkas PA, Yousef GM, Lianidou E.

Lung Cancer. 2013 Sep;81(3):388-96. doi: 10.1016/j.lungcan.2013.05.007. Epub 2013 Jun 10.


A closed-tube methylation-sensitive high resolution melting assay (MS-HRMA) for the semi-quantitative determination of CST6 promoter methylation in clinical samples.

Dimitrakopoulos L, Vorkas PA, Georgoulias V, Lianidou ES.

BMC Cancer. 2012 Oct 22;12:486. doi: 10.1186/1471-2407-12-486.


In-vitro identification of distinctive metabolic signatures of intact varicose vein tissue via magic angle spinning nuclear magnetic resonance spectroscopy.

Anwar MA, Shalhoub J, Vorkas PA, Lim CS, Want EJ, Nicholson JK, Holmes E, Davies AH.

Eur J Vasc Endovasc Surg. 2012 Oct;44(4):442-50. doi: 10.1016/j.ejvs.2012.05.020. Epub 2012 Jul 20.


Implementation of molecular phenotyping approaches in the personalized surgical patient journey.

Mirnezami R, Kinross JM, Vorkas PA, Goldin R, Holmes E, Nicholson J, Darzi A.

Ann Surg. 2012 May;255(5):881-9. doi: 10.1097/SLA.0b013e31823e3c43. Review.


PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolution small amplicon melting analysis method.

Vorkas PA, Poumpouridou N, Agelaki S, Kroupis C, Georgoulias V, Lianidou ES.

J Mol Diagn. 2010 Sep;12(5):697-704. doi: 10.2353/jmoldx.2010.100008. Epub 2010 Jul 8. Erratum in: J Mol Diagn. 2013 Sep;15(5):730.


Mutation scanning of exon 20 of the BRCA1 gene by high-resolution melting curve analysis.

Vorkas PA, Christopoulos K, Kroupis C, Lianidou ES.

Clin Biochem. 2010 Jan;43(1-2):178-85. doi: 10.1016/j.clinbiochem.2009.08.024. Epub 2009 Sep 9.


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