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Items: 1 to 50 of 74

1.

Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Carcinogenesis. 2018 Feb 9;39(2):232-241. doi: 10.1093/carcin/bgx135.

PMID:
29194532
2.
3.

Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2018 Jan 16;31(1):48-57. doi: 10.1021/acs.chemrestox.7b00281. Epub 2017 Nov 30.

4.

Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung.

Villalta PW, Hochalter JB, Hecht SS.

Anal Chem. 2017 Dec 5;89(23):12735-12742. doi: 10.1021/acs.analchem.7b02856. Epub 2017 Nov 17.

PMID:
29111668
5.

Data-Independent Mass Spectrometry Approach for Screening and Identification of DNA Adducts.

Guo J, Villalta PW, Turesky RJ.

Anal Chem. 2017 Nov 7;89(21):11728-11736. doi: 10.1021/acs.analchem.7b03208. Epub 2017 Oct 18.

PMID:
28977750
6.

Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon.

Cheng G, Zarth AT, Upadhyaya P, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2017 Aug 25;274:80-88. doi: 10.1016/j.cbi.2017.07.005. Epub 2017 Jul 8.

PMID:
28693886
7.

Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells.

Ming X, Groehler A 4th, Michaelson-Richie ED, Villalta PW, Campbell C, Tretyakova NY.

Chem Res Toxicol. 2017 Apr 17;30(4):980-995. doi: 10.1021/acs.chemrestox.6b00389. Epub 2017 Mar 29.

PMID:
28282121
8.

DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.

Stornetta A, Villalta PW, Gossner F, Wilson WR, Balbo S, Sturla SJ.

Chem Res Toxicol. 2017 Mar 20;30(3):830-839. doi: 10.1021/acs.chemrestox.6b00412. Epub 2017 Feb 19.

9.

Biomonitoring DNA Adducts of Cooked Meat Carcinogens in Human Prostate by Nano Liquid Chromatography-High Resolution Tandem Mass Spectrometry: Identification of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA Adduct.

Xiao S, Guo J, Yun BH, Villalta PW, Krishna S, Tejpaul R, Murugan P, Weight CJ, Turesky RJ.

Anal Chem. 2016 Dec 20;88(24):12508-12515. doi: 10.1021/acs.analchem.6b04157. Epub 2016 Dec 1.

10.

Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

Widen JC, Kempema AM, Villalta PW, Harki DA.

ACS Chem Biol. 2017 Jan 20;12(1):102-113. doi: 10.1021/acschembio.6b00751. Epub 2016 Nov 28.

11.

Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans.

Wang Y, Villalta PW, Peng L, Dingley K, Malfatti MA, Turteltaub KW, Turesky RJ.

Chem Res Toxicol. 2017 Feb 20;30(2):705-714. doi: 10.1021/acs.chemrestox.6b00426. Epub 2017 Jan 18.

12.

A High Resolution/Accurate Mass (HRAM) Data-Dependent MS3 Neutral Loss Screening, Classification, and Relative Quantitation Methodology for Carbonyl Compounds in Saliva.

Dator R, Carrà A, Maertens L, Guidolin V, Villalta PW, Balbo S.

J Am Soc Mass Spectrom. 2017 Apr;28(4):608-618. doi: 10.1007/s13361-016-1521-y. Epub 2016 Oct 26.

PMID:
27785693
13.

Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in human retinal DNA by liquid chromatography nanoelectrospray-tandem mass spectrometry.

Ma B, Jing M, Villalta PW, Kapphahn RJ, Montezuma SR, Ferrington DA, Stepanov I.

Sci Rep. 2016 Mar 16;6:22375. doi: 10.1038/srep22375.

14.

Covalent DNA-Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells.

Groehler A 4th, Villalta PW, Campbell C, Tretyakova N.

Chem Res Toxicol. 2016 Feb 15;29(2):190-202. doi: 10.1021/acs.chemrestox.5b00430. Epub 2016 Jan 20.

15.

Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine.

Yang J, Villalta PW, Upadhyaya P, Hecht SS.

Chem Res Toxicol. 2016 Jan 19;29(1):87-95. doi: 10.1021/acs.chemrestox.5b00425. Epub 2015 Dec 18.

16.

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic Approach.

Stornetta A, Villalta PW, Hecht SS, Sturla SJ, Balbo S.

Anal Chem. 2015 Dec 1;87(23):11706-13. doi: 10.1021/acs.analchem.5b02759. Epub 2015 Nov 10.

17.

Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Villalta PW, Zarth AT, Kotandeniya D, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2015 Nov 16;28(11):2151-9. doi: 10.1021/acs.chemrestox.5b00318. Epub 2015 Oct 12.

18.

Analysis of a malondialdehyde-deoxyguanosine adduct in human leukocyte DNA by liquid chromatography nanoelectrospray-high-resolution tandem mass spectrometry.

Ma B, Villalta PW, Balbo S, Stepanov I.

Chem Res Toxicol. 2014 Oct 20;27(10):1829-36. doi: 10.1021/tx5002699. Epub 2014 Sep 15.

19.

NanoLC/ESI+ HRMS3 quantitation of DNA adducts induced by 1,3-butadiene.

Sangaraju D, Villalta PW, Wickramaratne S, Swenberg J, Tretyakova N.

J Am Soc Mass Spectrom. 2014 Jul;25(7):1124-35. doi: 10.1007/s13361-014-0916-x. Epub 2014 May 28. Erratum in: J Am Soc Mass Spectrom. 2014 Sep;25(9):1674.

20.

Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans.

Zarth AT, Cheng G, Zhang Z, Wang M, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2014 May 25;215:40-5. doi: 10.1016/j.cbi.2014.03.002. Epub 2014 Mar 13.

21.

DNA adductomics.

Balbo S, Turesky RJ, Villalta PW.

Chem Res Toxicol. 2014 Mar 17;27(3):356-66. doi: 10.1021/tx4004352. Epub 2014 Feb 25. Review.

22.

Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures.

Balbo S, Hecht SS, Upadhyaya P, Villalta PW.

Anal Chem. 2014 Feb 4;86(3):1744-52. doi: 10.1021/ac403565m. Epub 2014 Jan 21.

23.

Covalent modification of cytochrome c by reactive metabolites of furan.

Phillips MB, Sullivan MM, Villalta PW, Peterson LA.

Chem Res Toxicol. 2014 Jan 21;27(1):129-35. doi: 10.1021/tx400368r. Epub 2013 Dec 23.

24.

Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a carcinogenicity study.

Zhao L, Balbo S, Wang M, Upadhyaya P, Khariwala SS, Villalta PW, Hecht SS.

Chem Res Toxicol. 2013 Oct 21;26(10):1526-35. doi: 10.1021/tx400235x. Epub 2013 Sep 18.

25.

Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation.

Wang M, Cheng G, Khariwala SS, Bandyopadhyay D, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2013 Oct 25;206(1):83-9. doi: 10.1016/j.cbi.2013.07.010. Epub 2013 Jul 30.

26.

Synthesis of sequence-specific DNA-protein conjugates via a reductive amination strategy.

Wickramaratne S, Mukherjee S, Villalta PW, Schärer OD, Tretyakova NY.

Bioconjug Chem. 2013 Sep 18;24(9):1496-506. doi: 10.1021/bc400018u. Epub 2013 Aug 16.

27.

1,2,3,4-Diepoxybutane-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells.

Gherezghiher TB, Ming X, Villalta PW, Campbell C, Tretyakova NY.

J Proteome Res. 2013 May 3;12(5):2151-64. doi: 10.1021/pr3011974. Epub 2013 Apr 3.

28.

DNA adducts in aldehyde dehydrogenase-positive lung stem cells of A/J mice treated with the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Balbo S, Upadhyaya P, Villalta PW, Qian X, Kassie F.

Chem Res Toxicol. 2013 Apr 15;26(4):511-3. doi: 10.1021/tx400054s. Epub 2013 Mar 15.

PMID:
23477619
29.

Mass spectrometry of structurally modified DNA.

Tretyakova N, Villalta PW, Kotapati S.

Chem Rev. 2013 Apr 10;113(4):2395-436. doi: 10.1021/cr300391r. Epub 2013 Feb 26. Review. No abstract available.

30.

Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities.

Pietsch KE, van Midwoud PM, Villalta PW, Sturla SJ.

Chem Res Toxicol. 2013 Jan 18;26(1):146-55. doi: 10.1021/tx300430r. Epub 2012 Dec 19.

31.

Quantitation of 7-ethylguanine in leukocyte DNA from smokers and nonsmokers by liquid chromatography-nanoelectrospray-high resolution tandem mass spectrometry.

Balbo S, Villalta PW, Hecht SS.

Chem Res Toxicol. 2011 Oct 17;24(10):1729-34. doi: 10.1021/tx200262d. Epub 2011 Sep 14.

32.

Detection of 7-(2'-carboxyethyl)guanine but not 7-carboxymethylguanine in human liver DNA.

Cheng G, Wang M, Villalta PW, Hecht SS.

Chem Res Toxicol. 2010 Jun 21;23(6):1089-96. doi: 10.1021/tx100062v.

33.
34.

Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry.

Stepanov I, Villalta PW, Knezevich A, Jensen J, Hatsukami D, Hecht SS.

Chem Res Toxicol. 2010 Jan;23(1):66-73. doi: 10.1021/tx900281u. Erratum in: Chem Res Toxicol. 2010 Apr 19;23(4):845.

35.

Mass spectrometric analysis of a cyclic 7,8-butanoguanine adduct of N-nitrosopyrrolidine: comparison to other N-nitrosopyrrolidine adducts in rat hepatic DNA.

Loureiro AP, Zhang W, Kassie F, Zhang S, Villalta PW, Wang M, Hecht SS.

Chem Res Toxicol. 2009 Oct;22(10):1728-35. doi: 10.1021/tx900238t.

36.

Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers.

Wang M, Cheng G, Balbo S, Carmella SG, Villalta PW, Hecht SS.

Cancer Res. 2009 Sep 15;69(18):7170-4. doi: 10.1158/0008-5472.CAN-09-1571. Epub 2009 Sep 8.

37.

Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine.

Zhang S, Wang M, Villalta PW, Lindgren BR, Lao Y, Hecht SS.

Chem Res Toxicol. 2009 May;22(5):949-56. doi: 10.1021/tx900040j.

39.

Simultaneous determination of inositol and inositol phosphates in complex biological matrices: quantitative ion-exchange chromatography/tandem mass spectrometry.

Liu X, Villalta PW, Sturla SJ.

Rapid Commun Mass Spectrom. 2009 Mar;23(5):705-12. doi: 10.1002/rcm.3923.

PMID:
19191261
40.

A study of the ground and excited states of Al3 and Al3(-). I. 488 nm anion photoelectron spectrum.

Villalta PW, Leopold DG.

J Chem Phys. 2009 Jan 14;130(2):024303. doi: 10.1063/1.2973625.

PMID:
19154024
41.
42.
44.

Liquid chromatography-electrospray ionization tandem mass spectrometry analysis of 7-ethylguanine in human liver DNA.

Chen L, Wang M, Villalta PW, Hecht SS.

Chem Res Toxicol. 2007 Oct;20(10):1498-502. Epub 2007 Sep 22.

PMID:
17887725
45.
46.

Nucleobase-dependent reactivity of a quinone metabolite of pentachlorophenol.

Vaidyanathan VG, Villalta PW, Sturla SJ.

Chem Res Toxicol. 2007 Jun;20(6):913-9. Epub 2007 May 12.

PMID:
17497895
47.

Analysis of adducts in hepatic DNA of rats treated with N-nitrosopyrrolidine.

Wang M, Lao Y, Cheng G, Shi Y, Villalta PW, Nishikawa A, Hecht SS.

Chem Res Toxicol. 2007 Apr;20(4):634-40. Epub 2007 Mar 30.

48.

Identification of adducts formed in the reaction of alpha-acetoxy-N-nitrosopyrrolidine with deoxyribonucleosides and DNA.

Wang M, Lao Y, Cheng G, Shi Y, Villalta PW, Hecht SS.

Chem Res Toxicol. 2007 Apr;20(4):625-33. Epub 2007 Mar 30.

49.
50.

Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine.

Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS.

Chem Res Toxicol. 2007 Feb;20(2):246-56.

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