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Items: 49

1.

CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats.

Sacaan AI, Thibault S, Hong M, Kondegowda NG, Nichols T, Li R, Rosselot C, Evering W, Fenutria R, Vitsky A, Brown T, Finkelstein M, Garcia-Ocaña A, Khan N, Stewart AF, Vasavada RC.

Mol Cancer Res. 2017 Nov;15(11):1531-1541. doi: 10.1158/1541-7786.MCR-17-0172. Epub 2017 Jul 31.

PMID:
28760782
2.

Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy.

Mozar A, Lin H, Williams K, Chin C, Li R, Kondegowda NG, Stewart AF, Garcia-Ocaña A, Vasavada RC.

PLoS One. 2016 Jul 8;11(7):e0158414. doi: 10.1371/journal.pone.0158414. eCollection 2016.

3.

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.

Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A.

Diabetes. 2016 May;65(5):1283-96. doi: 10.2337/db15-1398. Epub 2016 Feb 11.

4.

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway.

Kondegowda NG, Fenutria R, Pollack IR, Orthofer M, Garcia-Ocaña A, Penninger JM, Vasavada RC.

Cell Metab. 2015 Jul 7;22(1):77-85. doi: 10.1016/j.cmet.2015.05.021. Epub 2015 Jun 18.

5.

Human β-cell proliferation and intracellular signaling: part 3.

Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN.

Diabetes. 2015 Jun;64(6):1872-85. doi: 10.2337/db14-1843. Review.

6.

Diabetes mellitus--advances and challenges in human β-cell proliferation.

Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, García-Ocaña A, Stewart AF.

Nat Rev Endocrinol. 2015 Apr;11(4):201-12. doi: 10.1038/nrendo.2015.9. Epub 2015 Feb 17. Review.

PMID:
25687999
7.

Hepatocyte growth factor ameliorates hyperglycemia and corrects β-cell mass in IRS2-deficient mice.

Alvarez-Perez JC, Rosa TC, Casinelli GP, Valle SR, Lakshmipathi J, Rosselot C, Rausell-Palamos F, Vasavada RC, García-Ocaña A.

Mol Endocrinol. 2014 Dec;28(12):2038-48. doi: 10.1210/me.2014-1207.

8.

Hepatocyte growth factor/c-Met signaling is required for β-cell regeneration.

Alvarez-Perez JC, Ernst S, Demirci C, Casinelli GP, Mellado-Gil JM, Rausell-Palamos F, Vasavada RC, Garcia-Ocaña A.

Diabetes. 2014 Jan;63(1):216-23. doi: 10.2337/db13-0333. Epub 2013 Oct 2.

9.

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK.

Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14.

10.

Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus.

Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, García-Ocana A.

Diabetes. 2012 May;61(5):1143-52. doi: 10.2337/db11-1154. Epub 2012 Mar 16.

11.

Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling.

Kondegowda NG, Mozar A, Chin C, Otero A, Garcia-Ocaña A, Vasavada RC.

Diabetologia. 2012 Jun;55(6):1721-32. doi: 10.1007/s00125-012-2501-9. Epub 2012 Mar 3.

PMID:
22382519
12.

Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Oct;60(10):2546-59. doi: 10.2337/db10-1783. Epub 2011 Sep 12.

13.

Systemic and acute administration of parathyroid hormone-related peptide(1-36) stimulates endogenous beta cell proliferation while preserving function in adult mice.

Williams K, Abanquah D, Joshi-Gokhale S, Otero A, Lin H, Guthalu NK, Zhang X, Mozar A, Bisello A, Stewart AF, Garcia-Ocaña A, Vasavada RC.

Diabetologia. 2011 Nov;54(11):2867-77. doi: 10.1007/s00125-011-2260-z. Epub 2011 Jul 29.

PMID:
21800111
14.

Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Feb;60(2):525-36. doi: 10.2337/db09-1305. Epub 2010 Oct 27.

15.

Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.

Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC.

Diabetes. 2010 Dec;59(12):3131-8. doi: 10.2337/db09-1796. Epub 2010 Sep 28.

16.

Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis.

González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A.

Endocrinology. 2010 Apr;151(4):1487-98. doi: 10.1210/en.2009-0975. Epub 2010 Feb 22.

17.

Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen.

Zhang H, Zhang J, Pope CF, Crawford LA, Vasavada RC, Jagasia SM, Gannon M.

Diabetes. 2010 Jan;59(1):143-52. doi: 10.2337/db09-0050. Epub 2009 Oct 15.

18.

The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells.

Harb G, Vasavada RC, Cobrinik D, Stewart AF.

Diabetes. 2009 Aug;58(8):1852-62. doi: 10.2337/db08-0759. Epub 2009 Jun 9. Erratum in: Diabetes. 2009 Oct;58(10):2425.

19.

Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.

Fujinaka Y, Takane K, Yamashita H, Vasavada RC.

J Biol Chem. 2007 Oct 19;282(42):30707-17. Epub 2007 Aug 29.

20.

Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.

Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.

21.
22.

Growth factors and beta cell replication.

Vasavada RC, Gonzalez-Pertusa JA, Fujinaka Y, Fiaschi-Taesch N, Cozar-Castellano I, Garcia-Ocaña A.

Int J Biochem Cell Biol. 2006;38(5-6):931-50. Epub 2005 Aug 31. Review.

PMID:
16168703
23.
25.

Hepatocyte growth factor gene therapy for islet transplantation.

Rao P, Cozar-Castellano I, Roccisana J, Vasavada RC, Garcia-Ocaña A.

Expert Opin Biol Ther. 2004 Apr;4(4):507-18. Review.

PMID:
15102600
26.

Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.

Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF.

J Biol Chem. 2003 Jan 3;278(1):343-51. Epub 2002 Oct 25.

27.

Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro.

Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC.

Diabetes. 2002 Oct;51(10):3003-13.

28.

Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF.

Diabetes. 2001 Dec;50(12):2752-62.

29.

Using beta-cell growth factors to enhance human pancreatic Islet transplantation.

García-Ocaña A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, Stewart AF.

J Clin Endocrinol Metab. 2001 Mar;86(3):984-8. Review.

PMID:
11238473
30.

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, Stewart AF.

J Biol Chem. 2000 May 19;275(20):15399-406.

31.

Studies on microencapsulation of 5-fluorouracil with poly(ortho ester) polymers.

Lin YH, Vasavada RC.

J Microencapsul. 2000 Jan-Feb;17(1):1-11.

PMID:
10670936
32.

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

J Biol Chem. 2000 Jan 14;275(2):1226-32.

33.

Parathyroid hormone-related protein in the pancreatic islet and the cardiovascular system.

Vasavada RC, Garcia-Ocana A, Massfelder T, Dann P, Stewart AF.

Recent Prog Horm Res. 1998;53:305-38; discussion 338-40. Review.

PMID:
9769713
34.

Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse.

Porter SE, Sorenson RL, Dann P, Garcia-Ocana A, Stewart AF, Vasavada RC.

Endocrinology. 1998 Sep;139(9):3743-51.

PMID:
9724026
35.

Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38).

Reddy D, Pollock AS, Clark SA, Sooy K, Vasavada RC, Stewart AF, Honeyman T, Christakos S.

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1961-6.

36.

Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein.

Wu TL, Vasavada RC, Yang K, Massfelder T, Ganz M, Abbas SK, Care AD, Stewart AF.

J Biol Chem. 1996 Oct 4;271(40):24371-81.

37.

Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia.

Vasavada RC, Cavaliere C, D'Ercole AJ, Dann P, Burtis WJ, Madlener AL, Zawalich K, Zawalich W, Philbrick W, Stewart AF.

J Biol Chem. 1996 Jan 12;271(2):1200-8.

38.

Defining the roles of parathyroid hormone-related protein in normal physiology.

Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF.

Physiol Rev. 1996 Jan;76(1):127-73. Review.

PMID:
8592727
39.

Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines.

Orloff JJ, Kats Y, Urena P, Schipani E, Vasavada RC, Philbrick WM, Behal A, Abou-Samra AB, Segre GV, Jüppner H.

Endocrinology. 1995 Jul;136(7):3016-23.

PMID:
7789327
40.

Region-specific methylation of the parathyroid hormone-related peptide gene determines its expression in human renal carcinoma cell lines.

Holt EH, Vasavada RC, Bander NH, Broadus AE, Philbrick WM.

J Biol Chem. 1993 Sep 25;268(27):20639-45.

41.
42.

Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene.

Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM.

Mol Endocrinol. 1993 Feb;7(2):273-82.

PMID:
8469240
44.

In vitro release of salicylic acid from lanolin alcohols-ethylcellulose films.

Khan AR, Iyer BV, Cirelli RA, Vasavada RC.

J Pharm Sci. 1984 Mar;73(3):302-5.

PMID:
6716235
45.

Evaluation of lanolin alcohol films and kinetics of triamcinolone acetonide release.

Iyer BV, Vasavada RC.

J Pharm Sci. 1979 Jun;68(6):782-7.

PMID:
458584
46.

Competency characteristics of the industrial pharmacist.

Vasavada RC.

Am J Pharm Educ. 1977 Aug;41(3):303-5. No abstract available.

PMID:
10236658
47.

Synthesis of enantiomeric chloroacetylcarnitine chlorides.

Vasavada RC, Turcotte JG.

J Med Chem. 1971 Nov;14(11):1142. No abstract available.

PMID:
5115228
48.

Vagotomy and atropine antagonism of (plus or minus)-chloroacetyl carnitine chloride mediated blood pressure reduction in the rat.

Cutroneo KR, Louis-Ferdinand RT, Vasavada RC, Turcotte JG, DeFanti DR.

J Pharm Pharmacol. 1970 Dec;22(12):940-1. No abstract available.

PMID:
4395519
49.

Flow decrease through rat hind limb vasculature by (plus or minus)-carnitine, (plus or minus)-acetylcarnitine and (plus or minss)-chloroacetylcarnitine chlorides.

Louis-Ferdinand RT, Cutroneo KR, Kosegarten DC, Vasavada RC, Turcotte JG, DeFanti DR.

J Pharm Pharmacol. 1970 Sep;22(9):704-5. No abstract available.

PMID:
4395167

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