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Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.

Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C.

Nat Genet. 2018 Feb;50(2):180-185. doi: 10.1038/s41588-017-0020-9. Epub 2018 Jan 8.


Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW.

Cell Rep. 2017 Jun 13;19(11):2257-2271. doi: 10.1016/j.celrep.2017.05.060.


Cilia and Obesity.

Vaisse C, Reiter JF, Berbari NF.

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7). pii: a028217. doi: 10.1101/cshperspect.a028217. Review.


The Association of Serum Leptin with Mortality in Older Adults.

Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR.

PLoS One. 2015 Oct 16;10(10):e0140763. doi: 10.1371/journal.pone.0140763. eCollection 2015.


Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.

Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C.

PLoS One. 2014 May 12;9(5):e96805. doi: 10.1371/journal.pone.0096805. eCollection 2014.


Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.

Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR.

Obesity (Silver Spring). 2014 Feb;22 Suppl 1:S1-S17. doi: 10.1002/oby.20646.


Functional characterization of SIM1-associated enhancers.

Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N.

Hum Mol Genet. 2014 Apr 1;23(7):1700-8. doi: 10.1093/hmg/ddt559. Epub 2013 Nov 7.


The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus.

Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C.

Int J Obes (Lond). 2014 Jan;38(1):148-51. doi: 10.1038/ijo.2013.53. Epub 2013 May 7.


Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.

Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C.

Nat Chem Biol. 2012 Aug;8(8):725-30. doi: 10.1038/nchembio.1008. Epub 2012 Jun 24.


Replication and extension of association between common genetic variants in SIM1 and human adiposity.

Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC.

Obesity (Silver Spring). 2011 Dec;19(12):2394-2403. doi: 10.1038/oby.2011.79. Epub 2011 Apr 21.


Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations.

Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C.

Obes Surg. 2011 Jul;21(7):930-4. doi: 10.1007/s11695-010-0295-8.


Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.

Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW 3rd, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO.

Osteoporos Int. 2011 Aug;22(8):2283-93. doi: 10.1007/s00198-010-1432-x. Epub 2010 Oct 13.


Bariatric surgery in a patient with complete MC4R deficiency.

Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C.

Int J Obes (Lond). 2011 Mar;35(3):457-61. doi: 10.1038/ijo.2010.168. Epub 2010 Aug 24.


Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity.

Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW 3rd, Ager JW Jr, Alliston T, Vaisse C, Ritchie RO.

Bone. 2010 Jan;46(1):217-25. doi: 10.1016/j.bone.2009.10.015. Epub 2009 Oct 21.


In silico mutagenesis: a case study of the melanocortin 4 receptor.

Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B.

FASEB J. 2009 Sep;23(9):3059-69. doi: 10.1096/fj.08-127530. Epub 2009 May 5.


Narrowing down the role of common variants in the genetic predisposition to obesity.

Calton MA, Vaisse C.

Genome Med. 2009 Mar 11;1(3):31. doi: 10.1186/gm31.


Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus.

Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C.

Clin Endocrinol (Oxf). 2009 Sep;71(3):388-93. doi: 10.1111/j.1365-2265.2008.03513.x. Epub 2008 Dec 18.


Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.

Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C.

Hum Mol Genet. 2009 Mar 15;18(6):1140-7. doi: 10.1093/hmg/ddn431. Epub 2008 Dec 17.


Lessons from extreme human obesity: monogenic disorders.

Ranadive SA, Vaisse C.

Endocrinol Metab Clin North Am. 2008 Sep;37(3):733-51, x. doi: 10.1016/j.ecl.2008.07.003. Review.


Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene.

Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J.

J Clin Endocrinol Metab. 2008 Dec;93(12):4955-62. doi: 10.1210/jc.2008-1164. Epub 2008 Sep 2.


Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes.

Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F.

Diabetes Obes Metab. 2008 Sep;10(10):912-20. Epub 2007 Dec 17.


Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.

Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K.

Pediatr Res. 2008 Feb;63(2):211-6.


Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.

Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR.

PLoS One. 2007 Aug 1;2(7):e668.


Medical sequencing at the extremes of human body mass.

Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA.

Am J Hum Genet. 2007 Apr;80(4):779-91. Epub 2007 Mar 5.


Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.

Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C.

J Clin Endocrinol Metab. 2006 May;91(5):1811-8. Epub 2006 Feb 28.


Lack of support for the association between GAD2 polymorphisms and severe human obesity.

Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C.

PLoS Biol. 2005 Sep;3(9):e315. Epub 2005 Aug 30.


Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.

Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C.

Peptides. 2005 Oct;26(10):1909-19. Review.


High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes.

Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F.

J Clin Endocrinol Metab. 2005 Aug;90(8):4446-51. Epub 2005 May 24.


Leptin regulation of bone resorption by the sympathetic nervous system and CART.

Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G.

Nature. 2005 Mar 24;434(7032):514-20. Epub 2005 Feb 20.


A statistical approach for array CGH data analysis.

Picard F, Robin S, Lavielle M, Vaisse C, Daudin JJ.

BMC Bioinformatics. 2005 Feb 11;6:27.


PAX4 gene variations predispose to ketosis-prone diabetes.

Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C.

Hum Mol Genet. 2004 Dec 15;13(24):3151-9. Epub 2004 Oct 27.


Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C.

J Clin Invest. 2004 Oct;114(8):1158-64.


A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans.

Lubrano-Berthelier C, Le Stunff C, Bougnères P, Vaisse C.

J Clin Endocrinol Metab. 2004 May;89(5):2028-32.


Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance.

Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF.

Diabetes. 2004 Mar;53(3):645-53.


The human MC4R promoter: characterization and role in obesity.

Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C.

Diabetes. 2003 Dec;52(12):2996-3000.


Engineering the melanocortin-4 receptor to control G(s) signaling in vivo.

Srinivasan S, Vaisse C, Conklin BR.

Ann N Y Acad Sci. 2003 Jun;994:225-32. Review.


Molecular genetics of human obesity-associated MC4R mutations.

Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C.

Ann N Y Acad Sci. 2003 Jun;994:49-57. Review.


Emerging trends in the search for genetic variants predisposing to human obesity.

Swarbrick MM, Vaisse C.

Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):369-75. Review.


Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations.

Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C.

Hum Mol Genet. 2003 Jan 15;12(2):145-53.


Elevated plasma ghrelin levels in Prader Willi syndrome.

Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS.

Nat Med. 2002 Jul;8(7):643-4. No abstract available.


Glycodelin: a pane in the implantation window.

Mueller MD, Vigne JL, Vaisse C, Taylor RN.

Semin Reprod Med. 2000;18(3):289-98.


Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass.

Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M, Guy-Grand B.

Diabetes. 2000 Aug;49(8):1347-52.


Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.

Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P.

J Clin Invest. 2000 Jul;106(2):253-62.


The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M.

Hum Hered. 2000 Nov-Dec;50(6):370-81.


The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes.

Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner AR, Beamer BA, Charpentier G, Guy-Grand B, Froguel P, Vaisse C.

Int J Obes Relat Metab Disord. 2000 Mar;24(3):391-3.


Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.

Taylor RN, Savouret JF, Vaisse C, Vigne JL, Ryan I, Hornung D, Seppälä M, Milgrom E.

J Clin Endocrinol Metab. 1998 Nov;83(11):4006-12.


A frameshift mutation in human MC4R is associated with a dominant form of obesity.

Vaisse C, Clement K, Guy-Grand B, Froguel P.

Nat Genet. 1998 Oct;20(2):113-4. No abstract available.


A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.

Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnères P, Lebouc Y, Froguel P, Guy-Grand B.

Nature. 1998 Mar 26;392(6674):398-401.


Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM.

Nat Genet. 1996 Sep;14(1):95-7.


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