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Items: 1 to 50 of 578

1.

Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.

Danielsson F, Fasterius E, Sullivan D, Hases L, Sanli K, Zhang C, Mardinoglu A, Al-Khalili C, Huss M, Uhlén M, Williams C, Lundberg E.

Oncotarget. 2018 Apr 13;9(28):19730-19744. doi: 10.18632/oncotarget.24808. eCollection 2018 Apr 13.

2.

Systems biology in hepatology: approaches and applications.

Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J.

Nat Rev Gastroenterol Hepatol. 2018 Apr 23. doi: 10.1038/s41575-018-0007-8. [Epub ahead of print] Review.

PMID:
29686404
3.

Mining the human tissue proteome for protein citrullination.

Lee CY, Wang D, Wilhelm M, Zolg DP, Schmidt T, Schnatbaum K, Reimer U, Pontén F, Uhlén M, Hahne H, Kuster B.

Mol Cell Proteomics. 2018 Apr 2. pii: mcp.RA118.000696. doi: 10.1074/mcp.RA118.000696. [Epub ahead of print]

4.

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

Azimi A, Caramuta S, Seashore-Ludlow B, Boström J, Robinson JL, Edfors F, Tuominen R, Kemper K, Krijgsman O, Peeper DS, Nielsen J, Hansson J, Egyhazi Brage S, Altun M, Uhlen M, Maddalo G.

Mol Syst Biol. 2018 Mar 5;14(3):e7858. doi: 10.15252/msb.20177858.

5.

Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for improved patient stratification.

Karnevi E, Dror LB, Mardinoglu A, Elebro J, Heby M, Olofsson SE, Nodin B, Eberhard J, Gallagher W, Uhlén M, Jirström K.

Oncotarget. 2017 Dec 15;9(5):6188-6200. doi: 10.18632/oncotarget.23486. eCollection 2018 Jan 19.

6.

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.

Cell Metab. 2018 Mar 6;27(3):559-571.e5. doi: 10.1016/j.cmet.2018.01.005. Epub 2018 Feb 15.

PMID:
29456073
7.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

PMID:
29443976
8.

Broad Views of Non-alcoholic Fatty Liver Disease.

Mardinoglu A, Uhlen M, Borén J.

Cell Syst. 2018 Jan 24;6(1):7-9. doi: 10.1016/j.cels.2018.01.004.

PMID:
29401451
9.

The Human Cell Atlas.

Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N; Human Cell Atlas Meeting Participants.

Elife. 2017 Dec 5;6. pii: e27041. doi: 10.7554/eLife.27041.

10.

TCSBN: a database of tissue and cancer specific biological networks.

Lee S, Zhang C, Arif M, Liu Z, Benfeitas R, Bidkhori G, Deshmukh S, Al Shobky M, Lovric A, Boren J, Nielsen J, Uhlen M, Mardinoglu A.

Nucleic Acids Res. 2018 Jan 4;46(D1):D595-D600. doi: 10.1093/nar/gkx994.

11.

In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation.

Zieba A, Ponten F, Uhlén M, Landegren U.

Mod Pathol. 2018 Feb;31(2):253-263. doi: 10.1038/modpathol.2017.102. Epub 2017 Sep 22.

PMID:
28937142
12.

Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome.

Feizi A, Gatto F, Uhlen M, Nielsen J.

NPJ Syst Biol Appl. 2017 Aug 18;3:22. doi: 10.1038/s41540-017-0021-4. eCollection 2017.

13.

Network analyses identify liver-specific targets for treating liver diseases.

Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.

Mol Syst Biol. 2017 Aug 21;13(8):938. doi: 10.15252/msb.20177703.

14.

A pathology atlas of the human cancer transcriptome.

Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.

Science. 2017 Aug 18;357(6352). pii: eaan2507. doi: 10.1126/science.aan2507.

PMID:
28818916
15.

Combination of phage and Gram-positive bacterial display of human antibody repertoires enables isolation of functional high affinity binders.

Hu FJ, Volk AL, Persson H, Säll A, Borrebaeck C, Uhlen M, Rockberg J.

N Biotechnol. 2017 Aug 1. pii: S1871-6784(17)30212-1. doi: 10.1016/j.nbt.2017.07.011. [Epub ahead of print]

16.

New Challenges to Study Heterogeneity in Cancer Redox Metabolism.

Benfeitas R, Uhlen M, Nielsen J, Mardinoglu A.

Front Cell Dev Biol. 2017 Jul 11;5:65. doi: 10.3389/fcell.2017.00065. eCollection 2017. Review.

17.

Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis.

Zandian A, Wingård L, Nilsson H, Sjöstedt E, Johansson DX, Just D, Hellström C, Uhlén M, Schwenk JM, Häggmark-Månberg A, Norbeck O, Owe-Larsson B, Nilsson P, Persson MAA.

Transl Psychiatry. 2017 Jul 25;7(7):e1177. doi: 10.1038/tp.2017.160.

18.

Improving the economics of NASH/NAFLD treatment through the use of systems biology.

Bosley J, Boren C, Lee S, Grøtli M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.

Drug Discov Today. 2017 Oct;22(10):1532-1538. doi: 10.1016/j.drudis.2017.07.005. Epub 2017 Jul 20. Review.

PMID:
28736156
19.

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes.

Väremo L, Henriksen TI, Scheele C, Broholm C, Pedersen M, Uhlén M, Pedersen BK, Nielsen J.

Genome Med. 2017 May 25;9(1):47. doi: 10.1186/s13073-017-0432-2.

20.

A subcellular map of the human proteome.

Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.

Science. 2017 May 26;356(6340). pii: eaal3321. doi: 10.1126/science.aal3321. Epub 2017 May 11.

PMID:
28495876
21.

Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.

Byström S, Fredolini C, Edqvist PH, Nyaiesh EN, Drobin K, Uhlén M, Bergqvist M, Pontén F, Schwenk JM.

Transl Oncol. 2017 Jun;10(3):385-395. doi: 10.1016/j.tranon.2017.03.002. Epub 2017 Apr 20.

22.

Machine learning in computational biology to accelerate high-throughput protein expression.

Sastry A, Monk J, Tegel H, Uhlen M, Palsson BO, Rockberg J, Brunk E.

Bioinformatics. 2017 Aug 15;33(16):2487-2495. doi: 10.1093/bioinformatics/btx207.

PMID:
28398465
23.

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.

Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422.

24.

Response to: Should we ignore western blots when selecting antibodies for other applications?

Uhlen M.

Nat Methods. 2017 Feb 28;14(3):215-216. doi: 10.1038/nmeth.4194. No abstract available.

PMID:
28245211
25.

A novel RNA sequencing data analysis method for cell line authentication.

Fasterius E, Raso C, Kennedy S, Rauch N, Lundin P, Kolch W, Uhlén M, Al-Khalili Szigyarto C.

PLoS One. 2017 Feb 13;12(2):e0171435. doi: 10.1371/journal.pone.0171435. eCollection 2017.

26.

FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.

Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhlén M, Kostenis E, Mulder J, Schulte G.

Cell Signal. 2017 Apr;32:93-103. doi: 10.1016/j.cellsig.2017.01.023. Epub 2017 Jan 24.

PMID:
28126591
27.

Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy.

Zandian A, Forsström B, Häggmark-Månberg A, Schwenk JM, Uhlén M, Nilsson P, Ayoglu B.

J Proteome Res. 2017 Mar 3;16(3):1300-1314. doi: 10.1021/acs.jproteome.6b00916. Epub 2017 Feb 9.

28.

A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.

Gremel G, Djureinovic D, Niinivirta M, Laird A, Ljungqvist O, Johannesson H, Bergman J, Edqvist PH, Navani S, Khan N, Patil T, Sivertsson Å, Uhlén M, Harrison DJ, Ullenhag GJ, Stewart GD, Pontén F.

BMC Cancer. 2017 Jan 4;17(1):9. doi: 10.1186/s12885-016-3030-6.

29.

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.

Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T.

Nat Neurosci. 2017 Feb;20(2):176-188. doi: 10.1038/nn.4462. Epub 2016 Dec 19.

PMID:
27991900
30.

Gene-specific correlation of RNA and protein levels in human cells and tissues.

Edfors F, Danielsson F, Hallström BM, Käll L, Lundberg E, Pontén F, Forsström B, Uhlén M.

Mol Syst Biol. 2016 Oct 20;12(10):883. doi: 10.15252/msb.20167144.

31.

The Human Adrenal Gland Proteome Defined by Transcriptomics and Antibody-Based Profiling.

Bergman J, Botling J, Fagerberg L, Hallström BM, Djureinovic D, Uhlén M, Pontén F.

Endocrinology. 2017 Feb 1;158(2):239-251. doi: 10.1210/en.2016-1758.

PMID:
27901589
32.

ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer.

Magnusson K, Gremel G, Rydén L, Pontén V, Uhlén M, Dimberg A, Jirström K, Pontén F.

BMC Cancer. 2016 Nov 18;16(1):904.

33.

Flow-cytometric screening of aggregation-inhibitors using a fluorescence-assisted intracellular method.

Lindberg H, Sandersjöö L, Meister SW, Uhlén M, Löfblom J, Ståhl S.

Biotechnol J. 2017 Jan;12(1). doi: 10.1002/biot.201600364. Epub 2016 Dec 1.

PMID:
27860405
34.

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.

Remnestål J, Just D, Mitsios N, Fredolini C, Mulder J, Schwenk JM, Uhlén M, Kultima K, Ingelsson M, Kilander L, Lannfelt L, Svenningsson P, Nellgård B, Zetterberg H, Blennow K, Nilsson P, Häggmark-Månberg A.

Proteomics Clin Appl. 2016 Dec;10(12):1242-1253. doi: 10.1002/prca.201500150. Epub 2016 Oct 10.

35.

PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.

Bruzelius M, Iglesias MJ, Hong MG, Sanchez-Rivera L, Gyorgy B, Souto JC, Frånberg M, Fredolini C, Strawbridge RJ, Holmström M, Hamsten A, Uhlén M, Silveira A, Soria JM, Smadja DM, Butler LM, Schwenk JM, Morange PE, Trégouët DA, Odeberg J.

Blood. 2016 Dec 8;128(23):e59-e66. Epub 2016 Oct 14.

36.

Antibody Validation in Bioimaging Applications Based on Endogenous Expression of Tagged Proteins.

Skogs M, Stadler C, Schutten R, Hjelmare M, Gnann C, Björk L, Poser I, Hyman A, Uhlén M, Lundberg E.

J Proteome Res. 2017 Jan 6;16(1):147-155. doi: 10.1021/acs.jproteome.6b00821. Epub 2016 Oct 26.

PMID:
27723985
37.

Identification of a Novel Autoimmune Peptide Epitope of Prostein in Prostate Cancer.

Pin E, Henjes F, Hong MG, Wiklund F, Magnusson P, Bjartell A, Uhlén M, Nilsson P, Schwenk JM.

J Proteome Res. 2017 Jan 6;16(1):204-216. doi: 10.1021/acs.jproteome.6b00620. Epub 2016 Oct 24.

38.

Profiling cancer testis antigens in non-small-cell lung cancer.

Djureinovic D, Hallström BM, Horie M, Mattsson JS, La Fleur L, Fagerberg L, Brunnström H, Lindskog C, Madjar K, Rahnenführer J, Ekman S, Ståhle E, Koyi H, Brandén E, Edlund K, Hengstler JG, Lambe M, Saito A, Botling J, Pontén F, Uhlén M, Micke P.

JCI Insight. 2016 Jul 7;1(10):e86837.

39.

Genetic variation may explain why females are less susceptible to dental erosion.

Uhlen MM, Stenhagen KR, Dizak PM, Holme B, Mulic A, Tveit AB, Vieira AR.

Eur J Oral Sci. 2016 Oct;124(5):426-432. doi: 10.1111/eos.12297. Epub 2016 Sep 26.

PMID:
27666331
40.

Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome.

Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J.

Cell Syst. 2016 Sep 28;3(3):287-301.e3. doi: 10.1016/j.cels.2016.08.001. Epub 2016 Sep 15.

41.

A proposal for validation of antibodies.

Uhlen M, Bandrowski A, Carr S, Edwards A, Ellenberg J, Lundberg E, Rimm DL, Rodriguez H, Hiltke T, Snyder M, Yamamoto T.

Nat Methods. 2016 Oct;13(10):823-7. doi: 10.1038/nmeth.3995. Epub 2016 Sep 5. No abstract available.

PMID:
27595404
42.

Affibody Scaffolds Improve Sesquiterpene Production in Saccharomyces cerevisiae.

Tippmann S, Anfelt J, David F, Rand JM, Siewers V, Uhlén M, Nielsen J, Hudson EP.

ACS Synth Biol. 2017 Jan 20;6(1):19-28. doi: 10.1021/acssynbio.6b00109. Epub 2016 Aug 30.

PMID:
27560952
43.

Stratification of responders towards eculizumab using a structural epitope mapping strategy.

Volk AL, Hu FJ, Berglund MM, Nordling E, Strömberg P, Uhlen M, Rockberg J.

Sci Rep. 2016 Aug 11;6:31365. doi: 10.1038/srep31365.

44.

Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.

Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie MJ, Boren J, Mardinoglu A.

Cell Metab. 2016 Jul 12;24(1):172-84. doi: 10.1016/j.cmet.2016.05.026. Epub 2016 Jun 23.

45.

Liver: Phenotypic and genetic variance: a systems approach to the liver.

Mardinoglu A, Uhlén M.

Nat Rev Gastroenterol Hepatol. 2016 Aug;13(8):439-40. doi: 10.1038/nrgastro.2016.93. Epub 2016 Jun 22. No abstract available.

PMID:
27329803
46.

Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients.

Hamsten C, Wiklundh E, Grönlund H, Schwenk JM, Uhlén M, Eklund A, Nilsson P, Grunewald J, Häggmark-Månberg A.

Respir Res. 2016 Jun 4;17(1):69. doi: 10.1186/s12931-016-0381-0.

47.

Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.

Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, Göpfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, Uhlén M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I.

Liver Int. 2017 Jan;37(1):132-140. doi: 10.1111/liv.13174. Epub 2016 Jun 22.

48.

Autoantibody targets in vaccine-associated narcolepsy.

Häggmark-Månberg A, Zandian A, Forsström B, Khademi M, Lima Bomfim I, Hellström C, Arnheim-Dahlström L, Hallböök T, Darin N, Lundberg IE, Uhlén M, Partinen M, Schwenk JM, Olsson T, Nilsson P.

Autoimmunity. 2016 Sep;49(6):421-433. Epub 2016 May 20.

PMID:
27206786
49.

Erratum to: Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord.

Zhang MD, Barde S, Szodorai E, Josephson A, Mitsios N, Watanabe M, Attems J, Lubec G, Kovács GG, Uhlén M, Mulder J, Harkany T, Hökfelt T.

Brain Struct Funct. 2016 Sep;221(7):3843. No abstract available.

PMID:
27206425
50.

Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.

Larsson AH, Lehn S, Wangefjord S, Karnevi E, Kuteeva E, Sundström M, Nodin B, Uhlén M, Eberhard J, Birgisson H, Jirström K.

J Transl Med. 2016 May 10;14(1):128. doi: 10.1186/s12967-016-0882-0.

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