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Items: 44

1.

Coblation® intracapsular tonsillectomy (tonsillotomy) in children: A prospective study of 500 consecutive cases with long-term follow-up.

Hoey AW, Foden NM, Hadjisymeou Andreou S, Noonan F, Chowdhury AK, Greig SR, Sproson EL, Allin D, Amin N, Wouters KM, Jonas NE, Tweedie DJ.

Clin Otolaryngol. 2017 Dec;42(6):1211-1217. doi: 10.1111/coa.12849. Epub 2017 Mar 19.

PMID:
28198598
2.

Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes.

Sane RS, Ramsden D, Sabo JP, Cooper C, Rowland L, Ting N, Whitcher-Johnstone A, Tweedie DJ.

Drug Metab Dispos. 2016 Mar;44(3):466-75. doi: 10.1124/dmd.115.066985. Epub 2015 Dec 18.

3.

Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac.

Ramsden D, Zhou J, Tweedie DJ.

Drug Metab Dispos. 2015 Sep;43(9):1307-15. doi: 10.1124/dmd.115.065326. Epub 2015 Jun 15.

4.

Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir: In Vitro and In Vivo Studies.

McCabe M, Sane RS, Keith-Luzzi M, Xu J, King I, Whitcher-Johnstone A, Johnstone N, Tweedie DJ, Li Y.

Drug Metab Dispos. 2015 Oct;43(10):1612-8. doi: 10.1124/dmd.115.064477. Epub 2015 Jun 11.

5.

Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.

Ramsden D, Tweedie DJ, Chan TS, Tracy TS.

Drug Metab Dispos. 2014 Nov;42(11):1940-6. doi: 10.1124/dmd.114.057901. Epub 2014 Aug 25.

6.

Our experience. Coblation® intracapsular tonsillectomy (tonsillotomy) in children: a prospective study of 100 consecutive cases.

Hadjisymeou S, Modayil PC, Dean H, Jonas NE, Tweedie DJ.

Clin Otolaryngol. 2014 Oct;39(5):301-7. doi: 10.1111/coa.12278. No abstract available.

PMID:
24962435
7.

The role of transporters in toxicity and disease.

Schuetz JD, Swaan PW, Tweedie DJ.

Drug Metab Dispos. 2014 Apr;42(4):541-5. doi: 10.1124/dmd.114.057539. Review.

8.

Case study 7. Compiled aha moments in enzyme kinetics: authors' experiences.

Tweedie DJ.

Methods Mol Biol. 2014;1113:513-9. doi: 10.1007/978-1-62703-758-7_24.

PMID:
24523128
9.

Case study 3. Application of basic enzyme kinetics to metabolism studies: real-life examples.

Li Y, McCabe M, Podila L, Tracy TS, Tweedie DJ.

Methods Mol Biol. 2014;1113:441-60. doi: 10.1007/978-1-62703-758-7_20.

PMID:
24523124
10.

Enzyme kinetics in drug metabolism: fundamentals and applications.

Nagar S, Argikar UA, Tweedie DJ.

Methods Mol Biol. 2014;1113:1-6. doi: 10.1007/978-1-62703-758-7_1.

PMID:
24523105
11.

Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).

Ramsden D, Tweedie DJ, St George R, Chen LZ, Li Y.

Drug Metab Dispos. 2014 Mar;42(3):407-14. doi: 10.1124/dmd.113.055947. Epub 2013 Dec 23.

12.

Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.

Ramsden D, Tweedie DJ, Chan TS, Taub ME, Li Y.

Drug Metab Dispos. 2014 Mar;42(3):394-406. doi: 10.1124/dmd.113.055897. Epub 2013 Dec 23.

13.

Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.

Li Y, Zhou J, Ramsden D, Taub ME, O'Brien D, Xu J, Busacca CA, Gonnella N, Tweedie DJ.

Drug Metab Dispos. 2014 Mar;42(3):384-93. doi: 10.1124/dmd.113.055863. Epub 2013 Dec 17.

14.

Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?

Mathur A, Tweedie DJ, Maw HH, Li Y.

Drug Metabol Drug Interact. 2013;28(4):239-46. doi: 10.1515/dmdi-2013-0044.

PMID:
24166670
15.

Highlights from the International Transporter Consortium second workshop.

Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM.

Clin Pharmacol Ther. 2012 Nov;92(5):553-6. doi: 10.1038/clpt.2012.126.

PMID:
23085880
16.

Peri-operative complications after adenotonsillectomy in a UK pediatric tertiary referral centre.

Tweedie DJ, Bajaj Y, Ifeacho SN, Jonas NE, Jephson CG, Cochrane LA, Hartley BE, Albert DM, Wyatt ME.

Int J Pediatr Otorhinolaryngol. 2012 Jun;76(6):809-15. doi: 10.1016/j.ijporl.2012.02.048. Epub 2012 Apr 1.

PMID:
22469495
17.

Metabolic switching of BILR 355 in the presence of ritonavir. II. Uncovering novel contributions by gut bacteria and aldehyde oxidase.

Li Y, Xu J, Lai WG, Whitcher-Johnstone A, Tweedie DJ.

Drug Metab Dispos. 2012 Jun;40(6):1130-7. doi: 10.1124/dmd.111.044362. Epub 2012 Mar 5.

18.

Metabolic switching of BILR 355 in the presence of ritonavir. I. Identifying an unexpected disproportionate human metabolite.

Li Y, Lai WG, Whitcher-Johnstone A, Busacca CA, Eriksson MC, Lorenz JC, Tweedie DJ.

Drug Metab Dispos. 2012 Jun;40(6):1122-9. doi: 10.1124/dmd.111.044354. Epub 2012 Mar 5.

19.

Use of a post-operative nasopharyngeal prong airway after adenotonsillectomy in children with obstructive sleep apnoea: how we do it.

Tweedie DJ, Bajaj Y, Ifeacho SN, Lloyd-Thomas AR, Albert DM.

Clin Otolaryngol. 2011 Dec;36(6):578-83. doi: 10.1111/j.1749-4486.2011.02392.x. No abstract available.

PMID:
22212544
20.

Assessment of adenoid size using an anaesthetic laryngoscope.

Tweedie DJ, Babar-Craig H.

Clin Otolaryngol. 2011 Aug;36(4):401-2. doi: 10.1111/j.1749-4486.2011.02348.x. No abstract available.

PMID:
21848564
21.

Managing the challenge of chemically reactive metabolites in drug development.

Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA.

Nat Rev Drug Discov. 2011 Apr;10(4):292-306. doi: 10.1038/nrd3408. Review.

PMID:
21455238
22.

Reconstruction of the nasal septum using perforated and unperforated polydioxanone foil.

Tweedie DJ, Lo S, Rowe-Jones JM.

Arch Facial Plast Surg. 2010 Mar-Apr;12(2):106-13. doi: 10.1001/archfacial.2010.1.

PMID:
20231591
23.

Membrane transporters in drug development.

International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L.

Nat Rev Drug Discov. 2010 Mar;9(3):215-36. doi: 10.1038/nrd3028. Review.

24.

A tumour map for parotid surgery.

Tweedie DJ, Modayil PC, Jacob A.

Clin Otolaryngol. 2009 Oct;34(5):502-4. doi: 10.1111/j.1749-4486.2009.02003.x. No abstract available.

PMID:
19793298
25.

Partial adenoidectomy by suction diathermy in children with cleft palate, to avoid velopharyngeal insufficiency.

Tweedie DJ, Skilbeck CJ, Wyatt ME, Cochrane LA.

Int J Pediatr Otorhinolaryngol. 2009 Nov;73(11):1594-7. doi: 10.1016/j.ijporl.2009.08.014. Epub 2009 Sep 8.

PMID:
19740554
26.

Surgery of the parotid gland: evolution of techniques, nomenclature and a revised classification system.

Tweedie DJ, Jacob A.

Clin Otolaryngol. 2009 Aug;34(4):303-8. doi: 10.1111/j.1749-4486.2009.01953.x. No abstract available.

PMID:
19673976
27.

Choosing a paediatric tracheostomy tube: an update on current practice.

Tweedie DJ, Skilbeck CJ, Cochrane LA, Cooke J, Wyatt ME.

J Laryngol Otol. 2008 Feb;122(2):161-9. Epub 2007 Apr 10.

PMID:
17419893
28.

Suction diathermy for adenoidectomy: complications and risk of recurrence.

Skilbeck CJ, Tweedie DJ, Lloyd-Thomas AR, Albert DM.

Int J Pediatr Otorhinolaryngol. 2007 Jun;71(6):917-20. Epub 2007 Mar 30.

PMID:
17399802
29.

The nasopharyngeal prong airway: an effective post-operative adjunct after adenotonsillectomy for obstructive sleep apnoea in children.

Tweedie DJ, Skilbeck CJ, Lloyd-Thomas AR, Albert DM.

Int J Pediatr Otorhinolaryngol. 2007 Apr;71(4):563-9. Epub 2007 Jan 22.

PMID:
17241674
31.

Long-term outcome of laparoscopic mesh rectopexy for solitary rectal ulcer syndrome.

Tweedie DJ, Varma JS.

Colorectal Dis. 2005 Mar;7(2):151-5.

PMID:
15720353
32.

Molecular cloning, expression, and characterization of CYP2D17 from cynomolgus monkey liver.

Mankowski DC, Laddison KJ, Christopherson PA, Ekins S, Tweedie DJ, Lawton MP.

Arch Biochem Biophys. 1999 Dec 1;372(1):189-96.

PMID:
10562433
33.

Expression and characterization of canine cytochrome P450 2D15.

Roussel F, Duignan DB, Lawton MP, Obach RS, Strick CA, Tweedie DJ.

Arch Biochem Biophys. 1998 Sep 1;357(1):27-36.

PMID:
9721180
34.

Metabolism of azoxy derivatives of procarbazine by aldehyde dehydrogenase and xanthine oxidase.

Tweedie DJ, Fernandez D, Spearman ME, Feldhoff RC, Prough RA.

Drug Metab Dispos. 1991 Jul-Aug;19(4):793-803.

PMID:
1680657
35.

Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LA omega) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator.

Wu HQ, Masset-Brown J, Tweedie DJ, Milewich L, Frenkel RA, Martin-Wixtrom C, Estabrook RW, Prough RA.

Cancer Res. 1989 May 1;49(9):2337-43.

36.

Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells.

Erikson JM, Tweedie DJ, Ducore JM, Prough RA.

Cancer Res. 1989 Jan 1;49(1):127-33.

37.

Effects of induction on the metabolism and cytochrome P-450 binding of harman and other beta-carbolines.

Tweedie DJ, Prough RA, Burke MD.

Xenobiotica. 1988 Jul;18(7):785-96.

PMID:
3176517
38.

Metabolism of hydrazine anti-cancer agents.

Tweedie DJ, Erikson JM, Prough RA.

Pharmacol Ther. 1987;34(1):111-27. Review. No abstract available.

PMID:
3310042
40.
41.
42.

Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.

Thomson AW, Tweedie DJ, Pugh-Humphreys RG, Arthur M.

Br J Cancer. 1978 Jul;38(1):106-13.

43.

Effects of the antiprotease Trasylol on peripheral blood leucocytes.

Thomson AW, Pugh-Humphreys RG, Tweedie DJ, Horne CH.

Experientia. 1978 Apr 15;34(4):528-30.

PMID:
305854
44.

Trasylol (aprotinin) as an anti-tumour agent.

Tweedie DJ, Thomson AW, Horne CH.

Biomedicine. 1978 Feb;29(1):1-3.

PMID:
307409

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