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PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton.

Britton GJ, Ambler R, Clark DJ, Hill EV, Tunbridge HM, McNally KE, Burton BR, Butterweck P, Sabatos-Peyton C, Hampton-O'Neil LA, Verkade P, Wülfing ChC, Wraith DC.

Elife. 2017 Jan 31;6. pii: e20003. doi: 10.7554/eLife.20003.


Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics.

Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF.

Sci Signal. 2016 Apr 19;9(424):rs3. doi: 10.1126/scisignal.aad4149.


New inhibitory signaling by CTLA-4.

Wülfing C, Tunbridge HM, Wraith DC.

Nat Immunol. 2014 May;15(5):408-9. doi: 10.1038/ni.2870. No abstract available.


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