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Items: 1 to 50 of 712

1.

Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions.

Haga N, Saito S, Tsukumo Y, Sakurai J, Furuno A, Tsuruo T, Tomida A.

Cancer Sci. 2010 May;101(5):1125-32. doi: 10.1111/j.1349-7006.2010.01525.x. Epub 2010 Feb 5.

2.

TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.

Ohishi T, Hirota T, Tsuruo T, Seimiya H.

Cancer Res. 2010 Mar 1;70(5):2041-52. doi: 10.1158/0008-5472.CAN-09-2008. Epub 2010 Feb 16.

3.

Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment.

Takeuchi M, Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T, Yokota A, Tanaka R, Nagao R, Nakahata T, Fujiyama Y, Maekawa T.

Cell Death Differ. 2010 Jul;17(7):1211-20. doi: 10.1038/cdd.2010.6. Epub 2010 Feb 5.

4.

Glucose-regulated protein 78: a new partner of p53 in trophoblast.

Arnaudeau S, Arboit P, Bischof P, Shin-ya K, Tomida A, Tsuruo T, Irion O, Cohen M.

Proteomics. 2009 Dec;9(23):5316-27. doi: 10.1002/pmic.200800865.

PMID:
20017148
5.

Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L.

Katayama R, Ishioka T, Takada S, Takada R, Fujita N, Tsuruo T, Naito M.

J Cell Sci. 2010 Jan 1;123(Pt 1):23-8. doi: 10.1242/jcs.058602.

6.

Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.

Togano T, Sasaki M, Watanabe M, Nakashima M, Tsuruo T, Umezawa K, Higashihara M, Watanabe T, Horie R.

Biochem Biophys Res Commun. 2009 Dec 4;390(1):60-4. doi: 10.1016/j.bbrc.2009.09.066. Epub 2009 Sep 22.

PMID:
19778522
7.

Prevention of carbon nanohorn agglomeration using a conjugate composed of comb-shaped polyethylene glycol and a peptide aptamer.

Matsumura S, Sato S, Yudasaka M, Tomida A, Tsuruo T, Iijima S, Shiba K.

Mol Pharm. 2009 Mar-Apr;6(2):441-7. doi: 10.1021/mp800141v.

PMID:
19718797
8.

Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain.

Kim MH, Maeng HJ, Yu KH, Lee KR, Tsuruo T, Kim DD, Shim CK, Chung SJ.

J Pharm Sci. 2010 Mar;99(3):1548-66. doi: 10.1002/jps.21895.

PMID:
19691109
9.

Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export.

Katayama R, Koike S, Sato S, Sugimoto Y, Tsuruo T, Fujita N.

Cancer Sci. 2009 Nov;100(11):2060-8. doi: 10.1111/j.1349-7006.2009.01288.x. Epub 2009 Jul 17.

10.

A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site.

Tsukumo Y, Tsukahara S, Saito S, Tsuruo T, Tomida A.

J Biol Chem. 2009 Oct 2;284(40):27500-10. doi: 10.1074/jbc.M109.021592. Epub 2009 Aug 5.

11.

Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels.

Miyawaki J, Matsumura S, Yuge R, Murakami T, Sato S, Tomida A, Tsuruo T, Ichihashi T, Fujinami T, Irie H, Tsuchida K, Iijima S, Shiba K, Yudasaka M.

ACS Nano. 2009 Jun 23;3(6):1399-406. doi: 10.1021/nn9004846.

PMID:
19480401
12.

Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.

Demers MJ, Thibodeau S, Noël D, Fujita N, Tsuruo T, Gauthier R, Arguin M, Vachon PH.

J Cell Biochem. 2009 Jul 1;107(4):639-54. doi: 10.1002/jcb.22131.

PMID:
19479902
13.

Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.

Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, Tsuruo T, Seimiya H.

Cancer Sci. 2009 Aug;100(8):1556-62. doi: 10.1111/j.1349-7006.2009.01203.x. Epub 2009 May 13.

14.

Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.

Saito S, Furuno A, Sakurai J, Sakamoto A, Park HR, Shin-Ya K, Tsuruo T, Tomida A.

Cancer Res. 2009 May 15;69(10):4225-34. doi: 10.1158/0008-5472.CAN-08-2689. Epub 2009 May 12.

15.

PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via nuclear factor-kappaB activation.

Tanaka H, Hoshikawa Y, Oh-hara T, Koike S, Naito M, Noda T, Arai H, Tsuruo T, Fujita N.

Mol Cancer Res. 2009 Apr;7(4):557-69. doi: 10.1158/1541-7786.MCR-08-0197.

16.

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.

Mashima T, Seimiya H, Tsuruo T.

Br J Cancer. 2009 May 5;100(9):1369-72. doi: 10.1038/sj.bjc.6605007. Epub 2009 Apr 7. Review.

17.

Involvement of Fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells.

Schulz R, Vogel T, Mashima T, Tsuruo T, Krieglstein K.

Glia. 2009 Nov 15;57(15):1619-29. doi: 10.1002/glia.20875.

PMID:
19330858
18.

Retraction. Epigenetic regulator polycomb group protein complexes control cell fate and cancer, Cancer Science 2008; 99: 1077-84.

Tsuruo T.

Cancer Sci. 2008 Dec;99(12):2547. doi: 10.1111/j.1349-7006.2008.01039.x. No abstract available.

19.

Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.

Matsuo J, Tsukumo Y, Sakurai J, Tsukahara S, Park HR, Shin-ya K, Watanabe T, Tsuruo T, Tomida A.

Cancer Sci. 2009 Feb;100(2):327-33. doi: 10.1111/j.1349-7006.2008.01036.x.

20.

Apoptosis resistance in tumor cells.

Mashima T, Seimiya H, Chen Z, Kataoka S, Tsuruo T.

Cytotechnology. 1998 Sep;27(1-3):293-308. doi: 10.1023/A:1008058031511.

21.

[Introduction to the symposium "Bio-informatics for Pharmaceutical Sciences and Pharmacy Education". Foreword].

Tsuruo T, Tsujimoto G, Yamamoto H.

Yakugaku Zasshi. 2008 Nov;128(11):1517. Japanese. No abstract available.

22.

Platelet aggregation in the formation of tumor metastasis.

Tsuruo T, Fujita N.

Proc Jpn Acad Ser B Phys Biol Sci. 2008;84(6):189-98. Review.

23.

IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.

Isomura M, Oya N, Tachiiri S, Kaneyasu Y, Nishimura Y, Akimoto T, Hareyama M, Sugita T, Mitsuhashi N, Yamashita T, Aoki M, Sai H, Hirokawa Y, Sakata K, Karasawa K, Tomida A, Tsuruo T, Miki Y, Noda T, Hiraoka M.

Clin Cancer Res. 2008 Oct 15;14(20):6683-9. doi: 10.1158/1078-0432.CCR-07-4389.

24.

Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.

Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin S, Bai Z, Hayasaka H, Fukui Y, Aozasa K, Fujita N, Tsuruo T, Ozono K, Aoki J, Miyasaka M.

Am J Pathol. 2008 Nov;173(5):1566-76. doi: 10.2353/ajpath.2008.071153. Epub 2008 Sep 25.

25.

Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.

Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H.

Oncogene. 2009 Jan 8;28(1):9-19. doi: 10.1038/onc.2008.355. Epub 2008 Sep 22.

PMID:
18806831
26.

Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling.

Nakamura A, Naito M, Tsuruo T, Fujita N.

Mol Cell Biol. 2008 Oct;28(19):5996-6009. doi: 10.1128/MCB.00114-08. Epub 2008 Jul 28.

27.

[Pharmacogenomics: challenges in promoting its clinical usage].

Tsuruo T.

Nihon Yakurigaku Zasshi. 2008 Jul;132(1):31-8. Review. Japanese. No abstract available.

PMID:
18622101
28.

TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.

Kurata A, Katayama R, Watanabe T, Tsuruo T, Fujita N.

Cancer Sci. 2008 Sep;99(9):1827-34. doi: 10.1111/j.1349-7006.2008.00874.x. Epub 2008 Jul 4.

29.

Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2.

Yeung BH, Wong KY, Lin MC, Wong CK, Mashima T, Tsuruo T, Wong AS.

Br J Cancer. 2008 Jul 22;99(2):283-93. doi: 10.1038/sj.bjc.6604477. Epub 2008 Jul 1.

30.

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.

Morishita D, Katayama R, Sekimizu K, Tsuruo T, Fujita N.

Cancer Res. 2008 Jul 1;68(13):5076-85. doi: 10.1158/0008-5472.CAN-08-0634.

31.

Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.

Nakazawa Y, Sato S, Naito M, Kato Y, Mishima K, Arai H, Tsuruo T, Fujita N.

Blood. 2008 Sep 1;112(5):1730-9. doi: 10.1182/blood-2007-11-124693. Epub 2008 Jun 9.

32.

Evaluation of tankyrase inhibition in whole cells.

Ohishi T, Tsuruo T, Seimiya H.

Methods Mol Biol. 2007;405:133-46. doi: 10.1007/978-1-60327-070-0_11.

PMID:
18369822
33.

B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms.

Bouchard V, Harnois C, Demers MJ, Thibodeau S, Laquerre V, Gauthier R, Vézina A, Noël D, Fujita N, Tsuruo T, Arguin M, Vachon PH.

Apoptosis. 2008 Apr;13(4):531-42. doi: 10.1007/s10495-008-0192-y.

PMID:
18322799
34.

[Future directions of anticancer drug development in Japan].

Akaza H, Kawai K, Tsuruo T, Tsukagoshi S, Aiba K, Shimada Y, Kakeji Y, Ishikawa H, Ikeda T, Nakamura S, Tamura T, Yamamoto N, Isonishi S, Hinotsu S, Hirose M, Katsura J.

Gan To Kagaku Ryoho. 2008 Feb;35(2):351-60. Japanese.

PMID:
18281781
35.

Small molecules destabilize cIAP1 by activating auto-ubiquitylation.

Sekine K, Takubo K, Kikuchi R, Nishimoto M, Kitagawa M, Abe F, Nishikawa K, Tsuruo T, Naito M.

J Biol Chem. 2008 Apr 4;283(14):8961-8. doi: 10.1074/jbc.M709525200. Epub 2008 Jan 29.

36.

Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.

Muramatsu Y, Tahara H, Ono T, Tsuruo T, Seimiya H.

Exp Cell Res. 2008 Mar 10;314(5):1115-24. doi: 10.1016/j.yexcr.2007.12.005. Epub 2007 Dec 14.

PMID:
18221737
37.

Bioactive triterpene saponins from the roots of Phytolacca americana.

Wang L, Bai L, Nagasawa T, Hasegawa T, Yang X, Sakai J, Bai Y, Kataoka T, Oka S, Hirose K, Tomida A, Tsuruo T, Ando M.

J Nat Prod. 2008 Jan;71(1):35-40. doi: 10.1021/np078012m. Epub 2008 Jan 5.

PMID:
18177012
38.

Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.

Huang L, Shitashige M, Satow R, Honda K, Ono M, Yun J, Tomida A, Tsuruo T, Hirohashi S, Yamada T.

Gastroenterology. 2007 Nov;133(5):1569-78. Epub 2007 Aug 6.

PMID:
17983804
39.

Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.

Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T.

Cancer Res. 2007 Oct 15;67(20):9666-76.

40.

Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro.

Dohgu S, Nishioku T, Sumi N, Takata F, Nakagawa S, Naito M, Tsuruo T, Yamauchi A, Shuto H, Kataoka Y.

Cell Mol Neurobiol. 2007 Nov;27(7):889-99. Epub 2007 Oct 13.

PMID:
17934807
41.

FOXO transcription factor-dependent p15(INK4b) and p19(INK4d) expression.

Katayama K, Nakamura A, Sugimoto Y, Tsuruo T, Fujita N.

Oncogene. 2008 Mar 13;27(12):1677-86. Epub 2007 Sep 17.

PMID:
17873901
42.

Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.

Ishizu K, Sunose N, Yamazaki K, Tsuruo T, Sadahiro S, Makuuchi H, Yamori T.

Biol Pharm Bull. 2007 Sep;30(9):1779-83.

43.

Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation.

Tsukumo Y, Tomida A, Kitahara O, Nakamura Y, Asada S, Mori K, Tsuruo T.

J Biol Chem. 2007 Oct 5;282(40):29264-72. Epub 2007 Aug 8.

44.

Pilot study of MDR1 gene transfer into hematopoietic stem cells and chemoprotection in metastatic breast cancer patients.

Takahashi S, Aiba K, Ito Y, Hatake K, Nakane M, Kobayashi T, Minowa S, Shibata H, Mitsuhashi J, Tsukahara S, Ishikawa E, Suzuki R, Tsuruo T, Sugimoto Y.

Cancer Sci. 2007 Oct;98(10):1609-16. Epub 2007 Aug 7.

45.

Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad.

Ichikawa K, Sakabe E, Kuninobu K, Yamori T, Tsuruo T, Yao T, Tsuneyoshi M, Utsumi H.

Antioxid Redox Signal. 2007 Oct;9(10):1699-707.

PMID:
17665970
46.
47.

Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy.

Zembutsu H, Yanada M, Hishida A, Katagiri T, Tsuruo T, Sugiura I, Takeuchi J, Usui N, Naoe T, Nakamura Y, Ohno R.

Int J Oncol. 2007 Aug;31(2):313-22.

PMID:
17611687
48.

Bioactive cardenolides from the stems and twigs of Nerium oleander.

Zhao M, Bai L, Wang L, Toki A, Hasegawa T, Kikuchi M, Abe M, Sakai J, Hasegawa R, Bai Y, Mitsui T, Ogura H, Kataoka T, Oka S, Tsushima H, Kiuchi M, Hirose K, Tomida A, Tsuruo T, Ando M.

J Nat Prod. 2007 Jul;70(7):1098-103. Epub 2007 Jun 27.

PMID:
17595134
49.

Impairment of the ubiquitin-proteasome system by cellular FLIP.

Ishioka T, Katayama R, Kikuchi R, Nishimoto M, Takada S, Takada R, Matsuzawa S, Reed JC, Tsuruo T, Naito M.

Genes Cells. 2007 Jun;12(6):735-44.

50.

Bioactive polyketides from Peperomia duclouxii.

Li N, Wu JL, Hasegawa T, Sakai J, Bai LM, Wang LY, Kakuta S, Furuya Y, Ogura H, Kataoka T, Tomida A, Tsuruo T, Ando M.

J Nat Prod. 2007 Jun;70(6):998-1001. Epub 2007 Jun 5.

PMID:
17547458

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