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Items: 25

1.

Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma.

Gutova M, Goldstein L, Metz M, Hovsepyan A, Tsurkan LG, Tirughana R, Tsaturyan L, Annala AJ, Synold TW, Wan Z, Seeger R, Anderson C, Moats RA, Potter PM, Aboody KS.

Mol Ther Oncolytics. 2016 Dec 14;4:67-76. doi: 10.1016/j.omto.2016.11.004. eCollection 2017 Mar 17.

2.

Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer.

Wierdl M, Tsurkan L, Hatfield MJ, Potter PM.

Br J Pharmacol. 2016 Oct;173(19):2811-8. doi: 10.1111/bph.13553. Epub 2016 Aug 22. Review.

3.

Carboxylesterases: General detoxifying enzymes.

Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM.

Chem Biol Interact. 2016 Nov 25;259(Pt B):327-331. doi: 10.1016/j.cbi.2016.02.011. Epub 2016 Feb 15. Review.

4.

Targeting the DNA repair pathway in Ewing sarcoma.

Stewart E, Goshorn R, Bradley C, Griffiths LM, Benavente C, Twarog NR, Miller GM, Caufield W, Freeman BB 3rd, Bahrami A, Pappo A, Wu J, Loh A, Karlström Å, Calabrese C, Gordon B, Tsurkan L, Hatfield MJ, Potter PM, Snyder SE, Thiagarajan S, Shirinifard A, Sablauer A, Shelat AA, Dyer MA.

Cell Rep. 2014 Nov 6;9(3):829-41. doi: 10.1016/j.celrep.2014.09.028. Epub 2014 Oct 23.

5.

Targeting oxidative stress in embryonal rhabdomyosarcoma.

Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine MB, Valentine V, Krafcik F, Lang WH, Wierdl M, Tsurkan L, Tolleman V, Federico SM, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins DS, Ramirez N, Potter PM, Sandoval JA, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA; St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project.

Cancer Cell. 2013 Dec 9;24(6):710-24. doi: 10.1016/j.ccr.2013.11.002.

6.

Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").

Hatfield MJ, Tsurkan LG, Hyatt JL, Edwards CC, Lemoff A, Jeffries C, Yan B, Potter PM.

J Nat Prod. 2013 Jan 25;76(1):36-44. doi: 10.1021/np300628a. Epub 2013 Jan 3.

7.

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors.

Tsurkan LG, Hatfield MJ, Edwards CC, Hyatt JL, Potter PM.

Chem Biol Interact. 2013 Mar 25;203(1):226-30. doi: 10.1016/j.cbi.2012.10.018. Epub 2012 Nov 2.

8.

ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz JD.

J Biol Chem. 2012 Apr 13;287(16):12679-90. doi: 10.1074/jbc.M111.336180. Epub 2012 Jan 31.

9.

Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.

Parkinson EI, Jason Hatfield M, Tsurkan L, Hyatt JL, Edwards CC, Hicks LD, Yan B, Potter PM.

Bioorg Med Chem. 2011 Aug 1;19(15):4635-43. doi: 10.1016/j.bmc.2011.06.012. Epub 2011 Jul 4.

10.

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR.

PLoS One. 2011 Mar 18;6(3):e17441. doi: 10.1371/journal.pone.0017441. Erratum in: PLoS One. 2012;7(1). doi:10.1371/annotation/c5953f27-95f8-4a1b-a46c-639d90e182ac. Lewis, Steven L [corrected to Lewis, Steven M].

11.

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11.

Hatfield MJ, Tsurkan L, Garrett M, Shaver TM, Hyatt JL, Edwards CC, Hicks LD, Potter PM.

Biochem Pharmacol. 2011 Jan 1;81(1):24-31. doi: 10.1016/j.bcp.2010.09.001. Epub 2010 Sep 15.

12.

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.

Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM.

Br J Pharmacol. 2010 Aug;160(8):1916-28. doi: 10.1111/j.1476-5381.2010.00700.x.

13.

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.

Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM.

J Med Chem. 2009 Jun 25;52(12):3742-52. doi: 10.1021/jm9001296.

14.

Directed assembly of sub-nanometer thin organic materials with programmed-size nanopores.

Danila DC, Banner LT, Karimova EJ, Tsurkan L, Wang X, Pinkhassik E.

Angew Chem Int Ed Engl. 2008;47(37):7036-9. doi: 10.1002/anie.200801814. No abstract available.

PMID:
18677728
15.

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM.

Cancer Gene Ther. 2008 Mar;15(3):183-92. doi: 10.1038/sj.cgt.7701112. Epub 2008 Jan 11.

PMID:
18188187
16.

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM.

J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.

PMID:
17941623
17.

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM.

Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.

18.

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM.

J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.

PMID:
17378546
19.

Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.

Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS.

Cancer Res. 2007 Jan 1;67(1):22-5.

20.

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.

Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM.

Mol Pharmacol. 2007 Mar;71(3):713-23. Epub 2006 Dec 13.

21.

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM.

Mol Cancer Ther. 2006 Sep;5(9):2281-8.

22.

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM.

Chem Biol Interact. 2005 Dec 15;157-158:247-52. Epub 2005 Oct 28.

PMID:
16257398
23.

Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.

Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR.

J Mol Biol. 2005 Sep 9;352(1):165-77.

PMID:
16081098
24.

[Genetic activity of sim-triazine herbicides on Saccharomyces cerevisiae yeast strains].

Emnova EE, Mereniuk GV, Tsurkan LG.

Tsitol Genet. 1987 Mar-Apr;21(2):127-31. Russian.

PMID:
3296366
25.

[Study of the effect of the fungicide zineb on microorganisms].

Emnova EE, Mereniuk GV, Biriuzova VI, Kodrian VA, Tsurkan LG.

Mikrobiologiia. 1986 Jul-Aug;55(4):612-7. Russian.

PMID:
3534526

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