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Distinct sites in tropomyosin specify shared and isoform-specific regulation of myosins II and V.

Barua B, Sckolnick M, White HD, Trybus KM, Hitchcock-DeGregori SE.

Cytoskeleton (Hoboken). 2018 Mar 3. doi: 10.1002/cm.21440. [Epub ahead of print]


Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W.

Biophys J. 2017 Dec 5;113(11):2444-2451. doi: 10.1016/j.bpj.2017.10.004.


The structure of the actin-smooth muscle myosin motor domain complex in the rigor state.

Banerjee C, Hu Z, Huang Z, Warrington JA, Taylor DW, Trybus KM, Lowey S, Taylor KA.

J Struct Biol. 2017 Dec;200(3):325-333. doi: 10.1016/j.jsb.2017.10.003. Epub 2017 Oct 14.


Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin.

Bookwalter CS, Tay CL, McCrorie R, Previs MJ, Lu H, Krementsova EB, Fagnant PM, Baum J, Trybus KM.

J Biol Chem. 2017 Nov 24;292(47):19290-19303. doi: 10.1074/jbc.M117.813972. Epub 2017 Oct 4.


Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.

Zimmermann D, Homa KE, Hocky GM, Pollard LW, De La Cruz EM, Voth GA, Trybus KM, Kovar DR.

Nat Commun. 2017 Sep 26;8(1):703. doi: 10.1038/s41467-017-00445-3.


Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation.

Pollard LW, Bookwalter CS, Tang Q, Krementsova EB, Trybus KM, Lowey S.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7236-E7244. doi: 10.1073/pnas.1703161114. Epub 2017 Aug 14.


Vascular disease-causing mutation, smooth muscle α-actin R258C, dominantly suppresses functions of α-actin in human patient fibroblasts.

Liu Z, Chang AN, Grinnell F, Trybus KM, Milewicz DM, Stull JT, Kamm KE.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5569-E5578. doi: 10.1073/pnas.1703506114. Epub 2017 Jun 26.


Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro.

Lombardo AT, Nelson SR, Ali MY, Kennedy GG, Trybus KM, Walcott S, Warshaw DM.

Nat Commun. 2017 Jun 1;8:15692. doi: 10.1038/ncomms15692.


Small teams of myosin Vc motors coordinate their stepping for efficient cargo transport on actin bundles.

Krementsova EB, Furuta K, Oiwa K, Trybus KM, Ali MY.

J Biol Chem. 2017 Jun 30;292(26):10998-11008. doi: 10.1074/jbc.M117.780791. Epub 2017 May 5.


Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.

Milewicz DM, Trybus KM, Guo DC, Sweeney HL, Regalado E, Kamm K, Stull JT.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):26-34. doi: 10.1161/ATVBAHA.116.303229. Epub 2016 Nov 22. Review. Erratum in: Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):e12.


Cargo Transport by Two Coupled Myosin Va Motors on Actin Filaments and Bundles.

Ali MY, Vilfan A, Trybus KM, Warshaw DM.

Biophys J. 2016 Nov 15;111(10):2228-2240. doi: 10.1016/j.bpj.2016.09.046.


Severe Molecular Defects Exhibited by the R179H Mutation in Human Vascular Smooth Muscle α-Actin.

Lu H, Fagnant PM, Krementsova EB, Trybus KM.

J Biol Chem. 2016 Oct 7;291(41):21729-21739. Epub 2016 Aug 22.


Tropomyosin isoforms bias actin track selection by vertebrate myosin Va.

Sckolnick M, Krementsova EB, Warshaw DM, Trybus KM.

Mol Biol Cell. 2016 Oct 1;27(19):2889-97. doi: 10.1091/mbc.E15-09-0641. Epub 2016 Aug 17.


Myosin Vc Is Specialized for Transport on a Secretory Superhighway.

Sladewski TE, Krementsova EB, Trybus KM.

Curr Biol. 2016 Aug 22;26(16):2202-7. doi: 10.1016/j.cub.2016.06.029. Epub 2016 Aug 4.


A single-headed fission yeast myosin V transports actin in a tropomyosin-dependent manner.

Tang Q, Billington N, Krementsova EB, Bookwalter CS, Lord M, Trybus KM.

J Cell Biol. 2016 Jul 18;214(2):167-79. doi: 10.1083/jcb.201511102. Epub 2016 Jul 11.


Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin.

Lu H, Fagnant PM, Bookwalter CS, Joel P, Trybus KM.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4168-77. doi: 10.1073/pnas.1507587112. Epub 2015 Jul 7.


A single molecule approach to mRNA transport by a class V myosin.

Sladewski TE, Trybus KM.

RNA Biol. 2014;11(8):986-91. doi: 10.4161/rna.29947. Epub 2014 Oct 31.


A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility.

Bookwalter CS, Kelsen A, Leung JM, Ward GE, Trybus KM.

J Biol Chem. 2014 Oct 31;289(44):30832-41. doi: 10.1074/jbc.M114.572453. Epub 2014 Sep 17.


Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va.

Nelson SR, Trybus KM, Warshaw DM.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3986-95. doi: 10.1073/pnas.1406535111. Epub 2014 Sep 8.


Delineating cooperative responses of processive motors in living cells.

Efremov AK, Radhakrishnan A, Tsao DS, Bookwalter CS, Trybus KM, Diehl MR.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E334-43. doi: 10.1073/pnas.1313569111. Epub 2014 Jan 8.


Role of the essential light chain in the activation of smooth muscle myosin by regulatory light chain phosphorylation.

Taylor KA, Feig M, Brooks CL 3rd, Fagnant PM, Lowey S, Trybus KM.

J Struct Biol. 2014 Mar;185(3):375-82. doi: 10.1016/j.jsb.2013.12.008. Epub 2013 Dec 19.


Fission yeast tropomyosin specifies directed transport of myosin-V along actin cables.

Clayton JE, Pollard LW, Sckolnick M, Bookwalter CS, Hodges AR, Trybus KM, Lord M.

Mol Biol Cell. 2014 Jan;25(1):66-75. doi: 10.1091/mbc.E13-04-0200. Epub 2013 Nov 6.


Motor domain phosphorylation modulates kinesin-1 transport.

DeBerg HA, Blehm BH, Sheung J, Thompson AR, Bookwalter CS, Torabi SF, Schroer TA, Berger CL, Lu Y, Trybus KM, Selvin PR.

J Biol Chem. 2013 Nov 8;288(45):32612-21. doi: 10.1074/jbc.M113.515510. Epub 2013 Sep 26.


More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.

Sckolnick M, Krementsova EB, Warshaw DM, Trybus KM.

J Biol Chem. 2013 Oct 11;288(41):29313-22. doi: 10.1074/jbc.M113.476929. Epub 2013 Aug 26.


Intracellular transport: the causes for pauses.

Trybus KM.

Curr Biol. 2013 Jul 22;23(14):R623-5. doi: 10.1016/j.cub.2013.06.005.


Single-molecule reconstitution of mRNA transport by a class V myosin.

Sladewski TE, Bookwalter CS, Hong MS, Trybus KM.

Nat Struct Mol Biol. 2013 Aug;20(8):952-7. doi: 10.1038/nsmb.2614. Epub 2013 Jun 30.


Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

Lowey S, Bretton V, Gulick J, Robbins J, Trybus KM.

J Biol Chem. 2013 May 24;288(21):14780-7. doi: 10.1074/jbc.M113.450668. Epub 2013 Apr 11.


Molecular motors.

Trybus KM, Gelfand VI.

Mol Biol Cell. 2013 Mar;24(6):672. doi: 10.1091/mbc.E12-12-0873. No abstract available.


A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin.

Barua B, Fagnant PM, Winkelmann DA, Trybus KM, Hitchcock-DeGregori SE.

J Biol Chem. 2013 Apr 5;288(14):9602-9. doi: 10.1074/jbc.M113.451161. Epub 2013 Feb 18.


In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.

Blehm BH, Schroer TA, Trybus KM, Chemla YR, Selvin PR.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3381-6. doi: 10.1073/pnas.1219961110. Epub 2013 Feb 12. Erratum in: Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9613.


Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection.

Ali MY, Previs SB, Trybus KM, Sweeney HL, Warshaw DM.

Traffic. 2013 Jan;14(1):70-81. doi: 10.1111/tra.12017. Epub 2012 Oct 30.


Collective dynamics of elastically coupled myosin V motors.

Lu H, Efremov AK, Bookwalter CS, Krementsova EB, Driver JW, Trybus KM, Diehl MR.

J Biol Chem. 2012 Aug 10;287(33):27753-61. doi: 10.1074/jbc.M112.371393. Epub 2012 Jun 20.


Tropomyosin is essential for processive movement of a class V myosin from budding yeast.

Hodges AR, Krementsova EB, Bookwalter CS, Fagnant PM, Sladewski TE, Trybus KM.

Curr Biol. 2012 Aug 7;22(15):1410-6. doi: 10.1016/j.cub.2012.05.035. Epub 2012 Jun 14.


Full-length myosin Va exhibits altered gating during processive movement on actin.

Armstrong JM, Krementsova E, Michalek AJ, Heaslip AT, Nelson SR, Trybus KM, Warshaw DM.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E218-24. doi: 10.1073/pnas.1109709109. Epub 2012 Jan 6.


Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly.

Sitar T, Gallinger J, Ducka AM, Ikonen TP, Wohlhoefler M, Schmoller KM, Bausch AR, Joel P, Trybus KM, Noegel AA, Schleicher M, Huber R, Holak TA.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19575-80. doi: 10.1073/pnas.1115465108. Epub 2011 Nov 21. Erratum in: Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6721.


Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complex.

Krementsova EB, Hodges AR, Bookwalter CS, Sladewski TE, Travaglia M, Sweeney HL, Trybus KM.

J Cell Biol. 2011 Nov 14;195(4):631-41. doi: 10.1083/jcb.201106146.


Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation.

Baumann BA, Taylor DW, Huang Z, Tama F, Fagnant PM, Trybus KM, Taylor KA.

J Mol Biol. 2012 Jan 13;415(2):274-87. doi: 10.1016/j.jmb.2011.10.047. Epub 2011 Nov 4.


Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport.

Ali MY, Kennedy GG, Safer D, Trybus KM, Sweeney HL, Warshaw DM.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E535-41. doi: 10.1073/pnas.1104298108. Epub 2011 Aug 1.


Simultaneous observation of tail and head movements of myosin V during processive motion.

Lu H, Kennedy GG, Warshaw DM, Trybus KM.

J Biol Chem. 2010 Dec 31;285(53):42068-74. doi: 10.1074/jbc.M110.180265. Epub 2010 Oct 25.


Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.

Ducka AM, Joel P, Popowicz GM, Trybus KM, Schleicher M, Noegel AA, Huber R, Holak TA, Sitar T.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11757-62. doi: 10.1073/pnas.1005347107. Epub 2010 Jun 10.


Common structural motifs for the regulation of divergent class II myosins.

Lowey S, Trybus KM.

J Biol Chem. 2010 May 28;285(22):16403-7. doi: 10.1074/jbc.R109.025551. Epub 2010 Mar 25. Review.


A nonprocessive class V myosin drives cargo processively when a kinesin- related protein is a passenger.

Hodges AR, Bookwalter CS, Krementsova EB, Trybus KM.

Curr Biol. 2009 Dec 29;19(24):2121-5. doi: 10.1016/j.cub.2009.10.069. Epub 2009 Dec 10.


Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro.

Debold EP, Saber W, Cheema Y, Bookwalter CS, Trybus KM, Warshaw DM, Vanburen P.

J Mol Cell Cardiol. 2010 Feb;48(2):286-92. doi: 10.1016/j.yjmcc.2009.09.014. Epub 2009 Sep 30.


Diffusive movement of processive kinesin-1 on microtubules.

Lu H, Ali MY, Bookwalter CS, Warshaw DM, Trybus KM.

Traffic. 2009 Oct;10(10):1429-38. doi: 10.1111/j.1600-0854.2009.00964.x. Epub 2009 Jun 21.


Random walk of processive, quantum dot-labeled myosin Va molecules within the actin cortex of COS-7 cells.

Nelson SR, Ali MY, Trybus KM, Warshaw DM.

Biophys J. 2009 Jul 22;97(2):509-18. doi: 10.1016/j.bpj.2009.04.052.


Essential features of the class V myosin from budding yeast for ASH1 mRNA transport.

Bookwalter CS, Lord M, Trybus KM.

Mol Biol Cell. 2009 Jul;20(14):3414-21. doi: 10.1091/mbc.E08-08-0801. Epub 2009 May 28.


Smooth muscle heavy meromyosin phosphorylated on one of its two heads supports force and motion.

Walcott S, Fagnant PM, Trybus KM, Warshaw DM.

J Biol Chem. 2009 Jul 3;284(27):18244-51. doi: 10.1074/jbc.M109.003293. Epub 2009 May 6.


Crystal structures of monomeric actin bound to cytochalasin D.

Nair UB, Joel PB, Wan Q, Lowey S, Rould MA, Trybus KM.

J Mol Biol. 2008 Dec 26;384(4):848-64. doi: 10.1016/j.jmb.2008.09.082. Epub 2008 Oct 10.


Functional effects of nemaline myopathy mutations on human skeletal alpha-actin.

Miller BM, Trybus KM.

J Biol Chem. 2008 Jul 11;283(28):19379-88. doi: 10.1074/jbc.M801963200. Epub 2008 May 12.


Load and Pi control flux through the branched kinetic cycle of myosin V.

Kad NM, Trybus KM, Warshaw DM.

J Biol Chem. 2008 Jun 20;283(25):17477-84. doi: 10.1074/jbc.M800539200. Epub 2008 Apr 27.

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