Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 34

1.

SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer's disease.

Brunner D, Flunkert S, Neddens J, Duller S, Scopes DIC, Treherne JM, Hutter-Paier B.

Neurosci Lett. 2017 Nov 1;660:96-102. doi: 10.1016/j.neulet.2017.09.028. Epub 2017 Sep 14.

PMID:
28917978
2.

Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease.

O'Hare E, Scopes DI, Kim EM, Palmer P, Spanswick D, McMahon B, Amijee H, Nerou E, Treherne JM, Jeggo R.

Int J Neuropsychopharmacol. 2014 Jan;17(1):117-26. doi: 10.1017/S1461145713000886. Epub 2013 Oct 8.

PMID:
24103729
3.

Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500.

Lo AC, Tesseur I, Scopes DI, Nerou E, Callaerts-Vegh Z, Vermaercke B, Treherne JM, De Strooper B, D'Hooge R.

Neuropharmacology. 2013 Dec;75:458-66. doi: 10.1016/j.neuropharm.2013.08.030. Epub 2013 Sep 10.

PMID:
24035915
4.

Orally bioavailable small molecule drug protects memory in Alzheimer's disease models.

O'Hare E, Scopes DI, Kim EM, Palmer P, Jones M, Whyment AD, Spanswick D, Amijee H, Nerou E, McMahon B, Treherne JM, Jeggo R.

Neurobiol Aging. 2013 Apr;34(4):1116-25. doi: 10.1016/j.neurobiolaging.2012.10.016. Epub 2012 Nov 17.

PMID:
23164690
5.

The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.

Amijee H, Bate C, Williams A, Virdee J, Jeggo R, Spanswick D, Scopes DI, Treherne JM, Mazzitelli S, Chawner R, Eyers CE, Doig AJ.

Biochemistry. 2012 Oct 23;51(42):8338-52. doi: 10.1021/bi300415v. Epub 2012 Oct 12.

PMID:
23025847
6.

Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity.

Scopes DI, O'Hare E, Jeggo R, Whyment AD, Spanswick D, Kim EM, Gannon J, Amijee H, Treherne JM.

Br J Pharmacol. 2012 Sep;167(2):383-92. doi: 10.1111/j.1476-5381.2012.01973.x.

7.

Novel anti-inflammatory compound SEN1176 alleviates behavioral deficits induced following bilateral intrahippocampal injection of aggregated amyloid-β₁₋₄₂.

O'Hare E, Scopes DI, Treherne JM, Monaghan J, Palmer PM, Amijee H, Kim EM.

J Alzheimers Dis. 2011;25(2):219-29. doi: 10.3233/JAD-2011-100044.

PMID:
21654060
8.

RS-0406 arrests amyloid-beta oligomer-induced behavioural deterioration in vivo.

O'Hare E, Scopes DI, Treherne JM, Norwood K, Spanswick D, Kim EM.

Behav Brain Res. 2010 Jun 26;210(1):32-7. doi: 10.1016/j.bbr.2010.01.044. Epub 2010 Feb 5.

PMID:
20138088
9.

Inhibitors of amyloid aggregation: technologies for the discovery of novel lead compounds.

Doig AJ, Stott K, Treherne JM.

Biotechnol Genet Eng Rev. 2004;21:197-212. Review. No abstract available.

PMID:
17017033
10.
11.

Potassium channels: gene family, therapeutic relevance, high-throughput screening technologies and drug discovery.

Ford JW, Stevens EB, Treherne JM, Packer J, Bushfield M.

Prog Drug Res. 2002;58:133-68. Review.

PMID:
12079199
12.

Neuropeptides in drug research.

Poyner D, Cox H, Bushfield M, Treherne JM, Demetrikopoulos MK.

Prog Drug Res. 2000;54:121-49. Review.

PMID:
10857387
13.

The pharmacology of apoptosis.

Kinloch RA, Treherne JM, Furness LM, Hajimohamadreza I.

Trends Pharmacol Sci. 1999 Jan;20(1):35-42. Review.

PMID:
10101960
14.

The application of high-throughput screening to novel lead discovery.

Kenny BA, Bushfield M, Parry-Smith DJ, Fogarty S, Treherne JM.

Prog Drug Res. 1998;51:245-69. Review.

PMID:
9949864
15.

The role of apoptosis in neurodegenerative diseases.

Hajimohamadreza I, Treherne JM.

Prog Drug Res. 1997;48:55-98. Review. No abstract available.

PMID:
9204683
16.

Activation by intracellular ATP of a potassium channel in neurones from rat basomedial hypothalamus.

Rowe IC, Treherne JM, Ashford ML.

J Physiol. 1996 Jan 1;490 ( Pt 1):97-113.

17.

Development of spinal cord in the isolated CNS of a neonatal mammal (the opossum Monodelphis domestica) maintained in longterm culture.

Møllgård K, Balslev Y, Janas MS, Treherne JM, Saunders NR, Nichols JG.

J Neurocytol. 1994 Mar;23(3):151-65.

PMID:
8006676
18.

Development of connections by axons growing through injured spinal cord of neonatal opossum in culture.

Woodward SK, Treherne JM, Knott GW, Fernandez J, Varga ZM, Nicholls JG.

J Exp Biol. 1993 Mar;176:77-88.

19.

Growth of axons through a lesion in the intact CNS of fetal rat maintained in long-term culture.

Saunders NR, Balkwill P, Knott G, Habgood MD, Møllgård K, Treherne JM, Nicholls JG.

Proc Biol Sci. 1992 Dec 22;250(1329):171-80.

PMID:
1362987
20.
21.

Restoration of conduction and growth of axons through injured spinal cord of neonatal opossum in culture.

Treherne JM, Woodward SK, Varga ZM, Ritchie JM, Nicholls JG.

Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):431-4.

22.

The intact central nervous system of the newborn opossum in long-term culture: fine structure and GABA-mediated inhibition of electrical activity.

Stewart RR, Zou DJ, Treherne JM, Møllgård K, Saunders NR, Nicholls JG.

J Exp Biol. 1991 Nov;161:25-41.

23.

Regulation of GABAB receptors by histamine and neuronal activity in the isolated spinal cord of neonatal opossum in culture.

Zou DJ, Treherne JM, Stewart RR, Saunders NR, Nicholls JG.

Proc Biol Sci. 1991 Oct 22;246(1315):77-82.

PMID:
1684671
24.
25.

Calcium-activated potassium channels in rat dissociated ventromedial hypothalamic neurons.

Treherne JM, Ashford ML.

J Neuroendocrinol. 1991 Jun 1;3(3):323-9. doi: 10.1111/j.1365-2826.1991.tb00282.x.

PMID:
19215471
26.

The regional distribution of sulphonylurea binding sites in rat brain.

Treherne JM, Ashford ML.

Neuroscience. 1991;40(2):523-31.

PMID:
1902917
27.

Inhibition by cations of antagonist binding to histamine H1-receptors.

Treherne JM, Stern JS, Flack WJ, Young JM.

Agents Actions Suppl. 1991;33:271-6.

PMID:
1675834
28.
29.

Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels.

Ashford ML, Boden PR, Treherne JM.

Pflugers Arch. 1990 Jan;415(4):479-83.

PMID:
2315006
30.

Actions of sulfonylureas on neurones of rat ventromedial hypothalamus in vitro.

Boden P, Ashford ML, Treherne JM.

Br J Pharmacol. 1989 Dec;98 Suppl:830P. No abstract available.

31.

Digitonin-solubilized histamine H1-receptors bind to polyethylenimine-treated glass-fibre filters.

Treherne JM, Young JM.

J Pharm Pharmacol. 1988 Oct;40(10):730-3.

PMID:
2907544
33.
34.

Glial repair in an insect central nervous system: effects of surgical lesioning.

Treherne JE, Harrison JB, Treherne JM, Lane NJ.

J Neurosci. 1984 Nov;4(11):2689-97.

Supplemental Content

Loading ...
Support Center