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Items: 10


Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.

Hawksworth J, Satchwell TJ, Meinders M, Daniels DE, Regan F, Thornton NM, Wilson MC, Dobbe JG, Streekstra GJ, Trakarnsanga K, Heesom KJ, Anstee DJ, Frayne J, Toye AM.

EMBO Mol Med. 2018 Apr 26. pii: e8454. doi: 10.15252/emmm.201708454. [Epub ahead of print]


One-step genetic correction of hemoglobin E/beta-thalassemia patient-derived iPSCs by the CRISPR/Cas9 system.

Wattanapanitch M, Damkham N, Potirat P, Trakarnsanga K, Janan M, U-Pratya Y, Kheolamai P, Klincumhom N, Issaragrisil S.

Stem Cell Res Ther. 2018 Feb 26;9(1):46. doi: 10.1186/s13287-018-0779-3.


Secretory factors from OP9 stromal cells delay differentiation and increase the expansion potential of adult erythroid cells in vitro.

Trakarnsanga K, Wilson MC, Heesom KJ, Andrienko TN, Srisawat C, Frayne J.

Sci Rep. 2018 Jan 31;8(1):1983. doi: 10.1038/s41598-018-20491-1.


An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells.

Trakarnsanga K, Griffiths RE, Wilson MC, Blair A, Satchwell TJ, Meinders M, Cogan N, Kupzig S, Kurita R, Nakamura Y, Toye AM, Anstee DJ, Frayne J.

Nat Commun. 2017 Mar 14;8:14750. doi: 10.1038/ncomms14750.


Comparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation.

Wilson MC, Trakarnsanga K, Heesom KJ, Cogan N, Green C, Toye AM, Parsons SF, Anstee DJ, Frayne J.

Mol Cell Proteomics. 2016 Jun;15(6):1938-46. doi: 10.1074/mcp.M115.057315. Epub 2016 Mar 22.


Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL.

Trakarnsanga K, Wilson MC, Lau W, Singleton BK, Parsons SF, Sakuntanaga P, Kurita R, Nakamura Y, Anstee DJ, Frayne J.

Haematologica. 2014 Nov;99(11):1677-85. doi: 10.3324/haematol.2014.110155. Epub 2014 Aug 8.


Qualitative and quantitative comparison of the proteome of erythroid cells differentiated from human iPSCs and adult erythroid cells by multiplex TMT labelling and nanoLC-MS/MS.

Trakarnsanga K, Wilson MC, Griffiths RE, Toye AM, Carpenter L, Heesom KJ, Parsons SF, Anstee DJ, Frayne J.

PLoS One. 2014 Jul 14;9(7):e100874. doi: 10.1371/journal.pone.0100874. eCollection 2014.


The ins and outs of human reticulocyte maturation: autophagy and the endosome/exosome pathway.

Griffiths RE, Kupzig S, Cogan N, Mankelow TJ, Betin VM, Trakarnsanga K, Massey EJ, Parsons SF, Anstee DJ, Lane JD.

Autophagy. 2012 Jul 1;8(7):1150-1. doi: 10.4161/auto.20648. Epub 2012 Jun 4.


Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis.

Griffiths RE, Kupzig S, Cogan N, Mankelow TJ, Betin VM, Trakarnsanga K, Massey EJ, Lane JD, Parsons SF, Anstee DJ.

Blood. 2012 Jun 28;119(26):6296-306. doi: 10.1182/blood-2011-09-376475. Epub 2012 Apr 6.


Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes.

Singleton BK, Lau W, Fairweather VS, Burton NM, Wilson MC, Parsons SF, Richardson BM, Trakarnsanga K, Brady RL, Anstee DJ, Frayne J.

Blood. 2011 Sep 15;118(11):3137-45. doi: 10.1182/blood-2011-04-349985. Epub 2011 Jul 21.

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