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Relationship Between the Review Time and Various PMDA Consultations in Recent New Drug Approval Cases in Japan.

Nishiyama K, Toyoshima S, Yamada H, Suzuki H, Nagai N.

Ther Innov Regul Sci. 2018 Jan 1:2168479018762795. doi: 10.1177/2168479018762795. [Epub ahead of print]


Comparative study of the number of report and time-to-onset of the reported adverse event between the biosimilars and the originator of filgrastim.

Kobayashi T, Kamada I, Komura J, Toyoshima S, Ishii-Watabe A.

Pharmacoepidemiol Drug Saf. 2017 Aug;26(8):917-924. doi: 10.1002/pds.4218. Epub 2017 Jun 14.


Role of HER2-Related Biomarkers (HER2, p95HER2, HER3, PTEN, and PIK3CA) in the Efficacy of Lapatinib plus Capecitabine in HER2-Positive Advanced Breast Cancer Refractory to Trastuzumab.

Nishimura R, Toh U, Tanaka M, Saimura M, Okumura Y, Saito T, Tanaka T, Teraoka M, Shimada K, Katayama K, Koga T, Kurashita K, Hasegawa S, Todoroki H, Kai Y, Ohi Y, Toyoshima S, Arima N, Mitsuyama S, Tamura K.

Oncology. 2017;93(1):51-61. doi: 10.1159/000468521. Epub 2017 May 6.


The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis.

Okamura Y, Mishima S, Kashiwakura JI, Sasaki-Sakamoto T, Toyoshima S, Kuroda K, Saito S, Tokuhashi Y, Okayama Y.

Allergol Int. 2017 Sep;66S:S9-S20. doi: 10.1016/j.alit.2017.03.002. Epub 2017 Mar 31.


The spleen is the site where mast cells are induced in the development of food allergy.

Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R.

Int Immunol. 2017 Jan 1;29(1):31-45. doi: 10.1093/intimm/dxx005.


Perivascular epithelial cell tumor (PEComa) of the pancreas: a case report and review of previous literatures.

Mizuuchi Y, Nishihara K, Hayashi A, Tamiya S, Toyoshima S, Oda Y, Nakano T.

Surg Case Rep. 2016 Dec;2(1):59. doi: 10.1186/s40792-016-0186-x. Epub 2016 Jun 15.


Validity of the management strategy for intraductal papillary mucinous neoplasm advocated by the international consensus guidelines 2012: a retrospective review.

Watanabe Y, Nishihara K, Niina Y, Abe Y, Amaike T, Kibe S, Mizuuchi Y, Kakihara D, Ono M, Tamiya S, Toyoshima S, Nakano T, Mitsuyama S.

Surg Today. 2016 Sep;46(9):1045-52. doi: 10.1007/s00595-015-1292-2. Epub 2015 Dec 21.


[Effect of weekly paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide as neoadjuvant treatment for patients with triple-negative and luminal-type breast cancer - a multicenter study].

Anan K, Tanaka M, Yoshinaga Y, Maeda S, Yamaguchi Y, Hayashi M, Tanaka M, Kamata Y, Mashino K, Yamamoto Y, Nishimura J, Matsuo S, Toyoshima S, Tamura K, Mitsuyama S; Kuyshu Brest Cancer Study Group.

Gan To Kagaku Ryoho. 2015 Jan;42(1):45-50. Japanese.


Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.

Obata Y, Toyoshima S, Wakamatsu E, Suzuki S, Ogawa S, Esumi H, Abe R.

Nat Commun. 2014 Dec 10;5:5715. doi: 10.1038/ncomms6715.


Bilateral atrophic kidney-like tumors.

Oshiro Y, Hida AI, Tamiya S, Toyoshima S, Kuroda N, Hes O, Michal M.

Pathol Int. 2014 Sep;64(9):478-80. doi: 10.1111/pin.12193. Epub 2014 Aug 22. No abstract available.


Congenital peribronchial myofibroblastic tumor.

Hotokebuchi Y, Kohashi K, Toyoshima S, Matsumoto N, Nakashima T, Oda Y.

Pathol Int. 2014 Apr;64(4):189-91. doi: 10.1111/pin.12141. No abstract available.


Population survey of phytoseiid mites and spider mites on peach leaves and wild plants in Japanese peach orchard.

Wari D, Yamashita J, Kataoka Y, Kohara Y, Hinomoto N, Kishimoto H, Toyoshima S, Sonoda S.

Exp Appl Acarol. 2014 Jul;63(3):313-32.


Immunoglobulin G4-related multiple cardiovascular lesions successfully treated with a combination of open surgery and corticosteroid therapy.

Kan-o M, Kado Y, Sadanaga A, Tamiya S, Toyoshima S, Sakamoto M.

J Vasc Surg. 2015 Jun;61(6):1599-603. doi: 10.1016/j.jvs.2013.10.106. Epub 2013 Dec 17.


Surgical treatment of catamenial pneumothorax: Report of three cases.

Ichiki Y, Nagashima A, Yasuda M, Takenoyama M, Toyoshima S.

Asian J Surg. 2015 Jul;38(3):180-5. doi: 10.1016/j.asjsur.2013.09.014. Epub 2013 Nov 6.


Mucosal-incision assisted biopsy for suspected gastric gastrointestinal stromal tumors.

Ihara E, Matsuzaka H, Honda K, Hata Y, Sumida Y, Akiho H, Misawa T, Toyoshima S, Chijiiwa Y, Nakamura K, Takayanagi R.

World J Gastrointest Endosc. 2013 Apr 16;5(4):191-6. doi: 10.4253/wjge.v5.i4.191.


Endoscopy-assisted breast-conserving surgery for early breast cancer.

Saimura M, Mitsuyama S, Anan K, Koga K, Watanabe M, Ono M, Toyoshima S.

Asian J Endosc Surg. 2013 Aug;6(3):203-8. doi: 10.1111/ases.12018. Epub 2013 Feb 1.


Evaluation of PTEN loss and PIK3CA mutations and their correlation with efficacy of trastuzumab treatment in HER2-positive metastatic breast cancer: A retrospective study (KBC-SG 1001).

Nishimura R, Arima N, Toyoshima S, Ohi Y, Anan K, Sagara Y, Mitsuyama S, Tamura K.

Mol Clin Oncol. 2013 Jan;1(1):47-52. Epub 2012 Aug 9.


Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin.

Oku T, Nakano M, Kaneko Y, Ando Y, Kenmotsu H, Itoh S, Tsuiji M, Seyama Y, Toyoshima S, Tsuji T.

J Biol Chem. 2012 Dec 14;287(51):42910-20. doi: 10.1074/jbc.M112.349829. Epub 2012 Oct 24.


[A multicenter study of epirubicin-docetaxel(ET)as primary chemotherapy for patients with inflammatory breast cancer(IBC)].

Saimura M, Anan K, Mitsuyama S, Toyoshima S, Ikejiri K, Ohchi T, Rai Y, Oikawa T, Kudaka M, Nishimura R, Kuroki S, Namba K, Nakafusa Y, Tamura K.

Gan To Kagaku Ryoho. 2012 Jul;39(7):1075-9. Japanese.


Ductal carcinoma in situ arising in tubular adenoma of the breast.

Saimura M, Anan K, Mitsuyama S, Ono M, Toyoshima S.

Breast Cancer. 2015 Jul;22(4):428-31. doi: 10.1007/s12282-012-0375-9. Epub 2012 Jun 15.


Preparation of SRN1-type coupling adducts from aliphatic gem-dinitro compounds in ionic liquids.

Kamimura A, Toyoshima S.

Molecules. 2012 Apr 25;17(5):4782-90. doi: 10.3390/molecules17054782.


Primary pulmonary Ewing's sarcoma: report of a case.

Ichiki Y, Nagashima A, Chikaishi Y, Yasuda M, Yamamoto I, Toyoshima S.

Surg Today. 2012 Aug;42(8):812-5. doi: 10.1007/s00595-012-0170-4. Epub 2012 Apr 7.


Etiological factors in primary hepatic B-cell lymphoma.

Kikuma K, Watanabe J, Oshiro Y, Shimogama T, Honda Y, Okamura S, Higaki K, Uike N, Soda T, Momosaki S, Yokota T, Toyoshima S, Takeshita M.

Virchows Arch. 2012 Apr;460(4):379-87. doi: 10.1007/s00428-012-1199-x. Epub 2012 Mar 7.


Comparative molecular phylogeny and evolution of sex chromosome DNA sequences in the family Canidae (Mammalia: Carnivora).

Tsubouchi A, Fukui D, Ueda M, Tada K, Toyoshima S, Takami K, Tsujimoto T, Uraguchi K, Raichev E, Kaneko Y, Tsunoda H, Masuda R.

Zoolog Sci. 2012 Mar;29(3):151-61. doi: 10.2108/zsj.29.151.


Phytoseiid mite species composition in Japanese peach orchards estimated using quantitative sequencing.

Sonoda S, Kohara Y, Siqingerile, Toyoshima S, Kishimoto H, Hinomoto N.

Exp Appl Acarol. 2012 Jan;56(1):9-22. doi: 10.1007/s10493-011-9485-x. Epub 2011 Sep 10.


Ultrasonographic findings of invasive micropapillary carcinoma of the breast: correlation between internal echogenicity and histological findings.

Kamitani K, Kamitani T, Ono M, Toyoshima S, Mitsuyama S.

Breast Cancer. 2012 Oct;19(4):349-52. doi: 10.1007/s12282-011-0293-2. Epub 2011 Jul 13.


Leiomyoma of the male nipple.

Shibata S, Imafuku S, Tashiro A, Gondo CH, Toyoshima S, Furue M.

J Dermatol. 2011 Jul;38(7):727-9. doi: 10.1111/j.1346-8138.2010.01071.x. Epub 2010 Nov 2. No abstract available.


Enhanced photoluminescence spectroscopy for thin films using the attenuated total reflection method.

Wakamatsu T, Kitami T, Maruyama T, Toyoshima S.

Appl Opt. 2011 Feb 10;50(5):696-700. doi: 10.1364/AO.50.000696.


[Regulatory science for drug evaluation].

Toyoshima S.

Nihon Rinsho. 2010 Nov;68(11):2135-41. Japanese.


PMDA's challenge to accelerate clinical development and review of new drugs in Japan.

Ichimaru K, Toyoshima S, Uyama Y.

Clin Pharmacol Ther. 2010 Oct;88(4):454-7. doi: 10.1038/clpt.2010.190.


Extraspinal ependymoma of the broad ligament.

Matsuyama A, Hisaoka M, Yamamoto I, Toyoshima S, Hashimoto H.

Pathol Int. 2010 Mar;60(3):241-4. doi: 10.1111/j.1440-1827.2009.02509.x.


Participation of elderly patients in registration trials for oncology drug applications in Japan.

Yonemori K, Hirakawa A, Komiyama N, Kouno T, Ando M, Fujiwara Y, Urano T, Akagawa H, Maruyama H, Toyoshima S.

Ann Oncol. 2010 Oct;21(10):2112-8. doi: 10.1093/annonc/mdq070. Epub 2010 Mar 23.


Effective global drug development strategy for obtaining regulatory approval in Japan in the context of ethnicity-related drug response factors.

Ichimaru K, Toyoshima S, Uyama Y.

Clin Pharmacol Ther. 2010 Mar;87(3):362-6. doi: 10.1038/clpt.2009.285. Epub 2010 Jan 27. Review. No abstract available.


[In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007].

Yamaguchi K, Ohno A, Ishii Y, Tateda K, Iwata M, Kanda M, Akizawa K, Shimizu C, Kon S, Nakamura K, Matsuda K, Tominaga M, Nakagawa T, Sugita A, Ito T, Kato J, Suwabe A, Yamahata K, Kawamura C, Tashiro H, Horiuchi H, Katayama Y, Kondou S, Misawa S, Murata M, Kobayashi Y, Okamoto H, Yamazaki K, Okada M, Haruki K, Kanno H, Aihara M, Maesaki S, Hashikita G, Miyajima E, Sumitomo M, Saito T, Yamane N, Kawashima C, Akiyama T, Ieiri T, Yamamoto Y, Okamoto Y, Okabe H, Moro K, Shigeta M, Yoshida H, Yamashita M, Hida Y, Takubo T, Kusakabe T, Masaki H, Heijyou H, Nakaya H, Kawahara K, Sano R, Matsuo S, Kono H, Yuzuki Y, Ikeda N, Idomuki M, Soma M, Yamamoto G, Kinoshita S, Kawano S, Oka M, Kusano N, Kang D, Ono J, Yasujima M, Miki M, Hayashi M, Okubo S, Toyoshima S, Kaku M, Sekine I, Shiotani J, Horiuchi H, Tazawa Y, Yoneyama A, Kumasaka K, Koike K, Taniguchi N, Ozaki Y, Uchida T, Murakami M, Inuzuka K, Gonda H, Yamaguchi I, fujimoto Y, Iriyama J, Asano Y, Genma H, Maekawa M, Yoshimura H, Nakatani K, Baba H, Ichiyama S, Fujita S, Kuwabara M, Okazaki T, Fujiwara H, Ota H, Nagai A, Fujita J, Negayama K, Sugiura T, Kamioka M, Murase M, Yamane N, Nakasone I, Okayama A, Aoki Y, Kusaba K, Nakashima Y, Miyanohara H, Hiramatsu K, Saikawa T, Yanagihara K, Matsuda J, Kohno S, Mashiba K.

Jpn J Antibiot. 2009 Aug;62(4):346-70. Japanese.


Three-year outcomes after sirolimus-eluting stent implantation for unprotected left main coronary artery disease: insights from the j-Cypher registry.

Toyofuku M, Kimura T, Morimoto T, Hayashi Y, Ueda H, Kawai K, Nozaki Y, Hiramatsu S, Miura A, Yokoi Y, Toyoshima S, Nakashima H, Haze K, Tanaka M, Take S, Saito S, Isshiki T, Mitsudo K; j-Cypher Registry Investigators.

Circulation. 2009 Nov 10;120(19):1866-74. doi: 10.1161/CIRCULATIONAHA.109.873349. Epub 2009 Oct 26.


S1-state internal conversion of isolated azulene derivatives.

Numata Y, Toyoshima S, Okuyama K, Yasunami M, Suzuka I.

J Phys Chem A. 2009 Sep 3;113(35):9603-11. doi: 10.1021/jp8078502.


Disparities in the survival improvement of recurrent breast cancer.

Anan K, Mitsuyama S, Koga K, Tanabe R, Saimura M, Tanabe Y, Watanabe M, Suehara N, Matsunaga H, Nishihara K, Abe Y, Nakano T, Tamae K, Ono M, Toyoshima S.

Breast Cancer. 2010;17(1):48-55. doi: 10.1007/s12282-009-0103-2. Epub 2009 Apr 7.


What causes discrepancies in HER2 testing for breast cancer? A Japanese ring study in conjunction with the global standard.

Umemura S, Osamura RY, Akiyama F, Honma K, Kurosumi M, Sasano H, Toyoshima S, Tsuda H, Rüschoff J, Sakamoto G.

Am J Clin Pathol. 2008 Dec;130(6):883-91. doi: 10.1309/AJCP5UUMFMA5ZKII.


Effects of starvation on reproduction of the predacious mite Neoseiulus californicus (Acari: Phytoseiidae).

Toyoshima S, Michalik P, Talarico G, Klann AE, Alberti G.

Exp Appl Acarol. 2009 Mar;47(3):235-47. doi: 10.1007/s10493-008-9211-5. Epub 2008 Nov 6.


[A case of long survival with unresectable duodenal papilla cancer treated with oral chemotherapy using combination UFT and cyclophosphamide].

Mikami R, Nishihara K, Matsunaga H, Abe Y, Mitsuyama S, Nasu T, Yamamoto I, Toyoshima S, Motooka M.

Gan To Kagaku Ryoho. 2008 Aug;35(8):1399-401. Japanese.


Phorbol ester-dependent phosphorylation regulates the association of p57/coronin-1 with the actin cytoskeleton.

Oku T, Kaneko Y, Murofushi K, Seyama Y, Toyoshima S, Tsuji T.

J Biol Chem. 2008 Oct 24;283(43):28918-25. doi: 10.1074/jbc.M709990200. Epub 2008 Aug 7.


[A case of peritoneal disseminated sigmoid colon cancer with liver metastasis responding to S-1].

Tokunaga M, Tanabe Y, Nasu T, Abe Y, Mitsuyama S, Toyoshima S.

Gan To Kagaku Ryoho. 2008 Jul;35(7):1217-20. Japanese.


Current Japanese regulatory situations of pharmacogenomics in drug administration.

Ishiguro A, Toyoshima S, Uyama Y.

Expert Rev Clin Pharmacol. 2008 Jul;1(4):505-14. doi: 10.1586/17512433.1.4.505.


Exclusion of actin-binding protein p57/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella.

Hayashi T, Miyake M, Fukui T, Sugaya N, Daimon T, Itoh S, Oku T, Tsuji T, Toyoshima S, Imai Y.

Biol Pharm Bull. 2008 May;31(5):861-5.


[n0 adjuvant breast cancer].

Toyoshima S.

Nihon Rinsho. 2007 Jun 28;65 Suppl 6:97-9. Review. Japanese. No abstract available.


Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation.

Deghmane AE, Soualhine H, Bach H, Sendide K, Itoh S, Tam A, Noubir S, Talal A, Lo R, Toyoshima S, Av-Gay Y, Hmama Z.

J Cell Sci. 2007 Aug 15;120(Pt 16):2796-806. Epub 2007 Jul 24. Erratum in: J Cell Sci. 2007 Oct 1;120(Pt 19):3489. Soulhine, Hafid [corrected to Soualhine, Hafid].


Angiomyofibroblastoma-like tumor (cellular angiofibroma) in the male inguinal region.

Miyajima K, Hasegawa S, Oda Y, Toyoshima S, Tsuneyoshi M, Motooka M, Matsuura Y, Ishioka H, Ono M.

Radiat Med. 2007 May;25(4):173-7. Epub 2007 May 28.


[In-vitro susceptibilites to levofloxacin and various antibacterial agents of 18,639 clinical isolates obtained from 77 centers in 2004].

Yamaguchi K, Ohno A, Ishii Y, Tateda K, Iwata M, Kanda M, Tsujio Y, Kimoto H, Kaimori M, Nakamura T, Kawamura C, Nishimura M, Akizawa K, Katayama Y, Matsuda K, Hayashi T, Yasujima M, Kasai T, Kimura M, Tominaga M, Miki M, Nakanowatari S, Nakagawa T, Kaku M, Kanemitsu K, Kunishima H, Toyoshima S, Sakurai M, Shiotani J, Sugita A, Ito T, Okada J, Suwabe A, Yamahata K, Yoneyama A, Kumasaka K, Yamane N, Koike K, Ieiri T, Kominami H, Yamada T, Oguri T, Itoh K, Watanabe K, Kobayashi Y, Ohtake T, Uchida T, Totsuka K, Murakami M, Yomoda S, Takahashi A, Okamoto H, Inuzuka K, Yamazaki K, Gonda H, Yamashita T, Yamaguchi I, Okada M, Ikari H, Kurosawa N, Fujimoto Y, Ishigo S, Asano Y, Mikio M, Kano I, Nagano E, Kageyama F, Shaku E, Kanno H, Aihara M, Gemma H, Uemura K, Miyajima E, Maesaki S, Hashikita G, Horii T, Sumitomo M, Yoshimura H, Hiraoka M, Wada H, Yuzuki Y, Ikeda N, Baba H, Soma M, Yamamoto T, Ichiyama S, Kinosita S, Kawano S, Fujita S, Kageoka T, Hongo T, Okabe H, Tatewaki K, Moro K, Oka M, Niki Y, Yoshida H, Yamashita M, Kusano N, Mihara E, Nose M, Fushiwaki T, Kuwabara M, Fujiue Y, Shimuzu A, Takubo T, Kusakabe T, Hinoda Y, Tanaka N, Takahashi H, Heijyou H, Okazaki T, Asai K, Kawahara K, Masuda J, Sano R, Taminato T, Negayama K, Matsuo S, Komatsu M, Sugiura T, Murase M, Hiramatsu K, Yamane N, Nakasone I, Hirakata Y, Kohno S, Aizawa H, Honda J, Hamazaki N, Okayama A, Ono J, Aoki Y, Okada K, Miyanohara H.

Jpn J Antibiot. 2006 Dec;59(6):428-51. Japanese.


Isoechoic axillary lymph node metastases of mucinous carcinoma of the breast: a case report.

Kamitani K, Ono M, Toyoshima S, Mitsuyama S, Anan K, Ikeda Y.

Breast Cancer. 2006;13(4):382-5.


Pigmented cutaneous metastasis of mucinous carcinoma of the breast to the scalp mimicking malignant melanoma.

Hamada M, Toyoshima S, Duan H, Furue M.

Eur J Dermatol. 2006 Sep-Oct;16(5):592-3. No abstract available.


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