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Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer.

Yoshioka T, Shien K, Namba K, Torigoe H, Sato H, Tomida S, Yamamoto H, Asano H, Soh J, Tsukuda K, Nagasaka T, Fujiwara T, Toyooka S.

Cancer Sci. 2018 Feb 21. doi: 10.1111/cas.13546. [Epub ahead of print]


Second primary cancer in survivors of locally advanced non-small cell lung cancer treated with concurrent chemoradiation followed by surgery.

Makimoto G, Kubo T, Oze I, Ohashi K, Hotta K, Tabata M, Soh J, Toyooka S, Katsui K, Takigawa N, Tanimoto M, Kiura K.

Jpn J Clin Oncol. 2018 Feb 2. doi: 10.1093/jjco/hyy003. [Epub ahead of print]


Unique circulating microRNAs in relation to EGFR mutation status in Japanese smoker male with lung adenocarcinoma.

Ito S, Kamoto Y, Sakai A, Sasai K, Hayashi T, Toyooka S, Katayama H.

Oncotarget. 2017 Sep 30;8(70):114685-114697. doi: 10.18632/oncotarget.21425. eCollection 2017 Dec 29.


Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma.

Sato H, Sakaguchi M, Yamamoto H, Tomida S, Aoe K, Shien K, Yoshioka T, Namba K, Torigoe H, Soh J, Tsukuda K, Tao H, Okabe K, Miyoshi S, Pass HI, Toyooka S.

Oncogenesis. 2018 Jan 24;7(1):11. doi: 10.1038/s41389-017-0017-3.


A Phase II Study of Trastuzumab Emtansine in HER2-Positive Non-Small Cell Lung Cancer.

Hotta K, Aoe K, Kozuki T, Ohashi K, Ninomiya K, Ichihara E, Kubo T, Ninomiya T, Chikamori K, Harada D, Nogami N, Hirata T, Hinotsu S, Toyooka S, Kiura K.

J Thorac Oncol. 2018 Feb;13(2):273-279. doi: 10.1016/j.jtho.2017.10.032. Epub 2017 Dec 5.


Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung.

Tao H, Soh J, Yamamoto H, Fujiwara T, Ueno T, Hayama M, Okazaki M, Sugimoto R, Yamashita M, Sano Y, Okabe K, Matsuura M, Kataoka K, Moriyama S, Toyooka S, Miyoshi S.

J Thorac Dis. 2017 Nov;9(11):4325-4335. doi: 10.21037/jtd.2017.10.70.


Preoperative short hookwire placement for small pulmonary lesions: evaluation of technical success and risk factors for initial placement failure.

Iguchi T, Hiraki T, Matsui Y, Fujiwara H, Masaoka Y, Tanaka T, Sato T, Gobara H, Toyooka S, Kanazawa S.

Eur Radiol. 2017 Dec 15. doi: 10.1007/s00330-017-5176-2. [Epub ahead of print]


Induction chemoradiotherapy using docetaxel and cisplatin with definitive-dose radiation followed by surgery for locally advanced non-small cell lung cancer.

Torigoe H, Soh J, Tomida S, Namba K, Sato H, Katsui K, Hotta K, Shien K, Yamamoto H, Yamane M, Kanazawa S, Kiura K, Miyoshi S, Toyooka S.

J Thorac Dis. 2017 Sep;9(9):3076-3086. doi: 10.21037/jtd.2017.08.87.


Therapeutic Potential of Afatinib for Cancers with ERBB2 (HER2) Transmembrane Domain Mutations G660D and V659E.

Yamamoto H, Toyooka S, Ninomiya T, Matsumoto S, Kanai M, Tomida S, Kiura K, Muto M, Suzawa K, Desmeules P, Kris MG, Li BT, Ladanyi M.

Oncologist. 2018 Feb;23(2):150-154. doi: 10.1634/theoncologist.2017-0345. Epub 2017 Nov 16.


What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?

Miyajima M, Watanabe A, Sato T, Teramukai S, Ebina M, Kishi K, Sugiyama Y, Kondo H, Kobayashi S, Takahashi Y, Ito H, Yamamoto R, Sawada S, Fujimori H, Okabe K, Arikura J, Shintani Y, Nakamura H, Toyooka S, Hasumi T, Watanabe T, Hata Y, Iwata H, Aoki M, Funai K, Inoue S, Kawashima O, Iida T, Date H.

Surg Today. 2017 Nov 9. doi: 10.1007/s00595-017-1605-8. [Epub ahead of print]


Postoperative pyoderma gangrenosum exacerbated by granulocyte-colony stimulating factor after lung cancer surgery.

Yamamoto H, Sugimoto S, Otani S, Toyooka S.

Jpn J Clin Oncol. 2017 Oct 1;47(10):991-992. doi: 10.1093/jjco/hyx121. No abstract available.


Model of lung cancer surgery risk derived from a Japanese nationwide web-based database of 78 594 patients during 2014-2015.

Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, Chida M, Sato M, Toyooka S, Yoshida K, Okada Y, Sato Y, Okada M, Okumura M, Chihara K, Fukuchi E, Miyata H.

Eur J Cardiothorac Surg. 2017 Dec 1;52(6):1182-1189. doi: 10.1093/ejcts/ezx190.


Estimation of age-related DNA degradation from formalin-fixed and paraffin-embedded tissue according to the extraction methods.

Watanabe M, Hashida S, Yamamoto H, Matsubara T, Ohtsuka T, Suzawa K, Maki Y, Soh J, Asano H, Tsukuda K, Toyooka S, Miyoshi S.

Exp Ther Med. 2017 Sep;14(3):2683-2688. doi: 10.3892/etm.2017.4797. Epub 2017 Jul 17.


Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer.

Chen H, Shien K, Suzawa K, Tsukuda K, Tomida S, Sato H, Torigoe H, Watanabe M, Namba K, Yamamoto H, Soh J, Asano H, Miyoshi S, Toyooka S.

Oncol Lett. 2017 Oct;14(4):4349-4354. doi: 10.3892/ol.2017.6678. Epub 2017 Jul 26.


ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.

Sumardika IW, Youyi C, Kondo E, Inoue Y, Ruma IMW, Murata H, Kinoshita R, Yamamoto KI, Tomida S, Shien K, Satoh H, Yamauchi A, Futami J, Putranto EW, Hibino T, Toyooka S, Nishibori M, Sakaguchi M.

Oncol Res. 2017 Sep 18. doi: 10.3727/096504017X15031557924123. [Epub ahead of print]


Effects of Cold Ischemia on RNA Stability and Quality of Lung Tissues Based on Standard PREanalytical Code Categorization.

Matsubara T, Tomida S, Soh J, Uwabo T, Mori Y, Morita M, Nasu Y, Kanazawa S, Toyooka S.

Biopreserv Biobank. 2017 Oct;15(5):484-486. doi: 10.1089/bio.2017.0076. Epub 2017 Sep 14. No abstract available.


Correlation Between Recovery of Triceps Surae Muscle Strength and Level of Activity After Open Repair of Acute Achilles Tendon Rupture.

Toyooka S, Takeda H, Nakajima K, Masujima A, Miyamoto W, Pagliazzi G, Nakagawa T, Kawano H.

Foot Ankle Int. 2017 Dec;38(12):1324-1330. doi: 10.1177/1071100717728686. Epub 2017 Sep 9.


JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer.

Shien K, Papadimitrakopoulou VA, Ruder D, Behrens C, Shen L, Kalhor N, Song J, Lee JJ, Wang J, Tang X, Herbst RS, Toyooka S, Girard L, Minna JD, Kurie JM, Wistuba II, Izzo JG.

Mol Cancer Ther. 2017 Oct;16(10):2234-2245. doi: 10.1158/1535-7163.MCT-17-0148. Epub 2017 Jul 20.


Reconstruction of Anterior Chest Wall with Polypropylene Mesh: Two Primary Sternal Chondrosarcoma Cases.

Kawana S, Yamamoto H, Maki Y, Sugimoto S, Toyooka S, Miyoshi S.

Acta Med Okayama. 2017 Jun;71(3):259-262. doi: 10.18926/AMO/55210.


Is tumor location an independent prognostic factor in locally advanced non-small cell lung cancer treated with trimodality therapy?

Shien K, Toyooka S, Soh J, Yamamoto H, Miyoshi S.

J Thorac Dis. 2017 May;9(5):E489-E491. doi: 10.21037/jtd.2017.03.183. No abstract available.


Advantage of Induction Chemoradiotherapy for Lung Cancer in Securing Cancer-Free Bronchial Margin.

Sato H, Toyooka S, Soh J, Hotta K, Katsui K, Shien K, Yamamoto H, Oto T, Kanazawa S, Kiura K, Miyoshi S.

Ann Thorac Surg. 2017 Sep;104(3):971-978. doi: 10.1016/j.athoracsur.2017.03.045. Epub 2017 Jun 11.


Erratum to "Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer" [Lung Cancer 76 (1) (2012) 32-38].

Tanaka N, Toyooka S, Soh J, Kubo T, Yamamoto H, Maki Y, Muraoka T, Shien K, Furukawa M, Ueno T, Asano H, Tsukuda K, Aoe K, Miyoshi S.

Lung Cancer. 2017 Jun;108:254-255. doi: 10.1016/j.lungcan.2016.04.016. Epub 2017 Apr 27. No abstract available.


Diagnostic Value of Dual-time-point F-18 FDG PET/CT and Chest CT for the Prediction of Thymic Epithelial Neoplasms.

Shinya T, Tanaka T, Soh J, Matsushita T, Sato S, Toyooka S, Yoshino T, Miyoshi S, Kanazawa S.

Acta Med Okayama. 2017 Apr;71(2):105-112. doi: 10.18926/AMO/54978.


Optimal method for quantitative detection of plasma EGFR T790M mutation using droplet digital PCR system.

Suzawa K, Yamamoto H, Ohashi K, Hashida S, Tomida S, Kubo T, Maki Y, Soh J, Tsukuda K, Kiura K, Miyoshi S, Toyooka S.

Oncol Rep. 2017 May;37(5):3100-3106. doi: 10.3892/or.2017.5567. Epub 2017 Apr 11.


Radiofrequency ablation of pulmonary tumors near the diaphragm.

Iguchi T, Hiraki T, Gobara H, Fujiwara H, Sakurai J, Matsui Y, Mitsuhashi T, Toyooka S, Kanazawa S.

Diagn Interv Imaging. 2017 Jul - Aug;98(7-8):535-541. doi: 10.1016/j.diii.2017.01.008. Epub 2017 Feb 22.


Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer.

Takeda T, Yamamoto H, Kanzaki H, Suzawa K, Yoshioka T, Tomida S, Cui X, Murali R, Namba K, Sato H, Torigoe H, Watanabe M, Shien K, Soh J, Asano H, Tsukuda K, Kitamura Y, Miyoshi S, Sendo T, Toyooka S.

PLoS One. 2017 Feb 3;12(2):e0171356. doi: 10.1371/journal.pone.0171356. eCollection 2017. Erratum in: PLoS One. 2017 Mar 16;12 (3):e0174493.


Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.

Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.

Sci Rep. 2017 Jan 13;7:40847. doi: 10.1038/srep40847.


Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies.

Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y, Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S.

Anticancer Res. 2017 Jan;37(1):301-307.


Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.

Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S, Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S.

Sci Rep. 2016 Dec 23;6:39557. doi: 10.1038/srep39557.


Usefulness of Thoracoscopic Debridement for Chronic Empyema after an Extrapleural Pneumonectomy.

Torigoe H, Toyooka S, Yamamoto H, Soh J, Miyoshi S.

Acta Med Okayama. 2016 Dec;70(6):507-510.


Feasibility of adjuvant chemotherapy with S-1 plus carboplatin followed by single-agent maintenance therapy with S-1 for completely resected non-small-cell lung cancer: results of the Setouchi Lung Cancer Group Study 1001.

Okumura N, Sonobe M, Okabe K, Nakamura H, Kataoka M, Yamashita M, Nakata M, Kataoka K, Yamashita Y, Soh J, Yoshioka H, Hotta K, Matsuo K, Sakamoto J, Toyooka S, Date H.

Int J Clin Oncol. 2017 Apr;22(2):274-282. doi: 10.1007/s10147-016-1067-9. Epub 2016 Dec 5.


Radiofrequency ablation of pulmonary metastases from sarcoma: single-center retrospective evaluation of 46 patients.

Sato T, Iguchi T, Hiraki T, Gobara H, Fujiwara H, Sakurai J, Matsui Y, Mitsuhashi T, Soh J, Toyooka S, Kanazawa S.

Jpn J Radiol. 2017 Feb;35(2):61-67. doi: 10.1007/s11604-016-0601-z. Epub 2016 Nov 18.


Feasibility of Pulmonary Resection for Lung Cancer in Patients With Coronary Artery Disease or Atrial Fibrillation.

Kitamura Y, Suzuki K, Teramukai S, Sonobe M, Toyooka S, Nakagawa Y, Yokomise H, Date H; Japanese Association for Chest Surgery.

Ann Thorac Surg. 2017 Feb;103(2):432-440. doi: 10.1016/j.athoracsur.2016.08.077. Epub 2016 Oct 25.


Role of surgery in N2 NSCLC: pros.

Shien K, Toyooka S.

Jpn J Clin Oncol. 2016 Dec;46(12):1168-1173. Epub 2016 Sep 21.


Early postoperative complications after middle lobe-preserving surgery for secondary lung cancer.

Maki Y, Toyooka S, Soh J, Yamamoto H, Sugimoto S, Yamane M, Oto T, Miyoshi S.

Surg Today. 2017 May;47(5):601-605. doi: 10.1007/s00595-016-1413-6. Epub 2016 Sep 14.


Study about the Efficacy of Metformin to Immune Function in Cancer Patients.

Watanabe M, Yamamoto H, Eikawa S, Shien K, Shien T, Soh J, Hotta K, Wada J, Hinotsu S, Fujiwara T, Kiura K, Doihara H, Miyoshi S, Udono H, Toyooka S.

Acta Med Okayama. 2016 Aug;70(4):327-30.


Development of an annually updated Japanese national clinical database for chest surgery in 2014.

Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, Chida M, Sato M, Toyooka S, Yoshida K, Okada Y, Sato Y, Okumura M, Masuda M, Chihara K, Miyata H.

Gen Thorac Cardiovasc Surg. 2016 Oct;64(10):569-76. doi: 10.1007/s11748-016-0697-1. Epub 2016 Aug 8. Review.


Trastuzumab Emtansine in HER2+ Recurrent Metastatic Non-Small-Cell Lung Cancer: Study Protocol.

Ohashi K, Hotta K, Hirata T, Aoe K, Kozuki T, Ninomiya K, Kayatani H, Yanai H, Toyooka S, Hinotsu S, Takata M, Kiura K.

Clin Lung Cancer. 2017 Jan;18(1):92-95. doi: 10.1016/j.cllc.2016.06.014. Epub 2016 Jul 9.


Long-Term Survival after Radiofrequency Ablation of Lung Oligometastases from Five Types of Primary Lesions: A Retrospective Evaluation.

Omae K, Hiraki T, Gobara H, Iguchi T, Fujiwara H, Matsui Y, Toyooka S, Nagasaka T, Kanazawa S.

J Vasc Interv Radiol. 2016 Sep;27(9):1362-1370. doi: 10.1016/j.jvir.2016.05.017. Epub 2016 Jul 22.


Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells.

Saho S, Satoh H, Kondo E, Inoue Y, Yamauchi A, Murata H, Kinoshita R, Yamamoto KI, Futami J, Putranto EW, Ruma IM, Sumardika IW, Youyi C, Suzawa K, Yamamoto H, Soh J, Tomida S, Sakaguchi Y, Saito K, Iioka H, Huh NH, Toyooka S, Sakaguchi M.

Cancer Microenviron. 2016 Dec;9(2-3):93-105. doi: 10.1007/s12307-016-0185-2. Epub 2016 Jun 22.


The Feasibility of Median Sternotomy With or Without Thoracotomy for Locally Advanced Non-Small Cell Lung Cancer Treated With Induction Chemoradiotherapy.

Sato H, Toyooka S, Soh J, Hotta K, Katsui K, Yamamoto H, Sugimoto S, Oto T, Kanazawa S, Kiura K, Miyoshi S.

Ann Thorac Surg. 2016 Sep;102(3):985-992. doi: 10.1016/j.athoracsur.2016.03.092. Epub 2016 Jun 2.


Randomized feasibility study of S-1 for adjuvant chemotherapy in completely resected Stage IA non-small-cell lung cancer: results of the Setouchi Lung Cancer Group Study 0701.

Soh J, Okumura N, Nakata M, Nakamura H, Fukuda M, Kataoka M, Kajiwara S, Sano Y, Aoe M, Kataoka K, Hotta K, Matsuo K, Toyooka S, Date H.

Jpn J Clin Oncol. 2016 Aug;46(8):741-7. doi: 10.1093/jjco/hyw062. Epub 2016 May 20.


The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells.

Maki Y, Nishimura Y, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Ueno T, Tanaka N, Yamamoto H, Asano H, Maeda M, Kumagai-Takei N, Lee S, Matsuzaki H, Otsuki T, Miyoshi S.

Oncol Lett. 2016 May;11(5):3308-3316. Epub 2016 Apr 5.


[Cross-sectoral Approach of a Perioperative Management Center for General Thoracic Surgery].

Shimoda A, Soh J, Ashiba T, Murata N, Fukuda T, Kobayashi M, Torigoe H, Maki Y, Sugimoto S, Yamane M, Toyooka S, Oto T, Miyoshi S.

Kyobu Geka. 2016 Jan;69(1):20-4. Japanese.


Induction S-1+Concurrent Radiotherapy Followed by Surgical Resection of Locally Advanced Non-small-cell Lung Cancer in an Elderly Patient.

Torigoe H, Toyooka S, Katsui K, Soh J, Maki Y, Kiura K, Miyoshi S.

Acta Med Okayama. 2016;70(1):63-5.


Genetic alterations in lung adenocarcinoma with a micropapillary component.

Furukawa M, Toyooka S, Ichimura K, Yamamoto H, Soh J, Hashida S, Ouchida M, Shien K, Asano H, Tsukuda K, Miyoshi S.

Mol Clin Oncol. 2016 Feb;4(2):195-200. Epub 2015 Dec 2.


Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

Suzawa K, Yamamoto H, Murakami T, Katayama H, Furukawa M, Shien K, Hashida S, Okabe K, Aoe K, Soh J, Asano H, Tsukuda K, Mimura Y, Toyooka S, Miyoshi S.

Oncol Lett. 2016 Jan;11(1):705-712. Epub 2015 Nov 23.



Yamamoto H, Toyooka S, Maki Y, Soh J, Miyoshi S.

Nihon Geka Gakkai Zasshi. 2015 Nov;116(6):374-7. Japanese.


DNA copy number gains in malignant pleural mesothelioma.

Furukawa M, Toyooka S, Hayashi T, Yamamoto H, Fujimoto N, Soh J, Hashida S, Shien K, Asano H, Aoe K, Okabe K, Pass HI, Tsukuda K, Kishimoto T, Miyoshi S.

Oncol Lett. 2015 Nov;10(5):3274-3278. Epub 2015 Aug 27.


Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma.

Soh J, Toyooka S, Matsuo K, Yamamoto H, Wistuba II, Lam S, Fong KM, Gazdar AF, Miyoshi S.

Oncol Lett. 2015 Sep;10(3):1775-1782. Epub 2015 Jun 23.

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