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Items: 1 to 50 of 93


S-Glutathionylation of estrogen receptor alpha affects dendritic cell function.

Zhang J, Ye ZW, Chen W, Manevich Y, Mehrotra S, Ball LE, Janssen-Heininger YM, Tew KD, Townsend DM.

J Biol Chem. 2018 Jan 26. pii: jbc.M117.814327. doi: 10.1074/jbc.M117.814327. [Epub ahead of print]


Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study.

Monteiro LOF, Fernandes RS, Oda CMR, Lopes SC, Townsend DM, Cardoso VN, Oliveira MC, Leite EA, Rubello D, de Barros ALB.

Biomed Pharmacother. 2018 Jan;97:489-495. doi: 10.1016/j.biopha.2017.10.135. Epub 2017 Nov 6.


Nanostructured Lipid Carrier Co-loaded with Doxorubicin and Docosahexaenoic Acid as a Theranostic Agent: Evaluation of Biodistribution and Antitumor Activity in Experimental Model.

Fernandes RS, Silva JO, Mussi SV, Lopes SCA, Leite EA, Cassali GD, Cardoso VN, Townsend DM, Colletti PM, Ferreira LAM, Rubello D, de Barros ALB.

Mol Imaging Biol. 2017 Oct 17. doi: 10.1007/s11307-017-1133-3. [Epub ahead of print]


The role of radionuclide probes for monitoring anti-tumor drugs efficacy: A brief review.

Fernandes RS, de Aguiar Ferreira C, Soares DCF, Maffione AM, Townsend DM, Rubello D, de Barros ALB.

Biomed Pharmacother. 2017 Nov;95:469-476. doi: 10.1016/j.biopha.2017.08.079. Epub 2017 Sep 12. Review.


Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.

Marchiori E, Pelizzo MR, Herten M, Townsend DM, Rubello D, Boschin IM.

Biomed Pharmacother. 2017 Aug;92:843-848. doi: 10.1016/j.biopha.2017.05.028. Epub 2017 Jun 9.


Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications.

Soares DCF, de Paula Oliveira DC, Barcelos LS, Barbosa AS, Vieira LC, Townsend DM, Rubello D, de Barros ALB, Duarte LP, Silva-Cunha A.

Biomed Pharmacother. 2017 Aug;92:394-402. doi: 10.1016/j.biopha.2017.05.093. Epub 2017 May 27.


Cost-benefit effectiveness of angiotensin-II receptor blockers in patients with uncomplicated hypertension: A comparative analysis.

Mazza A, Sacco AP, Townsend DM, Bregola G, Contatto E, Cappello I, Schiavon L, Ramazzina E, Rubello D.

Biomed Pharmacother. 2017 Jun;90:665-669. doi: 10.1016/j.biopha.2017.04.008. Epub 2017 Apr 14.


Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ.

Prostaglandins Other Lipid Mediat. 2017 May;130:47-56. doi: 10.1016/j.prostaglandins.2017.03.006. Epub 2017 Apr 2.


Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes.

Manuel AM, Walla MD, Faccenda A, Martin SL, Tanis RM, Piroli GG, Adam J, Kantor B, Mutus B, Townsend DM, Frizzell N.

Antioxid Redox Signal. 2017 Dec 1;27(16):1281-1296. doi: 10.1089/ars.2016.6853. Epub 2017 May 19.


Synthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering.

Oda CMR, Fernandes RS, de Araújo Lopes SC, de Oliveira MC, Cardoso VN, Santos DM, de Castro Pimenta AM, Malachias A, Paniago R, Townsend DM, Colletti PM, Rubello D, Alves RJ, de Barros ALB, Leite EA.

Biomed Pharmacother. 2017 May;89:268-275. doi: 10.1016/j.biopha.2017.01.144. Epub 2017 Feb 24.


Technetium-99m radiolabeled paclitaxel as an imaging probe for breast cancer in vivo.

Monteiro LOF, Fernandes RS, Castro LC, Cardoso VN, Oliveira MC, Townsend DM, Ferretti A, Rubello D, Leite EA, de Barros ALB.

Biomed Pharmacother. 2017 May;89:146-151. doi: 10.1016/j.biopha.2017.02.003. Epub 2017 Mar 24.


Effect of hyperglycemia on brain and liver 18F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging.

Viglianti BL, Wong KK, Wimer SM, Parameswaran A, Nan B, Ky C, Townsend DM, Rubello D, Frey KA, Gross MD.

Biomed Pharmacother. 2017 Apr;88:1038-1045. doi: 10.1016/j.biopha.2017.01.166. Epub 2017 Feb 7.


Radiolabeled bombesin derivatives for preclinical oncological imaging.

Ferreira CA, Fuscaldi LL, Townsend DM, Rubello D, Barros ALB.

Biomed Pharmacother. 2017 Mar;87:58-72. doi: 10.1016/j.biopha.2016.12.083. Epub 2016 Dec 29. Review.


Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population.

Mazza A, Lenti S, Schiavon L, Monte AD, Townsend DM, Ramazzina E, Rubello D, Casiglia E.

Biomed Pharmacother. 2017 Feb;86:590-594. doi: 10.1016/j.biopha.2016.11.104. Epub 2016 Dec 24.


Estrogen and thyroid cancer is a stem affair: A preliminary study.

Zane M, Parello C, Pennelli G, Townsend DM, Merigliano S, Boscaro M, Toniato A, Baggio G, Pelizzo MR, Rubello D, Boschin IM.

Biomed Pharmacother. 2017 Jan;85:399-411. doi: 10.1016/j.biopha.2016.11.043. Epub 2016 Nov 26.


Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM.

JCI Insight. 2016 Jun 2;1(8). pii: e85717.


Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344.

Manevich Y, Reyes L, Britten CD, Townsend DM, Tew KD.

J Pharmacol Exp Ther. 2016 Aug;358(2):199-208. doi: 10.1124/jpet.115.229344. Epub 2016 Jun 2.


Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells.

van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, Tew KD, Townsend DM, Haenen GR, Drittij-Reijnders MJ, Saneyoshi H, Araki M, Shishido Y, Ito Y, Arnér ES, Abe H, Morgenstern R, Johansson K.

Mol Pharm. 2016 Jun 6;13(6):2010-25. doi: 10.1021/acs.molpharmaceut.6b00140. Epub 2016 Apr 28.


Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells.

Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM.

Redox Biol. 2016 Aug;8:375-82. doi: 10.1016/j.redox.2016.03.005. Epub 2016 Mar 26.


Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response.

Ye ZW, Zhang J, Ancrum T, Manevich Y, Townsend DM, Tew KD.

Antioxid Redox Signal. 2017 Feb 20;26(6):247-261. doi: 10.1089/ars.2015.6486. Epub 2016 Mar 16.


Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase.

Kenche H, Ye ZW, Vedagiri K, Richards DM, Gao XH, Tew KD, Townsend DM, Blumental-Perry A.

J Biol Chem. 2016 Feb 26;291(9):4763-78. doi: 10.1074/jbc.M115.712331. Epub 2016 Jan 4.


S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide.

Grek CL, Reyes L, Townsend DM, Tew KD.

BBA Clin. 2014 Sep 3;2:31-9. doi: 10.1016/j.bbacli.2014.08.003. eCollection 2014 Dec.


Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation.

Bartolini D, Piroddi M, Tidei C, Giovagnoli S, Pietrella D, Manevich Y, Tew KD, Giustarini D, Rossi R, Townsend DM, Santi C, Galli F.

Free Radic Biol Med. 2015 Jan;78:56-65. doi: 10.1016/j.freeradbiomed.2014.10.008. Epub 2014 Oct 18.


Oxidative stress, redox regulation and diseases of cellular differentiation.

Ye ZW, Zhang J, Townsend DM, Tew KD.

Biochim Biophys Acta. 2015 Aug;1850(8):1607-21. doi: 10.1016/j.bbagen.2014.11.010. Epub 2014 Nov 15. Review.


Protein Disulfide Isomerase Superfamily in Disease and the Regulation of Apoptosis.

Grek C, Townsend DM.

Endoplasmic Reticulum Stress Dis. 2014 Jan;1(1):4-17.


N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway.

Qanungo S, Uys JD, Manevich Y, Distler AM, Shaner B, Hill EG, Mieyal JJ, Lemasters JJ, Townsend DM, Nieminen AL.

Biomed Pharmacother. 2014 Sep;68(7):855-64. doi: 10.1016/j.biopha.2014.08.007. Epub 2014 Aug 28.


Glutathione S-transferase P influences redox and migration pathways in bone marrow.

Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD.

PLoS One. 2014 Sep 12;9(9):e107478. doi: 10.1371/journal.pone.0107478. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119266.


Glutathione and redox signaling in substance abuse.

Uys JD, Mulholland PJ, Townsend DM.

Biomed Pharmacother. 2014 Jul;68(6):799-807. doi: 10.1016/j.biopha.2014.06.001. Epub 2014 Jun 24. Review.


A comparison of reversible versus irreversible protein glutathionylation.

Townsend DM, Lushchak VI, Cooper AJ.

Adv Cancer Res. 2014;122:177-98. doi: 10.1016/B978-0-12-420117-0.00005-0.


Pleiotropic functions of glutathione S-transferase P.

Zhang J, Grek C, Ye ZW, Manevich Y, Tew KD, Townsend DM.

Adv Cancer Res. 2014;122:143-75. doi: 10.1016/B978-0-12-420117-0.00004-9.


Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome.

Manevich Y, Hutchens S, Halushka PV, Tew KD, Townsend DM, Jauch EC, Borg K.

Free Radic Biol Med. 2014 Jul;72:210-21. doi: 10.1016/j.freeradbiomed.2014.04.002. Epub 2014 Apr 12.


Causes and consequences of cysteine S-glutathionylation.

Grek CL, Zhang J, Manevich Y, Townsend DM, Tew KD.

J Biol Chem. 2013 Sep 13;288(37):26497-504. doi: 10.1074/jbc.R113.461368. Epub 2013 Jul 16. Review.


Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin.

Maldonado EN, Sheldon KL, DeHart DN, Patnaik J, Manevich Y, Townsend DM, Bezrukov SM, Rostovtseva TK, Lemasters JJ.

J Biol Chem. 2013 Apr 26;288(17):11920-9. doi: 10.1074/jbc.M112.433847. Epub 2013 Mar 7.


Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation.

Manevich Y, Hutchens S, Tew KD, Townsend DM.

Free Radic Biol Med. 2013 Jan;54:62-70. doi: 10.1016/j.freeradbiomed.2012.10.556. Epub 2012 Nov 6.


Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility.

Bowers RR, Manevich Y, Townsend DM, Tew KD.

Biochemistry. 2012 Oct 2;51(39):7740-54. doi: 10.1021/bi301006w. Epub 2012 Sep 19.


Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies.

Mack JT, Brown CB, Garrett TE, Uys JD, Townsend DM, Tew KD.

Biomed Pharmacother. 2012 Sep;66(6):403-8. doi: 10.1016/j.biopha.2012.06.007. Epub 2012 Jul 2.


S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function.

Xiong Y, Manevich Y, Tew KD, Townsend DM.

Int J Cell Biol. 2012;2012:273549. doi: 10.1155/2012/273549. Epub 2012 May 13.


Glutathione-s-transferases as determinants of cell survival and death.

Tew KD, Townsend DM.

Antioxid Redox Signal. 2012 Dec 15;17(12):1728-37. doi: 10.1089/ars.2012.4640. Epub 2012 Jun 13. Review.


S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs.

Grek CL, Townsend DM, Uys JD, Manevich Y, Coker WJ 3rd, Pazoles CJ, Tew KD.

Cancer Res. 2012 May 1;72(9):2383-93. doi: 10.1158/0008-5472.CAN-11-4088. Epub 2012 Mar 8.


Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.

Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T.

J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.


Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity.

Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW.

Neuropsychopharmacology. 2011 Nov;36(12):2551-60. doi: 10.1038/npp.2011.143. Epub 2011 Jul 27.


The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.

Tew KD, Manevich Y, Grek C, Xiong Y, Uys J, Townsend DM.

Free Radic Biol Med. 2011 Jul 15;51(2):299-313. doi: 10.1016/j.freeradbiomed.2011.04.013. Epub 2011 Apr 22. Review.


Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification.

Tew KD, Townsend DM.

Drug Metab Rev. 2011 May;43(2):179-93. doi: 10.3109/03602532.2011.552912. Epub 2011 Feb 25. Review.


Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase.

Uys JD, Xiong Y, Townsend DM.

Methods Enzymol. 2011;490:321-32. doi: 10.1016/B978-0-12-385114-7.00018-0.


S-glutathionylation: from molecular mechanisms to health outcomes.

Xiong Y, Uys JD, Tew KD, Townsend DM.

Antioxid Redox Signal. 2011 Jul 1;15(1):233-70. doi: 10.1089/ars.2010.3540. Epub 2011 May 25. Review.


Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase.

Manevich Y, Townsend DM, Hutchens S, Tew KD.

PLoS One. 2010 Nov 30;5(11):e14151. doi: 10.1371/journal.pone.0014151.


Redox platforms in cancer drug discovery and development.

Tew KD, Townsend DM.

Curr Opin Chem Biol. 2011 Feb;15(1):156-61. doi: 10.1016/j.cbpa.2010.10.016. Epub 2010 Nov 11. Review.


ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration.

Mack JT, Helke KL, Normand G, Green C, Townsend DM, Tew KD.

Cancer Lett. 2011 Jan 28;300(2):154-61. doi: 10.1016/j.canlet.2010.09.017. Epub 2010 Oct 30.


The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.

Grek CL, Townsend DM, Tew KD.

Pharmacol Ther. 2011 Feb;129(2):172-84. doi: 10.1016/j.pharmthera.2010.09.008. Epub 2010 Oct 15. Review.


Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic.

Uys JD, Manevich Y, Devane LC, He L, Garret TE, Pazoles CJ, Tew KD, Townsend DM.

Biomed Pharmacother. 2010 Sep;64(7):493-8. doi: 10.1016/j.biopha.2010.01.003. Epub 2010 Feb 24.

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