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Cystic artery pseudoaneurysm with haemobilia after laparoscopic cholecystectomy.

To K, Lai EC, Chung DT, Chan OC, Tang CN.

Hong Kong Med J. 2018 Apr;24(2):203-205. doi: 10.12809/hkmj176236. No abstract available.


Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity.

Zhou Y, Huang T, Zhang J, Cheng ASL, Yu J, Kang W, To KF.

Cancer Lett. 2018 Apr 11. pii: S0304-3835(18)30265-9. doi: 10.1016/j.canlet.2018.04.004. [Epub ahead of print]


The physiological role of Motin family and its dysregulation in tumorigenesis.

Huang T, Zhou Y, Zhang J, Cheng ASL, Yu J, To KF, Kang W.

J Transl Med. 2018 Apr 12;16(1):98. doi: 10.1186/s12967-018-1466-y. Review.


Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).

Ma BBY, Lim WT, Goh BC, Hui EP, Lo KW, Pettinger A, Foster NR, Riess JW, Agulnik M, Chang AYC, Chopra A, Kish JA, Chung CH, Adkins DR, Cullen KJ, Gitlitz BJ, Lim DW, To KF, Chan KCA, Lo YMD, King AD, Erlichman C, Yin J, Costello BA, Chan ATC.

J Clin Oncol. 2018 Mar 27:JCO2017770388. doi: 10.1200/JCO.2017.77.0388. [Epub ahead of print]


CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation.

Zhang Y, Wang S, Kang W, Liu C, Dong Y, Ren F, Wang Y, Zhang J, Wang G, To KF, Zhang X, Sung JJ, Chang Z, Yu J.

Oncogene. 2018 Mar 22. doi: 10.1038/s41388-018-0161-z. [Epub ahead of print]


Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Li X, Xu W, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To KF, Chan SL, Chan MTV, Sung JJY, Wu WKK, Yu J.

Theranostics. 2018 Feb 12;8(6):1740-1751. doi: 10.7150/thno.22010. eCollection 2018.


Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017.

Zhu H, Lee ACY, Li C, Mak WWN, Chen YY, Chan KH, Zhang AJX, Fung WF, Zhang RQ, Fung YF, Poon RWS, Lam JY, Tam S, Hung IFN, Chen H, Yuen KY, To KKW.

Emerg Microbes Infect. 2018 Mar 6;7(1):23. doi: 10.1038/s41426-018-0041-1.


ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.

Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM.

BMC Bioinformatics. 2018 Mar 5;19(1):80. doi: 10.1186/s12859-018-2089-2.


Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo.

Guo X, To KKW, Chen Z, Wang X, Zhang J, Luo M, Wang F, Yan S, Fu L.

J Exp Clin Cancer Res. 2018 Feb 20;37(1):31. doi: 10.1186/s13046-018-0690-x.


Rhinovirus respiratory tract infection in hospitalized adult patients is associated with TH2 response irrespective of asthma.

To KKW, Lu L, Fong CHY, Wu AKL, Mok KY, Yip CCY, Ke YH, Sze KH, Lau SKP, Hung IFN, Yuen KY.

J Infect. 2018 Feb 15. pii: S0163-4453(18)30058-6. doi: 10.1016/j.jinf.2018.02.005. [Epub ahead of print]


The role of human papillomavirus in laryngeal cancer in Southern China.

Lam EWH, Chan MMH, Wai CKC, Ngai CM, Chen Z, Wong MCS, Yeung ACM, Tong JHM, Chan ABW, To KF, Chan PKS.

J Med Virol. 2018 Jun;90(6):1150-1159. doi: 10.1002/jmv.25058. Epub 2018 Mar 6.


Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTime HCV Genotype II assay for hepatitis C genotyping.

Sridhar S, Yip CCY, Chan JFW, To KKW, Cheng VCC, Yuen KY.

Diagn Microbiol Infect Dis. 2018 May;91(1):34-37. doi: 10.1016/j.diagmicrobio.2017.12.024. Epub 2018 Jan 11.


PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy.

To KKW, Wu WKK, Loong HHF.

Eur J Pharmacol. 2018 Mar 15;823:19-26. doi: 10.1016/j.ejphar.2018.01.036. Epub 2018 Jan 31.


miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis.

Kang W, Huang T, Zhou Y, Zhang J, Lung RWM, Tong JHM, Chan AWH, Zhang B, Wong CC, Wu F, Dong Y, Wang S, Yang W, Pan Y, Chak WP, Cheung AHK, Pang JCS, Yu J, Cheng ASL, To KF.

Cell Death Dis. 2018 Jan 24;9(2):92. doi: 10.1038/s41419-017-0134-0.


A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro.

Tang PM, Tang PC, Chung JY, Hung JSC, Wang QM, Lian GY, Sheng J, Huang XR, To KF, Lan HY.

J Vis Exp. 2018 Jan 9;(131). doi: 10.3791/56785.


Flow and clog in a silo with oscillating exit.

To K, Tai HT.

Phys Rev E. 2017 Sep;96(3-1):032906. doi: 10.1103/PhysRevE.96.032906. Epub 2017 Sep 14.


GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer.

Ni YB, Tsang JYS, Shao MM, Chan SK, Cheung SY, Tong J, To KF, Tse GM.

Breast Cancer Res Treat. 2018 May;169(1):25-32. doi: 10.1007/s10549-017-4645-2. Epub 2018 Jan 16.


Molecular and functional characterization of tumor-induced factor (TIF): Hamster homolog of CXCL3 (GROγ) displays tumor suppressive activity.

Jin L, Li ZF, Wang DK, Sun M, Qi W, Ma Q, Zhang L, Chu C, Chan EYM, Lee SST, Wise H, To KF, Shi Y, Zhou N, Cheung WT.

Cytokine. 2018 Feb;102:62-75. doi: 10.1016/j.cyto.2017.12.019. Epub 2017 Dec 23.


Letter to the editor - Response to: Inspiring surgeons of the future: A school outreach event and possible solution to the imminent recruitment crisis.

Bartlett J, Kazzazi F, To K.

Int J Surg. 2018 Jan;49:93-94. doi: 10.1016/j.ijsu.2017.11.053. Epub 2017 Dec 13. No abstract available.


Identification of Clinically Approved Drugs Indacaterol and Canagliflozin for Repurposing to Treat Epidermal Growth Factor Tyrosine Kinase Inhibitor-Resistant Lung Cancer.

Li H, Tong CW, Leung Y, Wong MH, To KK, Leung KS.

Front Oncol. 2017 Nov 29;7:288. doi: 10.3389/fonc.2017.00288. eCollection 2017.


SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.

Huang T, Zhou Y, Zhang J, Wong CC, Li W, Kwan JSH, Yang R, Chan AKY, Dong Y, Wu F, Zhang B, Cheung AHK, Wu WKK, Cheng ASL, Yu J, Wong N, Kang W, To KF.

Oncogene. 2018 Mar;37(9):1159-1174. doi: 10.1038/s41388-017-0029-7. Epub 2017 Dec 13.


EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.

Lung RW, Hau PM, Yu KH, Yip KY, Tong JH, Chak WP, Chan AW, Lam KH, Lo AK, Tin EK, Chau SL, Pang JC, Kwan JS, Busson P, Young LS, Yap LF, Tsao SW, To KF, Lo KW.

J Pathol. 2018 Apr;244(4):394-407. doi: 10.1002/path.5018. Epub 2018 Feb 16.


Usefulness of Endoscopic Managements in Patients with Ceftriaxone-Induced Pseudolithiasis Causing Biliary Obstruction.

Doi Y, Takii Y, Ito H, Jingu N, To K, Kimura S, Kimura K, Sanefuji K, Ikeda H, Tachibana S, Otsuka T.

Case Rep Med. 2017;2017:3835825. doi: 10.1155/2017/3835825. Epub 2017 Nov 2.


Isolation of phage-display library-derived scFv antibody specific to Listeria monocytogenes by a novel immobilized method.

Nguyen XH, Trinh TL, Vu TB, Le QH, To KA.

J Appl Microbiol. 2018 Feb;124(2):591-597. doi: 10.1111/jam.13648.


Genomic profiles of nasopharyngeal carcinoma: The importance of histological subtyping and Epstein-Barr virus in situ assays.

Lui VWY, To KF, Lo KW.

Cancer. 2018 Jan 15;124(2):434-435. doi: 10.1002/cncr.31131. Epub 2017 Nov 22. No abstract available.


Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY.

Sci Adv. 2017 Nov 15;3(11):eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov.


Urachal sinus leading to pyourachus presenting as recurrent periumbilical sepsis in an infant.

To KW, Naidu L, Bilolikar H.

BMJ Case Rep. 2017 Nov 12;2017. pii: bcr-2017-222187. doi: 10.1136/bcr-2017-222187. No abstract available.


The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring.

Tang PM, Zhou S, Li CJ, Liao J, Xiao J, Wang QM, Lian GY, Li J, Huang XR, To KF, Ng CF, Chong CC, Ma RC, Lee TL, Lan HY.

Kidney Int. 2018 Jan;93(1):173-187. doi: 10.1016/j.kint.2017.07.026. Epub 2017 Oct 14.


The oncogenic role of Epstein-Barr virus-encoded microRNAs in Epstein-Barr virus-associated gastric carcinoma.

Zhang J, Huang T, Zhou Y, Cheng ASL, Yu J, To KF, Kang W.

J Cell Mol Med. 2018 Jan;22(1):38-45. doi: 10.1111/jcmm.13354. Epub 2017 Oct 9. Review.


Epstein-Barr virus-driven promoter hypermethylated genes in gastric cancer.

Yu J, To KF, Liang QY.

Hong Kong Med J. 2017 Aug;23 Suppl 5(4):17-22. No abstract available.


Human papillomavirus infection and squamous cell carcinoma in Hong Kong: a case-control study.

Chan PK, To KF, Tsang SH, Lau CH, Kwong WH, Chan YH.

Hong Kong Med J. 2017 Aug;23 Suppl 5(4):8-11. No abstract available.


Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS.

Gut. 2018 May;67(5):931-944. doi: 10.1136/gutjnl-2017-314032. Epub 2017 Sep 22.


The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma.

Zhang B, Zhang Y, Zou X, Chan AW, Zhang R, Lee TK, Liu H, Lau EY, Ho NP, Lai PB, Cheung YS, To KF, Wong HK, Choy KW, Keng VW, Chow LM, Chan KK, Cheng AS, Ko BC.

J Pathol. 2017 Dec;243(4):418-430. doi: 10.1002/path.4976. Epub 2017 Oct 27.


Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.

Wang X, Zhang X, Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chan HLY, Chan MTV, Sung JJY, Wu WKK, Yu J.

FASEB J. 2018 Jan;32(1):37-51. doi: 10.1096/fj.201601393R. Epub 2017 Aug 25.


The large tumor suppressor family: friend or foe?

Kang W, Zhou Y, To KF.

J Thorac Dis. 2017 Jul;9(7):1748-1751. doi: 10.21037/jtd.2017.06.26. No abstract available.


Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics.

Tsang JCH, Vong JSL, Ji L, Poon LCY, Jiang P, Lui KO, Ni YB, To KF, Cheng YKY, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7786-E7795. doi: 10.1073/pnas.1710470114. Epub 2017 Aug 22.


CUDC-907, a dual HDAC and PI3K inhibitor, reverses platinum drug resistance.

To KKW, Fu LW.

Invest New Drugs. 2018 Feb;36(1):10-19. doi: 10.1007/s10637-017-0501-9. Epub 2017 Aug 17.


Albumin-bilirubin grade predicts the outcomes of liver resection versus radiofrequency ablation for very early/early stage of hepatocellular carcinoma.

Chong CC, Chan AW, Wong J, Chu CM, Chan SL, Lee KF, Yu SC, To KF, Johnson P, Lai PB.

Surgeon. 2017 Aug 11. pii: S1479-666X(17)30112-9. doi: 10.1016/j.surge.2017.07.003. [Epub ahead of print]


Drug combination approach to overcome resistance to EGFR tyrosine kinase inhibitors in lung cancer.

Tong CWS, Wu WKK, Loong HHF, Cho WCS, To KKW.

Cancer Lett. 2017 Oct 1;405:100-110. doi: 10.1016/j.canlet.2017.07.023. Epub 2017 Jul 31. Review.


TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.

Zhou Y, Huang T, Zhang J, Wong CC, Zhang B, Dong Y, Wu F, Tong JHM, Wu WKK, Cheng ASL, Yu J, Kang W, To KF.

Oncogene. 2017 Nov 23;36(47):6518-6530. doi: 10.1038/onc.2017.257. Epub 2017 Jul 31.


Candidatus Dirofilaria hongkongensis as Causative Agent of Human Ocular Filariosis after Travel to India.

Winkler S, Pollreisz A, Georgopoulos M, Bagò-Horvath Z, Auer H, To KK, Krücken J, Poppert S, Walochnik J.

Emerg Infect Dis. 2017 Aug;23(8):1428-1431. doi: 10.3201/eid2308.170423.


The use of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange in 17 cases of subglottic stenosis.

To K, Harding F, Scott M, Milligan P, Nixon IJ, Adamson R, McNarry AF.

Clin Otolaryngol. 2017 Dec;42(6):1407-1410. doi: 10.1111/coa.12921. Epub 2017 Sep 7. No abstract available.


Topical Application of Mesenchymal Stromal Cells Ameliorated Liver Parenchyma Damage After Ischemia-Reperfusion Injury in an Animal Model.

Lam PK, Chong CCN, Lo AWI, Chan AWH, Tong CSW, Chin DWC, Wong KHK, Choy RKW, Fung AK, Wang YX, To KF, Lai PBS.

Transplant Direct. 2017 May 11;3(6):e160. doi: 10.1097/TXD.0000000000000675. eCollection 2017 Jun.


Additional molecular testing of saliva specimens improves the detection of respiratory viruses.

To KK, Lu L, Yip CC, Poon RW, Fung AM, Cheng A, Lui DH, Ho DT, Hung IF, Chan KH, Yuen KY.

Emerg Microbes Infect. 2017 Jun 7;6(6):e49. doi: 10.1038/emi.2017.35.


Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes.

Lee ACY, To KKW, Zhu H, Chu H, Li C, Mak WWN, Zhang AJX, Yuen KY.

J Gen Virol. 2017 May;98(5):922-934. doi: 10.1099/jgv.0.000751. Epub 2017 May 30.


Predictions of space radiation fatality risk for exploration missions.

Cucinotta FA, To K, Cacao E.

Life Sci Space Res (Amst). 2017 May;13:1-11. doi: 10.1016/j.lssr.2017.01.005. Epub 2017 Feb 1.


Individualized homeopathic treatment in addition to conventional treatment in type II diabetic patients in Hong Kong - a retrospective cohort study.

To KLA, Fok YYY, Chong KCM, Lee YCJ, Yiu LSS.

Homeopathy. 2017 May;106(2):79-86. doi: 10.1016/j.homp.2017.02.002. Epub 2017 Mar 17.


High prevalence of four novel astrovirus genotype species identified from rodents in China.

To KKW, Chan WM, Li KSM, Lam CSF, Chen Z, Tse H, Lau SKP, Woo PCY, Yuen KY.

J Gen Virol. 2017 May;98(5):1004-1015. doi: 10.1099/jgv.0.000766. Epub 2017 May 25.


Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial.

Georgoff PE, Nikolian VC, Bonham T, Pai MP, Tafatia C, Halaweish I, To K, Watcharotone K, Parameswaran A, Luo R, Sun D, Alam HB.

Clin Pharmacokinet. 2018 Feb;57(2):209-219. doi: 10.1007/s40262-017-0553-1.

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