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Items: 1 to 50 of 111

1.

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength.

Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ.

Biophys J. 2017 Feb 28;112(4):736-745. doi: 10.1016/j.bpj.2016.12.038.

2.

Introducing cancer convergence.

Blagoev KB, Ting DT, Levine H, Saenger Y, Tlsty TD, Sun B.

Cancer Converg. 2017;1(1):3. doi: 10.1186/s41236-017-0003-x. Epub 2017 Nov 1. No abstract available.

3.

SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73.

Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD.

Cell Signal. 2016 Dec;28(12):1923-1932. doi: 10.1016/j.cellsig.2016.09.008. Epub 2016 Oct 2.

4.

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.

Gascard P, Tlsty TD.

Genes Dev. 2016 May 1;30(9):1002-19. doi: 10.1101/gad.279737.116. Review.

5.

Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy.

Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K.

Breast Cancer Res Treat. 2016 Jun;157(2):351-361. doi: 10.1007/s10549-016-3814-z. Epub 2016 May 4.

PMID:
27146587
6.

Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.

Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL.

Sci Rep. 2015 Oct 16;5:15153. doi: 10.1038/srep15153.

7.

Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.

Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF.

Org Biomol Chem. 2015 Dec 7;13(45):11078-86. doi: 10.1039/c5ob01805f. Epub 2015 Sep 24.

8.

Integrative analysis of 111 reference human epigenomes.

Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M.

Nature. 2015 Feb 19;518(7539):317-30. doi: 10.1038/nature14248.

9.

Intermediate DNA methylation is a conserved signature of genome regulation.

Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, Milosavljevic A, Hirst M, Stormo GD, Wang T, Costello JF.

Nat Commun. 2015 Feb 18;6:6363. doi: 10.1038/ncomms7363.

10.

Epigenetic and transcriptional determinants of the human breast.

Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M.

Nat Commun. 2015 Feb 18;6:6351. doi: 10.1038/ncomms7351.

11.

Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.

Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB.

Nat Commun. 2014 Nov 25;5:5442. doi: 10.1038/ncomms6442.

12.

Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.

DeFilippis RA, Fordyce C, Patten K, Chang H, Zhao J, Fontenay GV, Kerlikowske K, Parvin B, Tlsty TD.

Cancer Res. 2014 Sep 15;74(18):5032-5044. doi: 10.1158/0008-5472.CAN-13-3390. Epub 2014 Aug 29.

13.
14.

Evolutionary game theory for physical and biological scientists. I. Training and validating population dynamics equations.

Liao D, Tlsty TD.

Interface Focus. 2014 Aug 6;4(4):20140037. doi: 10.1098/rsfs.2014.0037. Review.

15.

Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment.

Wu A, Liao D, Tlsty TD, Sturm JC, Austin RH.

Interface Focus. 2014 Aug 6;4(4):20140028. doi: 10.1098/rsfs.2014.0028.

16.

Cell motility and drug gradients in the emergence of resistance to chemotherapy.

Wu A, Loutherback K, Lambert G, Estévez-Salmerón L, Tlsty TD, Austin RH, Sturm JC.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16103-8. doi: 10.1073/pnas.1314385110. Epub 2013 Sep 17.

17.

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.

Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Maire CL, Ligon KL, Madden PA, Tam A, Moore R, Hirst M, Marra MA, Zhang B, Costello JF, Wang T.

Genome Res. 2013 Sep;23(9):1522-40. doi: 10.1101/gr.156539.113. Epub 2013 Jun 26.

18.

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.

Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T.

Nat Genet. 2013 Jul;45(7):836-41. doi: 10.1038/ng.2649. Epub 2013 May 26.

19.

Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response.

López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM.

Mol Cell. 2013 May 23;50(4):552-64. doi: 10.1016/j.molcel.2013.04.029.

20.

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep. 2013;3:1449. doi: 10.1038/srep01449.

21.

Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.

Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4598-603. doi: 10.1073/pnas.1218682110. Epub 2013 Mar 4.

22.

Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.

Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD.

Neoplasia. 2013 Mar;15(3):249-62.

23.

Hello out there...is anybody listening?

DeFilippis RA, Tlsty TD.

Cancer Discov. 2012 Dec;2(12):1084-6. doi: 10.1158/2159-8290.CD-12-0434.

24.

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.

Fordyce CA, Patten KT, Fessenden TB, DeFilippis R, Hwang ES, Zhao J, Tlsty TD.

Breast Cancer Res. 2012 Dec 7;14(6):R155. doi: 10.1186/bcr3368.

25.

Generalized principles of stochasticity can be used to control dynamic heterogeneity.

Liao D, Estévez-Salmerón L, Tlsty TD.

Phys Biol. 2012 Dec;9(6):065006. doi: 10.1088/1478-3975/9/6/065006. Epub 2012 Nov 29.

26.

Conceptualizing a tool to optimize therapy based on dynamic heterogeneity.

Liao D, Estévez-Salmerón L, Tlsty TD.

Phys Biol. 2012 Dec;9(6):065005. doi: 10.1088/1478-3975/9/6/065005. Epub 2012 Nov 29.

27.

CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues.

DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, Parvin B, Tlsty TD.

Cancer Discov. 2012 Sep;2(9):826-39. Epub 2012 Jul 9.

28.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S.

Nature. 2012 Apr 4;486(7403):395-9. doi: 10.1038/nature10933.

29.

p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia.

Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC.

Cancer Prev Res (Phila). 2011 Dec;4(12):1953-60. doi: 10.1158/1940-6207.CAPR-11-0282. Epub 2011 Sep 15.

30.

Tissue states provide novel insights into attributes that drive metastasis.

Tlsty TD.

Cancer Cell. 2011 Sep 13;20(3):285-6. doi: 10.1016/j.ccr.2011.08.018.

31.

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.

Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH.

Nat Rev Cancer. 2011 May;11(5):375-82. doi: 10.1038/nrc3039. Review.

32.

Tumor microenvironment and progression.

Dvorak HF, Weaver VM, Tlsty TD, Bergers G.

J Surg Oncol. 2011 May 1;103(6):468-74. doi: 10.1002/jso.21709. Review.

33.

A twist of cell fate.

Tlsty TD.

Cell Stem Cell. 2011 Feb 4;8(2):126-7. doi: 10.1016/j.stem.2011.01.004.

34.

Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis.

Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD.

J Natl Cancer Inst. 2010 May 5;102(9):627-37. doi: 10.1093/jnci/djq101. Epub 2010 Apr 28. Erratum in: J Natl Cancer Inst. 2010 Jul 7;102(13):993.

35.

Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications.

Berman HK, Gauthier ML, Tlsty TD.

Cancer Prev Res (Phila). 2010 May;3(5):579-87. doi: 10.1158/1940-6207.CAPR-10-0073. Epub 2010 Apr 27. Review.

36.

Primary cilia regulate branching morphogenesis during mammary gland development.

McDermott KM, Liu BY, Tlsty TD, Pazour GJ.

Curr Biol. 2010 Apr 27;20(8):731-7. doi: 10.1016/j.cub.2010.02.048. Epub 2010 Apr 8.

37.

Unprecedented opportunities and promise for cancer prevention research.

Blackburn EH, Tlsty TD, Lippman SM.

Cancer Prev Res (Phila). 2010 Apr;3(4):394-402. doi: 10.1158/1940-6207.CAPR-10-0051. Epub 2010 Mar 30.

38.

DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.

Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T.

Cancer Prev Res (Phila). 2010 Feb;3(2):190-201. doi: 10.1158/1940-6207.CAPR-09-0229. Epub 2009 Dec 22.

39.

Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.

Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S, Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD.

Breast Cancer Res. 2009;11(6):R87. doi: 10.1186/bcr2457. Epub 2009 Dec 8.

40.

Reflections on miR-ing effects in metastasis.

Dumont N, Tlsty TD.

Cancer Cell. 2009 Jul 7;16(1):3-4. doi: 10.1016/j.ccr.2009.06.013.

41.

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers.

Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14867-72. doi: 10.1073/pnas.0807146105. Epub 2008 Sep 19.

42.

Graphical methods for quantifying macromolecules through bright field imaging.

Chang H, DeFilippis RA, Tlsty TD, Parvin B.

Bioinformatics. 2009 Apr 15;25(8):1070-5. doi: 10.1093/bioinformatics/btn426. Epub 2008 Aug 14.

43.

Cancer: whispering sweet somethings.

Tlsty T.

Nature. 2008 May 29;453(7195):604-5. doi: 10.1038/453604a. No abstract available.

PMID:
18509432
44.

Tumor stroma and regulation of cancer development.

Tlsty TD, Coussens LM.

Annu Rev Pathol. 2006;1:119-50. Review.

PMID:
18039110
45.

Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.

Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC Jr, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL.

Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6834-41.

46.

Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors.

Gauthier ML, Berman HK, Miller C, Kozakeiwicz K, Chew K, Moore D, Rabban J, Chen YY, Kerlikowske K, Tlsty TD.

Cancer Cell. 2007 Nov;12(5):479-91.

47.

Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.

Garbe JC, Holst CR, Bassett E, Tlsty T, Stampfer MR.

Cell Cycle. 2007 Aug 1;6(15):1927-36. Epub 2007 May 30.

PMID:
17671422
48.

Stratification of breast cancer risk in women with atypia: a Mayo cohort study.

Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, Maloney SD, Pankratz VS, de Groen PC, Lingle WL, Ghosh K, Penheiter L, Tlsty T, Melton LJ 3rd, Reynolds CA, Hartmann LC.

J Clin Oncol. 2007 Jul 1;25(19):2671-7. Epub 2007 Jun 11.

PMID:
17563394
49.

Luminal cells GATA have it.

Tlsty TD.

Nat Cell Biol. 2007 Feb;9(2):135-6. No abstract available.

PMID:
17268476
50.

p16INK4a modulates p53 in primary human mammary epithelial cells.

Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD.

Cancer Res. 2006 Nov 1;66(21):10325-31.

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