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Items: 8

1.

Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.

Iwai K, Yaguchi M, Nishimura K, Yamamoto Y, Tamura T, Nakata D, Dairiki R, Kawakita Y, Mizojiri R, Ito Y, Asano M, Maezaki H, Nakayama Y, Kaishima M, Hayashi K, Teratani M, Miyakawa S, Iwatani M, Miyamoto M, Klein MG, Lane W, Snell G, Tjhen R, He X, Pulukuri S, Nomura T.

EMBO Mol Med. 2018 May 16. pii: e8289. doi: 10.15252/emmm.201708289. [Epub ahead of print]

2.

Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.

Iwatani-Yoshihara M, Ito M, Klein MG, Yamamoto T, Yonemori K, Tanaka T, Miwa M, Morishita D, Endo S, Tjhen R, Qin L, Nakanishi A, Maezaki H, Kawamoto T.

J Med Chem. 2017 Jul 13;60(13):5759-5771. doi: 10.1021/acs.jmedchem.7b00461. Epub 2017 Jun 20.

PMID:
28586220
3.

Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes.

Lanier M, Cole DC, Istratiy Y, Klein MG, Schwartz PA, Tjhen R, Jennings A, Hixon MS.

J Med Chem. 2017 Jun 22;60(12):5209-5215. doi: 10.1021/acs.jmedchem.6b01224. Epub 2017 Jun 9.

4.

Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms.

Du Z, Fenn S, Tjhen R, James TL.

J Biol Chem. 2008 Oct 17;283(42):28757-66. doi: 10.1074/jbc.M803046200. Epub 2008 Aug 13.

5.

Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage.

Du Z, Lee JK, Tjhen R, Stroud RM, James TL.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2391-6. doi: 10.1073/pnas.0711506105. Epub 2008 Feb 11.

6.
7.

Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.

Fenn S, Du Z, Lee JK, Tjhen R, Stroud RM, James TL.

Nucleic Acids Res. 2007;35(8):2651-60. Epub 2007 Apr 10.

8.

Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A.

Du Z, Lee JK, Tjhen R, Li S, Pan H, Stroud RM, James TL.

J Biol Chem. 2005 Nov 18;280(46):38823-30. Epub 2005 Sep 25.

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