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Items: 1 to 50 of 83

1.

Genetic hitchhiking and population bottlenecks contribute to prostate cancer disparities in men of African descent.

Lachance J, Berens AJ, Hansen MEB, Teng AK, Tishkoff SA, Rebbeck TR.

Cancer Res. 2018 Feb 8. pii: canres.1550.2017. doi: 10.1158/0008-5472.CAN-17-1550. [Epub ahead of print]

PMID:
29438991
2.

Divergent Patterns of Mitochondrial and Nuclear Ancestry Are Associated with the Risk for Preterm Birth.

Crawford N, Prendergast D, Oehlert JW, Shaw GM, Stevenson DK, Rappaport N, Sirota M, Tishkoff SA, Sondheimer N.

J Pediatr. 2017 Dec 13. pii: S0022-3476(17)31463-4. doi: 10.1016/j.jpeds.2017.10.052. [Epub ahead of print]

PMID:
29249523
3.

Loci associated with skin pigmentation identified in African populations.

Crawford NG, Kelly DE, Hansen MEB, Beltrame MH, Fan S, Bowman SL, Jewett E, Ranciaro A, Thompson S, Lo Y, Pfeifer SP, Jensen JD, Campbell MC, Beggs W, Hormozdiari F, Mpoloka SW, Mokone GG, Nyambo T, Meskel DW, Belay G, Haut J; NISC Comparative Sequencing Program, Rothschild H, Zon L, Zhou Y, Kovacs MA, Xu M, Zhang T, Bishop K, Sinclair J, Rivas C, Elliot E, Choi J, Li SA, Hicks B, Burgess S, Abnet C, Watkins-Chow DE, Oceana E, Song YS, Eskin E, Brown KM, Marks MS, Loftus SK, Pavan WJ, Yeager M, Chanock S, Tishkoff SA.

Science. 2017 Nov 17;358(6365). pii: eaan8433. doi: 10.1126/science.aan8433. Epub 2017 Oct 12.

PMID:
29025994
4.

Global variation in gene expression and the value of diverse sampling.

Kelly DE, Hansen MEB, Tishkoff SA.

Curr Opin Syst Biol. 2017 Feb;1:102-108. doi: 10.1016/j.coisb.2016.12.018. Epub 2017 Mar 3.

5.

Going global by adapting local: A review of recent human adaptation.

Fan S, Hansen ME, Lo Y, Tishkoff SA.

Science. 2016 Oct 7;354(6308):54-59. Review.

6.

Inferences of African evolutionary history from genomic data.

Beltrame MH, Rubel MA, Tishkoff SA.

Curr Opin Genet Dev. 2016 Dec;41:159-166. doi: 10.1016/j.gde.2016.10.002. Epub 2016 Nov 1. Review.

7.

Shorter telomere length in Europeans than in Africans due to polygenetic adaptation.

Hansen ME, Hunt SC, Stone RC, Horvath K, Herbig U, Ranciaro A, Hirbo J, Beggs W, Reiner AP, Wilson JG, Kimura M, De Vivo I, Chen MM, Kark JD, Levy D, Nyambo T, Tishkoff SA, Aviv A.

Hum Mol Genet. 2016 Jun 1;25(11):2324-2330. Epub 2016 Mar 2.

8.

The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.

Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D.

Nature. 2016 Oct 13;538(7624):201-206. doi: 10.1038/nature18964. Epub 2016 Sep 21.

9.

Telomere Length and the Cancer-Atherosclerosis Trade-Off.

Stone RC, Horvath K, Kark JD, Susser E, Tishkoff SA, Aviv A.

PLoS Genet. 2016 Jul 7;12(7):e1006144. doi: 10.1371/journal.pgen.1006144. eCollection 2016 Jul. Review.

10.

Corrigendum: Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies.

Hsieh P, Woerner AE, Wall JD, Lachance J, Tishkoff SA, Gutenkunst RN, Hammer MF.

Genome Res. 2016 May;26(5):717.1. doi: 10.1101/gr.206524.116. No abstract available.

11.

A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals.

Sobota RS, Stein CM, Kodaman N, Scheinfeldt LB, Maro I, Wieland-Alter W, Igo RP Jr, Magohe A, Malone LL, Chervenak K, Hall NB, Modongo C, Zetola N, Matee M, Joloba M, Froment A, Nyambo TB, Moore JH, Scott WK, Lahey T, Boom WH, von Reyn CF, Tishkoff SA, Sirugo G, Williams SM.

Am J Hum Genet. 2016 Mar 3;98(3):514-524. doi: 10.1016/j.ajhg.2016.01.015.

12.

Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies.

Hsieh P, Woerner AE, Wall JD, Lachance J, Tishkoff SA, Gutenkunst RN, Hammer MF.

Genome Res. 2016 Mar;26(3):291-300. doi: 10.1101/gr.196634.115. Epub 2016 Feb 17. Erratum in: Genome Res. 2016 May;26(5):717.1.

13.

Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection.

Hsieh P, Veeramah KR, Lachance J, Tishkoff SA, Wall JD, Hammer MF, Gutenkunst RN.

Genome Res. 2016 Mar;26(3):279-90. doi: 10.1101/gr.192971.115. Epub 2016 Feb 17.

14.

Global diversity, population stratification, and selection of human copy-number variation.

Sudmant PH, Mallick S, Nelson BJ, Hormozdiari F, Krumm N, Huddleston J, Coe BP, Baker C, Nordenfelt S, Bamshad M, Jorde LB, Posukh OL, Sahakyan H, Watkins WS, Yepiskoposyan L, Abdullah MS, Bravi CM, Capelli C, Hervig T, Wee JT, Tyler-Smith C, van Driem G, Romero IG, Jha AR, Karachanak-Yankova S, Toncheva D, Comas D, Henn B, Kivisild T, Ruiz-Linares A, Sajantila A, Metspalu E, Parik J, Villems R, Starikovskaya EB, Ayodo G, Beall CM, Di Rienzo A, Hammer MF, Khusainova R, Khusnutdinova E, Klitz W, Winkler C, Labuda D, Metspalu M, Tishkoff SA, Dryomov S, Sukernik R, Patterson N, Reich D, Eichler EE.

Science. 2015 Sep 11;349(6253):aab3761. doi: 10.1126/science.aab3761. Epub 2015 Aug 6.

15.

The peopling of the African continent and the diaspora into the new world.

Campbell MC, Hirbo JB, Townsend JP, Tishkoff SA.

Curr Opin Genet Dev. 2014 Dec;29:120-32. Review.

16.

Population Genomics of Human Adaptation.

Lachance J, Tishkoff SA.

Annu Rev Ecol Evol Syst. 2013 Nov;44:123-143.

17.

Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles.

Lachance J, Tishkoff SA.

Am J Hum Genet. 2014 Oct 2;95(4):408-20. doi: 10.1016/j.ajhg.2014.09.008.

18.

Ancient human genomes suggest three ancestral populations for present-day Europeans.

Lazaridis I, Patterson N, Mittnik A, Renaud G, Mallick S, Kirsanow K, Sudmant PH, Schraiber JG, Castellano S, Lipson M, Berger B, Economou C, Bollongino R, Fu Q, Bos KI, Nordenfelt S, Li H, de Filippo C, Prüfer K, Sawyer S, Posth C, Haak W, Hallgren F, Fornander E, Rohland N, Delsate D, Francken M, Guinet JM, Wahl J, Ayodo G, Babiker HA, Bailliet G, Balanovska E, Balanovsky O, Barrantes R, Bedoya G, Ben-Ami H, Bene J, Berrada F, Bravi CM, Brisighelli F, Busby GB, Cali F, Churnosov M, Cole DE, Corach D, Damba L, van Driem G, Dryomov S, Dugoujon JM, Fedorova SA, Gallego Romero I, Gubina M, Hammer M, Henn BM, Hervig T, Hodoglugil U, Jha AR, Karachanak-Yankova S, Khusainova R, Khusnutdinova E, Kittles R, Kivisild T, Klitz W, Kučinskas V, Kushniarevich A, Laredj L, Litvinov S, Loukidis T, Mahley RW, Melegh B, Metspalu E, Molina J, Mountain J, Näkkäläjärvi K, Nesheva D, Nyambo T, Osipova L, Parik J, Platonov F, Posukh O, Romano V, Rothhammer F, Rudan I, Ruizbakiev R, Sahakyan H, Sajantila A, Salas A, Starikovskaya EB, Tarekegn A, Toncheva D, Turdikulova S, Uktveryte I, Utevska O, Vasquez R, Villena M, Voevoda M, Winkler CA, Yepiskoposyan L, Zalloua P, Zemunik T, Cooper A, Capelli C, Thomas MG, Ruiz-Linares A, Tishkoff SA, Singh L, Thangaraj K, Villems R, Comas D, Sukernik R, Metspalu M, Meyer M, Eichler EE, Burger J, Slatkin M, Pääbo S, Kelso J, Reich D, Krause J.

Nature. 2014 Sep 18;513(7518):409-13. doi: 10.1038/nature13673.

19.

Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers.

Rawlings-Goss RA, Campbell MC, Tishkoff SA.

BMC Med Genomics. 2014 Aug 28;7:53. doi: 10.1186/1755-8794-7-53.

20.

Genetic variation and adaptation in Africa: implications for human evolution and disease.

Gomez F, Hirbo J, Tishkoff SA.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a008524. doi: 10.1101/cshperspect.a008524. Review.

21.

Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.

Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA.

J Hum Genet. 2014 Jun;59(6):349-52. doi: 10.1038/jhg.2014.29. Epub 2014 May 1.

22.

Genetic origins of lactase persistence and the spread of pastoralism in Africa.

Ranciaro A, Campbell MC, Hirbo JB, Ko WY, Froment A, Anagnostou P, Kotze MJ, Ibrahim M, Nyambo T, Omar SA, Tishkoff SA.

Am J Hum Genet. 2014 Apr 3;94(4):496-510. doi: 10.1016/j.ajhg.2014.02.009. Epub 2014 Mar 13.

23.

Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.

Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA.

Mol Biol Evol. 2014 Feb;31(2):288-302. doi: 10.1093/molbev/mst211. Epub 2013 Oct 30.

24.

Apparent variation in Neanderthal admixture among African populations is consistent with gene flow from Non-African populations.

Wang S, Lachance J, Tishkoff SA, Hey J, Xing J.

Genome Biol Evol. 2013;5(11):2075-81. doi: 10.1093/gbe/evt160.

25.

Recent human adaptation: genomic approaches, interpretation and insights.

Scheinfeldt LB, Tishkoff SA.

Nat Rev Genet. 2013 Oct;14(10):692-702. doi: 10.1038/nrg3604. Review.

26.

Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study.

Elbers CC, Garcia ME, Kimura M, Cummings SR, Nalls MA, Newman AB, Park V, Sanders JL, Tranah GJ, Tishkoff SA, Harris TB, Aviv A.

J Gerontol A Biol Sci Med Sci. 2014 May;69(5):527-31. doi: 10.1093/gerona/glt121. Epub 2013 Aug 14.

27.

SNP ascertainment bias in population genetic analyses: why it is important, and how to correct it.

Lachance J, Tishkoff SA.

Bioessays. 2013 Sep;35(9):780-6. doi: 10.1002/bies.201300014. Epub 2013 Jul 9. Review.

28.

Great ape genetic diversity and population history.

Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor TD, Santpere G, Cagan A, Theunert C, Casals F, Laayouni H, Munch K, Hobolth A, Halager AE, Malig M, Hernandez-Rodriguez J, Hernando-Herraez I, Prüfer K, Pybus M, Johnstone L, Lachmann M, Alkan C, Twigg D, Petit N, Baker C, Hormozdiari F, Fernandez-Callejo M, Dabad M, Wilson ML, Stevison L, Camprubí C, Carvalho T, Ruiz-Herrera A, Vives L, Mele M, Abello T, Kondova I, Bontrop RE, Pusey A, Lankester F, Kiyang JA, Bergl RA, Lonsdorf E, Myers S, Ventura M, Gagneux P, Comas D, Siegismund H, Blanc J, Agueda-Calpena L, Gut M, Fulton L, Tishkoff SA, Mullikin JC, Wilson RK, Gut IG, Gonder MK, Ryder OA, Hahn BH, Navarro A, Akey JM, Bertranpetit J, Reich D, Mailund T, Schierup MH, Hvilsom C, Andrés AM, Wall JD, Bustamante CD, Hammer MF, Eichler EE, Marques-Bonet T.

Nature. 2013 Jul 25;499(7459):471-5. doi: 10.1038/nature12228. Epub 2013 Jul 3.

29.

Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations.

Ko WY, Rajan P, Gomez F, Scheinfeldt L, An P, Winkler CA, Froment A, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA.

Am J Hum Genet. 2013 Jul 11;93(1):54-66. doi: 10.1016/j.ajhg.2013.05.014. Epub 2013 Jun 13. Erratum in: Am J Hum Genet. 2013 Jul 11;93(1):191. An, Ping [added]; Winkler, Cheryl A [added].

30.

Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure.

Gomez F, Tomas G, Ko WY, Ranciaro A, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Hirbo JB, Rocha J, Tishkoff SA.

Hum Genet. 2013 Sep;132(9):987-99. doi: 10.1007/s00439-013-1284-5. Epub 2013 Apr 23.

31.

The genetic prehistory of southern Africa.

Pickrell JK, Patterson N, Barbieri C, Berthold F, Gerlach L, Güldemann T, Kure B, Mpoloka SW, Nakagawa H, Naumann C, Lipson M, Loh PR, Lachance J, Mountain J, Bustamante CD, Berger B, Tishkoff SA, Henn BM, Stoneking M, Reich D, Pakendorf B.

Nat Commun. 2012;3:1143. doi: 10.1038/ncomms2140.

32.

Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers.

Lachance J, Vernot B, Elbers CC, Ferwerda B, Froment A, Bodo JM, Lema G, Fu W, Nyambo TB, Rebbeck TR, Zhang K, Akey JM, Tishkoff SA.

Cell. 2012 Aug 3;150(3):457-69. doi: 10.1016/j.cell.2012.07.009. Epub 2012 Jul 26.

33.

Structural diversity and African origin of the 17q21.31 inversion polymorphism.

Steinberg KM, Antonacci F, Sudmant PH, Kidd JM, Campbell CD, Vives L, Malig M, Scheinfeldt L, Beggs W, Ibrahim M, Lema G, Nyambo TB, Omar SA, Bodo JM, Froment A, Donnelly MP, Kidd KK, Tishkoff SA, Eichler EE.

Nat Genet. 2012 Jul 1;44(8):872-80. doi: 10.1038/ng.2335.

34.

Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.

Wang X, Mitra N, Secundino I, Banda K, Cruz P, Padler-Karavani V, Verhagen A, Reid C, Lari M, Rizzi E, Balsamo C, Corti G, De Bellis G, Longo L; NISC Comparative Sequencing Program, Beggs W, Caramelli D, Tishkoff SA, Hayakawa T, Green ED, Mullikin JC, Nizet V, Bui J, Varki A.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9935-40. doi: 10.1073/pnas.1119459109. Epub 2012 Jun 4.

35.

Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies.

Jarvis JP, Scheinfeldt LB, Soi S, Lambert C, Omberg L, Ferwerda B, Froment A, Bodo JM, Beggs W, Hoffman G, Mezey J, Tishkoff SA.

PLoS Genet. 2012;8(4):e1002641. doi: 10.1371/journal.pgen.1002641. Epub 2012 Apr 26.

36.

A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta.

Cabral WA, Barnes AM, Adeyemo A, Cushing K, Chitayat D, Porter FD, Panny SR, Gulamali-Majid F, Tishkoff SA, Rebbeck TR, Gueye SM, Bailey-Wilson JE, Brody LC, Rotimi CN, Marini JC.

Genet Med. 2012 May;14(5):543-51. doi: 10.1038/gim.2011.44. Epub 2012 Jan 26.

37.

Human evolutionary genomics: ethical and interpretive issues.

Vitti JJ, Cho MK, Tishkoff SA, Sabeti PC.

Trends Genet. 2012 Mar;28(3):137-45. doi: 10.1016/j.tig.2011.12.001. Epub 2012 Jan 20. Review. Erratum in: Trends Genet. 2012 Aug;28(8):417.

38.

Genetic adaptation to high altitude in the Ethiopian highlands.

Scheinfeldt LB, Soi S, Thompson S, Ranciaro A, Woldemeskel D, Beggs W, Lambert C, Jarvis JP, Abate D, Belay G, Tishkoff SA.

Genome Biol. 2012 Jan 20;13(1):R1. doi: 10.1186/gb-2012-13-1-r1.

39.

Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa.

Campbell MC, Ranciaro A, Froment A, Hirbo J, Omar S, Bodo JM, Nyambo T, Lema G, Zinshteyn D, Drayna D, Breslin PA, Tishkoff SA.

Mol Biol Evol. 2012 Apr;29(4):1141-53. doi: 10.1093/molbev/msr293. Epub 2011 Nov 29.

40.

Haplotype variation and genotype imputation in African populations.

Huang L, Jakobsson M, Pemberton TJ, Ibrahim M, Nyambo T, Omar S, Pritchard JK, Tishkoff SA, Rosenberg NA.

Genet Epidemiol. 2011 Dec;35(8):766-80. doi: 10.1002/gepi.20626.

41.

Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.

Mortensen HM, Froment A, Lema G, Bodo JM, Ibrahim M, Nyambo TB, Omar SA, Tishkoff SA.

Pharmacogenomics. 2011 Nov;12(11):1545-58. doi: 10.2217/pgs.11.88. Epub 2011 Oct 13.

42.

Exploring genomic studies in Africa.

Williams SM, Tishkoff SA.

Genome Med. 2011 Jul 8;3(7):45. doi: 10.1186/gm261.

43.

Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations.

Ko WY, Kaercher KA, Giombini E, Marcatili P, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA.

Am J Hum Genet. 2011 Jun 10;88(6):741-754. doi: 10.1016/j.ajhg.2011.05.005.

44.

Evidence from Cameroon reveals differences in the genetic structure and histories of chimpanzee populations.

Gonder MK, Locatelli S, Ghobrial L, Mitchell MW, Kujawski JT, Lankester FJ, Stewart CB, Tishkoff SA.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4766-71. doi: 10.1073/pnas.1015422108. Epub 2011 Feb 28.

45.

Living the high life: high-altitude adaptation.

Scheinfeldt LB, Tishkoff SA.

Genome Biol. 2010;11(9):133. doi: 10.1186/gb-2010-11-9-133. Epub 2010 Sep 10.

46.

Genetic structure in African populations: implications for human demographic history.

Lambert CA, Tishkoff SA.

Cold Spring Harb Symp Quant Biol. 2009;74:395-402. doi: 10.1101/sqb.2009.74.053. Epub 2010 May 7. Review.

47.

Colloquium paper: working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history.

Scheinfeldt LB, Soi S, Tishkoff SA.

Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2:8931-8. doi: 10.1073/pnas.1002563107. Epub 2010 May 5.

48.

The evolution of human genetic and phenotypic variation in Africa.

Campbell MC, Tishkoff SA.

Curr Biol. 2010 Feb 23;20(4):R166-73. doi: 10.1016/j.cub.2009.11.050. Review.

49.

Genome-wide patterns of population structure and admixture in West Africans and African Americans.

Bryc K, Auton A, Nelson MR, Oksenberg JR, Hauser SL, Williams S, Froment A, Bodo JM, Wambebe C, Tishkoff SA, Bustamante CD.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):786-91. doi: 10.1073/pnas.0909559107. Epub 2009 Dec 22.

50.

The genetic structure and history of Africans and African Americans.

Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A, Froment A, Hirbo JB, Awomoyi AA, Bodo JM, Doumbo O, Ibrahim M, Juma AT, Kotze MJ, Lema G, Moore JH, Mortensen H, Nyambo TB, Omar SA, Powell K, Pretorius GS, Smith MW, Thera MA, Wambebe C, Weber JL, Williams SM.

Science. 2009 May 22;324(5930):1035-44. doi: 10.1126/science.1172257. Epub 2009 Apr 30.

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