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Items: 27


PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice.

Christou-Kent M, Kherraf ZE, Amiri-Yekta A, Le Blévec E, Karaouzène T, Conne B, Escoffier J, Assou S, Guttin A, Lambert E, Martinez G, Boguenet M, Fourati Ben Mustapha S, Cedrin Durnerin I, Halouani L, Marrakchi O, Makni M, Latrous H, Kharouf M, Coutton C, Thierry-Mieg N, Nef S, Bottari SP, Zouari R, Issartel JP, Ray PF, Arnoult C.

EMBO Mol Med. 2018 Apr 16. pii: e8515. doi: 10.15252/emmm.201708515. [Epub ahead of print]


Encompassing new use cases - level 3.0 of the HUPO-PSI format for molecular interactions.

Sivade Dumousseau M, Alonso-López D, Ammari M, Bradley G, Campbell NH, Ceol A, Cesareni G, Combe C, De Las Rivas J, Del-Toro N, Heimbach J, Hermjakob H, Jurisica I, Koch M, Licata L, Lovering RC, Lynn DJ, Meldal BHM, Micklem G, Panni S, Porras P, Ricard-Blum S, Roechert B, Salwinski L, Shrivastava A, Sullivan J, Thierry-Mieg N, Yehudi Y, Van Roey K, Orchard S.

BMC Bioinformatics. 2018 Apr 11;19(1):134. doi: 10.1186/s12859-018-2118-1.


Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse.

Dong FN, Amiri-Yekta A, Martinez G, Saut A, Tek J, Stouvenel L, Lorès P, Karaouzène T, Thierry-Mieg N, Satre V, Brouillet S, Daneshipour A, Hosseini SH, Bonhivers M, Gourabi H, Dulioust E, Arnoult C, Touré A, Ray PF, Zhao H, Coutton C.

Am J Hum Genet. 2018 Apr 5;102(4):636-648. doi: 10.1016/j.ajhg.2018.03.007.


Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human.

Coutton C, Vargas AS, Amiri-Yekta A, Kherraf ZE, Ben Mustapha SF, Le Tanno P, Wambergue-Legrand C, Karaouzène T, Martinez G, Crouzy S, Daneshipour A, Hosseini SH, Mitchell V, Halouani L, Marrakchi O, Makni M, Latrous H, Kharouf M, Deleuze JF, Boland A, Hennebicq S, Satre V, Jouk PS, Thierry-Mieg N, Conne B, Dacheux D, Landrein N, Schmitt A, Stouvenel L, Lorès P, El Khouri E, Bottari SP, Fauré J, Wolf JP, Pernet-Gallay K, Escoffier J, Gourabi H, Robinson DR, Nef S, Dulioust E, Zouari R, Bonhivers M, Touré A, Arnoult C, Ray PF.

Nat Commun. 2018 Feb 15;9(1):686. doi: 10.1038/s41467-017-02792-7.


Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Touat-Todeschini L, Shichino Y, Dangin M, Thierry-Mieg N, Gilquin B, Hiriart E, Sachidanandam R, Lambert E, Brettschneider J, Reuter M, Kadlec J, Pillai R, Yamashita A, Yamamoto M, Verdel A.

EMBO J. 2017 Sep 1;36(17):2626-2641. doi: 10.15252/embj.201796571. Epub 2017 Aug 1.


SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes.

Kherraf ZE, Christou-Kent M, Karaouzene T, Amiri-Yekta A, Martinez G, Vargas AS, Lambert E, Borel C, Dorphin B, Aknin-Seifer I, Mitchell MJ, Metzler-Guillemain C, Escoffier J, Nef S, Grepillat M, Thierry-Mieg N, Satre V, Bailly M, Boitrelle F, Pernet-Gallay K, Hennebicq S, Fauré J, Bottari SP, Coutton C, Ray PF, Arnoult C.

EMBO Mol Med. 2017 Aug;9(8):1132-1149. doi: 10.15252/emmm.201607461.


Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.

Escoffier J, Lee HC, Yassine S, Zouari R, Martinez G, Karaouzène T, Coutton C, Kherraf ZE, Halouani L, Triki C, Nef S, Thierry-Mieg N, Savinov SN, Fissore R, Ray PF, Arnoult C.

Hum Mol Genet. 2016 Mar 1;25(5):878-91. doi: 10.1093/hmg/ddv617. Epub 2015 Dec 31.


MatrixDB, the extracellular matrix interaction database: updated content, a new navigator and expanded functionalities.

Launay G, Salza R, Multedo D, Thierry-Mieg N, Ricard-Blum S.

Nucleic Acids Res. 2015 Jan;43(Database issue):D321-7. doi: 10.1093/nar/gku1091. Epub 2014 Nov 6.


Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

Ben Khelifa M, Coutton C, Zouari R, Karaouzène T, Rendu J, Bidart M, Yassine S, Pierre V, Delaroche J, Hennebicq S, Grunwald D, Escalier D, Pernet-Gallay K, Jouk PS, Thierry-Mieg N, Touré A, Arnoult C, Ray PF.

Am J Hum Genet. 2014 Jan 2;94(1):95-104. doi: 10.1016/j.ajhg.2013.11.017. Epub 2013 Dec 19.


Fine characterisation of a recombination hotspot at the DPY19L2 locus and resolution of the paradoxical excess of duplications over deletions in the general population.

Coutton C, Abada F, Karaouzene T, Sanlaville D, Satre V, Lunardi J, Jouk PS, Arnoult C, Thierry-Mieg N, Ray PF.

PLoS Genet. 2013 Mar;9(3):e1003363. doi: 10.1371/journal.pgen.1003363. Epub 2013 Mar 21.


Proto-genes and de novo gene birth.

Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman JS, Regev A, Thierry-Mieg N, Cusick ME, Vidal M.

Nature. 2012 Jul 19;487(7407):370-4. doi: 10.1038/nature11184.


Mapping interactomes with high coverage and efficiency using the shifted transversal design.

Xin X, Boone C, Thierry-Mieg N.

Methods Mol Biol. 2012;812:147-59. doi: 10.1007/978-1-61779-455-1_8.


New insights into protein-protein interaction data lead to increased estimates of the S. cerevisiae interactome size.

Sambourg L, Thierry-Mieg N.

BMC Bioinformatics. 2010 Dec 21;11:605. doi: 10.1186/1471-2105-11-605.


MatrixDB, the extracellular matrix interaction database.

Chautard E, Fatoux-Ardore M, Ballut L, Thierry-Mieg N, Ricard-Blum S.

Nucleic Acids Res. 2011 Jan;39(Database issue):D235-40. doi: 10.1093/nar/gkq830. Epub 2010 Sep 17.


Interaction networks as a tool to investigate the mechanisms of aging.

Chautard E, Thierry-Mieg N, Ricard-Blum S.

Biogerontology. 2010 Aug;11(4):463-73. doi: 10.1007/s10522-010-9268-5. Epub 2010 Mar 7.


[Systems biology: from yesterday's concepts to tomorrow's discoveries].

Carvunis AR, Gomez E, Thierry-Mieg N, Trilling L, Vidal M.

Med Sci (Paris). 2009 Jun-Jul;25(6-7):578-84. doi: 10.1051/medsci/2009256-7578. French.


Shifted Transversal Design smart-pooling for high coverage interactome mapping.

Xin X, Rual JF, Hirozane-Kishikawa T, Hill DE, Vidal M, Boone C, Thierry-Mieg N.

Genome Res. 2009 Jul;19(7):1262-9. doi: 10.1101/gr.090019.108. Epub 2009 May 15.


T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice.

Sultan A, Strodthoff D, Robertson AK, Paulsson-Berne G, Fauconnier J, Parini P, Rydén M, Thierry-Mieg N, Johansson ME, Chibalin AV, Zierath JR, Arner P, Hansson GK.

Circ Res. 2009 Apr 24;104(8):961-8. doi: 10.1161/CIRCRESAHA.108.190280. Epub 2009 Mar 19.


MatrixDB, a database focused on extracellular protein-protein and protein-carbohydrate interactions.

Chautard E, Ballut L, Thierry-Mieg N, Ricard-Blum S.

Bioinformatics. 2009 Mar 1;25(5):690-1. doi: 10.1093/bioinformatics/btp025. Epub 2009 Jan 15.


Interaction networks: from protein functions to drug discovery. A review.

Chautard E, Thierry-Mieg N, Ricard-Blum S.

Pathol Biol (Paris). 2009 Jun;57(4):324-33. doi: 10.1016/j.patbio.2008.10.004. Epub 2008 Dec 13. Review.


Interpool: interpreting smart-pooling results.

Thierry-Mieg N, Bailly G.

Bioinformatics. 2008 Mar 1;24(5):696-703. doi: 10.1093/bioinformatics/btn001. Epub 2008 Jan 9.


Pooling in systems biology becomes smart.

Thierry-Mieg N.

Nat Methods. 2006 Mar;3(3):161-2. No abstract available.


A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome.

Davy A, Bello P, Thierry-Mieg N, Vaglio P, Hitti J, Doucette-Stamm L, Thierry-Mieg D, Reboul J, Boulton S, Walhout AJ, Coux O, Vidal M.

EMBO Rep. 2001 Sep;2(9):821-8.


Open-reading-frame sequence tags (OSTs) support the existence of at least 17,300 genes in C. elegans.

Reboul J, Vaglio P, Tzellas N, Thierry-Mieg N, Moore T, Jackson C, Shin-i T, Kohara Y, Thierry-Mieg D, Thierry-Mieg J, Lee H, Hitti J, Doucette-Stamm L, Hartley JL, Temple GF, Brasch MA, Vandenhaute J, Lamesch PE, Hill DE, Vidal M.

Nat Genet. 2001 Mar;27(3):332-6.


Protein interaction mapping in C. elegans using proteins involved in vulval development.

Walhout AJ, Sordella R, Lu X, Hartley JL, Temple GF, Brasch MA, Thierry-Mieg N, Vidal M.

Science. 2000 Jan 7;287(5450):116-22.


A model of elegance.

Walhout M, Endoh H, Thierry-Mieg N, Wong W, Vidal M.

Am J Hum Genet. 1998 Oct;63(4):955-61. Review. No abstract available.

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