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Items: 1 to 50 of 111

1.

The effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling and hepatic inflammation.

Gai Z, Visentin M, Gui T, Zhao L, Thasler WE, Hausler S, Hartling I, Cremonesi A, Hiller C, Kullak-Ublick GA.

Mol Pharmacol. 2018 May 9. pii: mol.117.111047. doi: 10.1124/mol.117.111047. [Epub ahead of print]

2.

Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" option.

Dietrich P, Freese K, Mahli A, Thasler WE, Hellerbrand C, Bosserhoff AK.

Oncotarget. 2017 Dec 11;9(3):3605-3618. doi: 10.18632/oncotarget.23188. eCollection 2018 Jan 9.

3.

Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation.

Feng H, Zhao JK, Schiergens TS, Wang PX, Ou BC, Al-Sayegh R, Li ML, Lu AG, Yin S, Thasler WE.

Br J Cancer. 2018 Feb 6;118(3):353-365. doi: 10.1038/bjc.2017.415. Epub 2018 Jan 2.

PMID:
29384527
4.

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B.

Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22.

PMID:
29356861
5.

Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth.

Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, Königshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfußer S, Endres S, Kobold S.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073/pnas.1705165114. Epub 2017 Nov 17.

PMID:
29150554
6.

IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.

Li Y, Xia Y, Han M, Chen G, Zhang D, Thasler WE, Protzer U, Ning Q.

Sci Rep. 2017 Oct 5;7(1):12715. doi: 10.1038/s41598-017-13082-z.

7.

Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer.

Feng H, Ou BC, Zhao JK, Yin S, Lu AG, Oechsle E, Thasler WE.

J Cancer Res Clin Oncol. 2017 Sep;143(9):1771-1786. doi: 10.1007/s00432-017-2434-2. Epub 2017 May 11. Erratum in: J Cancer Res Clin Oncol. 2017 Jun 16;:.

PMID:
28497169
8.

Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O.

Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13.

PMID:
28414139
9.

Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O.

Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3. Epub 2017 Mar 13.

PMID:
28289823
10.

Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice.

Sommer J, Mahli A, Freese K, Schiergens TS, Kuecuekoktay FS, Teufel A, Thasler WE, Müller M, Bosserhoff AK, Hellerbrand C.

Oncotarget. 2017 Feb 21;8(8):13059-13072. doi: 10.18632/oncotarget.14371.

11.

Osseous differentiation of human fat tissue grafts: From tissue engineering to tissue differentiation.

Bondarava M, Cattaneo C, Ren B, Thasler WE, Jansson V, Müller PE, Betz OB.

Sci Rep. 2017 Jan 5;7:39712. doi: 10.1038/srep39712.

12.

ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis.

Mahli A, Saugspier M, Koch A, Sommer J, Dietrich P, Lee S, Thasler R, Schulze-Luehrmann J, Luehrmann A, Thasler WE, Müller M, Bosserhoff A, Hellerbrand C.

Gut. 2018 Apr;67(4):746-756. doi: 10.1136/gutjnl-2016-312485. Epub 2017 Jan 4.

PMID:
28053052
13.

Federated Biobanking with Corporate Service Unit: The Munich Biobank Alliance Blueprint.

Thasler RM, Berghammer AJ, Kirchner T, Slotta-Huspenina J, Becker KF, Schiergens T, Thasler WE, Wichmann HE.

Biopreserv Biobank. 2017 Feb;15(1):75-79. doi: 10.1089/bio.2016.0101. Epub 2016 Dec 19. No abstract available.

PMID:
27991833
14.

Long-term outcomes and propensity score matching analysis: rectal cancer resection for patients with elevated preoperative risk.

Feng H, Schiergens TS, Mao ZH, Zhao J, Shen X, Lu AG, Thasler WE.

Oncotarget. 2017 Apr 11;8(15):25679-25690. doi: 10.18632/oncotarget.13827.

15.

Long-term Quality of Life of Patients With Permanent End Ileostomy: Results of a Nationwide Cross-Sectional Survey.

Schiergens TS, Hoffmann V, Schobel TN, Englert GH, Kreis ME, Thasler WE, Werner J, Kasparek MS.

Dis Colon Rectum. 2017 Jan;60(1):51-60.

PMID:
27926557
16.

Isolation of Hepatocytes and Stellate Cells from a Single Piece of Human Liver.

Lee SM, Schiergens TS, Demmel M, Thasler RM, Thasler WE.

Methods Mol Biol. 2017;1506:247-258.

PMID:
27830558
17.

Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues.

Marzi C, Holdt LM, Fiorito G, Tsai PC, Kretschmer A, Wahl S, Guarrera S, Teupser D, Spector TD, Iacoviello L, Sacerdote C, Strauch K, Lee S, Thasler WE, Peters A, Thorand B, Wolf P, Prokisch H, Tumino R, Gieger C, Krogh V, Panico S, Bell JT, Matullo G, Waldenberger M, Grallert H, Koenig W.

PLoS One. 2016 Nov 8;11(11):e0166015. doi: 10.1371/journal.pone.0166015. eCollection 2016.

18.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.

19.

Laparoscopic Complete Mesocolic Excision for Stage II/III Left-Sided Colon Cancers: A Prospective Study and Comparison with D3 Lymph Node Dissection.

Feng H, Zhao XW, Zhang Z, Han DP, Mao ZH, Lu AG, Thasler WE.

J Laparoendosc Adv Surg Tech A. 2016 Aug;26(8):606-13. doi: 10.1089/lap.2016.0120. Epub 2016 May 16.

PMID:
27183112
20.

Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes.

Krattinger R, Boström A, Lee SML, Thasler WE, Schiöth HB, Kullak-Ublick GA, Mwinyi J.

Life Sci. 2016 Jul 1;156:47-56. doi: 10.1016/j.lfs.2016.04.037. Epub 2016 May 10.

21.

microRNA-192 suppresses the expression of the farnesoid X receptor.

Krattinger R, Boström A, Schiöth HB, Thasler WE, Mwinyi J, Kullak-Ublick GA.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1044-51. doi: 10.1152/ajpgi.00297.2015. Epub 2016 Apr 14.

22.

Liver Resection for Non-colorectal Non-neuroendocrine Metastases: Where Do We Stand Today Compared to Colorectal Cancer?

Schiergens TS, Lüning J, Renz BW, Thomas M, Pratschke S, Feng H, Lee SM, Engel J, Rentsch M, Guba M, Werner J, Thasler WE.

J Gastrointest Surg. 2016 Jun;20(6):1163-72. doi: 10.1007/s11605-016-3115-1. Epub 2016 Feb 26.

PMID:
26921025
23.

Time-dependent impact of age and comorbidities on long-term overall survival after liver resection.

Schiergens TS, Lindenthaler A, Thomas MN, Rentsch M, Mittermeier L, Brand K, Küchenhoff H, Lee S, Guba M, Werner J, Thasler WE.

Liver Int. 2016 Sep;36(9):1340-50. doi: 10.1111/liv.13068. Epub 2016 Mar 24.

PMID:
26778517
24.

Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling.

Keller R, Klein M, Thomas M, Dräger A, Metzger U, Templin MF, Joos TO, Thasler WE, Zell A, Zanger UM.

PLoS Comput Biol. 2016 Jan 4;12(1):e1004431. doi: 10.1371/journal.pcbi.1004431. eCollection 2016 Jan.

25.

Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro.

Mahli A, Thasler WE, Patsenker E, Müller S, Stickel F, Müller M, Seitz HK, Cederbaum AI, Hellerbrand C.

Oncotarget. 2015 Dec 8;6(39):41464-78. doi: 10.18632/oncotarget.6203.

26.

Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.

Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U.

Gastroenterology. 2016 Jan;150(1):194-205. doi: 10.1053/j.gastro.2015.09.026. Epub 2015 Sep 28.

PMID:
26416327
27.

Pre-Analytical Determination of the Effect of Extended Warm or Cold Ischaemia on RNA Stability in the Human Ileum Mucosa.

Lee SM, Schelcher C, Thasler R, Schiergens TS, Thasler WE.

PLoS One. 2015 Sep 15;10(9):e0138214. doi: 10.1371/journal.pone.0138214. eCollection 2015.

28.

Thirty-day mortality leads to underestimation of postoperative death after liver resection: A novel method to define the acute postoperative period.

Schiergens TS, Dörsch M, Mittermeier L, Brand K, Küchenhoff H, Lee SM, Feng H, Jauch KW, Werner J, Thasler WE.

Surgery. 2015 Dec;158(6):1530-7. doi: 10.1016/j.surg.2015.07.019. Epub 2015 Aug 19.

PMID:
26298028
29.

Comparison of non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer.

Feng H, Lu AG, Zhao XW, Han DP, Zhao JK, Shi L, Schiergens TS, Lee SM, Zhang WP, Thasler WE.

World J Gastroenterol. 2015 Jun 21;21(23):7225-32. doi: 10.3748/wjg.v21.i23.7225.

30.

Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma.

Engelmann JC, Amann T, Ott-Rötzer B, Nützel M, Reinders Y, Reinders J, Thasler WE, Kristl T, Teufel A, Huber CG, Oefner PJ, Spang R, Hellerbrand C.

PLoS Comput Biol. 2015 May 28;11(5):e1004293. doi: 10.1371/journal.pcbi.1004293. eCollection 2015 May.

31.

STAT3 inhibition reduces toxicity of oncolytic VSV and provides a potentially synergistic combination therapy for hepatocellular carcinoma.

Marozin S, Altomonte J, Muñoz-Álvarez KA, Rizzani A, De Toni EN, Thasler WE, Schmid RM, Ebert O.

Cancer Gene Ther. 2015 Jun;22(6):317-25. doi: 10.1038/cgt.2015.23. Epub 2015 May 1.

PMID:
25930184
32.

Effect of suture technique on the occurrence of incisional hernia after elective midline abdominal wall closure: study protocol for a randomized controlled trial.

Fortelny RH, Baumann P, Thasler WE, Albertsmeier M, Riedl S, Steurer W, Kewer JL, Shamiyeh A.

Trials. 2015 Feb 15;16:52. doi: 10.1186/s13063-015-0572-x.

33.

Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.

Lichtenauer UD, Di Dalmazi G, Slater EP, Wieland T, Kuebart A, Schmittfull A, Schwarzmayr T, Diener S, Wiese D, Thasler WE, Reincke M, Meitinger T, Schott M, Fassnacht M, Bartsch DK, Strom TM, Beuschlein F.

J Clin Endocrinol Metab. 2015 May;100(5):E776-82. doi: 10.1210/jc.2015-1100. Epub 2015 Mar 12.

PMID:
25763608
34.

Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry.

Weiß F, Schnabel A, Planatscher H, van den Berg BH, Serschnitzki B, Nuessler AK, Thasler WE, Weiss TS, Reuss M, Stoll D, Templin MF, Joos TO, Marcus K, Poetz O.

Sci Rep. 2015 Mar 4;5:8759. doi: 10.1038/srep08759.

35.

Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

Bitter A, Nüssler AK, Thasler WE, Klein K, Zanger UM, Schwab M, Burk O.

Cell Physiol Biochem. 2015;35(2):803-15. doi: 10.1159/000369739. Epub 2015 Jan 30.

36.

DNA methylation of lipid-related genes affects blood lipid levels.

Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, Klopp N, Illig T, Hedman ÅK, Roden M, Hernandez DG, Singleton AB, Thasler WE, Grallert H, Gieger C, Herder C, Teupser D, Meisinger C, Spector TD, Kronenberg F, Prokisch H, Melzer D, Peters A, Deloukas P, Ferrucci L, Waldenberger M.

Circ Cardiovasc Genet. 2015 Apr;8(2):334-42. doi: 10.1161/CIRCGENETICS.114.000804. Epub 2015 Jan 12.

37.

Abdominal bone formation.

Schiergens TS, Reichelt A, Thasler WE, Rentsch M.

J Gastrointest Surg. 2015 Mar;19(3):579-80. doi: 10.1007/s11605-014-2737-4. Epub 2015 Jan 9.

PMID:
25572973
38.

Impact of perioperative allogeneic red blood cell transfusion on recurrence and overall survival after resection of colorectal liver metastases.

Schiergens TS, Rentsch M, Kasparek MS, Frenes K, Jauch KW, Thasler WE.

Dis Colon Rectum. 2015 Jan;58(1):74-82. doi: 10.1097/DCR.0000000000000233.

PMID:
25489697
39.

Toxicogenomics directory of chemically exposed human hepatocytes.

Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.

PMID:
25399406
40.

Modulating CD4+ T cell migration in the postischemic liver: hepatic stellate cells as new therapeutic target?

Reifart J, Rentsch M, Mende K, Coletti R, Sobocan M, Thasler WE, Khandoga A.

Transplantation. 2015 Jan;99(1):41-7. doi: 10.1097/TP.0000000000000461.

PMID:
25360872
41.

Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity.

Bauer R, Valletta D, Bauer K, Thasler WE, Hartmann A, Müller M, Reichert TE, Hellerbrand C.

Int J Clin Exp Pathol. 2014 Aug 15;7(9):6125-32. eCollection 2014.

42.

An algorithm that predicts the viability and the yield of human hepatocytes isolated from remnant liver pieces obtained from liver resections.

Lee SM, Schelcher C, Laubender RP, Fröse N, Thasler RM, Schiergens TS, Mansmann U, Thasler WE.

PLoS One. 2014 Oct 14;9(10):e107567. doi: 10.1371/journal.pone.0107567. eCollection 2014.

43.

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease.

Arndt S, Wacker E, Dorn C, Koch A, Saugspier M, Thasler WE, Hartmann A, Bosserhoff AK, Hellerbrand C.

Gut. 2015 Jun;64(6):973-81. doi: 10.1136/gutjnl-2014-306968. Epub 2014 Jul 10.

PMID:
25011936
44.

Augmenter of liver regeneration attenuates inflammatory response in the postischemic mouse liver in vivo.

Khandoga A, Mende K, Iskandarov E, Rosentreter D, Schelcher C, Reifart J, Jauch KW, Thasler WE.

J Surg Res. 2014 Nov;192(1):187-94. doi: 10.1016/j.jss.2014.05.026. Epub 2014 May 20.

PMID:
24948544
45.

Randomized controlled multicenter trial on the effectiveness of the collagen hemostat Sangustop® compared with a carrier-bound fibrin sealant during liver resection (ESSCALIVER study, NCT00918619).

Moench C, Mihaljevic AL, Hermanutz V, Thasler WE, Suna K, Diener MK, Seehofer D, Mischinger HJ, Jansen-Winkeln B, Knaebel HP, Bechstein WO.

Langenbecks Arch Surg. 2014 Aug;399(6):725-33. doi: 10.1007/s00423-014-1203-9. Epub 2014 Jun 1.

46.

Liver resection in the elderly: significance of comorbidities and blood loss.

Schiergens TS, Stielow C, Schreiber S, Hornuss C, Jauch KW, Rentsch M, Thasler WE.

J Gastrointest Surg. 2014 Jun;18(6):1161-70. doi: 10.1007/s11605-014-2516-2. Epub 2014 Apr 9.

PMID:
24715360
47.

The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.

Schaffner CA, Mwinyi J, Gai Z, Thasler WE, Eloranta JJ, Kullak-Ublick GA.

Liver Int. 2015 Apr;35(4):1152-61. doi: 10.1111/liv.12558. Epub 2014 Apr 29.

48.

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U.

Science. 2014 Mar 14;343(6176):1221-8. doi: 10.1126/science.1243462. Epub 2014 Feb 20.

PMID:
24557838
49.

Expression and function of methylthioadenosine phosphorylase in chronic liver disease.

Czech B, Dettmer K, Valletta D, Saugspier M, Koch A, Stevens AP, Thasler WE, Müller M, Oefner PJ, Bosserhoff AK, Hellerbrand C.

PLoS One. 2013 Dec 6;8(12):e80703. doi: 10.1371/journal.pone.0080703. eCollection 2013.

50.

No activation of human pregnane X receptor by hyperforin-related phloroglucinols.

Kandel BA, Ekins S, Leuner K, Thasler WE, Harteneck C, Zanger UM.

J Pharmacol Exp Ther. 2014 Mar;348(3):393-400. doi: 10.1124/jpet.113.209916. Epub 2013 Nov 20.

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