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Mouse GTSF1 is an essential factor for secondary piRNA biogenesis.

Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki JI.

EMBO Rep. 2018 Feb 7. pii: e42054. doi: 10.15252/embr.201642054. [Epub ahead of print]


Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas.

Fukumoto M, Kondo K, Uni K, Ishiguro T, Hayashi M, Ueda S, Mori I, Niimi K, Tashiro F, Miyazaki S, Miyazaki JI, Inagaki S, Furuyama T.

Angiogenesis. 2017 Nov 28. doi: 10.1007/s10456-017-9588-z. [Epub ahead of print]


Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.

Matsuura T, Miyazaki S, Miyazaki T, Tashiro F, Miyazaki JI.

Sci Rep. 2017 Sep 29;7(1):12462. doi: 10.1038/s41598-017-12772-y.


Transgenic Expression of a Single Transcription Factor Pdx1 Induces Transdifferentiation of Pancreatic Acinar Cells to Endocrine Cells in Adult Mice.

Miyazaki S, Tashiro F, Miyazaki J.

PLoS One. 2016 Aug 15;11(8):e0161190. doi: 10.1371/journal.pone.0161190. eCollection 2016.


Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells.

Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Kobayashi Y, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R.

Cancer Sci. 2016 Jun;107(6):734-45. doi: 10.1111/cas.12933. Epub 2016 May 16.


Functional Analysis of Novel Candidate Regulators of Insulin Secretion in the MIN6 Mouse Pancreatic β Cell Line.

Kobayashi M, Yamato E, Tanabe K, Tashiro F, Miyazaki S, Miyazaki J.

PLoS One. 2016 Mar 17;11(3):e0151927. doi: 10.1371/journal.pone.0151927. eCollection 2016.


Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis.

Takemoto N, Yoshimura T, Miyazaki S, Tashiro F, Miyazaki J.

PLoS One. 2016 Mar 1;11(3):e0150390. doi: 10.1371/journal.pone.0150390. eCollection 2016.


IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R.

Sci Rep. 2016 Jan 12;6:19174. doi: 10.1038/srep19174.


SGF29 and Sry pathway in hepatocarcinogenesis.

Kurabe N, Murakami S, Tashiro F.

World J Biol Chem. 2015 Aug 26;6(3):139-47. doi: 10.4331/wjbc.v6.i3.139. Review.


SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell-Like Properties and Are Potential Differentiation Therapy Targets.

Murakami S, Ninomiya W, Sakamoto E, Shibata T, Akiyama H, Tashiro F.

Stem Cells. 2015 Sep;33(9):2652-63. doi: 10.1002/stem.2059. Epub 2015 Jun 23.


TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion.

Otomo R, Otsubo C, Matsushima-Hibiya Y, Miyazaki M, Tashiro F, Ichikawa H, Kohno T, Ochiya T, Yokota J, Nakagama H, Taya Y, Enari M.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18691-6. doi: 10.1073/pnas.1412062112. Epub 2014 Dec 15.


Aralin, a type II ribosome-inactivating protein from Aralia elata, exhibits selective anticancer activity through the processed form of a 110-kDa high-density lipoprotein-binding protein: a promising anticancer drug.

Otsuka H, Gotoh Y, Komeno T, Ono T, Kawasaki Y, Iida N, Shibagaki Y, Hattori S, Tomatsu M, Akiyama H, Tashiro F.

Biochem Biophys Res Commun. 2014 Oct 10;453(1):117-23. doi: 10.1016/j.bbrc.2014.09.067. Epub 2014 Sep 26.


TSPAN2 is involved in cell invasion and motility during lung cancer progression.

Otsubo C, Otomo R, Miyazaki M, Matsushima-Hibiya Y, Kohno T, Iwakawa R, Takeshita F, Okayama H, Ichikawa H, Saya H, Kiyono T, Ochiya T, Tashiro F, Nakagama H, Yokota J, Enari M.

Cell Rep. 2014 Apr 24;7(2):527-38. doi: 10.1016/j.celrep.2014.03.027. Epub 2014 Apr 13.


FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.

Komiya Y, Akiyama H, Sakumoto R, Tashiro F.

Biochem Biophys Res Commun. 2014 Feb 14;444(3):382-6. doi: 10.1016/j.bbrc.2014.01.064. Epub 2014 Jan 24.


Expression of Nephrin Homologue in the Freshwater Planarian, Dugesia japonica.

Nakamura T, Takagi S, Matsumoto M, Tashiro F, Sakai T, Ichimura K.

Acta Histochem Cytochem. 2014;47(6):303-10. doi: 10.1267/ahc.14044. Epub 2014 Dec 20.


The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.

Akiyama H, Iwahana Y, Suda M, Yoshimura A, Kogai H, Nagashima A, Ohtsuka H, Komiya Y, Tashiro F.

PLoS One. 2013 Nov 6;8(11):e78716. doi: 10.1371/journal.pone.0078716. eCollection 2013.


Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells.

Miyazaki T, Miyazaki S, Ashida M, Tanaka T, Tashiro F, Miyazaki J.

PLoS One. 2013 Aug 5;8(8):e71645. doi: 10.1371/journal.pone.0071645. Print 2013. Erratum in: PLoS One. 2013;8(11). doi:0.1371/annotation/cc1568d0-4299-47b9-896b-d1d12b551224.


The male-specific factor Sry harbors an oncogenic function.

Murakami S, Chishima S, Uemoto H, Sakamoto E, Sato T, Kurabe N, Kawasaki Y, Shibata T, Akiyama H, Tashiro F.

Oncogene. 2014 Jun 5;33(23):2978-86. doi: 10.1038/onc.2013.262. Epub 2013 Jul 29.


The U-box-type ubiquitin ligase PRP19β regulates astrocyte differentiation via ubiquitination of PTP1B.

Yamada T, Urano-Tashiro Y, Hashi Y, Sakumoto M, Akiyama H, Tashiro F.

Brain Res. 2013 Aug 2;1524:12-25. doi: 10.1016/j.brainres.2013.06.007. Epub 2013 Jun 14.


Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6.

Yamato E, Tashiro F, Miyazaki J.

PLoS One. 2013;8(4):e61211. doi: 10.1371/journal.pone.0061211. Epub 2013 Apr 3.


The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.

Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka K.

J Biol Chem. 2013 May 10;288(19):13269-77. doi: 10.1074/jbc.M112.402560. Epub 2013 Mar 27.


Involvement of crosstalk between Oct4 and Meis1a in neural cell fate decision.

Yamada T, Urano-Tashiro Y, Tanaka S, Akiyama H, Tashiro F.

PLoS One. 2013;8(2):e56997. doi: 10.1371/journal.pone.0056997. Epub 2013 Feb 25.


Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes.

Osawa T, Atsumi Y, Sugihara E, Saya H, Kanno M, Tashiro F, Masutani M, Yoshioka K.

Biochem Biophys Res Commun. 2013 Mar 1;432(1):34-9. doi: 10.1016/j.bbrc.2013.01.091. Epub 2013 Jan 31.


Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis.

Fujiki R, Sato A, Hata K, Tashiro F, Yasuhara N, Miyazaki J, Yoneda Y, Fujitani M, Yamashita T.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):604-9. doi: 10.1016/j.bbrc.2012.11.106. Epub 2012 Dec 5. Erratum in: Biochem Biophys Res Commun. 2016 Apr 1;472(2):399.


Acinar-to-ductal metaplasia induced by adenovirus-mediated pancreatic expression of Isl1.

Miyazaki S, Tashiro F, Fujikura J, Yamato E, Miyazaki J.

PLoS One. 2012;7(10):e47536. doi: 10.1371/journal.pone.0047536. Epub 2012 Oct 15.


Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic β cells.

Miyazaki S, Minamida R, Furuyama T, Tashiro F, Yamato E, Inagaki S, Miyazaki J.

Genes Cells. 2012 Sep;17(9):758-67. doi: 10.1111/j.1365-2443.2012.01625.x. Epub 2012 Jul 30.


Individual identification with high frequency ECG : preprocessing and classification by neural network.

Tashiro F, Aoyama T, Shimuta T, Ishikawa H, Shimatani Y, Ishijima M, Kyoso M.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2749-51. doi: 10.1109/IEMBS.2011.6090753.


Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.

Ozeki C, Sawai Y, Shibata T, Kohno T, Okamoto K, Yokota J, Tashiro F, Tanuma S, Sakai R, Kawase T, Kitabayashi I, Taya Y, Ohki R.

J Biol Chem. 2011 May 20;286(20):18251-60. doi: 10.1074/jbc.M110.208587. Epub 2011 Mar 28.


Interaction of Hand2 and E2a is important for transcription of Phox2b in sympathetic nervous system neuron differentiation.

Hashimoto Y, Tsutsumi M, Myojin R, Maruta K, Onoda F, Tashiro F, Ohtsu M, Murakami Y.

Biochem Biophys Res Commun. 2011 Apr 29;408(1):38-44. doi: 10.1016/j.bbrc.2011.03.113. Epub 2011 Mar 29.


Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.

Miyazaki S, Taniguchi H, Moritoh Y, Tashiro F, Yamamoto T, Yamato E, Ikegami H, Ozato K, Miyazaki J.

Diabetes. 2010 Nov;59(11):2854-61. doi: 10.2337/db09-1897. Epub 2010 Aug 26.


Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation.

Urano-Tashiro Y, Sasaki H, Sugawara-Kawasaki M, Yamada T, Sugiyama A, Akiyama H, Kawasaki Y, Tashiro F.

J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455.


Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition.

Tashiro F, Kanai-Azuma M, Miyazaki S, Kato M, Tanaka T, Toyoda S, Yamato E, Kawakami H, Miyazaki T, Miyazaki J.

Genes Cells. 2010 Aug;15(8):813-28. doi: 10.1111/j.1365-2443.2010.01420.x. Epub 2010 Jun 29.


The bHLH transcription factor Hand2 regulates the expression of nanog in ANS differentiation.

Hashimoto Y, Myojin R, Katoh N, Ohtsu M, Tashiro F, Onoda F, Murakami Y.

Biochem Biophys Res Commun. 2009 Dec 11;390(2):223-9. doi: 10.1016/j.bbrc.2009.09.090. Epub 2009 Sep 26.


Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes.

Yoshimura T, Toyoda S, Kuramochi-Miyagawa S, Miyazaki T, Miyazaki S, Tashiro F, Yamato E, Nakano T, Miyazaki J.

Dev Biol. 2009 Nov 1;335(1):216-27. doi: 10.1016/j.ydbio.2009.09.003. Epub 2009 Sep 6.


Sema4D deficiency results in an increase in the number of oligodendrocytes in healthy and injured mouse brains.

Taniguchi Y, Amazaki M, Furuyama T, Yamaguchi W, Takahara M, Saino O, Wada T, Niwa H, Tashiro F, Miyazaki J, Kogo M, Matsuyama T, Inagaki S.

J Neurosci Res. 2009 Oct;87(13):2833-41. doi: 10.1002/jnr.22124.


PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.

Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y.

Cell. 2009 Feb 6;136(3):535-50. doi: 10.1016/j.cell.2008.12.002.


The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.

Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T.

J Biol Chem. 2009 Feb 20;284(8):5050-5. doi: 10.1074/jbc.M808598200. Epub 2008 Dec 22.


Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy.

Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T.

Hum Mol Genet. 2009 Feb 15;18(4):621-31. doi: 10.1093/hmg/ddn387. Epub 2008 Nov 18.


Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.

Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, Yamato E, Miyazaki J.

Dev Biol. 2009 Jan 1;325(1):238-48. doi: 10.1016/j.ydbio.2008.10.019. Epub 2008 Oct 29.


Enrichment of undifferentiated mouse embryonic stem cells on a culture surface with a glucose-displaying dendrimer.

Mashayekhan S, Kim MH, Miyazaki S, Tashiro F, Kino-oka M, Taya M, Miyazaki J.

Biomaterials. 2008 Nov;29(31):4236-43. doi: 10.1016/j.biomaterials.2008.07.027. Epub 2008 Aug 8.


Association of p16 homozygous deletions with clinicopathologic characteristics and EGFR/KRAS/p53 mutations in lung adenocarcinoma.

Iwakawa R, Kohno T, Anami Y, Noguchi M, Suzuki K, Matsuno Y, Mishima K, Nishikawa R, Tashiro F, Yokota J.

Clin Cancer Res. 2008 Jun 15;14(12):3746-53. doi: 10.1158/1078-0432.CCR-07-4552.


A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.

Komiya Y, Kurabe N, Katagiri K, Ogawa M, Sugiyama A, Kawasaki Y, Tashiro F.

J Biol Chem. 2008 Jul 4;283(27):18753-64. doi: 10.1074/jbc.M802530200. Epub 2008 May 5.


ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress.

Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y.

Cell Metab. 2008 Mar;7(3):269-76. doi: 10.1016/j.cmet.2008.01.008.


p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.

Kawase T, Ichikawa H, Ohta T, Nozaki N, Tashiro F, Ohki R, Taya Y.

Oncogene. 2008 Jun 19;27(27):3797-810. doi: 10.1038/onc.2008.32. Epub 2008 Feb 11.


Phosphorylation of PML is essential for activation of C/EBP epsilon and PU.1 to accelerate granulocytic differentiation.

Tagata Y, Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I.

Leukemia. 2008 Feb;22(2):273-80. Epub 2007 Nov 8.


Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus.

Yamamoto M, Yamato E, Toyoda S, Tashiro F, Ikegami H, Yodoi J, Miyazaki J.

Antioxid Redox Signal. 2008 Jan;10(1):43-9.


Gene expression pattern of Cue110: a member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells.

Yoshimura T, Miyazaki T, Toyoda S, Miyazaki S, Tashiro F, Yamato E, Miyazaki J.

Gene Expr Patterns. 2007 Dec;8(1):27-35. Epub 2007 Sep 2.


Pdx-1-independent differentiation of mouse embryonic stem cells into insulin-expressing cells.

Takayama I, Miyazaki S, Tashiro F, Fujikura J, Miyazaki J, Yamato E.

Diabetes Res Clin Pract. 2008 Feb;79(2):e8-10. Epub 2007 Sep 27.


Crystallization and preliminary X-ray diffraction data of the rat histone H1(0) globular domain.

Matsui T, Nishimura S, Kijima K, Kawasaki Y, Tashiro F, Miura S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt 5):403-5. Epub 2007 Apr 14.


Disruption of the mouse protein Ser/Thr phosphatase 2Cbeta gene leads to early pre-implantation lethality.

Sasaki M, Ohnishi M, Tashiro F, Niwa H, Suzuki A, Miyazaki J, Kobayashi T, Tamura S.

Mech Dev. 2007 Jul;124(6):489-99. Epub 2007 Apr 11.

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