Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 334

1.

Contribution of Equilibrative Nucleoside Transporters 1 and 2 to Gemcitabine Uptake in Pancreatic Cancer Cells.

Hioki M, Shimada T, Yuan T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Sawamoto K, Akashita G, Miyamoto KI, Ohta T, Tamai I, Shimada T, Sai Y.

Biopharm Drug Dispos. 2018 Apr 22. doi: 10.1002/bdd.2131. [Epub ahead of print]

PMID:
29682747
2.

Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter-Enzyme Interplay.

Matsunaga N, Fukuchi Y, Imawaka H, Tamai I.

Drug Metab Dispos. 2018 May;46(5):680-691. doi: 10.1124/dmd.117.079236. Epub 2018 Jan 19.

PMID:
29352067
3.

Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells.

Komori H, Yamada K, Tamai I.

Biochim Biophys Acta. 2018 Jan 6;1860(5):973-980. doi: 10.1016/j.bbamem.2018.01.006. [Epub ahead of print]

PMID:
29317200
4.

Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines.

Washio I, Nakanishi T, Ishiguro N, Yamamura N, Tamai I.

Drug Metab Dispos. 2018 Mar;46(3):214-222. doi: 10.1124/dmd.117.078402. Epub 2017 Dec 15.

PMID:
29246888
5.

Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins.

Nakanishi T, Tamai I.

AAPS J. 2017 Dec 4;20(1):13. doi: 10.1208/s12248-017-0163-8. Review.

PMID:
29204966
6.

A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer.

Nakanishi T, Ohno Y, Aotani R, Maruyama S, Shimada H, Kamo S, Oshima H, Oshima M, Schuetz JD, Tamai I.

Sci Rep. 2017 Nov 29;7(1):16567. doi: 10.1038/s41598-017-16738-y.

7.

Contribution of equilibrative nucleoside transporter(s) to intestinal basolateral and apical transports of anticancer trifluridine.

Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I.

Biopharm Drug Dispos. 2018 Jan;39(1):38-46. doi: 10.1002/bdd.2110. Epub 2017 Dec 15.

PMID:
29055025
8.

Usefulness of kidney slices for functional analysis of apical reabsorptive transporters.

Arakawa H, Washio I, Matsuoka N, Kubo H, Staub AY, Nakamichi N, Ishiguro N, Kato Y, Nakanishi T, Tamai I.

Sci Rep. 2017 Oct 9;7(1):12814. doi: 10.1038/s41598-017-12828-z.

9.

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts.

Inagaki M, Nishimura T, Akanuma SI, Nakanishi T, Tachikawa M, Tamai I, Hosoya KI, Nakashima E, Tomi M.

Placenta. 2017 May;53:76-82. doi: 10.1016/j.placenta.2017.04.002. Epub 2017 Apr 6.

PMID:
28487024
10.

Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1.

Kamo S, Nakanishi T, Aotani R, Nakamura Y, Gose T, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2483-2490. doi: 10.1016/j.xphs.2017.04.046. Epub 2017 May 4.

PMID:
28479361
11.

Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban.

Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, Ikukawa K, Kishimoto W, Ito S, Schaefer O, Ebner T, Yamamura N, Kusuhara H, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2524-2534. doi: 10.1016/j.xphs.2017.04.044. Epub 2017 Apr 26.

PMID:
28456731
12.

Association of miR-145 With Statin-Induced Skeletal Muscle Toxicity in Human Rhabdomyosarcoma RD Cells.

Saito S, Nakanishi T, Shirasaki Y, Nakajima M, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2873-2880. doi: 10.1016/j.xphs.2017.04.005. Epub 2017 Apr 21.

PMID:
28438533
13.

JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation.

Kurimoto T, Tamai I, Miyai A, Kosugi Y, Nakagawa T, Yamamoto Y, Deai K, Misaki S, Bessho Y, Negoro T, Yamaguchi T, Hata T, Matsushita M.

Eur J Pharmacol. 2017 May 15;803:179-186. doi: 10.1016/j.ejphar.2017.03.057. Epub 2017 Mar 31.

PMID:
28366807
14.

Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2.

Arakawa H, Omote S, Tamai I.

J Pharm Sci. 2017 Sep;106(9):2899-2903. doi: 10.1016/j.xphs.2017.03.013. Epub 2017 Mar 21.

PMID:
28336299
15.

Revisiting the role of gut wall in the fate of orally administered drugs: Why now and to what effect?

Rostami-Hodjegan A, Tamai I, Pang KS.

Biopharm Drug Dispos. 2017 Mar;38(2):87-93. doi: 10.1002/bdd.2071. No abstract available.

PMID:
28317174
16.

Comparative Evaluation of Dehydroepiandrosterone Sulfate Potential to Predict Hepatic Organic Anion Transporting Polypeptide Transporter-Based Drug-Drug Interactions.

Nishizawa K, Nakanishi T, Tamai I.

Drug Metab Dispos. 2017 Feb;45(2):224-227. doi: 10.1124/dmd.116.072355. Epub 2016 Dec 1.

17.

Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.

Visentin M, van Rosmalen BV, Hiller C, Bieze M, Hofstetter L, Verheij J, Kullak-Ublick GA, Koepsell H, Phoa SS, Tamai I, Bennink RJ, van Gulik TM, Stieger B.

Drug Metab Dispos. 2017 Feb;45(2):166-173. doi: 10.1124/dmd.116.072371. Epub 2016 Nov 30.

18.

Molecular characterization of Salmonella enterica serotype Enteritidis isolates from food and human samples by serotyping, antimicrobial resistance, plasmid profiling, (GTG)5-PCR and ERIC-PCR.

Fardsanei F, Nikkhahi F, Bakhshi B, Salehi TZ, Tamai IA, Soltan Dallal MM.

New Microbes New Infect. 2016 Aug 4;14:24-30. doi: 10.1016/j.nmni.2016.07.016. eCollection 2016 Nov.

19.

A retrospective study of treatment and prophylaxis of ifosfamide-induced hemorrhagic cystitis in pediatric and adolescent and young adult (AYA) patients with solid tumors.

Saito Y, Kumamoto T, Makino Y, Tamai I, Ogawa C, Terakado H.

Jpn J Clin Oncol. 2016 Sep;46(9):856-61. doi: 10.1093/jjco/hyw093. Epub 2016 Jul 5.

PMID:
27380806
20.

Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue.

Incecayir T, Sun J, Tsume Y, Xu H, Gose T, Nakanishi T, Tamai I, Hilfinger J, Lipka E, Amidon GL.

J Pharm Sci. 2016 Feb;105(2):925-934. doi: 10.1016/j.xphs.2015.11.036.

21.

Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.

Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I.

Exp Cell Res. 2016 Feb 15;341(2):123-31. doi: 10.1016/j.yexcr.2016.02.002. Epub 2016 Feb 2.

PMID:
26850138
22.

Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.

Gose T, Nakanishi T, Kamo S, Shimada H, Otake K, Tamai I.

Prostaglandins Other Lipid Mediat. 2016 Jan;122:10-7. doi: 10.1016/j.prostaglandins.2015.12.003. Epub 2015 Dec 10.

PMID:
26692285
23.

Interaction of Drug or Food with Drug Transporters in Intestine and Liver.

Nakanishi T, Tamai I.

Curr Drug Metab. 2015;16(9):753-64. Review.

PMID:
26630906
24.

Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride.

Fujita D, Saito Y, Nakanishi T, Tamai I.

Drug Metab Dispos. 2016 Jan;44(1):1-7. doi: 10.1124/dmd.115.066712. Epub 2015 Nov 2.

25.

Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes.

Matsunaga N, Kaneko N, Staub AY, Nakanishi T, Nunoya K, Imawaka H, Tamai I.

Drug Metab Dispos. 2016 Jan;44(1):16-27. doi: 10.1124/dmd.115.067074. Epub 2015 Oct 26.

26.

OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion.

Shimada H, Nakamura Y, Nakanishi T, Tamai I.

Biochem Pharmacol. 2015 Dec 15;98(4):629-38. doi: 10.1016/j.bcp.2015.10.009. Epub 2015 Oct 22.

PMID:
26474801
27.

Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart.

Takeuchi R, Shinozaki K, Nakanishi T, Tamai I.

Drug Metab Dispos. 2016 Jan;44(1):68-74. doi: 10.1124/dmd.115.066654. Epub 2015 Oct 14.

28.

The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.

Akamine Y, Miura M, Komori H, Tamai I, Ieiri I, Yasui-Furukori N, Uno T.

Drug Metab Pharmacokinet. 2015 Oct;30(5):352-7. doi: 10.1016/j.dmpk.2015.06.005. Epub 2015 Jun 26.

PMID:
26213156
29.

Gordon L. Amidon: Very Sustained Drug Absorption.

Donovan MD, Polli JE, Langguth P, Tamai I, Vig B, Yu LX.

J Pharm Sci. 2015 Sep;104(9):2650-63. doi: 10.1002/jps.24523. Epub 2015 Jun 5. No abstract available.

PMID:
26053319
30.

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.

Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto K, Kitagawa H, Ohta T, Tamai I, Sai Y.

J Pharm Sci. 2015 Sep;104(9):3162-9. doi: 10.1002/jps.24498. Epub 2015 Jun 2.

PMID:
26037416
31.

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.

Watanabe M, Watanabe T, Yabuki M, Tamai I.

Drug Metab Pharmacokinet. 2015 Apr;30(2):198-204. doi: 10.1016/j.dmpk.2014.12.009. Epub 2015 Jan 6.

PMID:
25989893
32.

Modeling approach for multiple transporters-mediated drug-drug interactions in sandwich-cultured human hepatocytes: effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide.

Matsunaga N, Suzuki K, Nakanishi T, Ogawa M, Imawaka H, Tamai I.

Drug Metab Pharmacokinet. 2015 Apr;30(2):142-8. doi: 10.1016/j.dmpk.2014.10.006. Epub 2014 Nov 14.

PMID:
25989889
33.

Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy.

Nakanishi T, Ogawa T, Yanagihara C, Tamai I.

J Pharm Sci. 2015 Sep;104(9):3092-100. doi: 10.1002/jps.24462. Epub 2015 May 8.

PMID:
25959076
34.

Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.

Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma S, Hosoya K, Tamai I.

PLoS One. 2015 Apr 29;10(4):e0123895. doi: 10.1371/journal.pone.0123895. eCollection 2015.

35.

Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells.

Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I.

J Pharm Sci. 2015 Sep;104(9):3146-53. doi: 10.1002/jps.24455. Epub 2015 Apr 21.

PMID:
25900515
36.

Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells.

Matsumoto J, Ariyoshi N, Sakakibara M, Nakanishi T, Okubo Y, Shiina N, Fujisaki K, Nagashima T, Nakatani Y, Tamai I, Yamada H, Takeda H, Ishii I.

Drug Metab Pharmacokinet. 2015 Apr;30(2):133-41. doi: 10.1016/j.dmpk.2014.10.005. Epub 2014 Nov 14.

PMID:
25857231
37.

Repetitive sequences based on genotyping of Candida albicans isolates obtained from Iranian patients with human immunodeficiency virus.

Tamai IA, Salehi TZ, Sharifzadeh A, Shokri H, Khosravi AR.

Iran J Basic Med Sci. 2014 Nov;17(11):831-5.

38.

In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.

Lu Y, Nakanishi T, Hosomi A, Komori H, Tamai I.

J Pharm Pharmacol. 2015 Feb;67(2):170-7. doi: 10.1111/jphp.12328. Epub 2014 Dec 17.

PMID:
25515305
39.

High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans.

Nguyen MA, Staubach P, Tamai I, Langguth P.

Eur J Pharm Sci. 2015 Feb 20;68:36-42. doi: 10.1016/j.ejps.2014.12.001. Epub 2014 Dec 5.

PMID:
25486333
40.

Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers.

Nakanishi T, Tamai I.

Biopharm Drug Dispos. 2014 Nov;35(8):463-84. doi: 10.1002/bdd.1915. Epub 2014 Oct 13. Review.

PMID:
25156339
41.

SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria.

Chino Y, Samukawa Y, Sakai S, Nakai Y, Yamaguchi J, Nakanishi T, Tamai I.

Biopharm Drug Dispos. 2014 Oct;35(7):391-404. doi: 10.1002/bdd.1909. Epub 2014 Aug 6.

42.

Accumulation of trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid in prostate cancer due to androgen-induced expression of amino acid transporters.

Okudaira H, Oka S, Ono M, Nakanishi T, Schuster DM, Kobayashi M, Goodman MM, Tamai I, Kawai K, Shirakami Y.

Mol Imaging Biol. 2014 Dec;16(6):756-64. doi: 10.1007/s11307-014-0756-x.

43.

Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers.

Akamine Y, Miura M, Komori H, Saito S, Kusuhara H, Tamai I, Ieiri I, Uno T, Yasui-Furukori N.

Eur J Clin Pharmacol. 2014 Sep;70(9):1087-95. doi: 10.1007/s00228-014-1705-y. Epub 2014 Jun 7.

PMID:
24903351
44.

[Transporter-mediated drug interaction].

Komori H, Tamai I.

Nihon Yakurigaku Zasshi. 2014 May;143(5):243-8. Review. Japanese. No abstract available.

PMID:
24813795
45.

Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan.

Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K.

Nucl Med Biol. 2014 Apr;41(4):338-42. doi: 10.1016/j.nucmedbio.2014.01.004. Epub 2014 Jan 13.

PMID:
24607436
46.

Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.

Shirasaka Y, Mori T, Murata Y, Nakanishi T, Tamai I.

Pharm Res. 2014 Aug;31(8):2035-43. doi: 10.1007/s11095-014-1305-7. Epub 2014 Feb 19.

PMID:
24549825
48.

Mathematical modeling of the in vitro hepatic disposition of mycophenolic acid and its glucuronide in sandwich-cultured human hepatocytes.

Matsunaga N, Wada S, Nakanishi T, Ikenaga M, Ogawa M, Tamai I.

Mol Pharm. 2014 Feb 3;11(2):568-79. doi: 10.1021/mp400513k. Epub 2013 Dec 13.

PMID:
24320552
49.

MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid.

Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, Itoh Y.

Cell Physiol Biochem. 2013;32(4):942-50. doi: 10.1159/000354497. Epub 2013 Oct 1.

50.

OATP transporter-mediated drug absorption and interaction.

Tamai I, Nakanishi T.

Curr Opin Pharmacol. 2013 Dec;13(6):859-63. doi: 10.1016/j.coph.2013.09.001. Epub 2013 Sep 20. Review.

PMID:
24060700

Supplemental Content

Support Center