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Items: 1 to 50 of 243

1.

Sulforaphane from Broccoli Reduces Symptoms of Autism: A Follow-up Case Series from a Randomized Double-blind Study.

Lynch R, Diggins EL, Connors SL, Zimmerman AW, Singh K, Liu H, Talalay P, Fahey JW.

Glob Adv Health Med. 2017 Oct 26;6:2164957X17735826. doi: 10.1177/2164957X17735826. eCollection 2017.

2.

Transcription factors NRF2 and HSF1 have opposing functions in autophagy.

Dayalan Naidu S, Dikovskaya D, Gaurilcikaite E, Knatko EV, Healy ZR, Mohan H, Koh G, Laurell A, Ball G, Olagnier D, de la Vega L, Ganley IG, Talalay P, Dinkova-Kostova AT.

Sci Rep. 2017 Sep 8;7(1):11023. doi: 10.1038/s41598-017-11262-5.

3.

Quantification of skin erythema response to topical alcohol in alcohol-intolerant East Asians.

Aoki Y, Wehage SL, Talalay P.

Skin Res Technol. 2017 Nov;23(4):593-596. doi: 10.1111/srt.12376. Epub 2017 May 17.

PMID:
28513003
4.

Correction: Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.

Wise RA, Holbrook JT, Criner G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S; Broccoli Sprout Extract Trial Research Group.

PLoS One. 2017 Mar 28;12(3):e0175077. doi: 10.1371/journal.pone.0175077. eCollection 2017.

5.

Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency.

Fahey JW, Wade KL, Wehage SL, Holtzclaw WD, Liu H, Talalay P, Fuchs E, Stephenson KK.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600766. Epub 2017 Feb 8.

PMID:
27935214
6.

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.

Wise RA, Holbrook JT, Criner G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S; Broccoli Sprout Extract Trial Research Group.

PLoS One. 2016 Nov 10;11(11):e0163716. doi: 10.1371/journal.pone.0163716. eCollection 2016. Erratum in: PLoS One. 2017 Mar 28;12 (3):e0175077.

7.

Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD).

Liu H, Talalay P, Fahey JW.

CNS Neurol Disord Drug Targets. 2016;15(5):602-13. Review.

PMID:
27071792
8.

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase.

Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson KK, Talalay P.

PLoS One. 2015 Nov 2;10(11):e0140963. doi: 10.1371/journal.pone.0140963. eCollection 2015.

9.

Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.

Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW.

Respir Res. 2015 Sep 15;16:106. doi: 10.1186/s12931-015-0253-z.

10.

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.

Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24.

11.

Reply to Scahill: Behavioral outcome measures in autism.

Talalay P, Zimmerman AW.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E350. doi: 10.1073/pnas.1422473112. Epub 2015 Jan 13. No abstract available.

12.

Sulforaphane treatment of autism spectrum disorder (ASD).

Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15550-5. doi: 10.1073/pnas.1416940111. Epub 2014 Oct 13.

13.

Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.

14.

Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention.

Liu H, Talalay P.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19065-70. doi: 10.1073/pnas.1318247110. Epub 2013 Nov 4.

15.

Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance.

Ushida Y, Talalay P.

Alcohol Alcohol. 2013 Sep-Oct;48(5):526-34. doi: 10.1093/alcalc/agt063. Epub 2013 Jul 3.

PMID:
23825090
16.

Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates.

Fahey JW, Stephenson KK, Wade KL, Talalay P.

Biochem Biophys Res Commun. 2013 May 24;435(1):1-7. doi: 10.1016/j.bbrc.2013.03.126. Epub 2013 Apr 11.

17.

Neuroprotective effects of sulforaphane after contusive spinal cord injury.

Benedict AL, Mountney A, Hurtado A, Bryan KE, Schnaar RL, Dinkova-Kostova AT, Talalay P.

J Neurotrauma. 2012 Nov 1;29(16):2576-86. doi: 10.1089/neu.2012.2474. Epub 2012 Sep 20.

18.

Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.

Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P.

Top Curr Chem. 2013;329:163-77. doi: 10.1007/128_2012_339. Review.

19.

Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P.

Cancer Prev Res (Phila). 2012 Apr;5(4):603-11. doi: 10.1158/1940-6207.CAPR-11-0538. Epub 2012 Feb 7.

20.

Notes from the field: "green" chemoprevention as frugal medicine.

Fahey JW, Talalay P, Kensler TW.

Cancer Prev Res (Phila). 2012 Feb;5(2):179-88. doi: 10.1158/1940-6207.CAPR-11-0572. Review.

21.

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS.

Carcinogenesis. 2012 Jan;33(1):101-7. doi: 10.1093/carcin/bgr229. Epub 2011 Nov 1. Erratum in: Carcinogenesis. 2012 Mar;33(3):722.

22.

Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.

Healy ZR, Liu H, Holtzclaw WD, Talalay P.

Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1516-23. doi: 10.1158/1055-9965.EPI-11-0279. Epub 2011 May 20.

23.

Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.

Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen MD, Jacobson LP, Muñoz A, Ng D, Qian GS, Zhu YR, Chen TY, Botting NP, Zhang Q, Fahey JW, Talalay P, Groopman JD, Kensler TW.

Cancer Prev Res (Phila). 2011 Mar;4(3):384-95. doi: 10.1158/1940-6207.CAPR-10-0296.

24.

Stimulation of phagocytosis by sulforaphane.

Suganuma H, Fahey JW, Bryan KE, Healy ZR, Talalay P.

Biochem Biophys Res Commun. 2011 Feb 4;405(1):146-51. doi: 10.1016/j.bbrc.2011.01.025. Epub 2011 Jan 8.

25.

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.

Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T.

J Biol Chem. 2010 Oct 29;285(44):33747-55. doi: 10.1074/jbc.M110.163485. Epub 2010 Aug 26.

26.

Electrophilic tuning of the chemoprotective natural product sulforaphane.

Ahn YH, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova AT, Talalay P, Cole PA.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9590-5. doi: 10.1073/pnas.1004104107. Epub 2010 May 3.

27.

Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.

Bensasson RV, Zoete V, Berthier G, Talalay P, Dinkova-Kostova AT.

Chem Biol Interact. 2010 Jul 30;186(2):118-26. doi: 10.1016/j.cbi.2010.04.026. Epub 2010 Apr 28.

28.

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.

Dinkova-Kostova AT, Talalay P.

Arch Biochem Biophys. 2010 Sep 1;501(1):116-23. doi: 10.1016/j.abb.2010.03.019. Epub 2010 Mar 31. Review.

29.

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

Dinkova-Kostova AT, Fahey JW, Benedict AL, Jenkins SN, Ye L, Wehage SL, Talalay P.

Photochem Photobiol Sci. 2010 Apr;9(4):597-600. doi: 10.1039/b9pp00130a.

30.

Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors.

Healy ZR, Dinkova-Kostova AT, Wehage SL, Thompson RE, Fahey JW, Talalay P.

Photodermatol Photoimmunol Photomed. 2009 Feb;25(1):45-50. doi: 10.1111/j.1600-0781.2009.00404.x.

31.

Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

Dinkova-Kostova AT, Fahey JW, Jenkins SN, Wehage SL, Talalay P.

Nutr Res. 2008 Aug;28(8):539-43. doi: 10.1016/j.nutres.2008.05.009.

32.

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

Liu H, Dinkova-Kostova AT, Talalay P.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15926-31. doi: 10.1073/pnas.0808346105. Epub 2008 Oct 6.

33.

Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

Bensasson RV, Zoete V, Dinkova-Kostova AT, Talalay P.

Chem Res Toxicol. 2008 Apr;21(4):805-12. doi: 10.1021/tx7002883. Epub 2008 Mar 25.

PMID:
18361512
34.

Direct and indirect antioxidant properties of inducers of cytoprotective proteins.

Dinkova-Kostova AT, Talalay P.

Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S128-38. doi: 10.1002/mnfr.200700195. Review.

PMID:
18327872
35.

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.

Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P.

Biochem Biophys Res Commun. 2008 Mar 21;367(4):859-65. doi: 10.1016/j.bbrc.2008.01.026. Epub 2008 Jan 17.

PMID:
18206646
36.

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation.

Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, Min C, Dinkova-Kostova AT.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23.

37.

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.

Kerns ML, DePianto D, Dinkova-Kostova AT, Talalay P, Coulombe PA.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14460-5. Epub 2007 Aug 27.

38.

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

Liby K, Honda T, Williams CR, Risingsong R, Royce DB, Suh N, Dinkova-Kostova AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB.

Mol Cancer Ther. 2007 Jul;6(7):2113-9.

39.

Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants.

Dinkova-Kostova AT, Cheah J, Samouilov A, Zweier JL, Bozak RE, Hicks RJ, Talalay P.

Med Chem. 2007 May;3(3):261-8.

PMID:
17504197
40.

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay P.

Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51.

41.

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MS, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K.

Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7.

PMID:
17347138
42.

Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

Shapiro TA, Fahey JW, Dinkova-Kostova AT, Holtzclaw WD, Stephenson KK, Wade KL, Ye L, Talalay P.

Nutr Cancer. 2006;55(1):53-62.

PMID:
16965241
43.

Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.

Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang JB, Wu Y, Sun Y, Zhang QN, Zhang BC, Zhu YR, Qian GS, Carmella SG, Hecht SS, Benning L, Gange SJ, Groopman JD, Talalay P.

Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2605-13.

44.

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.

Dinkova-Kostova AT, Jenkins SN, Fahey JW, Ye L, Wehage SL, Liby KT, Stephenson KK, Wade KL, Talalay P.

Cancer Lett. 2006 Aug 28;240(2):243-52. Epub 2005 Nov 3.

PMID:
16271437
45.

Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.

Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14010-5. Epub 2005 Sep 19.

46.

A fascination with enzymes: the journey not the arrival matters.

Talalay P.

J Biol Chem. 2005 Aug 12;280(32):28829-47. Epub 2005 Jun 7. No abstract available.

47.

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.

Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P.

Carcinogenesis. 2005 Jul;26(7):1247-55. Epub 2005 Mar 17.

PMID:
15774490
48.

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.

Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. Epub 2005 Mar 14.

49.

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

Holtzclaw WD, Dinkova-Kostova AT, Talalay P.

Adv Enzyme Regul. 2004;44:335-67. Review. No abstract available.

PMID:
15581500
50.

Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial.

Fahey JW, Muñoz A, Matsuzaki Y, Suzuki H, Talalay P, Tauchi M, Zhang S, Hurt C, Yanaka A.

Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1610-6.

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