Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 36

1.

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF.

Nat Commun. 2017 Oct 3;8(1):767. doi: 10.1038/s41467-017-00992-9.

2.

Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion.

Tiwari S, Roel C, Wills R, Casinelli G, Tanwir M, Takane KK, Fiaschi-Taesch NM.

Diabetes. 2015 Oct;64(10):3485-98. doi: 10.2337/db14-1885. Epub 2015 Jul 9.

3.

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells.

Chen H, Kleinberger JW, Takane KK, Salim F, Fiaschi-Taesch N, Pappas K, Parsons R, Jiang J, Zhang Y, Liu H, Wang P, Bender AS, Frank SJ, Stewart AF.

Diabetes. 2015 Nov;64(11):3784-97. doi: 10.2337/db15-0083. Epub 2015 Jul 9.

4.

Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S control.

Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Srinivas H, Scott DK, Stewart AF.

Diabetes. 2013 Jul;62(7):2460-70. doi: 10.2337/db12-0778. Epub 2013 Mar 14.

5.

Human pancreatic β-cell G1/S molecule cell cycle atlas.

Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Scott DK, Stewart AF.

Diabetes. 2013 Jul;62(7):2450-9. doi: 10.2337/db12-0777. Epub 2013 Mar 14.

6.

Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets.

Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH.

Mol Endocrinol. 2012 Sep;26(9):1590-602. doi: 10.1210/me.2012-1019. Epub 2012 Jul 13.

7.

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK.

Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14.

8.

c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein.

Sicari BM, Troxell R, Salim F, Tanwir M, Takane KK, Fiaschi-Taesch N.

Endocrinology. 2012 Feb;153(2):861-72. doi: 10.1210/en.2011-1590. Epub 2011 Dec 30.

PMID:
22210745
9.

Regulated and reversible induction of adult human β-cell replication.

Takane KK, Kleinberger JW, Salim FG, Fiaschi-Taesch NM, Stewart AF.

Diabetes. 2012 Feb;61(2):418-24. doi: 10.2337/db11-0580. Epub 2011 Dec 30.

10.

A human islet cell culture system for high-throughput screening.

Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK.

J Biomol Screen. 2012 Apr;17(4):509-18. doi: 10.1177/1087057111430253. Epub 2011 Dec 7.

11.

Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Oct;60(10):2546-59. doi: 10.2337/db10-1783. Epub 2011 Sep 12.

12.

cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication.

Karslioglu E, Kleinberger JW, Salim FG, Cox AE, Takane KK, Scott DK, Stewart AF.

Mol Endocrinol. 2011 Oct;25(10):1760-72. doi: 10.1210/me.2011-1074. Epub 2011 Sep 1.

13.

Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.

Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC.

Diabetes. 2010 Dec;59(12):3131-8. doi: 10.2337/db09-1796. Epub 2010 Sep 28.

14.

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.

Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF.

Diabetes. 2010 Aug;59(8):1926-36. doi: 10.2337/db09-1776.

15.

Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis.

González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A.

Endocrinology. 2010 Apr;151(4):1487-98. doi: 10.1210/en.2009-0975. Epub 2010 Feb 22.

16.

Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling.

Blouin CM, Prado C, Takane KK, Lasnier F, Garcia-Ocana A, Ferré P, Dugail I, Hajduch E.

Diabetes. 2010 Mar;59(3):600-10. doi: 10.2337/db09-0897. Epub 2009 Dec 3.

17.

Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo.

Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF.

Diabetes. 2009 Apr;58(4):882-93. doi: 10.2337/db08-0631. Epub 2009 Jan 9.

18.

Mutant parathyroid hormone-related protein, devoid of the nuclear localization signal, markedly inhibits arterial smooth muscle cell cycle and neointima formation by coordinate up-regulation of p15Ink4b and p27kip1.

Fiaschi-Taesch N, Sicari B, Ubriani K, Cozar-Castellano I, Takane KK, Stewart AF.

Endocrinology. 2009 Mar;150(3):1429-39. doi: 10.1210/en.2008-0737. Epub 2008 Oct 9.

PMID:
18845646
19.

Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets.

Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF.

Diabetes. 2008 Oct;57(10):2745-54. doi: 10.2337/db08-1085.

20.

Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.

Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.

21.

Cellular mechanism through which parathyroid hormone-related protein induces proliferation in arterial smooth muscle cells: definition of an arterial smooth muscle PTHrP/p27kip1 pathway.

Fiaschi-Taesch N, Sicari BM, Ubriani K, Bigatel T, Takane KK, Cozar-Castellano I, Bisello A, Law B, Stewart AF.

Circ Res. 2006 Oct 27;99(9):933-42. Epub 2006 Oct 5.

22.

Molecular control of cell cycle progression in the pancreatic beta-cell.

Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, Stewart AF.

Endocr Rev. 2006 Jun;27(4):356-70. Epub 2006 Apr 25. Review.

PMID:
16638909
23.

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice.

Rao P, Roccisana J, Takane KK, Bottino R, Zhao A, Trucco M, García-Ocaña A.

Diabetes. 2005 Jun;54(6):1664-75.

24.

Parathyroid-hormone-related protein as a regulator of pRb and the cell cycle in arterial smooth muscle.

Fiaschi-Taesch N, Takane KK, Masters S, Lopez-Talavera JC, Stewart AF.

Circulation. 2004 Jul 13;110(2):177-85. Epub 2004 Jun 21.

25.
26.

Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation.

Lopez-Talavera JC, Garcia-Ocaña A, Sipula I, Takane KK, Cozar-Castellano I, Stewart AF.

Endocrinology. 2004 Feb;145(2):467-74. Epub 2003 Oct 9.

PMID:
14551233
27.

Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.

Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF.

J Biol Chem. 2003 Jan 3;278(1):343-51. Epub 2002 Oct 25.

28.

Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro.

Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC.

Diabetes. 2002 Oct;51(10):3003-13.

29.

Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF.

Diabetes. 2001 Dec;50(12):2752-62.

30.

The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells.

de Miguel F, Fiaschi-Taesch N, López-Talavera JC, Takane KK, Massfelder T, Helwig JJ, Stewart AF.

Endocrinology. 2001 Sep;142(9):4096-105.

PMID:
11517189
31.

Using beta-cell growth factors to enhance human pancreatic Islet transplantation.

García-Ocaña A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, Stewart AF.

J Clin Endocrinol Metab. 2001 Mar;86(3):984-8. Review.

PMID:
11238473
32.

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

J Biol Chem. 2000 Jan 14;275(2):1226-32.

33.

Functional analysis of the human androgen receptor promoter.

Takane KK, McPhaul MJ.

Mol Cell Endocrinol. 1996 May 17;119(1):83-93.

PMID:
8793857
35.

Androgen receptor levels in the rat penis are controlled differently in distinctive cell types.

Takane KK, Husmann DA, McPhaul MJ, Wilson JD.

Endocrinology. 1991 May;128(5):2234-8.

PMID:
2019249
36.

Androgen receptor of rat penis is down-regulated by androgen.

Takane KK, George FW, Wilson JD.

Am J Physiol. 1990 Jan;258(1 Pt 1):E46-50.

PMID:
2301571

Supplemental Content

Loading ...
Support Center