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Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients.

Miloushev VZ, Granlund KL, Boltyanskiy R, Lyashchenko SK, DeAngelis LM, Mellinghoff IK, Brennan CW, Tabar V, Yang TJ, Holodny AI, Sosa RE, Guo YW, Chen AP, Tropp J, Robb F, Keshari KR.

Cancer Res. 2018 May 16. pii: canres.0221.2018. doi: 10.1158/0008-5472.CAN-18-0221. [Epub ahead of print]


Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.

Omuro A, Beal K, McNeill K, Young RJ, Thomas A, Lin X, Terziev R, Kaley TJ, DeAngelis LM, Daras M, Gavrilovic IT, Mellinghoff I, Diamond EL, McKeown A, Manne M, Caterfino A, Patel K, Bavisotto L, Gorman G, Lamson M, Gutin P, Tabar V, Chakravarty D, Chan TA, Brennan CW, Garrett-Mayer E, Karmali RA, Pentsova E.

J Clin Oncol. 2018 Apr 23:JCO2017769992. doi: 10.1200/JCO.2017.76.9992. [Epub ahead of print]


Brain Metastases in Pancreatic Ductal Adenocarcinoma: Assessment of Molecular Genotype-Phenotype Features-An Entity With an Increasing Incidence?

Jordan EJ, Lowery MA, Basturk O, Allen PJ, Yu KH, Tabar V, Beal K, Reidy DL, Yamada Y, Janjigian Y, Abou-Alfa GK, O'Reilly EM.

Clin Colorectal Cancer. 2018 Feb 7. pii: S1533-0028(17)30290-6. doi: 10.1016/j.clcc.2018.01.009. [Epub ahead of print]


The relationship between repeat resection and overall survival in patients with glioblastoma: a time-dependent analysis.

Goldman DA, Hovinga K, Reiner AS, Esquenazi Y, Tabar V, Panageas KS.

J Neurosurg. 2018 Jan 5:1-9. doi: 10.3171/2017.6.JNS17393. [Epub ahead of print]


Factors associated with a primary surgical approach for sinonasal squamous cell carcinoma.

Cracchiolo JR, Patel K, Migliacci JC, Morris LT, Ganly I, Roman BR, McBride SM, Tabar VS, Cohen MA.

J Surg Oncol. 2018 Mar;117(4):756-764. doi: 10.1002/jso.24923. Epub 2017 Nov 28.


Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.

Major T, Powers A, Tabar V.

Curr Protoc Stem Cell Biol. 2017 Nov 8;39:1H.10.1-1H.10.23. doi: 10.1002/cpsc.17.


Association of Surgical Approach and Margin Status With Oncologic Outcomes Following Gross Total Resection for Sinonasal Melanoma.

Sayed Z, Migliacci JC, Cracchiolo JR, Barker CA, Lee NY, McBride SM, Tabar VS, Ganly I, Patel SG, Morris LT, Roman BR, Shoushtari AN, Cohen MA.

JAMA Otolaryngol Head Neck Surg. 2017 Dec 1;143(12):1220-1227. doi: 10.1001/jamaoto.2017.2011. No abstract available.


Thalamic Glioblastoma: Clinical Presentation, Management Strategies, and Outcomes.

Esquenazi Y, Moussazadeh N, Link TW, Hovinga KE, Reiner AS, DiStefano NM, Brennan C, Gutin P, Tabar V.

Neurosurgery. 2017 Jul 21. doi: 10.1093/neuros/nyx349. [Epub ahead of print]


The Role of Extent of Resection in IDH1 Wild-Type or Mutant Low-Grade Gliomas.

Patel T, Bander ED, Venn RA, Powell T, Cederquist GY, Schaefer PM, Puchi LA, Akhmerov A, Ogilvie S, Reiner AS, Moussazadeh N, Tabar V.

Neurosurgery. 2018 Jun 1;82(6):808-814. doi: 10.1093/neuros/nyx265.


Predictors of Treatment Response and Survival Outcomes in Meningioma Recurrence with Atypical or Anaplastic Histology.

Chohan MO, Ryan CT, Singh R, Lanning RM, Reiner AS, Rosenblum MK, Tabar V, Gutin PH.

Neurosurgery. 2018 Jun 1;82(6):824-832. doi: 10.1093/neuros/nyx312.


Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.

Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK.

Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15.


Human Pluripotent-Derived Lineages for Repairing Hypopituitarism.

Studer L, Tabar V.

In: Pfaff D, Christen Y, editors. Stem Cells in Neuroendocrinology [Internet]. Cham (CH): Springer; 2016.
2016 Jul 27.


Prior malignancies in patients harboring glioblastoma: an institutional case-study of 2164 patients.

Zacharia BE, DiStefano N, Mader MM, Chohan MO, Ogilvie S, Brennan C, Gutin P, Tabar V.

J Neurooncol. 2017 Sep;134(2):245-251. doi: 10.1007/s11060-017-2512-y. Epub 2017 May 27. Review.


Clinical outcomes of patients with limited brain metastases treated with hypofractionated (5×6Gy) conformal radiotherapy.

Lockney NA, Wang DG, Gutin PH, Brennan C, Tabar V, Ballangrud A, Pei X, Chan TA, Yamada Y, Yang TJ, Beal K.

Radiother Oncol. 2017 May;123(2):203-208. doi: 10.1016/j.radonc.2017.03.018. Epub 2017 Apr 5.


Longitudinal analysis of treatment-induced genomic alterations in gliomas.

Erson-Omay EZ, Henegariu O, Omay SB, Harmancı AS, Youngblood MW, Mishra-Gorur K, Li J, Özduman K, Carrión-Grant G, Clark VE, Çağlar C, Bakırcıoğlu M, Pamir MN, Tabar V, Vortmeyer AO, Bilguvar K, Yasuno K, DeAngelis LM, Baehring JM, Moliterno J, Günel M.

Genome Med. 2017 Feb 2;9(1):12. doi: 10.1186/s13073-017-0401-9.


Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA.

Cell Rep. 2016 Nov 22;17(9):2445-2459. doi: 10.1016/j.celrep.2016.10.052. Epub 2016 Nov 10.


Anti-Epidermal Growth Factor Receptor Gene Therapy for Glioblastoma.

Hicks MJ, Chiuchiolo MJ, Ballon D, Dyke JP, Aronowitz E, Funato K, Tabar V, Havlicek D, Fan F, Sondhi D, Kaminsky SM, Crystal RG.

PLoS One. 2016 Oct 6;11(10):e0162978. doi: 10.1371/journal.pone.0162978. eCollection 2016.


Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells.

Zimmer B, Piao J, Ramnarine K, Tomishima MJ, Tabar V, Studer L.

Stem Cell Reports. 2016 Jun 14;6(6):858-72. doi: 10.1016/j.stemcr.2016.05.005.


Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial.

Xu R, Shimizu F, Hovinga K, Beal K, Karimi S, Droms L, Peck KK, Gutin P, Iorgulescu JB, Kaley T, DeAngelis L, Pentsova E, Nolan C, Grommes C, Chan T, Bobrow D, Hormigo A, Cross JR, Wu N, Takebe N, Panageas K, Ivy P, Supko JG, Tabar V, Omuro A.

Clin Cancer Res. 2016 Oct 1;22(19):4786-4796. Epub 2016 May 6.


Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma.

Cook PJ, Thomas R, Kingsley PJ, Shimizu F, Montrose DC, Marnett LJ, Tabar VS, Dannenberg AJ, Benezra R.

Neuro Oncol. 2016 Oct;18(10):1379-89. doi: 10.1093/neuonc/now049. Epub 2016 Mar 28.


Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases.

Kohutek ZA, Yamada Y, Chan TA, Brennan CW, Tabar V, Gutin PH, Yang TJ, Rosenblum MK, Ballangrud Å, Young RJ, Zhang Z, Beal K.

J Neurooncol. 2015 Oct;125(1):149-56. doi: 10.1007/s11060-015-1881-3. Epub 2015 Aug 26.


Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.

Calder EL, Tchieu J, Steinbeck JA, Tu E, Keros S, Ying SW, Jaiswal MK, Cornacchia D, Goldstein PA, Tabar V, Studer L.

J Neurosci. 2015 Aug 19;35(33):11462-81. doi: 10.1523/JNEUROSCI.3046-14.2015.


Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: safety profile and efficacy of combined treatment.

Kiess AP, Wolchok JD, Barker CA, Postow MA, Tabar V, Huse JT, Chan TA, Yamada Y, Beal K.

Int J Radiat Oncol Biol Phys. 2015 Jun 1;92(2):368-75. doi: 10.1016/j.ijrobp.2015.01.004. Epub 2015 Mar 5.


Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.

Piao J, Major T, Auyeung G, Policarpio E, Menon J, Droms L, Gutin P, Uryu K, Tchieu J, Soulet D, Tabar V.

Cell Stem Cell. 2015 Feb 5;16(2):198-210. doi: 10.1016/j.stem.2015.01.004.


Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.

Funato K, Major T, Lewis PW, Allis CD, Tabar V.

Science. 2014 Dec 19;346(6216):1529-33. doi: 10.1126/science.1253799. Epub 2014 Nov 20.


Genetic modification of neurons to express bevacizumab for local anti-angiogenesis treatment of glioblastoma.

Hicks MJ, Funato K, Wang L, Aronowitz E, Dyke JP, Ballon DJ, Havlicek DF, Frenk EZ, De BP, Chiuchiolo MJ, Sondhi D, Hackett NR, Kaminsky SM, Tabar V, Crystal RG.

Cancer Gene Ther. 2015 Jan;22(1):1-8. doi: 10.1038/cgt.2014.58. Epub 2014 Dec 12.


Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma.

Omuro A, Beal K, Gutin P, Karimi S, Correa DD, Kaley TJ, DeAngelis LM, Chan TA, Gavrilovic IT, Nolan C, Hormigo A, Lassman AB, Mellinghoff I, Grommes C, Reiner AS, Panageas KS, Baser RE, Tabar V, Pentsova E, Sanchez J, Barradas-Panchal R, Zhang J, Faivre G, Brennan CW, Abrey LE, Huse JT.

Clin Cancer Res. 2014 Oct 1;20(19):5023-31. doi: 10.1158/1078-0432.CCR-14-0822. Epub 2014 Aug 8.


Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study.

Morikawa A, Peereboom DM, Thorsheim HR, Samala R, Balyan R, Murphy CG, Lockman PR, Simmons A, Weil RJ, Tabar V, Steeg PS, Smith QR, Seidman AD.

Neuro Oncol. 2015 Feb;17(2):289-95. doi: 10.1093/neuonc/nou141. Epub 2014 Jul 11. Erratum in: Neuro Oncol. 2015 Oct;17(10):1423.


Pluripotent stem cells in regenerative medicine: challenges and recent progress.

Tabar V, Studer L.

Nat Rev Genet. 2014 Feb;15(2):82-92. doi: 10.1038/nrg3563. Review.


A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases.

Brennan C, Yang TJ, Hilden P, Zhang Z, Chan K, Yamada Y, Chan TA, Lymberis SC, Narayana A, Tabar V, Gutin PH, Ballangrud Å, Lis E, Beal K.

Int J Radiat Oncol Biol Phys. 2014 Jan 1;88(1):130-6. doi: 10.1016/j.ijrobp.2013.09.051.


Specification of functional cranial placode derivatives from human pluripotent stem cells.

Dincer Z, Piao J, Niu L, Ganat Y, Kriks S, Zimmer B, Shi SH, Tabar V, Studer L.

Cell Rep. 2013 Dec 12;5(5):1387-402. doi: 10.1016/j.celrep.2013.10.048. Epub 2013 Nov 27.


Radiation therapy for epithelial ovarian cancer brain metastases: clinical outcomes and predictors of survival.

Teckie S, Makker V, Tabar V, Alektiar K, Aghajanian C, Hensley M, Beal K.

Radiat Oncol. 2013 Feb 15;8:36. doi: 10.1186/1748-717X-8-36.


MEF promotes stemness in the pathogenesis of gliomas.

Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, Huse JT, Fomchenko EI, Voza F, Tabar V, Brennan CW, DeAngelis LM, Nimer SD, Holland EC, Squatrito M.

Cell Stem Cell. 2012 Dec 7;11(6):836-44. doi: 10.1016/j.stem.2012.09.012.


The role of radiotherapy following gross-total resection of atypical meningiomas.

Komotar RJ, Iorgulescu JB, Raper DM, Holland EC, Beal K, Bilsky MH, Brennan CW, Tabar V, Sherman JH, Yamada Y, Gutin PH.

J Neurosurg. 2012 Oct;117(4):679-86. doi: 10.3171/2012.7.JNS112113. Epub 2012 Aug 24.


Transsphenoidal resection of sellar tumors using high-field intraoperative magnetic resonance imaging.

Szerlip NJ, Zhang YC, Placantonakis DG, Goldman M, Colevas KB, Rubin DG, Kobylarz EJ, Karimi S, Girotra M, Tabar V.

Skull Base. 2011 Jul;21(4):223-32. doi: 10.1055/s-0031-1277262.


Making a pituitary gland in a dish.

Tabar V.

Cell Stem Cell. 2011 Dec 2;9(6):490-1. doi: 10.1016/j.stem.2011.11.013.


Organotypic explant culture of glioblastoma multiforme and subsequent single-cell suspension.

Shimizu F, Hovinga KE, Metzner M, Soulet D, Tabar V.

Curr Protoc Stem Cell Biol. 2011 Dec;Chapter 3:Unit3.5. doi: 10.1002/9780470151808.sc0305s19.


Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.

Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, Studer L.

Nature. 2011 Nov 6;480(7378):547-51. doi: 10.1038/nature10648.


Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas.

Pulvirenti T, Van Der Heijden M, Droms LA, Huse JT, Tabar V, Hall A.

Cancer Res. 2011 Dec 1;71(23):7280-90. doi: 10.1158/0008-5472.CAN-11-1531. Epub 2011 Oct 11.


Transgene excision has no impact on in vivo integration of human iPS derived neural precursors.

Major T, Menon J, Auyeung G, Soldner F, Hockemeyer D, Jaenisch R, Tabar V.

PLoS One. 2011;6(9):e24687. doi: 10.1371/journal.pone.0024687. Epub 2011 Sep 22.


Glioblastoma stem-like cells give rise to tumour endothelium.

Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, Geber A, Fligelman B, Leversha M, Brennan C, Tabar V.

Nature. 2010 Dec 9;468(7325):829-33. doi: 10.1038/nature09624. Epub 2010 Nov 21.


Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate.

Hovinga KE, Shimizu F, Wang R, Panagiotakos G, Van Der Heijden M, Moayedpardazi H, Correia AS, Soulet D, Major T, Menon J, Tabar V.

Stem Cells. 2010 Jun;28(6):1019-29. doi: 10.1002/stem.429.


Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

Lee G, Papapetrou EP, Kim H, Chambers SM, Tomishima MJ, Fasano CA, Ganat YM, Menon J, Shimizu F, Viale A, Tabar V, Sadelain M, Studer L.

Nature. 2009 Sep 17;461(7262):402-6. doi: 10.1038/nature08320. Epub 2009 Aug 19.


Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation.

Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, Sadelain M.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12759-64. doi: 10.1073/pnas.0904825106. Epub 2009 Jun 23.


Presurgical evaluation of language using functional magnetic resonance imaging in brain tumor patients with previous surgery.

Peck KK, Bradbury M, Petrovich N, Hou BL, Ishill N, Brennan C, Tabar V, Holodny AI.

Neurosurgery. 2009 Apr;64(4):644-52; discussion 652-3. doi: 10.1227/01.NEU.0000339122.01957.0A.


Enriched motor neuron populations derived from bacterial artificial chromosome-transgenic human embryonic stem cells.

Placantonakis DG, Tomishima MJ, Lafaille F, Desbordes SC, Jia F, Socci ND, Viale A, Lee H, Harrison N, Studer L, Tabar VS.

Clin Neurosurg. 2009;56:125-32. No abstract available.


BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage.

Placantonakis DG, Tomishima MJ, Lafaille F, Desbordes SC, Jia F, Socci ND, Viale A, Lee H, Harrison N, Tabar V, Studer L.

Stem Cells. 2009 Mar;27(3):521-32. doi: 10.1634/stemcells.2008-0884.


Therapeutic cloning in individual parkinsonian mice.

Tabar V, Tomishima M, Panagiotakos G, Wakayama S, Menon J, Chan B, Mizutani E, Al-Shamy G, Ohta H, Wakayama T, Studer L.

Nat Med. 2008 Apr;14(4):379-81. doi: 10.1038/nm1732. Epub 2008 Mar 23.


Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.

Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L.

Genes Dev. 2008 Jan 15;22(2):152-65. doi: 10.1101/gad.1616208. Erratum in: Genes Dev. 2008 May 1;22(9):1257.


Assessment of the language laterality index in patients with brain tumor using functional MR imaging: effects of thresholding, task selection, and prior surgery.

Ruff IM, Petrovich Brennan NM, Peck KK, Hou BL, Tabar V, Brennan CW, Holodny AI.

AJNR Am J Neuroradiol. 2008 Mar;29(3):528-35. doi: 10.3174/ajnr.A0841. Epub 2008 Jan 9.

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