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Items: 1 to 50 of 408

1.

An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.

Takagawa T, Kitani A, Fuss I, Levine B, Brant SR, Peter I, Tajima M, Nakamura S, Strober W.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaan8162. doi: 10.1126/scitranslmed.aan8162.

PMID:
29875204
2.

Autoimmune Pancreatitis Mouse Model.

Kamata K, Watanabe T, Minaga K, Strober W, Kudo M.

Curr Protoc Immunol. 2018 Feb 21;120:15.31.1-15.31.8. doi: 10.1002/cpim.41.

PMID:
29512140
3.

Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.

Mao L, Kitani A, Similuk M, Oler AJ, Albenberg L, Kelsen J, Aktay A, Quezado M, Yao M, Montgomery-Recht K, Fuss IJ, Strober W.

J Clin Invest. 2018 May 1;128(5):1793-1806. doi: 10.1172/JCI98642. Epub 2018 Mar 26.

4.

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.

Yao X, Zhang C, Xing Y, Xue G, Zhang Q, Pan F, Wu G, Hu Y, Guo Q, Lu A, Zhang X, Zhou R, Tian Z, Zeng B, Wei H, Strober W, Zhao L, Meng G.

Nat Commun. 2017 Dec 1;8(1):1896. doi: 10.1038/s41467-017-01917-2.

5.

T cells expressing chimeric antigen receptor promote immune tolerance.

Pierini A, Iliopoulou BP, Peiris H, Pérez-Cruz M, Baker J, Hsu K, Gu X, Zheng PP, Erkers T, Tang SW, Strober W, Alvarez M, Ring A, Velardi A, Negrin RS, Kim SK, Meyer EH.

JCI Insight. 2017 Oct 19;2(20). pii: 92865. doi: 10.1172/jci.insight.92865. [Epub ahead of print]

6.

Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders.

Watanabe T, Asano N, Kudo M, Strober W.

Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(8):578-599. doi: 10.2183/pjab.93.037.

7.

Venipuncture Procedures: Sources of Human Peripheral Blood Cells, Serum, and Plasma.

Bierer BE, Strober W.

Curr Protoc Immunol. 2017 Aug 1;118:A.3F.1-A.3F.5. doi: 10.1002/cpim.27.

PMID:
28762484
8.

Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities.

Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjo Y, Ichinohe T, Tokuno SI, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H, Mizuno-Kamiya M, Kondoh N, Seno M.

Oncol Rep. 2017 Jul;38(1):449-455. doi: 10.3892/or.2017.5646. Epub 2017 May 17.

PMID:
28535011
9.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.

10.

Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis.

Pierini A, Nishikii H, Baker J, Kimura T, Kwon HS, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, Negrin RS.

Nat Commun. 2017 May 9;8:15068. doi: 10.1038/ncomms15068.

11.

Chronic Fibro-Inflammatory Responses in Autoimmune Pancreatitis Depend on IFN-α and IL-33 Produced by Plasmacytoid Dendritic Cells.

Watanabe T, Yamashita K, Arai Y, Minaga K, Kamata K, Nagai T, Komeda Y, Takenaka M, Hagiwara S, Ida H, Sakurai T, Nishida N, Strober W, Kudo M.

J Immunol. 2017 May 15;198(10):3886-3896. doi: 10.4049/jimmunol.1700060. Epub 2017 Apr 3.

12.

The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice.

Gao P, Liu H, Huang H, Zhang Q, Strober W, Zhang F.

J Immunol. 2017 Mar 15;198(6):2457-2467. doi: 10.4049/jimmunol.1502652. Epub 2017 Feb 15.

13.

Immunopathogenesis of pancreatitis.

Watanabe T, Kudo M, Strober W.

Mucosal Immunol. 2017 Mar;10(2):283-298. doi: 10.1038/mi.2016.101. Epub 2016 Nov 16. Review.

PMID:
27848953
14.

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.

Greer RL, Dong X, Moraes AC, Zielke RA, Fernandes GR, Peremyslova E, Vasquez-Perez S, Schoenborn AA, Gomes EP, Pereira AC, Ferreira SR, Yao M, Fuss IJ, Strober W, Sikora AE, Taylor GA, Gulati AS, Morgun A, Shulzhenko N.

Nat Commun. 2016 Nov 14;7:13329. doi: 10.1038/ncomms13329.

15.

Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting.

Masuda J, Kawamoto H, Strober W, Takayama E, Mizutani A, Murakami H, Ikawa T, Kitani A, Maeno N, Shigehiro T, Satoh A, Seno A, Arun V, Kasai T, Fuss IJ, Katsura Y, Seno M.

Appl Biochem Biotechnol. 2016 Dec;180(8):1559-1573. Epub 2016 Jul 12.

PMID:
27406037
16.

TNF-α priming enhances CD4+FoxP3+ regulatory T-cell suppressive function in murine GVHD prevention and treatment.

Pierini A, Strober W, Moffett C, Baker J, Nishikii H, Alvarez M, Pan Y, Schneidawind D, Meyer E, Negrin RS.

Blood. 2016 Aug 11;128(6):866-71. doi: 10.1182/blood-2016-04-711275. Epub 2016 Jun 30.

17.

Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis.

Watanabe T, Sadakane Y, Yagama N, Sakurai T, Ezoe H, Kudo M, Chiba T, Strober W.

Mucosal Immunol. 2016 Sep;9(5):1234-49. doi: 10.1038/mi.2015.144. Epub 2016 Jan 27.

PMID:
26813347
18.

Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses.

Asano N, Imatani A, Watanabe T, Fushiya J, Kondo Y, Jin X, Ara N, Uno K, Iijima K, Koike T, Strober W, Shimosegawa T.

Cancer Res. 2016 Mar 1;76(5):1135-45. doi: 10.1158/0008-5472.CAN-15-2272. Epub 2016 Jan 12.

19.

Trypan Blue Exclusion Test of Cell Viability.

Strober W.

Curr Protoc Immunol. 2015 Nov 2;111:A3.B.1-3. doi: 10.1002/0471142735.ima03bs111.

PMID:
26529666
20.

Plasmacytoid Dendritic Cell Activation and IFN-α Production Are Prominent Features of Murine Autoimmune Pancreatitis and Human IgG4-Related Autoimmune Pancreatitis.

Arai Y, Yamashita K, Kuriyama K, Shiokawa M, Kodama Y, Sakurai T, Mizugishi K, Uchida K, Kadowaki N, Takaori-Kondo A, Kudo M, Okazaki K, Strober W, Chiba T, Watanabe T.

J Immunol. 2015 Oct 1;195(7):3033-44. doi: 10.4049/jimmunol.1500971. Epub 2015 Aug 21.

21.

Chronic inflammation and the development of malignancy in the GI tract.

Fichtner-Feigl S, Kesselring R, Strober W.

Trends Immunol. 2015 Aug;36(8):451-9. doi: 10.1016/j.it.2015.06.007. Epub 2015 Jul 18. Review.

22.

Experimental Models of Inflammatory Bowel Diseases.

Kiesler P, Fuss IJ, Strober W.

Cell Mol Gastroenterol Hepatol. 2015 Mar 1;1(2):154-170.

23.

Dynamic changes in E-protein activity regulate T reg cell development.

Gao P, Han X, Zhang Q, Yang Z, Fuss IJ, Myers TG, Gardina PJ, Zhang F, Strober W.

J Exp Med. 2014 Dec 15;211(13):2651-68. doi: 10.1084/jem.20132681. Epub 2014 Dec 8.

24.

Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease.

Strober W, Asano N, Fuss I, Kitani A, Watanabe T.

Immunol Rev. 2014 Jul;260(1):249-60. doi: 10.1111/imr.12193. Review.

PMID:
24942694
25.

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

Watanabe T, Asano N, Meng G, Yamashita K, Arai Y, Sakurai T, Kudo M, Fuss IJ, Kitani A, Shimosegawa T, Chiba T, Strober W.

Mucosal Immunol. 2014 Nov;7(6):1312-25. doi: 10.1038/mi.2014.19. Epub 2014 Mar 26.

26.

IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β.

Fichtner-Feigl S, Kesselring R, Martin M, Obermeier F, Ruemmele P, Kitani A, Brunner SM, Haimerl M, Geissler EK, Strober W, Schlitt HJ.

J Immunol. 2014 Apr 15;192(8):3969-80. doi: 10.4049/jimmunol.1301072. Epub 2014 Mar 14.

27.

IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis.

Fuss IJ, Joshi B, Yang Z, Degheidy H, Fichtner-Feigl S, de Souza H, Rieder F, Scaldaferri F, Schirbel A, Scarpa M, West G, Yi C, Xu L, Leland P, Yao M, Mannon P, Puri RK, Fiocchi C, Strober W.

Gut. 2014 Nov;63(11):1728-36. doi: 10.1136/gutjnl-2013-305671. Epub 2014 Feb 10.

28.

Transcription of RORγt in developing Th17 cells is regulated by E-proteins.

Zhang F, Fuss IJ, Yang Z, Strober W.

Mucosal Immunol. 2014 May;7(3):521-32. doi: 10.1038/mi.2013.69. Epub 2013 Sep 25.

29.

Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms.

Amendola A, Butera A, Sanchez M, Strober W, Boirivant M.

Mucosal Immunol. 2014 Mar;7(2):391-404. doi: 10.1038/mi.2013.58. Epub 2013 Aug 21.

30.

Impact of the gut microbiome on mucosal inflammation.

Strober W.

Trends Immunol. 2013 Sep;34(9):423-30. doi: 10.1016/j.it.2013.07.001. Epub 2013 Aug 16. Review.

31.

Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice.

Blois SM, Sulkowski G, Tirado-González I, Warren J, Freitag N, Klapp BF, Rifkin D, Fuss I, Strober W, Dveksler GS.

Mucosal Immunol. 2014 Mar;7(2):348-58. doi: 10.1038/mi.2013.53. Epub 2013 Aug 14.

32.

Nodular regenerative hyperplasia in common variable immunodeficiency.

Fuss IJ, Friend J, Yang Z, He JP, Hooda L, Boyer J, Xi L, Raffeld M, Kleiner DE, Heller T, Strober W.

J Clin Immunol. 2013 May;33(4):748-58. doi: 10.1007/s10875-013-9873-6. Epub 2013 Feb 19.

33.

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.

Mao K, Chen S, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W, Chen C, Meng G, Sun B.

Cell Res. 2013 Feb;23(2):201-12. doi: 10.1038/cr.2013.6. Epub 2013 Jan 15.

34.

Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.

Tsuji Y, Watanabe T, Kudo M, Arai H, Strober W, Chiba T.

Immunity. 2012 Aug 24;37(2):326-38. doi: 10.1016/j.immuni.2012.05.024. Epub 2012 Aug 16.

35.

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein.

Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Núñez G.

Immunity. 2012 Jul 27;37(1):85-95. doi: 10.1016/j.immuni.2012.04.013. Epub 2012 Jul 19.

36.

TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⁺ memory T cell loss in SIVmac251-challenged rhesus macaques.

Sui Y, Gagnon S, Dzutsev A, Zhu Q, Yu H, Hogg A, Wang Y, Xia Z, Belyakov IM, Venzon D, Klinman D, Strober W, Kelsall B, Franchini G, Berzofsky JA.

Vaccine. 2011 Dec 9;30(1):59-68. doi: 10.1016/j.vaccine.2011.10.043. Epub 2011 Oct 29.

37.

MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases.

Dagur PK, Biancotto A, Wei L, Sen HN, Yao M, Strober W, Nussenblatt RB, McCoy JP Jr.

J Autoimmun. 2011 Dec;37(4):319-27. doi: 10.1016/j.jaut.2011.09.003. Epub 2011 Sep 29.

38.

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease.

Strober W, Watanabe T.

Mucosal Immunol. 2011 Sep;4(5):484-95. doi: 10.1038/mi.2011.29. Epub 2011 Jul 13. Review.

39.

Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases.

Strober W, Fuss IJ.

Gastroenterology. 2011 May;140(6):1756-1767. doi: 10.1053/j.gastro.2011.02.016. Review.

40.

Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.

Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P, Rose-John S, Neurath MF, Geissler EK, Schlitt HJ, Strober W, Fichtner-Feigl S.

J Clin Invest. 2011 May;121(5):1692-708. doi: 10.1172/JCI42540. Epub 2011 Apr 25.

41.

Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur".

Strober W.

J Clin Invest. 2011 Mar;121(3):841-4. doi: 10.1172/JCI46333. Epub 2011 Feb 21.

42.

A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation.

Zwiers A, Fuss IJ, Seegers D, Konijn T, Garcia-Vallejo JJ, Samsom JN, Strober W, Kraal G, Bouma G.

J Immunol. 2011 Mar 15;186(6):3572-80. doi: 10.4049/jimmunol.1001330. Epub 2011 Feb 14.

43.

NOD1-Mediated Mucosal Host Defense against Helicobacter pylori.

Watanabe T, Asano N, Kitani A, Fuss IJ, Chiba T, Strober W.

Int J Inflam. 2010 Jul 15;2010:476482. doi: 10.4061/2010/476482.

44.

The LTi cell, an immunologic chameleon.

Strober W.

Immunity. 2010 Nov 24;33(5):650-2. doi: 10.1016/j.immuni.2010.11.016.

45.

Inside the microbial and immune labyrinth: Gut microbes: friends or fiends?

Strober W.

Nat Med. 2010 Nov;16(11):1195-7. doi: 10.1038/nm1110-1195. No abstract available.

46.

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation.

Meylan F, Song YJ, Fuss I, Villarreal S, Kahle E, Malm IJ, Acharya K, Ramos HL, Lo L, Mentink-Kane MM, Wynn TA, Migone TS, Strober W, Siegel RM.

Mucosal Immunol. 2011 Mar;4(2):172-85. doi: 10.1038/mi.2010.67. Epub 2010 Oct 27.

47.

Suppression of inflammation in ulcerative colitis by interferon-β-1a is accompanied by inhibition of IL-13 production.

Mannon PJ, Hornung RL, Yang Z, Yi C, Groden C, Friend J, Yao M, Strober W, Fuss IJ.

Gut. 2011 Apr;60(4):449-55. doi: 10.1136/gut.2010.226860. Epub 2010 Oct 22.

48.

Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I.

Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W.

Immunity. 2010 Sep 24;33(3):313-25. doi: 10.1016/j.immuni.2010.09.001.

49.

National Institutes of Health Center for Human Immunology Conference, September 2009.

Nussenblatt RB, Bielekova B, Childs R, Krensky A, Strober W, Trinchieri G; Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health.

Ann N Y Acad Sci. 2010 Jul;1200 Suppl 1:E1-23. doi: 10.1111/j.1749-6632.2010.05682.x.

PMID:
20633145
50.

Proinflammatory cytokines underlying the inflammation of Crohn's disease.

Strober W, Zhang F, Kitani A, Fuss I, Fichtner-Feigl S.

Curr Opin Gastroenterol. 2010 Jul;26(4):310-7. doi: 10.1097/MOG.0b013e328339d099.

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