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Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.

Allen A, Wang C, Caproni LJ, Sugiyarto G, Harden E, Douglas LR, Duriez PJ, Karbowniczek K, Extance J, Rothwell PJ, Orefo I, Tite JP, Stevenson FK, Ottensmeier CH, Savelyeva N.

Cancer Immunol Immunother. 2018 Jan 12. doi: 10.1007/s00262-017-2111-y. [Epub ahead of print]


Introduction to a review series on therapeutic antibodies.

Stevenson FK, Bollard CM.

Blood. 2018 Jan 4;131(1):1. doi: 10.1182/blood-2017-10-798769. Epub 2017 Nov 8. No abstract available.


Early stages in the ontogeny of small B-cell lymphomas: genetics and microenvironment.

Ghia P, Nadel B, Sander B, Stamatopoulos K, Stevenson FK.

J Intern Med. 2017 Nov;282(5):395-414. doi: 10.1111/joim.12608. Epub 2017 Apr 10. Review.


Chronic lymphocytic leukaemia.

Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K.

Nat Rev Dis Primers. 2017 Feb 9;3:17008. doi: 10.1038/nrdp.2017.8. No abstract available.


Chronic lymphocytic leukaemia.

Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K.

Nat Rev Dis Primers. 2017 Jan 19;3:16096. doi: 10.1038/nrdp.2016.96. Review.


IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus.

Drennan S, D'Avola A, Gao Y, Weigel C, Chrysostomou E, Steele AJ, Zenz T, Plass C, Johnson PW, Williams AP, Packham G, Stevenson FK, Oakes CC, Forconi F.

Leukemia. 2017 Aug;31(8):1686-1694. doi: 10.1038/leu.2016.356. Epub 2016 Nov 28.


The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia.

Blunt MD, Koehrer S, Dobson RC, Larrayoz M, Wilmore S, Hayman A, Parnell J, Smith LD, Davies A, Johnson PWM, Conley PB, Pandey A, Strefford JC, Stevenson FK, Packham G, Forconi F, Coffey GP, Burger JA, Steele AJ.

Clin Cancer Res. 2017 May 1;23(9):2313-2324. doi: 10.1158/1078-0432.CCR-16-1662. Epub 2016 Oct 3.


PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

Yeomans A, Lemm E, Wilmore S, Cavell BE, Valle-Argos B, Krysov S, Hidalgo MS, Leonard E, Willis AE, Forconi F, Stevenson FK, Steele AJ, Coldwell MJ, Packham G.

Oncotarget. 2016 Nov 15;7(46):74807-74819. doi: 10.18632/oncotarget.11655.


A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer.

Chotprakaikiat W, Allen A, Bui-Minh D, Harden E, Jobsri J, Cavallo F, Gleba Y, Stevenson FK, Ottensmeier C, Klimyuk V, Savelyeva N.

Oncoimmunology. 2016 Apr 22;5(6):e1166323. doi: 10.1080/2162402X.2016.1166323. eCollection 2016 Jun.


Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

D'Avola A, Drennan S, Tracy I, Henderson I, Chiecchio L, Larrayoz M, Rose-Zerilli M, Strefford J, Plass C, Johnson PW, Steele AJ, Packham G, Stevenson FK, Oakes CC, Forconi F.

Blood. 2016 Aug 11;128(6):816-26. doi: 10.1182/blood-2016-03-707786. Epub 2016 Jun 14.


Introduction to a review series on advances in cell-based immune therapeutics in hematology.

Bollard CM, Stevenson FK.

Blood. 2016 Jun 30;127(26):3293. doi: 10.1182/blood-2016-05-713255. Epub 2016 May 20. No abstract available.


Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.

McCann KJ, Mander A, Cazaly A, Chudley L, Stasakova J, Thirdborough S, King A, Lloyd-Evans P, Buxton E, Edwards C, Halford S, Bateman A, O'Callaghan A, Clive S, Anthoney A, Jodrell DI, Weinschenk T, Simon P, Sahin U, Thomas GJ, Stevenson FK, Ottensmeier CH.

Clin Cancer Res. 2016 Oct 1;22(19):4827-4836. doi: 10.1158/1078-0432.CCR-15-2507. Epub 2016 Apr 18.


IL-4 enhances expression and function of surface IgM in CLL cells.

Aguilar-Hernandez MM, Blunt MD, Dobson R, Yeomans A, Thirdborough S, Larrayoz M, Smith LD, Linley A, Strefford JC, Davies A, Johnson PM, Savelyeva N, Cragg MS, Forconi F, Packham G, Stevenson FK, Steele AJ.

Blood. 2016 Jun 16;127(24):3015-25. doi: 10.1182/blood-2015-11-682906. Epub 2016 Mar 21.


Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G.

Blood. 2016 Jan 28;127(4):449-57. doi: 10.1182/blood-2015-07-660969. Epub 2015 Oct 21.


Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells.

Li Causi E, Parikh SC, Chudley L, Layfield DM, Ottensmeier CH, Stevenson FK, Di Genova G.

PLoS One. 2015 Sep 2;10(9):e0136717. doi: 10.1371/journal.pone.0136717. eCollection 2015.


Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells.

Linley A, Krysov S, Ponzoni M, Johnson PW, Packham G, Stevenson FK.

Blood. 2015 Oct 15;126(16):1902-10. doi: 10.1182/blood-2015-04-640805. Epub 2015 Jul 20.


Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study.

McCann KJ, Godeseth R, Chudley L, Mander A, Di Genova G, Lloyd-Evans P, Kerr JP, Malykh VB, Jenner MW, Orchard KH, Stevenson FK, Ottensmeier CH.

Cancer Immunol Immunother. 2015 Aug;64(8):1021-32. doi: 10.1007/s00262-015-1703-7. Epub 2015 May 16.


The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model.

Blunt MD, Carter MJ, Larrayoz M, Smith LD, Aguilar-Hernandez M, Cox KL, Tipton T, Reynolds M, Murphy S, Lemm E, Dias S, Duncombe A, Strefford JC, Johnson PW, Forconi F, Stevenson FK, Packham G, Cragg MS, Steele AJ.

Blood. 2015 Jun 25;125(26):4032-41. doi: 10.1182/blood-2014-11-610329. Epub 2015 May 8.


Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma.

Schneider D, Dühren-von Minden M, Alkhatib A, Setz C, van Bergen CA, Benkißer-Petersen M, Wilhelm I, Villringer S, Krysov S, Packham G, Zirlik K, Römer W, Buske C, Stevenson FK, Veelken H, Jumaa H.

Blood. 2015 May 21;125(21):3287-96. doi: 10.1182/blood-2014-11-609404. Epub 2015 Mar 17.


Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.

Linley A, Valle-Argos B, Steele AJ, Stevenson FK, Forconi F, Packham G.

Haematologica. 2015 Jul;100(7):e265-8. doi: 10.3324/haematol.2014.120824. Epub 2015 Mar 6. No abstract available.


Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody.

Jobsri J, Allen A, Rajagopal D, Shipton M, Kanyuka K, Lomonossoff GP, Ottensmeier C, Diebold SS, Stevenson FK, Savelyeva N.

PLoS One. 2015 Feb 18;10(2):e0118096. doi: 10.1371/journal.pone.0118096. eCollection 2015.


Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition.

Pepper C, Buggins AG, Jones CH, Walsby EJ, Forconi F, Pratt G, Devereux S, Stevenson FK, Fegan C.

Leukemia. 2015 Mar;29(3):744-7. doi: 10.1038/leu.2014.308. Epub 2014 Oct 28. No abstract available.


Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.

Krysov S, Steele AJ, Coelho V, Linley A, Sanchez Hidalgo M, Carter M, Potter KN, Kennedy B, Duncombe AS, Ashton-Key M, Forconi F, Stevenson FK, Packham G.

Blood. 2014 Nov 13;124(20):3101-9. doi: 10.1182/blood-2014-04-567198. Epub 2014 Aug 28.


The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia.

Stevenson FK, Forconi F, Packham G.

Semin Hematol. 2014 Jul;51(3):158-67. doi: 10.1053/j.seminhematol.2014.05.003. Epub 2014 May 15. Review.


The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy.

Packham G, Krysov S, Allen A, Savelyeva N, Steele AJ, Forconi F, Stevenson FK.

Haematologica. 2014 Jul;99(7):1138-48. doi: 10.3324/haematol.2013.098384. Review.


Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function.

Coelho V, Krysov S, Steele A, Sanchez Hidalgo M, Johnson PW, Chana PS, Packham G, Stevenson FK, Forconi F.

Blood. 2013 Oct 10;122(15):2664-72. doi: 10.1182/blood-2013-02-485425. Epub 2013 Aug 16.


DNA fusion vaccine designs to induce tumor-lytic CD8+ T-cell attack via the immunodominant cysteine-containing epitope of NY-ESO 1.

Campos-Perez J, Rice J, Escors D, Collins M, Paterson A, Savelyeva N, Stevenson FK.

Int J Cancer. 2013 Sep 15;133(6):1400-7. doi: 10.1002/ijc.28156. Epub 2013 Apr 11.


Follicular lymphoma and the immune system: from pathogenesis to antibody therapy.

Stevenson FK, Stevenson GT.

Blood. 2012 Apr 19;119(16):3659-67. doi: 10.1182/blood-2011-11-367730. Epub 2012 Feb 15.


The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.

Forconi F, Potter KN, Sozzi E, Henderson I, Cencini E, Rossi D, Bomben R, Gattei V, Gaidano G, Packham G, Stevenson FK.

Blood. 2012 Mar 1;119(9):2106-9. doi: 10.1182/blood-2011-08-375501. Epub 2012 Jan 10.


Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

Paterson A, Mockridge CI, Adams JE, Krysov S, Potter KN, Duncombe AS, Cook SJ, Stevenson FK, Packham G.

Blood. 2012 Feb 16;119(7):1726-36. doi: 10.1182/blood-2011-07-367417. Epub 2011 Dec 7.


Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.

Krysov S, Dias S, Paterson A, Mockridge CI, Potter KN, Smith KA, Ashton-Key M, Stevenson FK, Packham G.

Blood. 2012 Jan 5;119(1):170-9. doi: 10.1182/blood-2011-07-370403. Epub 2011 Nov 15.


B-cell receptor signaling in chronic lymphocytic leukemia.

Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G.

Blood. 2011 Oct 20;118(16):4313-20. doi: 10.1182/blood-2011-06-338855. Epub 2011 Aug 3.


DNA fusion vaccines enter the clinic.

Stevenson FK, Mander A, Chudley L, Ottensmeier CH.

Cancer Immunol Immunother. 2011 Aug;60(8):1147-51. doi: 10.1007/s00262-011-1042-2. Epub 2011 Jun 5. Review.


High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen.

Savelyeva N, Shipton M, Suchacki A, Babbage G, Stevenson FK.

Blood. 2011 Jul 21;118(3):650-9. doi: 10.1182/blood-2011-01-328864. Epub 2011 May 25.


DNA fusion gene vaccines induce cytotoxic T-cell attack on naturally processed peptides of human prostate-specific membrane antigen.

Vittes GE, Harden EL, Ottensmeier CH, Rice J, Stevenson FK.

Eur J Immunol. 2011 Aug;41(8):2447-56. doi: 10.1002/eji.201141518. Epub 2011 Jul 4.


Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses.

Zuckerman NS, McCann KJ, Ottensmeier CH, Barak M, Shahaf G, Edelman H, Dunn-Walters D, Abraham RS, Stevenson FK, Mehr R.

Int Immunol. 2010 Nov;22(11):875-87. doi: 10.1093/intimm/dxq441. Epub 2010 Nov 8.


Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.

Coelho V, Krysov S, Ghaemmaghami AM, Emara M, Potter KN, Johnson P, Packham G, Martinez-Pomares L, Stevenson FK.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18587-92. doi: 10.1073/pnas.1009388107. Epub 2010 Oct 11.


Harnessing innate immunity to suppress lymphoma.

Stevenson FK, Johnson PW.

J Clin Oncol. 2010 Oct 1;28(28):4295-6. doi: 10.1200/JCO.2010.30.4212. Epub 2010 Aug 9. No abstract available.


Understanding and activating immunity against human cancer.

Stevenson FK, Palucka K.

Curr Opin Immunol. 2010 Apr;22(2):212-4. doi: 10.1016/j.coi.2010.03.001. Epub 2010 Mar 24. No abstract available.


Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo.

Krysov S, Potter KN, Mockridge CI, Coelho V, Wheatley I, Packham G, Stevenson FK.

Blood. 2010 May 27;115(21):4198-205. doi: 10.1182/blood-2009-12-254847. Epub 2010 Mar 17.


DNA vaccines against cancer come of age.

Stevenson FK, Ottensmeier CH, Rice J.

Curr Opin Immunol. 2010 Apr;22(2):264-70. doi: 10.1016/j.coi.2010.01.019. Epub 2010 Feb 19. Review.


Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid.

Di Genova G, Savelyeva N, Suchacki A, Thirdborough SM, Stevenson FK.

Eur J Immunol. 2010 Apr;40(4):976-85. doi: 10.1002/eji.200940017.


The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

Forconi F, Potter KN, Wheatley I, Darzentas N, Sozzi E, Stamatopoulos K, Mockridge CI, Packham G, Stevenson FK.

Blood. 2010 Jan 7;115(1):71-7. doi: 10.1182/blood-2009-06-225813. Epub 2009 Nov 3.


Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin.

Chen CG, Lu YT, Lin M, Savelyeva N, Stevenson FK, Zhu D.

Vaccine. 2009 Jul 9;27(32):4289-96. doi: 10.1016/j.vaccine.2009.05.025. Epub 2009 May 29.


Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development.

McCann KJ, Ashton-Key M, Smith K, Stevenson FK, Ottensmeier CH.

Blood. 2009 May 7;113(19):4677-80. doi: 10.1182/blood-2008-09-179366. Epub 2008 Dec 18.


DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire.

Rice J, Dossett ML, Ohlén C, Buchan SL, Kendall TJ, Dunn SN, Stevenson FK, Greenberg PD.

Eur J Immunol. 2008 Aug;38(8):2118-30. doi: 10.1002/eji.200838213.


DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance.

Chaise C, Buchan SL, Rice J, Marquet J, Rouard H, Kuentz M, Vittes GE, Molinier-Frenkel V, Farcet JP, Stauss HJ, Delfau-Larue MH, Stevenson FK.

Blood. 2008 Oct 1;112(7):2956-64. doi: 10.1182/blood-2008-02-137695. Epub 2008 May 23.


DNA vaccines: precision tools for activating effective immunity against cancer.

Rice J, Ottensmeier CH, Stevenson FK.

Nat Rev Cancer. 2008 Feb;8(2):108-20. doi: 10.1038/nrc2326. Review.


Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.

Thirdborough SM, Roddick JS, Radcliffe JN, Howarth M, Stevenson FK, Elliott T.

Eur J Immunol. 2008 Feb;38(2):364-9. doi: 10.1002/eji.200737832.


Public T cell receptor beta-chains are not advantaged during positive selection.

Furmanski AL, Ferreira C, Bartok I, Dimakou S, Rice J, Stevenson FK, Millrain MM, Simpson E, Dyson J.

J Immunol. 2008 Jan 15;180(2):1029-39.

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