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Pillars Article: Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking. Science. 1998. 282: 480-483.

Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA.

J Immunol. 2017 Jun 1;198(11):4191-4194. No abstract available.


In vivo targeting of protein antigens to dendritic cells using anti-DEC-205 single chain antibody improves HIV Gag specific CD4+ T cell responses protecting from airway challenge with recombinant vaccinia-gag virus.

Ngu LN, Nji NN, Ambada GE, Sagnia B, Sake CN, Tchadji JC, Njambe Priso GD, Lissom A, Tchouangueu TF, Manga Tebit D, Waffo AB, Park CG, Steinman RM, Überla K, Nchinda GW.

Immun Inflamm Dis. 2017 Mar 13. doi: 10.1002/iid3.151. [Epub ahead of print]


Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.

Sela U, Park CG, Park A, Olds P, Wang S, Steinman RM, Fischetti VA.

PLoS One. 2016 Jan 8;11(1):e0146412. doi: 10.1371/journal.pone.0146412. eCollection 2016.


ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis.

Silva-Sánchez A, Meza-Pérez S, Flores-Langarica A, Donis-Maturano L, Estrada-García I, Calderón-Amador J, Hernández-Pando R, Idoyaga J, Steinman RM, Flores-Romo L.

PLoS One. 2015 Apr 27;10(4):e0124828. doi: 10.1371/journal.pone.0124828. eCollection 2015.


Classical Flt3L-dependent dendritic cells control immunity to protein vaccine.

Anandasabapathy N, Feder R, Mollah S, Tse SW, Longhi MP, Mehandru S, Matos I, Cheong C, Ruane D, Brane L, Teixeira A, Dobrin J, Mizenina O, Park CG, Meredith M, Clausen BE, Nussenzweig MC, Steinman RM.

J Exp Med. 2014 Aug 25;211(9):1875-91. doi: 10.1084/jem.20131397. Epub 2014 Aug 18.


Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance.

Flacher V, Tripp CH, Mairhofer DG, Steinman RM, Stoitzner P, Idoyaga J, Romani N.

EMBO Mol Med. 2014 Sep;6(9):1191-204. doi: 10.15252/emmm.201303283. Erratum in: EMBO Mol Med. 2014 Dec;6(12):1638.


Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation.

Pantel A, Teixeira A, Haddad E, Wood EG, Steinman RM, Longhi MP.

PLoS Biol. 2014 Jan;12(1):e1001759. doi: 10.1371/journal.pbio.1001759. Epub 2014 Jan 7.


Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells.

Mollah SA, Dobrin JS, Feder RE, Tse SW, Matos IG, Cheong C, Steinman RM, Anandasabapathy N.

J Invest Dermatol. 2014 May;134(5):1265-1275. doi: 10.1038/jid.2013.515. Epub 2013 Nov 28. Erratum in: J Invest Dermatol. 2014 Nov;134(11):2850-1.


Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract.

Ruane D, Brane L, Reis BS, Cheong C, Poles J, Do Y, Zhu H, Velinzon K, Choi JH, Studt N, Mayer L, Lavelle EC, Steinman RM, Mucida D, Mehandru S.

J Exp Med. 2013 Aug 26;210(9):1871-88. doi: 10.1084/jem.20122762. Epub 2013 Aug 19.


Targeting Leishmania major Antigens to Dendritic Cells In Vivo Induces Protective Immunity.

Matos I, Mizenina O, Lubkin A, Steinman RM, Idoyaga J.

PLoS One. 2013 Jun 26;8(6):e67453. doi: 10.1371/journal.pone.0067453. Print 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/5149bf8e-3843-4865-a726-0ca2820ee8f8.


Targeting of envelope domain III protein of DENV type 2 to DEC-205 receptor elicits neutralizing antibodies in mice.

Coconi-Linares N, Ortega-Dávila E, López-González M, García-Machorro J, García-Cordero J, Steinman RM, Cedillo-Barrón L, Gómez-Lim MA.

Vaccine. 2013 May 1;31(19):2366-71. doi: 10.1016/j.vaccine.2013.03.009. Epub 2013 Mar 15.


CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice.

Meixlsperger S, Leung CS, Rämer PC, Pack M, Vanoaica LD, Breton G, Pascolo S, Salazar AM, Dzionek A, Schmitz J, Steinman RM, Münz C.

Blood. 2013 Jun 20;121(25):5034-44. doi: 10.1182/blood-2012-12-473413. Epub 2013 Mar 12.


Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells.

Barbuto S, Idoyaga J, Vila-Perelló M, Longhi MP, Breton G, Steinman RM, Muir TW.

Nat Chem Biol. 2013 Apr;9(4):250-6. doi: 10.1038/nchembio.1186. Epub 2013 Feb 17.


Specialized role of migratory dendritic cells in peripheral tolerance induction.

Idoyaga J, Fiorese C, Zbytnuik L, Lubkin A, Miller J, Malissen B, Mucida D, Merad M, Steinman RM.

J Clin Invest. 2013 Feb;123(2):844-54. doi: 10.1172/JCI65260. Epub 2013 Jan 9.


Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor.

Do Y, Didierlaurent AM, Ryu S, Koh H, Park CG, Park S, Perlin DS, Powell BS, Steinman RM.

Vaccine. 2012 Oct 5;30(45):6359-67. doi: 10.1016/j.vaccine.2012.08.051. Epub 2012 Sep 1.


Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein.

Bozzacco L, Yu H, Dengjel J, Trumpfheller C, Zebroski HA 3rd, Zhang N, Küttner V, Ueberheide BM, Deng H, Chait BT, Steinman RM, Mojsov S, Fenyö D.

PLoS One. 2012;7(7):e41897. doi: 10.1371/journal.pone.0041897. Epub 2012 Jul 30.


PE-Cy5.5 conjugates bind to the cells expressing mouse DEC205/CD205.

Park CG, Rodriguez A, Steinman RM.

J Immunol Methods. 2012 Oct 31;384(1-2):184-90. doi: 10.1016/j.jim.2012.07.011. Epub 2012 Jul 25.


Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.

Billiard F, Lobry C, Darrasse-Jèze G, Waite J, Liu X, Mouquet H, DaNave A, Tait M, Idoyaga J, Leboeuf M, Kyratsous CA, Burton J, Kalter J, Klinakis A, Zhang W, Thurston G, Merad M, Steinman RM, Murphy AJ, Yancopoulos GD, Aifantis I, Skokos D.

J Exp Med. 2012 May 7;209(5):1011-28. doi: 10.1084/jem.20111615. Epub 2012 Apr 30.


Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals.

Park CG, Rodriguez A, Ueta H, Lee H, Pack M, Matsuno K, Steinman RM.

J Immunol Methods. 2012 Mar 30;377(1-2):15-22. doi: 10.1016/j.jim.2011.12.009. Epub 2012 Jan 16.


Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.

Hemmi H, Zaidi N, Wang B, Matos I, Fiorese C, Lubkin A, Zbytnuik L, Suda K, Zhang K, Noda M, Kaisho T, Steinman RM, Idoyaga J.

J Immunol. 2012 Feb 1;188(3):1147-55. doi: 10.4049/jimmunol.1102541. Epub 2011 Dec 30.


Decisions about dendritic cells: past, present, and future.

Steinman RM.

Annu Rev Immunol. 2012;30:1-22. doi: 10.1146/annurev-immunol-100311-102839. Epub 2011 Nov 17. Review.


Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity.

Trumpfheller C, Longhi MP, Caskey M, Idoyaga J, Bozzacco L, Keler T, Schlesinger SJ, Steinman RM.

J Intern Med. 2012 Feb;271(2):183-92. doi: 10.1111/j.1365-2796.2011.02496.x. Epub 2012 Jan 4. Review.


Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice.

Sela U, Olds P, Park A, Schlesinger SJ, Steinman RM.

J Exp Med. 2011 Nov 21;208(12):2489-96. doi: 10.1084/jem.20110466. Epub 2011 Nov 14.


Flt3 signaling-dependent dendritic cells protect against atherosclerosis.

Choi JH, Cheong C, Dandamudi DB, Park CG, Rodriguez A, Mehandru S, Velinzon K, Jung IH, Yoo JY, Oh GT, Steinman RM.

Immunity. 2011 Nov 23;35(5):819-31. doi: 10.1016/j.immuni.2011.09.014. Epub 2011 Nov 10.


Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.

Caskey M, Lefebvre F, Filali-Mouhim A, Cameron MJ, Goulet JP, Haddad EK, Breton G, Trumpfheller C, Pollak S, Shimeliovich I, Duque-Alarcon A, Pan L, Nelkenbaum A, Salazar AM, Schlesinger SJ, Steinman RM, Sékaly RP.

J Exp Med. 2011 Nov 21;208(12):2357-66. doi: 10.1084/jem.20111171. Epub 2011 Nov 7.


A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo.

Pantel A, Cheong C, Dandamudi D, Shrestha E, Mehandru S, Brane L, Ruane D, Teixeira A, Bozzacco L, Steinman RM, Longhi MP.

Eur J Immunol. 2012 Jan;42(1):101-9. doi: 10.1002/eji.201141855. Epub 2011 Dec 12.


Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells.

Bozzacco L, Yu H, Zebroski HA, Dengjel J, Deng H, Mojsov S, Steinman RM.

J Proteome Res. 2011 Nov 4;10(11):5016-30. doi: 10.1021/pr200503g. Epub 2011 Oct 14.


SnapShot: Dendritic Cells.

Idoyaga J, Steinman RM.

Cell. 2011 Aug 19;146(4):660-660.e2. doi: 10.1016/j.cell.2011.08.010. No abstract available.


Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain.

Anandasabapathy N, Victora GD, Meredith M, Feder R, Dong B, Kluger C, Yao K, Dustin ML, Nussenzweig MC, Steinman RM, Liu K.

J Exp Med. 2011 Aug 1;208(8):1695-705. doi: 10.1084/jem.20102657. Epub 2011 Jul 25.


Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.

Flynn BJ, Kastenmüller K, Wille-Reece U, Tomaras GD, Alam M, Lindsay RW, Salazar AM, Perdiguero B, Gomez CE, Wagner R, Esteban M, Park CG, Trumpfheller C, Keler T, Pantaleo G, Steinman RM, Seder R.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7131-6. doi: 10.1073/pnas.1103869108. Epub 2011 Apr 5.


Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.

Idoyaga J, Lubkin A, Fiorese C, Lahoud MH, Caminschi I, Huang Y, Rodriguez A, Clausen BE, Park CG, Trumpfheller C, Steinman RM.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2384-9. doi: 10.1073/pnas.1019547108. Epub 2011 Jan 24.


Newcastle disease virus expressing a dendritic cell-targeted HIV gag protein induces a potent gag-specific immune response in mice.

Maamary J, Array F, Gao Q, García-Sastre A, Steinman RM, Palese P, Nchinda G.

J Virol. 2011 Mar;85(5):2235-46. doi: 10.1128/JVI.02036-10. Epub 2010 Dec 15.


Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.

Cheong C, Matos I, Choi JH, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM, Kluger C, Nchinda G, Koh H, Rodriguez A, Idoyaga J, Pack M, Velinzon K, Park CG, Steinman RM.

Cell. 2010 Oct 29;143(3):416-29. doi: 10.1016/j.cell.2010.09.039.


Some active areas of DC research and their medical potential.

Steinman RM.

Eur J Immunol. 2010 Aug;40(8):2085-8. doi: 10.1002/eji.201040733.


Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates.

Tewari K, Flynn BJ, Boscardin SB, Kastenmueller K, Salazar AM, Anderson CA, Soundarapandian V, Ahumada A, Keler T, Hoffman SL, Nussenzweig MC, Steinman RM, Seder RA.

Vaccine. 2010 Oct 21;28(45):7256-66. doi: 10.1016/j.vaccine.2010.08.098. Epub 2010 Sep 21.


Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague.

Do Y, Koh H, Park CG, Dudziak D, Seo P, Mehandru S, Choi JH, Cheong C, Park S, Perlin DS, Powell BS, Steinman RM.

Eur J Immunol. 2010 Oct;40(10):2791-6. doi: 10.1002/eji.201040511.


Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody.

Cheong C, Choi JH, Vitale L, He LZ, Trumpfheller C, Bozzacco L, Do Y, Nchinda G, Park SH, Dandamudi DB, Shrestha E, Pack M, Lee HW, Keler T, Steinman RM, Park CG.

Blood. 2010 Nov 11;116(19):3828-38. doi: 10.1182/blood-2010-06-288068. Epub 2010 Jul 28.


New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells.

Cheong C, Matos I, Choi JH, Schauer JD, Dandamudi DB, Shrestha E, Makeyeva JA, Li X, Li P, Steinman RM, Park CG.

J Immunol Methods. 2010 Aug 31;360(1-2):66-75. doi: 10.1016/j.jim.2010.06.006. Epub 2010 Jun 15.


Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy.

Romani N, Thurnher M, Idoyaga J, Steinman RM, Flacher V.

Immunol Cell Biol. 2010 May-Jun;88(4):424-30. doi: 10.1038/icb.2010.39. Epub 2010 Apr 6. Review.


Features of the dendritic cell lineage.

Steinman RM, Idoyaga J.

Immunol Rev. 2010 Mar;234(1):5-17. doi: 10.1111/j.0105-2896.2009.00888.x. No abstract available.


Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells.

Nchinda G, Amadu D, Trumpfheller C, Mizenina O, Uberla K, Steinman RM.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4281-6. doi: 10.1073/pnas.1000621107. Epub 2010 Feb 16.


Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis.

Flacher V, Tripp CH, Stoitzner P, Haid B, Ebner S, Del Frari B, Koch F, Park CG, Steinman RM, Idoyaga J, Romani N.

J Invest Dermatol. 2010 Mar;130(3):755-62. doi: 10.1038/jid.2009.343. Epub 2009 Nov 5.


Epitope mapping on the dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) pathogen-attachment factor.

Sierra-Filardi E, Estecha A, Samaniego R, Fernández-Ruiz E, Colmenares M, Sánchez-Mateos P, Steinman RM, Granelli-Piperno A, Corbí AL.

Mol Immunol. 2010 Jan;47(4):840-8. doi: 10.1016/j.molimm.2009.09.036. Epub 2009 Oct 30.


HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC.

Bozzacco L, Trumpfheller C, Huang Y, Longhi MP, Shimeliovich I, Schauer JD, Park CG, Steinman RM.

Eur J Immunol. 2010 Jan;40(1):36-46. doi: 10.1002/eji.200939748.


New approach to the perception of 3D shape based on veridicality, complexity, symmetry and volume.

Pizlo Z, Sawada T, Li Y, Kropatsch WG, Steinman RM.

Vision Res. 2010 Jan;50(1):1-11. doi: 10.1016/j.visres.2009.09.024.


The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells.

Wang B, Kuroiwa JM, He LZ, Charalambous A, Keler T, Steinman RM.

Ann N Y Acad Sci. 2009 Sep;1174:6-17. doi: 10.1111/j.1749-6632.2009.04933.x.


Some scientific and organizational challenges in cancer immunology.

Steinman RM.

Ann N Y Acad Sci. 2009 Sep;1174:1-5. doi: 10.1111/j.1749-6632.2009.05060.x.


Isolation of dendritic cells.

Inaba K, Swiggard WJ, Steinman RM, Romani N, Schuler G, Brinster C.

Curr Protoc Immunol. 2009 Aug;Chapter 3:Unit 3.7. doi: 10.1002/0471142735.im0307s86.


Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant.

Longhi MP, Trumpfheller C, Idoyaga J, Caskey M, Matos I, Kluger C, Salazar AM, Colonna M, Steinman RM.

J Exp Med. 2009 Jul 6;206(7):1589-602. doi: 10.1084/jem.20090247. Epub 2009 Jun 29.

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