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Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis.

El Ghachi M, Howe N, Huang CY, Olieric V, Warshamanage R, Touzé T, Weichert D, Stansfeld PJ, Wang M, Kerff F, Caffrey M.

Nat Commun. 2018 Mar 14;9(1):1078. doi: 10.1038/s41467-018-03477-5.


Balancing Force Field Protein-Lipid Interactions To Capture Transmembrane Helix-Helix Association.

Domański J, Sansom MSP, Stansfeld PJ, Best RB.

J Chem Theory Comput. 2018 Mar 13;14(3):1706-1715. doi: 10.1021/acs.jctc.7b00983. Epub 2018 Feb 9.


Substrate-triggered position switching of TatA and TatB during Tat transport in Escherichia coli.

Habersetzer J, Moore K, Cherry J, Buchanan G, Stansfeld PJ, Palmer T.

Open Biol. 2017 Aug;7(8). pii: 170091. doi: 10.1098/rsob.170091.


Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions.

Cutts EE, Laasch N, Reiter DM, Trenker R, Slater LM, Stansfeld PJ, Vakonakis I.

PLoS Pathog. 2017 Aug 14;13(8):e1006552. doi: 10.1371/journal.ppat.1006552. eCollection 2017 Aug.


Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Wiktor M, Weichert D, Howe N, Huang CY, Olieric V, Boland C, Bailey J, Vogeley L, Stansfeld PJ, Buddelmeijer N, Wang M, Caffrey M.

Nat Commun. 2017 Jul 4;8:15952. doi: 10.1038/ncomms15952.


Computational studies of membrane proteins: from sequence to structure to simulation.

Stansfeld PJ.

Curr Opin Struct Biol. 2017 Aug;45:133-141. doi: 10.1016/ Epub 2017 May 13. Review.


A BEST example of channel structure annotation by molecular simulation.

Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MSP.

Channels (Austin). 2017 Jul 4;11(4):347-353. doi: 10.1080/19336950.2017.1306163. Epub 2017 Mar 20.


The role of interfacial lipids in stabilizing membrane protein oligomers.

Gupta K, Donlan JAC, Hopper JTS, Uzdavinys P, Landreh M, Struwe WB, Drew D, Baldwin AJ, Stansfeld PJ, Robinson CV.

Nature. 2017 Jan 19;541(7637):421-424. doi: 10.1038/nature20820. Epub 2017 Jan 11.


Assembling the Tat protein translocase.

Alcock F, Stansfeld PJ, Basit H, Habersetzer J, Baker MA, Palmer T, Wallace MI, Berks BC.

Elife. 2016 Dec 3;5. pii: e20718. doi: 10.7554/eLife.20718.


Convergence and Sampling in Determining Free Energy Landscapes for Membrane Protein Association.

Domański J, Hedger G, Best RB, Stansfeld PJ, Sansom MSP.

J Phys Chem B. 2017 Apr 20;121(15):3364-3375. doi: 10.1021/acs.jpcb.6b08445. Epub 2016 Nov 17.


Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain.

Lörinczi E, Helliwell M, Finch A, Stansfeld PJ, Davies NW, Mahaut-Smith M, Muskett FW, Mitcheson JS.

J Biol Chem. 2016 Aug 19;291(34):17907-18. doi: 10.1074/jbc.M116.733576. Epub 2016 Jun 20.


Interaction of lipids with the neurotensin receptor 1.

Bolivar JH, Muñoz-García JC, Castro-Dopico T, Dijkman PM, Stansfeld PJ, Watts A.

Biochim Biophys Acta. 2016 Jun;1858(6):1278-87. doi: 10.1016/j.bbamem.2016.02.032. Epub 2016 Mar 21.


Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin.

Vogeley L, El Arnaout T, Bailey J, Stansfeld PJ, Boland C, Caffrey M.

Science. 2016 Feb 19;351(6275):876-80. doi: 10.1126/science.aad3747.


Structural basis of outer membrane protein insertion by the BAM complex.

Gu Y, Li H, Dong H, Zeng Y, Zhang Z, Paterson NG, Stansfeld PJ, Wang Z, Zhang Y, Wang W, Dong C.

Nature. 2016 Mar 3;531(7592):64-9. doi: 10.1038/nature17199. Epub 2016 Feb 22.


Ternary structure reveals mechanism of a membrane diacylglycerol kinase.

Li D, Stansfeld PJ, Sansom MS, Keogh A, Vogeley L, Howe N, Lyons JA, Aragao D, Fromme P, Fromme R, Basu S, Grotjohann I, Kupitz C, Rendek K, Weierstall U, Zatsepin NA, Cherezov V, Liu W, Bandaru S, English NJ, Gati C, Barty A, Yefanov O, Chapman HN, Diederichs K, Messerschmidt M, Boutet S, Williams GJ, Marvin Seibert M, Caffrey M.

Nat Commun. 2015 Dec 17;6:10140. doi: 10.1038/ncomms10140.


A Coarse Grained Model for a Lipid Membrane with Physiological Composition and Leaflet Asymmetry.

Sharma S, Kim BN, Stansfeld PJ, Sansom MS, Lindau M.

PLoS One. 2015 Dec 14;10(12):e0144814. doi: 10.1371/journal.pone.0144814. eCollection 2015.


The centriolar protein CPAP G-box: an amyloid fibril in a single domain.

Cutts EE, Inglis A, Stansfeld PJ, Vakonakis I, Hatzopoulos GN.

Biochem Soc Trans. 2015 Oct;43(5):838-43. doi: 10.1042/BST20150082. Review.


Structure and function of the Escherichia coli Tol-Pal stator protein TolR.

Wojdyla JA, Cutts E, Kaminska R, Papadakos G, Hopper JT, Stansfeld PJ, Staunton D, Robinson CV, Kleanthous C.

J Biol Chem. 2015 Oct 30;290(44):26675-87. doi: 10.1074/jbc.M115.671586. Epub 2015 Sep 9.


The TatC component of the twin-arginine protein translocase functions as an obligate oligomer.

Cléon F, Habersetzer J, Alcock F, Kneuper H, Stansfeld PJ, Basit H, Wallace MI, Berks BC, Palmer T.

Mol Microbiol. 2015 Oct;98(1):111-29. doi: 10.1111/mmi.13106. Epub 2015 Jul 22.


MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

Stansfeld PJ, Goose JE, Caffrey M, Carpenter EP, Parker JL, Newstead S, Sansom MS.

Structure. 2015 Jul 7;23(7):1350-61. doi: 10.1016/j.str.2015.05.006. Epub 2015 Jun 11.


Lipopolysaccharide is inserted into the outer membrane through an intramembrane hole, a lumen gate, and the lateral opening of LptD.

Gu Y, Stansfeld PJ, Zeng Y, Dong H, Wang W, Dong C.

Structure. 2015 Mar 3;23(3):496-504. doi: 10.1016/j.str.2015.01.001. Epub 2015 Feb 12.


Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation.

Chavent M, Chetwynd AP, Stansfeld PJ, Sansom MS.

Biochemistry. 2014 Oct 28;53(42):6641-52. doi: 10.1021/bi500800x. Epub 2014 Oct 17.


Structural basis for outer membrane lipopolysaccharide insertion.

Dong H, Xiang Q, Gu Y, Wang Z, Paterson NG, Stansfeld PJ, He C, Zhang Y, Wang W, Dong C.

Nature. 2014 Jul 3;511(7507):52-6. doi: 10.1038/nature13464. Epub 2014 Jun 18.


Structural biology of Tat protein transport.

Berks BC, Lea SM, Stansfeld PJ.

Curr Opin Struct Biol. 2014 Aug;27:32-7. doi: 10.1016/ Epub 2014 Apr 5. Review.


Direct gating of ATP-activated ion channels (P2X2 receptors) by lipophilic attachment at the outer end of the second transmembrane domain.

Rothwell SW, Stansfeld PJ, Bragg L, Verkhratsky A, North RA.

J Biol Chem. 2014 Jan 10;289(2):618-26. doi: 10.1074/jbc.M113.529099. Epub 2013 Nov 22.


Structural analysis of the G-box domain of the microcephaly protein CPAP suggests a role in centriole architecture.

Hatzopoulos GN, Erat MC, Cutts E, Rogala KB, Slater LM, Stansfeld PJ, Vakonakis I.

Structure. 2013 Nov 5;21(11):2069-77. doi: 10.1016/j.str.2013.08.019. Epub 2013 Sep 26.


Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N.

Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2.


Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28.


Multiscale simulations reveal conserved patterns of lipid interactions with aquaporins.

Stansfeld PJ, Jefferys EE, Sansom MS.

Structure. 2013 May 7;21(5):810-9. doi: 10.1016/j.str.2013.03.005. Epub 2013 Apr 18.


The structural basis of ZMPSTE24-dependent laminopathies.

Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP.

Science. 2013 Mar 29;339(6127):1604-7. doi: 10.1126/science.1231513.


Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.

Schmidt MR, Stansfeld PJ, Tucker SJ, Sansom MS.

Biochemistry. 2013 Jan 15;52(2):279-81. doi: 10.1021/bi301350s. Epub 2012 Dec 28.


Structure of the TatC core of the twin-arginine protein transport system.

Rollauer SE, Tarry MJ, Graham JE, Jääskeläinen M, Jäger F, Johnson S, Krehenbrink M, Liu SM, Lukey MJ, Marcoux J, McDowell MA, Rodriguez F, Roversi P, Stansfeld PJ, Robinson CV, Sansom MS, Palmer T, Högbom M, Berks BC, Lea SM.

Nature. 2012 Dec 13;492(7428):210-4. doi: 10.1038/nature11683. Epub 2012 Dec 2.


A leucine zipper motif essential for gating of hyperpolarization-activated channels.

Wemhöner K, Silbernagel N, Marzian S, Netter MF, Rinné S, Stansfeld PJ, Decher N.

J Biol Chem. 2012 Nov 23;287(48):40150-60. doi: 10.1074/jbc.M112.378513. Epub 2012 Oct 9.


State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.

Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ.

Channels (Austin). 2012 Nov-Dec;6(6):473-8. doi: 10.4161/chan.22153. Epub 2012 Sep 18.


Functional analysis of missense variants in the TRESK (KCNK18) K channel.

Andres-Enguix I, Shang L, Stansfeld PJ, Morahan JM, Sansom MS, Lafrenière RG, Roy B, Griffiths LR, Rouleau GA, Ebers GC, Cader ZM, Tucker SJ.

Sci Rep. 2012;2:237. doi: 10.1038/srep00237. Epub 2012 Jan 27.


Molecular simulation approaches to membrane proteins.

Stansfeld PJ, Sansom MS.

Structure. 2011 Nov 9;19(11):1562-72. doi: 10.1016/j.str.2011.10.002. Review.


Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.

Lumb CN, He J, Xue Y, Stansfeld PJ, Stahelin RV, Kutateladze TG, Sansom MS.

Structure. 2011 Sep 7;19(9):1338-46. doi: 10.1016/j.str.2011.04.010.


The pore structure and gating mechanism of K2P channels.

Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T.

EMBO J. 2011 Aug 5;30(17):3607-19. doi: 10.1038/emboj.2011.268. Erratum in: EMBO J. 2011 Nov 2;30(21):4515. Erhlich, Gunter [corrected to Ehrlich, Gunter].


A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.

Männikkö R, Stansfeld PJ, Ashcroft AS, Hattersley AT, Sansom MS, Ellard S, Ashcroft FM.

J Physiol. 2011 Jul 1;589(Pt 13):3071-83. doi: 10.1113/jphysiol.2011.209700. Epub 2011 May 3.


From Coarse Grained to Atomistic: A Serial Multiscale Approach to Membrane Protein Simulations.

Stansfeld PJ, Sansom MS.

J Chem Theory Comput. 2011 Apr 12;7(4):1157-66. doi: 10.1021/ct100569y. Epub 2011 Mar 16.


A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore.

Streit AK, Netter MF, Kempf F, Walecki M, Rinné S, Bollepalli MK, Preisig-Müller R, Renigunta V, Daut J, Baukrowitz T, Sansom MS, Stansfeld PJ, Decher N.

J Biol Chem. 2011 Apr 22;286(16):13977-84. doi: 10.1074/jbc.M111.227884. Epub 2011 Mar 1.


Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.

Muskett FW, Thouta S, Thomson SJ, Bowen A, Stansfeld PJ, Mitcheson JS.

J Biol Chem. 2011 Feb 25;286(8):6184-91. doi: 10.1074/jbc.M110.199364. Epub 2010 Dec 6.


Lipidbook: a public repository for force-field parameters used in membrane simulations.

Domański J, Stansfeld PJ, Sansom MS, Beckstein O.

J Membr Biol. 2010 Aug;236(3):255-8. doi: 10.1007/s00232-010-9296-8. Epub 2010 Aug 11.


PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.

Stansfeld PJ, Hopkinson R, Ashcroft FM, Sansom MS.

Biochemistry. 2009 Nov 24;48(46):10926-33. doi: 10.1021/bi9013193.


Simulations of the BM2 proton channel transmembrane domain from influenza virus B.

Rouse SL, Carpenter T, Stansfeld PJ, Sansom MS.

Biochemistry. 2009 Oct 27;48(42):9949-51. doi: 10.1021/bi901166n.


The response of the tandem pore potassium channel TASK-3 (K(2P)9.1) to voltage: gating at the cytoplasmic mouth.

Ashmole I, Vavoulis DV, Stansfeld PJ, Mehta PR, Feng JF, Sutcliffe MJ, Stanfield PR.

J Physiol. 2009 Oct 15;587(Pt 20):4769-83. doi: 10.1113/jphysiol.2009.175430. Epub 2009 Aug 24.


Ion-blocking sites of the Kir2.1 channel revealed by multiscale modeling.

Tai K, Stansfeld PJ, Sansom MS.

Biochemistry. 2009 Sep 15;48(36):8758-63. doi: 10.1021/bi9007808.


Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

Stansfeld PJ, Grottesi A, Sands ZA, Sansom MS, Gedeck P, Gosling M, Cox B, Stanfield PR, Mitcheson JS, Sutcliffe MJ.

Biochemistry. 2008 Jul 15;47(28):7414-22. doi: 10.1021/bi800475j. Epub 2008 Jun 18.


Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.

Hardman RM, Stansfeld PJ, Dalibalta S, Sutcliffe MJ, Mitcheson JS.

J Biol Chem. 2007 Nov 2;282(44):31972-81. Epub 2007 Sep 6.


The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: contributions of the pore domains.

Yuill KH, Stansfeld PJ, Ashmole I, Sutcliffe MJ, Stanfield PR.

Pflugers Arch. 2007 Nov;455(2):333-48. Epub 2007 Jun 1.

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