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Blood Pressure in Acute Stroke: To Treat or Not to Treat: That Is Still the Question.

Bath PM, Appleton JP, Krishnan K, Sprigg N.

Stroke. 2018 Jun 12. pii: STROKEAHA.118.021254. doi: 10.1161/STROKEAHA.118.021254. [Epub ahead of print] Review. No abstract available.


Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial.

Ovesen C, Jakobsen JC, Gluud C, Steiner T, Law Z, Flaherty K, Dineen RA, Bath PM, Sprigg N, Christensen H.

BMC Res Notes. 2018 Jun 13;11(1):379. doi: 10.1186/s13104-018-3481-8.


Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Sprigg N, Flaherty K, Appleton JP, Salman RA, Bereczki D, Beridze M, Christensen H, Ciccone A, Collins R, Czlonkowska A, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Krishnan K, Laska AC, Law ZK, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Seiffge D, Scutt P, Thanabalan J, Werring D, Whynes D, Bath PM; TICH-2 Investigators.

Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16.


Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3.

Sandset EC, Sanossian N, Woodhouse LJ, Anderson C, Berge E, Lees KR, Potter JF, Robinson TG, Sprigg N, Wardlaw JM, Bath PM; Blood pressure in Acute Stroke Collaboration Investigators.

Int J Stroke. 2018 Jan 1:1747493018772733. doi: 10.1177/1747493018772733. [Epub ahead of print]


Haemostatic therapies for acute spontaneous intracerebral haemorrhage.

Al-Shahi Salman R, Law ZK, Bath PM, Steiner T, Sprigg N.

Cochrane Database Syst Rev. 2018 Apr 17;4:CD005951. doi: 10.1002/14651858.CD005951.pub4. Review.


The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

Al-Shahi Salman R, Dennis MS, Murray GD, Innes K, Drever J, Dinsmore L, Williams C, White PM, Whiteley WN, Sandercock PAG, Sudlow CLM, Newby DE, Sprigg N, Werring DJ; RESTART collaborators.

Trials. 2018 Mar 5;19(1):162. doi: 10.1186/s13063-018-2542-6.


Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial.

Dineen RA, Pszczolkowski S, Flaherty K, Law ZK, Morgan PS, Roberts I, Werring DJ, Salman RA, England T, Bath PM, Sprigg N.

BMJ Open. 2018 Feb 3;8(2):e019930. doi: 10.1136/bmjopen-2017-019930. Erratum in: BMJ Open. 2018 Apr 20;8(4):e019930corr1.


The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis.

Ker K, Prieto-Merino D, Sprigg N, Mahmood A, Bath P, Kang Law Z, Flaherty K, Roberts I.

Wellcome Open Res. 2017 Dec 20;2:120. doi: 10.12688/wellcomeopenres.13262.2. eCollection 2017.


Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, Heptinstall S, James M, Krishnan K, Markus HS, Montgomery AA, Pocock SJ, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N; TARDIS Investigators.

Lancet. 2018 Mar 3;391(10123):850-859. doi: 10.1016/S0140-6736(17)32849-0. Epub 2017 Dec 20.


Statistical analysis plan for the 'Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage' (TICH-2) trial.

Flaherty K, Bath PM, Dineen R, Law Z, Scutt P, Pocock S, Sprigg N; TICH-2 investigators.

Trials. 2017 Dec 20;18(1):607. doi: 10.1186/s13063-017-2341-5.


Relationship between race and outcome in Asian, Black, and Caucasian patients with spontaneous intracerebral hemorrhage: Data from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke trial.

Krishnan K, Beishon L, Berge E, Christensen H, Dineen RA, Ozturk S, Sprigg N, Wardlaw JM, Bath PM; VISTA-ICH collaboration and ENOS Investigators.

Int J Stroke. 2018 Jun;13(4):362-373. doi: 10.1177/1747493017744463. Epub 2017 Nov 22.


Cerebral misery perfusion due to carotid occlusive disease.

Maddula M, Sprigg N, Bath PM, Munshi S.

Stroke Vasc Neurol. 2017 May 18;2(2):88-93. doi: 10.1136/svn-2017-000067. eCollection 2017 Jun. Review.


The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression.

Drummond A, Hawkins L, Sprigg N, Ward NS, Mistri A, Tyrrell P, Mead GE, Worthington E, Lincoln NB.

Clin Rehabil. 2017 Oct;31(10):1406-1415. doi: 10.1177/0269215517695857. Epub 2017 Mar 1.


Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination.

Blair GW, Appleton JP, Law ZK, Doubal F, Flaherty K, Dooley R, Shuler K, Richardson C, Hamilton I, Shi Y, Stringer M, Boyd J, Thrippleton MJ, Sprigg N, Bath PM, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):530-538. doi: 10.1177/1747493017731947. Epub 2017 Sep 14.


The Nottingham Fatigue After Stroke (NotFAST) study: results from follow-up six months after stroke.

Hawkins L, Lincoln NB, Sprigg N, Ward NS, Mistri A, Tyrrell P, Worthington E, Drummond A.

Top Stroke Rehabil. 2017 Dec;24(8):592-596. doi: 10.1080/10749357.2017.1368912. Epub 2017 Sep 11.


Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial.

Woodhouse LJ, Scutt P, Hamdy S, Smithard DG, Cohen DL, Roffe C, Bereczki D, Berge E, Bladin CF, Caso V, Christensen HK, Collins R, Czlonkowska A, de Silva A, Etribi A, Laska AC, Ntaios G, Ozturk S, Phillips SJ, Prasad K, Szatmari S, Sprigg N, Bath PM.

Transl Stroke Res. 2018 Apr;9(2):120-129. doi: 10.1007/s12975-017-0548-0. Epub 2017 Aug 2.


Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053).

Appleton JP, Scutt P, Dixon M, Howard H, Haywood L, Havard D, Hepburn T, England T, Sprigg N, Woodhouse LJ, Wardlaw JM, Montgomery AA, Pocock S, Bath PM; RIGHT-2 Investigators.

Int J Stroke. 2017 Jan 1:1747493017724627. doi: 10.1177/1747493017724627. [Epub ahead of print]


Infections Up to 76 Days After Stroke Increase Disability and Death.

Learoyd AE, Woodhouse L, Shaw L, Sprigg N, Bereczki D, Berge E, Caso V, Christensen H, Collins R, Czlonkowska A, El Etribi A, Farr TD, Gommans J, Laska AC, Ntaios G, Ozturk S, Pocock SJ, Prasad K, Wardlaw JM, Fone KC, Bath PM, Trueman RC; ENOS Trial investigators.

Transl Stroke Res. 2017 Dec;8(6):541-548. doi: 10.1007/s12975-017-0553-3. Epub 2017 Jul 27.


Stroke in women - from evidence to inequalities.

Cordonnier C, Sprigg N, Sandset EC, Pavlovic A, Sunnerhagen KS, Caso V, Christensen H; Women Initiative for Stroke in Europe (WISE) group.

Nat Rev Neurol. 2017 Sep;13(9):521-532. doi: 10.1038/nrneurol.2017.95. Epub 2017 Jul 21. Review.


Hypercholesterolaemia and vascular dementia.

Appleton JP, Scutt P, Sprigg N, Bath PM.

Clin Sci (Lond). 2017 Jun 30;131(14):1561-1578. doi: 10.1042/CS20160382. Print 2017 Jul 15. Review.


Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack.

Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, Heptinstall S, Investigators T.

Stroke Res Treat. 2017;2017:7365684. doi: 10.1155/2017/7365684. Epub 2017 May 24.


Incidence of First Stroke in Pregnant and Nonpregnant Women of Childbearing Age: A Population-Based Cohort Study From England.

Ban L, Sprigg N, Abdul Sultan A, Nelson-Piercy C, Bath PM, Ludvigsson JF, Stephansson O, Tata LJ.

J Am Heart Assoc. 2017 Apr 21;6(4). pii: e004601. doi: 10.1161/JAHA.116.004601.


Increasing value and reducing waste in stroke research.

Berge E, Al-Shahi Salman R, van der Worp HB, Stapf C, Sandercock P, Sprigg N, Macleod MR, Kelly PJ, Nederkoorn PJ, Ford GA; European Stroke Organisation Trials Network Committee.

Lancet Neurol. 2017 May;16(5):399-408. doi: 10.1016/S1474-4422(17)30078-9. Review.


Management of acute intracerebral haemorrhage - an update.

Law ZK, Appleton JP, Bath PM, Sprigg N.

Clin Med (Lond). 2017 Apr;17(2):166-172. doi: 10.7861/clinmedicine.17-2-166.


RECAST (Remote Ischemic Conditioning After Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke.

England TJ, Hedstrom A, O'Sullivan S, Donnelly R, Barrett DA, Sarmad S, Sprigg N, Bath PM.

Stroke. 2017 May;48(5):1412-1415. doi: 10.1161/STROKEAHA.116.016429. Epub 2017 Mar 6.


Continuing or Temporarily Stopping Prestroke Antihypertensive Medication in Acute Stroke: An Individual Patient Data Meta-Analysis.

Woodhouse LJ, Manning L, Potter JF, Berge E, Sprigg N, Wardlaw J, Lees KR, Bath PM, Robinson TG; Blood Pressure in Acute Stroke Collaboration.

Hypertension. 2017 May;69(5):933-941. doi: 10.1161/HYPERTENSIONAHA.116.07982. Epub 2017 Mar 6.


Intensive versus Guideline Blood Pressure and Lipid Lowering in Patients with Previous Stroke: Main Results from the Pilot 'Prevention of Decline in Cognition after Stroke Trial' (PODCAST) Randomised Controlled Trial.

Bath PM, Scutt P, Blackburn DJ, Ankolekar S, Krishnan K, Ballard C, Burns A, Mant J, Passmore P, Pocock S, Reckless J, Sprigg N, Stewart R, Wardlaw JM, Ford GA; PODCAST Trial Investigators.

PLoS One. 2017 Jan 17;12(1):e0164608. doi: 10.1371/journal.pone.0164608. eCollection 2017.


Pregnancy, Hormonal Treatments for Infertility, Contraception, and Menopause in Women After Ischemic Stroke: A Consensus Document.

Caso V, Falorni A, Bushnell CD, Acciarresi M, Remohí J, Sprigg N, Gerli S.

Stroke. 2017 Feb;48(2):501-506. doi: 10.1161/STROKEAHA.116.013964. Epub 2017 Jan 9. No abstract available.


Therapeutic Potential of Transdermal Glyceryl Trinitrate in the Management of Acute Stroke.

Appleton JP, Sprigg N, Bath PM.

CNS Drugs. 2017 Jan;31(1):1-9. doi: 10.1007/s40263-016-0387-7. Review.


Granulocyte-Colony Stimulating Factor (G-CSF) for stroke: an individual patient data meta-analysis.

England TJ, Sprigg N, Alasheev AM, Belkin AA, Kumar A, Prasad K, Bath PM.

Sci Rep. 2016 Nov 15;6:36567. doi: 10.1038/srep36567. Review.


Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial.

Bath PM, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Heptinstall S, James M, Krishnan K, Markus HS, Pocock S, Ranta A, Robinson TG, Flaherty K, Scutt P, Venables GS, Woodhouse LJ, Sprigg N.

Int J Stroke. 2017 Jul;12(5):524-538. doi: 10.1177/1747493016677988. Epub 2016 Nov 4.


Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730).

Sprigg N, O'Connor R, Woodhouse L, Krishnan K, England TJ, Connell LA, Walker MF, Bath PM.

PLoS One. 2016 Sep 9;11(9):e0161359. doi: 10.1371/journal.pone.0161359. eCollection 2016.


The Insulin Resistance Intervention after Stroke trial: A perspective on future practice and research.

Bath PM, Appleton JP, Sprigg N.

Int J Stroke. 2016 Oct;11(7):741-3. doi: 10.1177/1747493016660099. Epub 2016 Jul 12.


Blood pressure management in acute stroke.

Appleton JP, Sprigg N, Bath PM.

Stroke Vasc Neurol. 2016 Jun 24;1(2):72-82. doi: 10.1136/svn-2016-000020. eCollection 2016 Jun. Review.


Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials.

Bath PM, Woodhouse L, Krishnan K, Anderson C, Berge E, Ford GA, Robinson TG, Saver JL, Sprigg N, Wardlaw JM, In Acute Stroke Collaboration Basc BP.

Stroke Res Treat. 2016;2016:9706720. doi: 10.1155/2016/9706720. Epub 2016 Apr 17.


Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.

Sprigg N, Robson K, Bath P, Dineen R, Roberts I, Robinson T, Roffe C, Werring D, Al-Shahi Salman R, Pocock S, Duley L, England T, Whynes D, Ciccone A, Laska AC, Christensen H, Ozturk S, Collins R, Bereczki D, Egea-Guerrero JJ, Law ZK, Czlonkowska A, Seiffge D, Beredzie M; TICH-2 Investigators.

Int J Stroke. 2016 Aug;11(6):683-94. doi: 10.1177/1747493016641960. Epub 2016 Apr 5.


Post-stroke dysphagia: A review and design considerations for future trials.

Cohen DL, Roffe C, Beavan J, Blackett B, Fairfield CA, Hamdy S, Havard D, McFarlane M, McLauglin C, Randall M, Robson K, Scutt P, Smith C, Smithard D, Sprigg N, Warusevitane A, Watkins C, Woodhouse L, Bath PM.

Int J Stroke. 2016 Jun;11(4):399-411. doi: 10.1177/1747493016639057. Epub 2016 Mar 22. Review.


Can illness beliefs, from the common-sense model, prospectively predict adherence to self-management behaviours? A systematic review and meta-analysis.

Aujla N, Walker M, Sprigg N, Abrams K, Massey A, Vedhara K.

Psychol Health. 2016 Aug;31(8):931-58. doi: 10.1080/08870446.2016.1153640. Epub 2016 Mar 28. Review.


Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial.

Krishnan K, Scutt P, Woodhouse L, Adami A, Becker JL, Cala LA, Casado AM, Chen C, Dineen RA, Gommans J, Koumellis P, Christensen H, Collins R, Czlonkowska A, Lees KR, Ntaios G, Ozturk S, Phillips SJ, Sprigg N, Szatmari S, Wardlaw JM, Bath PM; ENOS Investigators.

J Stroke Cerebrovasc Dis. 2016 May;25(5):1017-1026. doi: 10.1016/j.jstrokecerebrovasdis.2016.01.010. Epub 2016 Feb 4.


ESCAPS study protocol: a feasibility randomised controlled trial of 'Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm'.

Fletcher-Smith JC, Walker DM, Sprigg N, James M, Walker MF, Allatt K, Mehta R, Pandyan AD.

BMJ Open. 2016 Jan 4;6(1):e010079. doi: 10.1136/bmjopen-2015-010079.


Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis.

Krishnan K, Scutt P, Woodhouse L, Adami A, Becker JL, Berge E, Cala LA, Casado AM, Caso V, Chen C, Christensen H, Collins R, Czlonkowska A, Dineen RA, Gommans J, Koumellis P, Lees KR, Ntaios G, Ozturk S, Phillips SJ, Pocock SJ, de Silva A, Sprigg N, Szatmari S, Wardlaw JM, Bath PM.

Stroke. 2016 Jan;47(1):44-52. doi: 10.1161/STROKEAHA.115.010368. Epub 2015 Dec 8.


Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST).

Scutt P, Blackburn D, Krishnan K, Ballard C, Burns A, Ford GA, Mant J, Passmore P, Pocock S, Reckless J, Sprigg N, Stewart R, Wardlaw JM, Bath PM.

Trials. 2015 Nov 7;16:509. doi: 10.1186/s13063-015-1033-2.


Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke: Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial.

Woodhouse L, Scutt P, Krishnan K, Berge E, Gommans J, Ntaios G, Wardlaw J, Sprigg N, Bath PM; ENOS Investigators.

Stroke. 2015 Nov;46(11):3194-201. doi: 10.1161/STROKEAHA.115.009647. Epub 2015 Oct 13.


Statistical analysis plan for the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial.

Bath PM, Robson K, Woodhouse LJ, Sprigg N, Dineen R, Pocock S; TARDIS Trialists.

Int J Stroke. 2015 Apr;10(3):449-51. doi: 10.1111/ijs.12445. Epub 2014 Dec 30.


Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial.

Krishnan K, Mukhtar SF, Lingard J, Houlton A, Walker E, Jones T, Sprigg N, Cala LA, Becker JL, Dineen RA, Koumellis P, Adami A, Casado AM, Bath PM, Wardlaw JM.

J Neurol Neurosurg Psychiatry. 2015 Nov;86(11):1258-66. doi: 10.1136/jnnp-2014-309845. Epub 2015 Jan 9.


Relationship between poststroke cognition, baseline factors, and functional outcome: data from "efficacy of nitric oxide in stroke" trial.

Ankolekar S, Renton C, Sare G, Ellender S, Sprigg N, Wardlaw JM, Bath PM; ENOS Trial Investigators.

J Stroke Cerebrovasc Dis. 2014 Aug;23(7):1821-9. doi: 10.1016/j.jstrokecerebrovasdis.2014.04.022. Epub 2014 Jun 21.


Views of paramedics on their role in an out-of-hospital ambulance-based trial in ultra-acute stroke: qualitative data from the Rapid Intervention With Glyceryl Trinitrate in Hypertensive Stroke Trial (RIGHT).

Ankolekar S, Parry R, Sprigg N, Siriwardena AN, Bath PM.

Ann Emerg Med. 2014 Dec;64(6):640-8. doi: 10.1016/j.annemergmed.2014.03.016. Epub 2014 Apr 18.


Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461).

Sprigg N, Renton CJ, Dineen RA, Kwong Y, Bath PM.

J Stroke Cerebrovasc Dis. 2014 Jul;23(6):1312-8. doi: 10.1016/j.jstrokecerebrovasdis.2013.11.007. Epub 2014 Mar 27.


Statistical analysis plan for the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial.

Bath PM, Houlton A, Woodhouse L, Sprigg N, Wardlaw J, Pocock S; ENOS Trialists.

Int J Stroke. 2014 Apr;9(3):372-4. doi: 10.1111/ijs.12235. Epub 2014 Mar 3.


Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.

Gibson CL, Srivastava K, Sprigg N, Bath PM, Bayraktutan U.

J Neurochem. 2014 Jun;129(5):816-26. doi: 10.1111/jnc.12681. Epub 2014 Mar 18.

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